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刘家瑞（1938年3月－2025年5月），男，吉林榆树人，中国物理学家，中国科学院物理研究所教授【1】。 教育与早期经历 刘家瑞于1961年毕业于苏联列宁格勒大学（现圣彼得堡国立大学）物理系。
人物经历 刘家瑞教授出生于吉林阿城的世代书香门第，其父亲上世纪20年代毕业于北京师范大学数学系，是当地废除科举后的首位大学生。刘家瑞中学毕业后，以吉林省第一名的成绩被选派至苏联留学，进入列宁格勒大学（现俄罗斯共和国圣彼得堡国立大学）物理系学习理论物理与原子物理，师从诺贝尔奖得主，20世纪最具影响力的苏联物理学家列夫·戴维多维奇·朗道博士。因学业优异，毕业后被保送至苏联科学院从事原子物理研究。当时正值中国三年自然灾害时期，中国大地一穷二白，中苏关系破裂，中央政府急需年轻的人才回国。刘家瑞不顾苏联政府的挽留和阻挠，毅然决然地终止了在苏联的科研工作，返回中国，加入钱三强、何泽慧、彭桓武领导的团队，投身到开发中国原子弹和氢弹的伟大事业中。 
1959年，刘家瑞在苏联列宁格勒大学物理系学习 60年代和70年代，刘家瑞在从事原子物体的研究 1959年，中共中央政治局决定自主研制原子弹，并于1964年成功爆炸第一颗原子弹，1967年成功爆炸第一颗氢弹。 
杨桢（左1）与钱三强（前排右3）、宋任穷（左4）、何泽慧（前排右2）等在苏联
因保密需要，刘家瑞长期隐姓埋名，在艰苦环境下工作，包括在寒冷干燥的沙漠野外进行科学实验，生活条件简陋，导致其呼吸与消化系统健康受损。1974年10月1日，他作为科技工作者代表受周恩来总理邀请参加国务院在北京人民大会堂举办的建国25周年国宴，此事通过《人民日报》公布的嘉宾名单为家人所知。名单中其名后列有数学家陈景润、物理学家汪德昭院士及“中国海防导弹之父”梁守槃院士。 
1978年刘家瑞代表中国政府，出访德意志联邦共和国马克思布兰克研究所进行访问，并发表物理学术演讲。
在刘家瑞教授的言传身教下，其子刘洪斌博士以曾子的“士不可以不弘毅”为人生信条，以“任重而道远” 为毕生追求，将这份“任重道远”的责任感融入实业，自美国斯坦福大学学成并积累足够的工作经验后，创立浙江亚瑟医药有限公司并担任董事长兼CEO。立志通过持续创新，让百姓能用上疗效更好、价格更优的药品，以此践行“救死扶伤”的承诺，履行企业对社会的崇高责任。 工作经历 1961年—1973年，于中国科学院原子能研究所工作，从事实验原子核物理、等离子体物理研究。 1973年—1992年，于中国科学院物理研究所工作，继续从事实验原子核与等离子体物理，后从事离子与固体相互作用及离子与分子和原子相互作用的研究。在此期间，被邀请到意大利弗拉斯卡蒂、澳大利亚悉尼大学、澳大利亚皇家墨尔本理工学院，以及美国德克萨斯 A&M 大学担任访问科学家。 1987年，晋升为副教授。 1980年，出任中国科学院物理研究所离子束实验室负责人。 1986年，被任命为正研究教授。
主要贡献 1、CT‑6 托卡马克装置：参与监督中国首个用于等离子体物理和聚变研究的托卡马克装置（CT-6）的设计、建造、运行和实验【5】【6】。系统地研究了托卡马克中逃逸电子与放电清洗时第一壁杂质释放的关系【7】。 2、离子束物理与技术：负责设计并组建了离子束实验室，发展了卢瑟福背散射（RBS）、质子诱发X射线发射（PIXE）等多种离子束分析技术，并应用于超导体、半导体等材料研究【2】【3】【4】。 3、α‑LiIO₃ 质子通道效应研究：在α-LiIO₃等离子晶体的研究中，首次利用离子束沟道效应研究了静电场中锂原子的运动过程；测量了α- LiIO₃中质子沟道的基本参数。该方法对其他离子导体的研究提供了新的可能【8】【9】。
科研获奖 总结 刘家瑞教授在原子核物理、等离子体物理以及离子束材料科学三个领域均有深厚的研究积累。其主导的 CT‑6 托卡马克项目为我国早期核聚变实验奠定了重要基础；随后在离子束通道效应和离子‑固体相互作用方面的系统实验，为材料改性与核材料研究提供了关键技术平台。迄今为止在国内外已发表600余篇学术论文或专利，主持或参与的科研项目多次获国家级奖励，在国内外核物理与材料科学领域的显著影响，是中国核物理与等离子体物理研究领域的先驱者之一。 参考资料 【1】中国科学院干部局, ed. 中国科学院科学家人名录 [M]. 北京: 科学出版社, 1990: 379. 【2】刘家瑞等. “La、Ce 及 Nd 稀土金属硅化物的生成”. 《物理学报》, 1990 【3】高文玉、李宏成、王瑞兰、刘家瑞. “Mo/Si 体系的离子束混合机制研究”. 《核技术》, 1988 【4】雷子明、刘家瑞、潘广炎. “He⁺ 离子和 Ne 原子碰撞过程中激发态的研究”. 《物理学报》, 1986 【5】中国科学院物理研究所. “CT‑6 托卡马克研究 (I)”. 《Acta Physica Sinica》, 1980 【6】中国科学院物理研究所. “CT‑6 托卡马克研究 (II)——实验结果”. 《Acta Physica Sinica》, 1980 【7】Cross, R. C.; Liu, J. R.; Giannone, L. Effects of discharge cleaning on the production of runaway electrons in TORTUS tokamak. Nuclear Fusion 23 (1983) 791. 【8】刘家瑞、章其初. “质子在 α‑LiIO₃ 单晶中的通道效应研究”. 《核技术》, 1986 【9】刘家瑞、章其初. “在直流电场作用下 α‑LiIO₃ 单晶的通道行为”. 《核技术》, 1986 相关文献 | Document Type | Authors | Current Patent Assignee | Journal Title (Short) | (Series) Volume | Number | Publication Year | Page | DOI | ISSN | Patent Number | Title | Abstract | | Article | Shi, Y. H.; Zhao, B. R.; Zhao, Y. Y.; Li, L.; Liu, J. R. |
| Phys. Rev. B Condens. Matter Mater. Phys. | 38 |
| 1988 | 4488 - 4491 | 10.1103/PhysRevB.38.4488 | 1098-0121 |
| Superconducting and normal-state properties of MoNx thin films | We report here the results of measurements of the superconducting critical temperature, the resistivity ρ(T), the valence band of the electronic density of states, and dH_c2/dT∣_(T_c ) of MoNx thin films and discuss the variation of these experimental results with the concentration of nitrogen. | | Article | Shiduan, Yin; Chunwu, Wu; Jingping, Zhang; Jiarui, Liu; Peiran, Zhu; Yu, Wang |
| Solid State Commun. | 65 |
| 1988 | 1181 - 1184 | 10.1016/0038-1098(88)90918-0 | 0038-1098 |
| AXIAL CHANNELING STUDIES OF HETEROEPITAXIAL In0.25 Ga0.75 As ON GaAs | Axial channeling results are presented for the analysis of the heteroepitaxial growth structure of In0.25 Ga0.75 As on (100) GaAs by MBE. The strain measurements have utilized inclined-direction axial dechanneling and angular scans. Anomalously large dechanneling along the declined (110) axis relative to the (100) growth direction indicates the presence of lattice strain due to lattice mismatch. Imperfections or lattice defects in dislocation nature in the epitaxial layer also give rise to significant dechanneling. | | Article | Zhao, Y. J.; Chu, W. K.; Liu, J. R.; Kulik, J.; Zandbergen, H.; Tao, Y. K. |
| Appl. Phys. Lett. | 61 |
| 1992 | 1968 - 1970 | 10.1063/1.108332 | 0003-6951 |
| Highresolution transmission electron microscopy study of the radiation damage
defects in high temperature superconductors | High resolution transmission electron microscopy (HREM) reveals that MeV heavy ions like Au generate radiation damage defects, a few nanometers in size, in surface regions (about 100 Å) of the superconductors. Much larger defects have been found in the deeper regions of the superconductor sample, which is believed to be due to the larger damage cascade created by the slower ions after their electronic energy loss along the track. Monte Carlo simulation (TRIM) shows the same result in damage size as the HREM study. Light ions, like protons, generate mostly point defects, which are not visible to current electron microscopy. These point defects, although they can pin the flux, are not ideal for flux pinning, due to their small sizes. | | Article | Zhao, Y. J.; Liu, J. R.; Meng, R. L.; Chu, W. K. |
| Physica. C. Supercond.; Physica C (Amsterdam) | 198 |
| 1992 | 256 - 260 | 10.1016/0921-4534(92)90199-M | 0921-4534 |
| Thermal neutron irradiation of 6Li doped Y1Ba2Cu3O7-δ and flux pinning enhancement | Up to 25 times enhancement of magnetic critical current density has been observed at 70 K and 2500 Oe for 3% 6Li-doped sintered YBCO sample irradiated with thermal neutrons at a dose of 1 × 1018 n/cm2. The energetic fusion fragment of 6Li after capturing a thermal neutron can create a uniformly distributed radiation damage. The short life time and small quantity of the radioactive byproducts of the thermal neutron irradiation make this technique quite feasible for practical applications. | | Article | Jin, Jian-Yue; Liu, Jiarui; Van Der Heide, Paul A. W.; Chu, Wei-Kan |
| Appl. Phys. Lett. | 76 | 5 | 2000 | 574 - 576 | 10.1063/1.125821 | 0003-6951 |
| Implantation damage effect on boron annealing behavior using low-energy polyatomic ion implantation | We have studied ion-implantation damage effects on boron clustering and transient enhanced diffusion (TED) by using polyatomic boron (Bn-, n = 1-3) ion implantation with the same atomic boron dose and energy. This Bn- series implantation can produce different amounts of damage with the same boron as-implanted profile and same amount of excess interstitials, hence a net effect of implantation damage can be extracted. Secondary ion mass spectrometry measurements indicate that for 1 keV boron atomic energy implantation and 10 s 1050 C rapid thermal annealing, B1- implantation has less TED and less boron-interstitial clustering than B2- and B3- implantation. A boron trapping peak at the SiO2/Si interface is also speculated since the amount of boron trapped is correlated to the size of implanted ions. | | Article | Shao, Lin; Lu, Xinming; Jin, Jianyue; Li, Qinmian; Liu, Jiarui; Van Der Heide; Chu, Wei-Kan |
| Appl. Phys. Lett. | 76 | 26 | 2000 | 3953 - 3955 | 10.1063/1.126832 | 0003-6951 |
| High-energy recoil implantation of boron into silicon | One approach to fabricate shallow junctions made of B-doped Si is to deposit B on Si, followed by knocking the B into the Si substrate with Si ions. Conventional belief is that the higher the implantation energy, the deeper the recoil profile. While this is true for low-energy incident ions, we show here that the situation is reversed for incident Si ions of higher energy due to the fact that recoil probability at a given angle is a strong function of the energy of the primary projectile. Our experiments show that 500 keV high-energy recoil implantation produces a shallower B profile than lower-energy implantation such as 10 and 50 keV. The secondary ion mass spectrometry analysis shows that the distribution of recoiled B atoms scattered by the energetic Si ions agrees with that calculated on the basis of interatomic potential suggested by W. D. Wilson, L. G. Haagmark, and J. P. Biersack [Phys. Rev. B 15, 2458 (1977)]. Sub-100 nm p+ /n junctions have been realized with a 500 keV Si ion beam. | | Article | Shao, Lin; Lu, Xinming; Wang, Xuemei; Rusakova, Irene; Liu, Jiarui; Chu, Wei-Kan |
| Appl. Phys. Lett. | 78 | 16 | 2001 | 2321 - 2323 | 10.1063/1.1361280 | 0003-6951 |
| Retardation of boron diffusion in silicon by defect engineering | By judiciously placing vacancy and interstitial defects at different depths, we are able to enhance or retard boron diffusion. This opens up a new approach for the formation of shallow P+ n junction in silicon. After preimplantation with 50 or 500 keV Si+ ions to produce a surface vacancy-rich region, we studied the diffusion of deposited B on predamaged samples with annealing between 900 and 1010C. Boron diffusion retardation was observed in both implantation conditions after low temperature annealing with enhancement occurring in a 50 keV implanted sample at high temperature. Choosing high energy implantation to separate vacancies and interstitials can reduce the boron diffusion significantly. Such suppression became more obvious with higher implant doses. A junction less than 10 nm deep (at 1 × 1017 cm-3 according to carrier concentration profiles) can be formed. | | Article | Shao, Lin; Thompson, Phillip E.; Bennett, Joe; Dharmaiahgari, Bhanu P.; Trombetta, Len; Wang, Xuemei; Chen, Hui; Seo, Hye-Won; Chen, Quark Y.; Liu, Jiarui; Chu, Wei-Kan |
| Appl. Phys. Lett. | 83 | 14 | 2003 | 2823 - 2825 | 10.1063/1.1615685 | 0003-6951 |
| Using point-defect engineering to increase stability of highly doped ultrashallow junctions formed by molecular-beam-epitaxy growth | The use of point-defect engineering (PDE) to increase stability of highly doped ultrashallow junctions formed by molecular-beam-epitaxy growth was discussed. It was found that with the MeV implantation, the as-implanted B profile became slightly deeper due to recoil implantation. The analysis showed that the PDE process was advantageous for postgrowth thermal processes above 70℃. | | Article | Shao, Lin; Wang, Xuemei; Rusakova, Irene; Chen, Hui; Liu, Jiarui; Thompson, Phillip E.; Chu, Wei-Kan |
| Appl. Phys. Lett. | 83 | 5 | 2003 | 934 - 936 | 10.1063/1.1596385 | 0003-6951 |
| Study on interfacial dislocations of Si substrate/epitaxial layer by self-interstitial decoration technique | The interfacial dislocation of Si substrate/epitaxial layer by self-interstitial decoration technique was presented. The trapped Si interstitials at the interface were quantitatively measured by Rutherford backscattering spectrometry. It was shown that the interface of Si/Si layer, grown by molecular-beam epitaxy is a strong sink for self-interstitials during MeV bombardment at room temperature. | | Article | Chu; Li; Liu; Wu; Tidrow; Toyoda; Matsuo; Yamada |
| Appl. Phys. Lett. | 72 | 2 | 1998 | 246 - 248 | 10.1063/1.120699 | 0003-6951 |
| Smoothing of YBa2Cu3O7-δ films by ion cluster beam bombardment | Smoothing high-temperature superconductor (HTS) surfaces, especially HTS thin-film surfaces, is crucial for HTS thin-film device processing. In this letter, we describe a method to planarize the surface of a YBa2Cu3O7-δ HTS film down to a smoothness with a standard deviation of 1 nm or better. The method includes first smoothing the HTS surface by ion cluster beam bombardment, followed by annealing in oxygen ambient to regrow the damaged surface layer. Additional YBCO layers can be grown epitaxially on the treated surface, even without removing the top surface layer, which contained some residual damage after annealing. This method can be integrated into HTS circuit fabrication as a key step of planarization. | | Article | Ignatiev; Zhong; Chou; Zhang; Liu; Chu |
| Appl. Phys. Lett. | 70 | 11 | 1997 | 1474 - 1476 | 10.1063/1.118566 | 0003-6951 |
| Large Jc enhancement by ion irradiation for thick YBa2Cu3O7-δ films prepared by photoassisted metalorganic chemical vapor deposition | Thick superconducting films of YBa2Cu3O7-δ grown by photoassisted metalorganic chemical vapor deposition that have shown a decrease of Jc with increasing thickness (>1 μm) have been exposed to ion irradiation in an attempt to enhance Jc. A 4.5 μm thick film irradiated with 1 MeV protons at a dose of 3×1014/cm2 has shown an increase of Jc by a factor of nearly 20-1.7×106 A/cm2 corroborating the proposal that a lack of pinning centers in the grown thick films, due to their high crystalline quality, contributed to the observed decrease of Jc with increasing film thickness. | | Article | Li; Kilner; Liu; Chu; Wagner; Somekh |
| Appl. Phys. Lett. | 68 | 19 | 1996 | 2738 - 2740 | 10.1063/1.115582 | 0003-6951 |
| Secondary ion mass spectroscopy study of Au trapping and migration in the Au+-irradiated YBa2Cu3O7-δ film | A report is presented of the range data for 1.5 MeV Au+ implantation at room temperature and the activating temperature for migration of the implanted Au in a c-oriented YBCO film during annealing. An YBCO film was deposited on a 〈100〉 LaAlO3 single crystal, in situ, by sputtering from a stoichiometric target, using a high-pressure planar dc-sputtering device. The results indicate Au implantation at higher temperatures (about 700C) as providing an alternative method for uniformly doping Au into YBCO films. | | Article | Li; Liu; Cui; Qu; Chen; Chu |
| Appl. Phys. Lett. | 70 | 22 | 1997 | 3029 - 3031 | 10.1063/1.118739 | 0003-6951 |
| Doping silver into YBa2Cu3O7-δ films by 800 keV Ag+ implantation at room temperature and elevated temperatures | A combination of ion implantation and in situ annealing schedule has been used to dope Ag into YBCO films. C-axis oriented YBCO films on (100) LaAlO3 single crystals were prepared by inverted cylindrical magnetron sputtering of a stoichiometric YBa2Cu3O7-δ target. Two films of different thicknesses were chosen for the implantation. After implantation, the samples were in situ annealed in flowing O2 ambient. The results of the study indicate that by designing the energy and the dose of the ion and the thickness of the film, Ag+ implantation at higher temperature can provide an alternative method for doping Ag into YBCO films. | | Article | Shao, Lin; Liu, Jiarui; Wang, Chong; Ma, Ki B.; Zhang, Jianming; Chen, John; Tang, Daniel; Patel, Sanjay; Chu, Wei-Kan |
| Appl. Phys. Lett. | 83 | 26 | 2003 | 5467 - 5469 | 10.1063/1.1636269 | 0003-6951 |
| Response function during oxygen sputter profiling and its application to deconvolution of ultrashallow B depth profiles in Si | Decay length of B yields by secondary ion mass spectrometry (SIMS) with a B δlayer deposited on the Si layer was discussed. Electron-gun evaporation combined with liquid nitrogen cooling of target was used. Deconvolution with the response function was applied to reconstruct the spatial distribution of ultra-low-energy B implants. The results show the decay length as a linear function of the incident oxygen energy. | | Article | Shao, Lin; Zhang, Jianming; Chen, John; Tang; Thompson, Phillip E.; Patel, Sanjay; Wang, Xuemei; Chen, Hui; Liu, Jiarui; Chu, Wei-Kan |
| Appl. Phys. Lett. | 84 | 17 | 2004 | 3325 - 3327 | 10.1063/1.1711179 | 0003-6951 |
| Enhancement of boron solid solubility in Si by point-defect engineering | The application of point-defect engineering (PDE) to enhance the solid solubility of boron (B) in Si was discussed. It was observed that the PDE was used to control boron transient enhanced diffusion (TED) and boride-enhanced diffusion (BED). The boron solid solubility was enhanced by an enhancement factor of 2.5 at 900C over 750-100C range, foe 1×10 15/cm2, 0.5 keV B implant. It was found that the PDE reduced the boron clustering and enhanced boron activation. The results show that the shallow and sharp box-like boron junctions are achieved by PDE with ultralow energy 0.5 keV B implantation. | | Article | Yan; Xie; Wu; Aytug; Gapud; Kang; Fang; He; Tidrow; Kirchner; Liu; Chu |
| Appl. Phys. Lett. | 73 | 20 | 1998 | 2989 - 2991 | 10.1063/1.122653 | 0003-6951 |
| High critical current density in epitaxial HgBa2CaCu2Ox thin films | High-quality epitaxial Hg-1212 thin films were fabricated by reacting Tl-Ba-Ca-Cu-O precursor films in controlled Hg-vapor pressure through Tl-Hg exchange. The high superconducting transition temperatures (Tc) of the films were in the range of 120-124 K. Critical currents densities (Jc) were obtained up to 110 K. The films were found to have shiny, dense and smooth surfaces. | | Article | Gapud; Aytug; Yoo; Xie; Kang; Gapud; Wu; Wu; Liang; Cui; Liu; Chu |
| Physica. C. Supercond. | 308 | 3-4 | 1998 | 264 - 278 | 10.1016/S0921-4534(98)00570-X | 0921-4534 |
| Lithium-doping-assisted growth of HgBa2Ca2Cu3O8+δ superconducting phase in bulks and thin films | The superconducting HgBa2Ca2Cu3O8+δ (Hg-1223) phase has been successfully formed at temperatures as low as 720C, by the addition of Li at a level of 0.1 to 0.4 per unit cell, thus effectively lowering the processing temperature by more than 100C. Data indicate that Li most likely forms a flux which catalyzes the reaction of constituents and the formation of superconducting domains at low temperatures. There are indications that the Li may also help improve the onset of superconductivity by locally perturbing the electronic structure as an interstitial. Applying the process to thin-film fabrication has successfully produced c-oriented film with 73% Hg-1223 phase purity at a processing temperature of 800C and 0.2 Li doping level. | | Article | Chen; Chen; Wang; Yu; Liu; Ma; Chu; Cheng; Yu; Ho; Horng |
| Appl. Phys. Lett. | 87 | 10 | 2005 |
| 10.1063/1.2041829 | 0003-6951 |
| Smoothing of Si0.7 Ge0.3 virtual substrates by gas-cluster-ion beam | The planarization of the SiGe virtual substrate surface is crucial for the fabrication of high-performance strained-Si metal-oxide-semiconductor field-effect transistors. In this letter, we report on the smoothing of the inherently crosshatched rough surfaces of SiGe deposited by molecular beam epitaxy on Si substrates by gas cluster ion beams. Atomic force microscopy measurements show that the average surface roughness (Ra) of the SiGe layer could be reduced considerably from 3.2 to 0.7 nm without any crosshatched pattern. Rutherford backscattering in combination with channeling was used to study the damage produced by cluster bombardment. No visible surface damage was observed for the normal-incidence smoothed SiGe with postsmoothing glancing angle cluster ion beam etching. | | Article | Yuan; Liu; Chen; Wang; Luo; Chen; Kim; Huang; Wang; Jacobson; Donner |
| Appl. Phys. Lett. | 90 | 21 | 2007 |
| 10.1063/1.2741407 | 0003-6951 |
| Epitaxial behavior and transport properties of PrBa Co2 O5 thin films on (001) SrTi O3 | Highly conductive PrBa Co2 O5.5+δ thin films were grown on (001) SrTi O3 by pulsed laser deposition. Microstructural studies from synchrotron x-ray diffraction and transmission electron microscopy reveal that the as-grown PrBa Co2 O5.5+δ films are a -axis oriented with excellent single crystallinity. Two domain structures with c axes in the plane directions parallel to the substrate surface were found with an atomic sharp interface. Transport property and isothermal magnetoresistance measurements for both as-grown and post-annealing were done to understand the physical properties of the films. An abnormal positive magnetoresistance effect was observed in the postannealed films, which suggests that the spins in the system are polarized easier. | | Article | Shao, Lin; Thompson; Chen; Ma; Liu; Chu, Wei-Kan |
| Appl. Phys. Lett. | 93 | 4 | 2008 |
| 10.1063/1.2963480 | 0003-6951 |
| High thermal stability of vacancy clusters formed in MeV Si-self-ion-implanted Si | We have shown that considerable vacancy defects, introduced by MeV Si self-ion implantation, can survive a 900 C5 min annealing for gate formation. By analyzing the trap-limited Si interstitial diffusion, we have characterized these vacancy clusters. Furthermore, we show that the remaining vacancies are sufficient to reduce B diffusion. The study suggests that MeV ion implantation, a promising approach for ultrashallow junction formation in metal-oxide-semiconductor device fabrication, can be inserted before gate formation (involving high temperature annealing) to avoid irradiation damage on gate structures. | | Article | Zhang, Rui; Zhang, Zaodi; Wang, Zesong; Wang, Shixu; Wang, Wei; Fu, Dejun; Liu, Jiarui |
| Appl. Phys. Lett. | 101 | 1 | 2012 |
| 10.1063/1.4732088 | 0003-6951 |
| Nonlinear damage effect in graphene synthesis by C-cluster ion implantation | We present few-layer graphene synthesis by negative carbon cluster ion implantation with C1, C2, and C4 at energies below 20 keV. The small C-clusters were produced by a source of negative ion by cesium sputtering with medium beam current. We show that the nonlinear effect in cluster-induced damage is favorable for graphene precipitation compared with monomer carbon ions. The nonlinear damage effect in cluster ion implantation shows positive impact on disorder reduction, film uniformity, and the surface smoothness in graphene synthesis. | | Conference Paper | Hoover, Brian G.; McMichael, Chase K.; Wood, Lowell T.; Zhang, Zuhua; Liu, Jia-Rui; Chu, Wei-Kan |
| Proc. SPIE Int. Soc. Opt. Eng. | 5897 |
| 2005 | 1 - 10 | 10.1117/12.619144 | 0277-786X |
| Laser-array generators produced by patterned ion irradiation of acrylic films | Ion irradiation of polymer films is a promising process technology for photonics applications that require flexible, lightweight devices resistant to selected environmental variables. Crossed phase gratings that may serve as laser-beam array generators are fabricated using the dry process of irradiation of acrylic (PMMA) films with various doses of high-energy alpha particles through a stencil mask. The gratings are examined with the aid of AFM and SEM images, and Raman-Nath diffraction analysis is applied to estimate the generated refractive-index modulation as a function of the dose. SEM images of a stained grating cross-section suggest a mechanism of unsaturated bond formation and accompanying contraction of the irradiated polymer. Post-irradiation baking is shown to increase the contraction or generated surface relief by around an order of magnitude. Since the index modulation and surface relief due to irradiation tend to cancel, the overall diffraction efficiencies of unbaked gratings do not surpass 67%, although baked gratings can provide higher diffraction efficiencies. | | Article | Yu, Xiangkun; Shao, Lin; Chen; Trombetta; Wang, Chunyu; Dharmaiahgari, Bhanu; Wang, Xuemei; Chen, Hui; Ma; Liu, Jiarui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 249 | 1-2 SPEC. ISS. | 2006 | 414 - 416 | 10.1016/j.nimb.2006.04.041 | 0168-583X |
| MeV-Si ion irradiation effects on the electrical properties of HfO2 thin films on Si | We studied the irradiation effect of 2-MeV Si ions on HfO2 films deposited on Si substrates. HfO2 films ∼11 nm thick were deposited onto 〈1 0 0〉 Si substrates by chemical vapor deposition. The samples were then irradiated by 2-MeV Si ions at a fluence of 1 × 1014 cm-2 at room temperature, followed by rapid thermal annealing at 1000 C for 10 s. After annealing, a layer of aluminum was deposited on the samples as the gate electrode to form metal-oxide-semiconductor (MOS) capacitor structures. Rutherford backscattering spectrometry and electrical measurement of both capacitance and current as a function of voltage were used to characterize the samples before and after annealing. Non-insulating properties of the HfO2 films deteriorated immediately after the ion irradiation, but rapid thermal annealing effectively repaired the irradiation damages, as reflected in improved capacitance versus voltage characteristics and significant reduction of leakage current in the MOS capacitors. | | Conference Paper | Chen, John; Shao, Lin; Lin, Tony; Liu, Jiarui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 237 | 1-2 | 2005 | 155 - 159 | 10.1016/j.nimb.2005.04.091 | 0168-583X |
| The effects of energy non-monochromaticity of 11B ion beams on 11B diffusion | We have shown that energy contamination introduced by ion beam deceleration technology that is used to increase the beam currents available for low energy boron implants, can affect fabricated junctions adversely. A 4 keV 11B beam is extracted and retarded by a potential of -3.5 keV for 0.5 keV 11B implantation, or by a potential of -3.8 keV for 0.2 keV 11B implantation. Intentional beam contamination was introduced by turning off the retarding potential to allow the 4 keV 11B ions to irradiate Si wafers directly. The percentage of contamination, at levels of 0.1%, 0.2% and 0.3% was introduced. Rapid thermal annealing of all the implanted samples was performed under N2 ambient at 1050 C for 1 s. The dopant tail profiles themselves are not significant if the contamination levels are low. However, the much higher damage level coming from high energy contamination increases the transient enhanced diffusion of 11B more than proportionately, resulting in considerable boron diffusion. Energy contamination at a level of 0.1% can extend the profile of 0. 5 keV 11B implants 10 nm deeper after a 1050 C spike annealing. The study shows a highly monoenergetic beam with energy contamination less than 0.1% is required for sub-micron devices. | | Conference Paper | Liu, Jiarui; Wang, Xuemai; Lin, Shao; Chen, Hui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 241 | 1-4 | 2005 | 636 - 640 | 10.1016/j.nimb.2005.07.106 | 0168-583X |
| Small B-cluster ions induced damage in silicon | Small molecule-cluster ions, such as BF2, BSi, BGe, B 10H14 and Bn can be used for shallow junction formation. We studied the cluster induced damage in silicon with different small clusters in keV energy range. The radiation damage was measured by glancing angle RBS/channeling. The measurement shows that the cluster induced damage per atom is quite different from the monomer ion induced damage at the same velocity. The small-cluster ions show strong enhanced radiation damage per atom. In this paper we will show non-linear effects on small boron-cluster induced damage in silicon. The cluster size dependence of this non-linear effect will also be presented. | | Conference Paper | Wang; Liu; Shao; Ma; Chen; Yu; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 241 | 1-4 | 2005 | 885 - 889 | 10.1016/j.nimb.2005.07.146 | 0168-583X |
| Extraction of SiN- ions from source of negative ions by cesium sputtering | We investigated the production of SiN- ions from a source of negative ions by cesium sputtering (SNICS) ion source. Currents up to 17 μA were obtained by optimizing the operation parameters such as the cathode voltage, ionizer current, temperature of the cesium reservoir and fine turning the focussing system. Damage and damage annealing of low energy SiN- implanted in silicon are also studied and reported in this presentation. | | Conference Paper | Chen; Liu; Wang; Iliev; Chen; Yu; Liu; Ma; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 241 | 1-4 | 2005 | 630 - 635 | 10.1016/j.nimb.2005.07.100 | 0168-583X |
| Smoothing of ZnO films by gas cluster ion beam | Planarization of wide-band-gap semiconductor ZnO surface is crucial for thin-film device performance. In this study, the rough initial surfaces of ZnO films deposited by r.f. magnetron sputtering on Si substrates were smoothed by gas cluster ion beams. AFM measurements show that the average surface roughness (Ra) of the ZnO films could be reduced considerably from 16.1 nm to 0.9 nm. Raman spectroscopy was used to monitor the structure of both the as-grown and the smoothed ZnO films. Rutherford back-scattering in combination with channeling effect was used to study the damage production induced by the cluster bombardment. | | Conference Paper | Yu; Shao, Lin; Rusakova, Irene; Wang; Ma; Chen; Liu, Jiarui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 242 | 1-2 | 2006 | 434 - 436 | 10.1016/j.nimb.2005.08.139 | 0168-583X |
| Effect of substrate temperature on the radiation damage from MeV Si implantation in Si | We have investigated the radiation damage by MeV implantation of Si in Si and its evolution under thermal annealing. Si wafers were implanted with MeV Si at various substrate temperatures. Damages were characterized by Rutherford-backscattering (RBS) channeling and by transmission electron microscopy (TEM). Defect formation after post-implantation annealing is very sensitive to the substrate temperatures during implantation. When the substrate temperature was decreased to 200 K, TEM revealed two distinct bands of damage after annealing: one around the mean projected ion range and another at half the projected range. Our study indicates that the formation of defects at half range results from the solid phase epitaxy growth of initial buried amorphous layers. | | Conference Paper | Shao, Lin; Nastasi, Michael; Wang, Xuemei; Liu, Jiarui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 242 | 1-2 | 2006 | 503 - 505 | 10.1016/j.nimb.2005.08.194 | 0168-583X |
| A model for damage caused by cluster implantation: Non-linear effect due to damage overlap | We have developed a mathematical approach to predict the non-linear damages caused by cluster ion-solid interaction. It is based on the Gibbons overlap model, and assuming that two cascades must overlap to form complete disorder and that the level of overlapping is determined by the volume ratio between the cascade from a single atom and the averaged cascades of atoms in the cluster. The calculated results agree well with our experimental data. | | Conference Paper | Shao, Lin; Nastasi, Michael; Thompson, Phillip E.; Rusakova, Irene; Chen, Quark Y.; Liu, Jiarui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 242 | 1-2 | 2006 | 506 - 508 | 10.1016/j.nimb.2005.08.193 | 0168-583X |
| The energy dependence of excessive vacancies created by high energy Si + ion implantation in Si | We have used molecular beam epitaxy grown Sb markers within Si to detect vacancy fluxes created by high energy Si+ ion implants at various energies. Our experiments show that for a constant ion fluence of 1 × 1015 cm-2, the number of free vacancies created by ion implantation, followed by annealing at 900 C, increases with implantation energy. This is in contrast to the instantaneous vacancy creation rate during ion bombardment at the surface, which decreases with increasing ion energy. The possible mechanisms are discussed based on the separation distance between excessive interstitials (at the projected range of ions) and vacancies (near the surface), and the interaction between free vacancies and vacancy clusters. | | Conference Paper | Shao, Lin; Lee; Höchbauer; Nastasi; Thompson, Phillip E.; Rusakova; Seo; Chen; Liu; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 242 | 1-2 | 2006 | 509 - 511 | 10.1016/j.nimb.2005.08.192 | 0168-583X |
| Ion-cut of Si facilitated by interfacial defects of Si substrate/epitaxial layer grown by molecular-beam epitaxy | We have shown that the Si/Si interface produced by molecular-beam epitaxy (MBE) growth of Si on a Si substrate can significantly enhance the efficiency of ion cutting. MBE growth is performed at 650 C. Samples are then implanted at room temperature by 62 keV H- to a dose of 7 × 10 16 ions/cm2. The implantation energy locates H-peak in the vicinity of the Si/Si interface, which is 600 nm below the Si surface. Scanning electron microscopy shows that, after post-implantation annealing at 300 C for 50 min, the H implanted MBE Si has bubbles formed with an average diameters of 33 μm, which is around one order of magnitude larger than that observed in the control bulk silicon sample. It is also observed that the area covered with blisters is a factor of 2 larger for the MBE samples, a trend that is systematically observed for anneals carried out in the range of 300-550 C. | | Conference Paper | Shao, Lin; Nastasi; Thompson, Phillip E.; Chen, Quark Y.; Liu, Jiarui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 242 | 1-2 | 2006 | 670 - 672 | 10.1016/j.nimb.2005.08.191 | 0168-583X |
| Application of high energy ion beam for the control of boron diffusion | For the purpose of optimizing the process of co-implantation of MeV Si ions to reduce boron transient enhanced diffusion and boron-enhanced diffusion in Si, multiple MeV implantations and annealing at different temperatures have been performed. A slight improvement on the suppression of B diffusion is observed by adding a low temperature annealing step after the MeV implantation. No differences in B diffusion are observed when the Si doses are increased from 1 × 1015 to 1 × 1016 cm-2. This dose independent behavior is speculated to be a quasi-steady state of vacancy cluster evaporation. | | Article | Chen; Iliev; Liu; Ma; Chu; Badi; Bensaoula; Svedberg |
| Nucl. Instrum. Methods Phys. Res. B. | 243 | 1 | 2006 | 75 - 78 | 10.1016/j.nimb.2005.08.119 | 0168-583X |
| Room-temperature deposition of diamond-like carbon field emitter on flexible substrates | Room-temperature fabrication of diamond-like carbon electron field emitters on flexible polyimide substrate is reported. These thin film field emitters are made using an Ar gas cluster ion beam assisted C60 vapor deposition method. The bond structure of the as-deposited diamond-like carbon film was studied using Raman spectroscopy. The field emission characteristics of the deposited films were also measured. Electron current densities over 15 mA/cm2 have been recorded under an electrical field of about 65 V/μm. These diamond-like carbon field emitters are easy and inexpensive to fabricate. The results are promising for flexible field-emission fabrication without the need of complex patterning and tip shaping as compared to the Spindt-type field emitters. | | Article | Yu, Xiangkun; Ma; Chen; Wang, Xuemei; Liu, Jiarui; Chu, Wei-Kan; Shao, Lin; Thompson, Phillip E. |
| Nucl. Instrum. Methods Phys. Res. B. | 261 | 1-2 SPEC. ISS. | 2007 | 1146 - 1149 | 10.1016/j.nimb.2007.04.178 | 0168-583X |
| Diffusion of antimony in silicon in the presence of point defects | We have investigated the diffusion of Sb in Si in the presence of defects injected by high-energy implantation of Si ions at room temperature. MeV ion implantation increases the concentrations of vacancies, which induce transient-enhanced diffusion of Sb deposited in Si. We observed a significant enhancement of Sb diffusion. Secondary ions mass spectroscopy has been performed on the implanted samples before and after annealing. Rutherford-backscattering spectrometry has been used to characterize the high-energy implantation damage. By fitting diffusion profiles to a linear diffusive model, information about atomic scale diffusion of Sb, i.e. the generation rate of mobile state Sb and its mean migration length were extracted. | | Article | Zhu, Lei; Martin; Hollander; Wang; Chen; Ma; Yu; Liu; Chu, Wei-Kan; Shao, Lin |
| J Vac Sci Technol B. Microelectron Nanometer Struct | 25 | 4 | 2007 | 1276 - 1279 | 10.1116/1.2749529 | 1071-1023 |
| Instability of junctions formed by low energy B implant and low temperature solid phase epitaxy growth | The stability of p+ n junctions remains a critical issue for device performance. Shallow junctions formed by low temperature solid phase epitaxy growth (LTSPEG) are not stable during additional thermal processes. Anomalous boron diffusion and boron trapping by end-of-range defects are observed during additional furnace annealing. The study shows that, by adding a (MeV) implantation step before LTSPEG, B trapping and B diffusion are significantly reduced during post-LTSPEG annealing. The technique can be used as a method to increase the stability of shallow junctions formed by LTSPEG. | | Conference Paper | Fang, Hui; Alessandrini, Matteo; Wang; Liu; Liang; Chu; Salama |
| IEEE Trans. Appl. Supercond. | 19 | 3 | 2009 | 3520 - 3523 | 10.1109/TASC.2009.2018458 | 1051-8223 |
| Effects of thermal neutron irradiation and oxygen on ti-sheathed MgB 2 wires | The ffects of thermal neutron irradiation and excess oxygen on the properties of Ti-sheathed MgB2 wires were investigated separately in this paper. No significant influence was observed when thermal neutron irradiation with fluence levels of 1.23 × 1014 and 5.75 × 1014 cm-2 were applied on the sample, while fluence level of 3.16 × 1015 cm-2 provided a strong suppression of in-field critical current density. Excess oxygen in sample preparation process had negative effect on the properties of the MgB2 wires. The samples prepared in air possessed lower critical temperature and in-field current carrying capability in comparison with the sample prepared in glove box. | | Article | Wang, Hong-Jun; Zou, Chang-Wei; Yang, Bing; Lu, Hong-Bing; Tian, Can-Xin; Yang, Hui-Juan; Li, Ming; Liu, Chuan-Sheng; Fu, De-Jun; Liu, Jia-Rui |
| Electrochem. Commun. | 11 | 10 | 2009 | 2019 - 2022 | 10.1016/j.elecom.2009.08.042 | 1388-2481 |
| Electrodeposition of tubular-rod structure gold nanowires using nanoporous anodic alumina oxide as template | One-dimensional tubular-rod structure gold nanowires have been prepared using electrodeposition method at constant current mode with confined nanochannels of porous anodic aluminum oxide template. The reduction mechanism of gold ions and formation process of tubular-rod structure gold nanowires are studied. Electron microscopy results show that the tubular-rod structure gold nanowires transform to solid nanorods when the electrodeposition time is long enough. The tubular-rod structure gold nanowires have an average diameter of 180 nm, which coincide with the diameter of the template used. X-ray diffraction results confirm that the tubular-rod structure gold nanowires are crystalline structure. | | Article | Wijesundera, Dharshana; Ma, Ki; Wang, Xuemei; Liu, Biao; Liu, Jia-Rui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 267 | 11 | 2009 | 1948 - 1951 | 10.1016/j.nimb.2009.03.104 | 0168-583X |
| A geometric procedure for improved Rutherford backscattering channeling analysis of materials | Solving geometric and sample alignment issues is a major part of multi-axial Rutherford backscattering channeling (RBS-C) analysis of materials, especially involving complicated samples. However, a geometric standard does not exist for RBS-C, which complicates experimental procedures and makes experimental methods and data presentation inconsistent among different experiments. Our approach to solving RBS-C geometric issues, discussed here, is to introduce a geometric adjustment and sample manipulation procedure which defines the orientation and rotation of the sample with respect to a fixed coordinate system. This method makes rotational, alignment and sample manipulation operations involved in RBS-C more flexible and simpler. As a test case, we present multi-axial RBS-C maps of Si obtained via this methodology. Distortions arising in such RBS-C maps due to geometric effects, how they can affect alignment procedure and data extraction, and how our approach treats these issues are discussed. | | Article | Wang; Ma; Wijesundera; Liu; Liu; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 267 | 20 | 2009 | 3466 - 3470 | 10.1016/j.nimb.2009.08.001 | 0168-583X |
| Azimuthal dependence and accurate determination of the half-angle in RBS channeling | Rutherford Backscattering Channeling (RBSC) is often used in the studies of single crystalline materials with regard to issues hinging upon the location of specific atomic species within the crystal lattice. Results are deduced from the characteristics of an angular scan curve representing the yield of close collision events from the constant scattering of the probing projectiles from the crystalline sample in a sequence of directions lying in a plane perpendicular to one particular crystal lattice direction. Such angular scans exhibit dips near major channels, and their angular widths are of concern. On a fundamental level, accurate determination of these angular widths in the case of axial channeling and their interpretation come up against uncertainties arising out of the absence of a preferred choice for the plane of scan. Here, we shall illustrate these uncertainties in a representative case, channeling of 2 MeV He+ ions in the 〈1 0 0〉 direction of Si. | | Conference Paper | Liu, Qingkai; Liu, Jiarui |
| Proc. SPIE Int. Soc. Opt. Eng. | 7381 |
| 2009 |
| 10.1117/12.835518 | 0277-786X |
| Double-crystal probe with one transmitter and multiple receivers for automatic inspection | A novel type of double-crystal probe with one transmitter and multiple receivers is developed. Based on the probe with one transmitter and one receiver, this designed probe includes one longer transmitting crystal plate and multiple receiving crystal plates with the same length each other. These receiving crystal plates can receive respectively ultrasound echo at the same time. We have manufactured the probe with one transmitter and three or four receivers. Finally we carry out the integrated experiment to test the performance of probe. The testing result shows that three receiving crystal plates have the equal effective sound beam width and uniform sound field distribution. Contrasted to the conventional probe, the novel probe not only overcomes the disadvantage that flaw quantitative error enlarges with the increment of transmitting crystal plate length, but also improves the dynamic coupling stability of probe at the mean time of increasing effective sound beam width. Moreover, resolution to detect flaw near the surface is also advanced. This type of probe can improve effectively the testing speed and flaw detection sensitivity. So the qualification of thick steel plates' automatic inspection is also improved greatly. | | Article | Luo; Luo; Xu; Liu; Yin |
| Appl. Phys. B. | 100 | 4 | 2010 | 811 - 820 | 10.1007/s00340-010-4068-9 | 0946-2171 |
| Modulation instability induced by cross-phase modulation in a dual-wavelength dispersion-managed soliton fiber ring laser | We report on the observation of the modulation instability induced by cross-phase modulation in a dual-wavelength operation dispersion-managed soliton fiber ring laser with net negative cavity dispersion. The passively mode-locked operation is achieved by using a nonlinear polarization rotation technique. A new type of dualwavelength operation, where one is femtosecond pulse and the other is picosecond pulse operation, is obtained by properly rotating the polarization controllers. When the dualwavelength pulses are simultaneously circulating in the laser ring cavity, a series of stable modulation sidebands appears in the picosecond pulse spectrum at longer wavelength with lower peak power due to modulation instability induced by cross-phase modulation between the two lasing wavelengths. Moreover, the intensities and wavelength shifts of the modulation sidebands can be tuned by varying the power of the femtosecond pulse or the lasing central wavelengths of the dual-wavelength pulses. The theoretical analysis of the modulation instability induced by cross-phase modulation in our fiber laser is also presented. Springer-Verlag 2010. | | Article | Yin, Haisen; Xu, Wencheng; Luo, Ai-Ping; Luo, Zhi-Chao; Liu, Jiarui |
| Opt. Commun. | 283 | 21 | 2010 | 4338 - 4341 | 10.1016/j.optcom.2010.06.076 | 0030-4018 |
| Observation of dark pulse in a dispersion-managed fiber ring laser | The observation of dark pulse in a dispersion-managed fiber ring laser with net negative cavity group velocity dispersion (GVD) is reported. Both bright and dark pulses can be obtained in our fiber laser. When we appropriately adjust the cavity birefringence to achieve triple-wavelength mode-locked operation in the laser by rotating the polarization controller, the bright pulse could be switched to dark pulse. It is believed that the dark dispersion-managed (DM) pulse generation is caused by the linear and nonlinear intermodulation effects among the three wavelength pulses. | | Article | Liu, Chuansheng; Li, Ming; He, Jun; Yang, Zheng; Zhou, Lin; Wang, Zesong; Guo, Liping; Jiang, Changzhong; Yang, Shibo; Liu, Jiarui; Lee; Fu, Dejun; Fan, Xiangjun |
| He Jishu. | 33 | 12 | 2010 | 891 - 897 |
| 0253-3219 |
| Accelerator-TEM interface facility and application | An accelerator-TEM interface facility has been established at Wuhan University in 2008. The system consists of an H800 TEM linked to a 200 kV ion implanter and a 2 × 1.7 MV tandem accelerator. Nitrogen ions at 115 keV were successfully transported from the implanter into the TEM chamber through the interface system, and the ion currents measured at the entrance of the TEM column were between 20 and 180 nA. Structural evolution caused by ion irradiation in Si, GaAs, nanocrystal Ag was observed in situ. The in situ observation showed that the critical implantation dose for amorphization of Si is 1014 cm-2. The nuclear material C276 samples implanted with 115 keV Ar+ was also studied, and dislocation loops sized at 3-12 nm were clearly observed after implantation to doses of over 1 × 1015 cm-2. The density of the loops increased with the dose. Evolution to polycrystalline and amorphous structures were observed at 5 × 1015 cm-2 and 3 × 1016 cm-2, respectively. An in situ RBS/C chamber was installed on the transport line of the accelerator-TEM interface system. This enables in situ measurement of composition and location of the implanted species in lattice of the samples. In addition, a 50 kV low-energy gaseous ion generator was installed close to the TEM chamber, which facilitates in situ TEM observation of helium bubbles formed in helium-implanted materials. | | Article | Liu, Jia-Rui; Luo, Zhi-Chao; Luo, Ai-Ping; Yin, Hai-Sen; Xu, Wen-Cheng |
| Microwave Opt. Technol. Lett. | 53 | 5 | 2011 | 1000 - 1003 | 10.1002/mop.25930 | 0895-2477 |
| Switchable dual-wavelength passively Q-switched Erbium-doped fiber ring laser using nonlinear polarization rotation technique | We experimentally demonstrate a switchable dual-wavelength passively Q-switched pulsed operation in an Erbium-doped all-fiber ring laser utilizing the nonlinear polarization rotation technique.At a low pump power of 25 mW, Q-switched pulse train possessing a temporal repetition rate of 12.7 kHz as well as a pulse width of 8.4 μs is generated stably with dual wavelengths centered at 1569.92 nm and 1587.28 nm. In addition, the switching operation between the two wavelengths can be facilely implemented by carefully adjusting the polarization controllers. Self-mode-locking effect is also observed and discussed. | | Article | Liu, Jia-Rui; Xu, Wen-Cheng; Luo, Zhi-Chao; Luo, Ai-Ping; Yin, Hai-Sen |
| Chin. Phys. | 20 | 5 | 2011 |
| 10.1088/1674-1056/20/5/054203 | 1674-1056 |
| Transition state to mode locking in a passively mode-locked erbium-doped fibre ring laser | The transition state between the continuous wave region and the mode-locked region in a passively mode-locked erbium-doped fibre ring laser has been experimentally observed by utilizing the nonlinear polarization rotation technique. When the pump power reaches the mode-locked threshold, the metastable pulse train with a tunable repetition rate is obtained in the transition from the continuous wave state to the passive mode-locked state via proper adjustment of the polarization controller. A simple model has been established to explain the experimental observation. | | Conference Paper | Sun, Dawei; Liu, Jiarui |
|
| 155-156 |
| 2012 | 406 - 410 | 10.4028/www.scientific.net/AMM.155-156.406 | 1660-9336 |
| Computations of hamiltonian homeomorphisms under symplectic reduction in the new sense | This paper studies the extended Hofer norm of hamiltonian homeomorphisms on the symplectic quotient by a compact Lie group.The hamiltonian property is proved for the maps under the symplectic reduction, and the relation between the hamiltonian homeomorphism's extended Hofer norm and the induced one is also shown in the new sense. (2012) Trans Tech Publications. | | Conference Paper | Sun, Dawei; Liu, Jiarui |
|
| 155-156 |
| 2012 | 678 - 681 | 10.4028/www.scientific.net/AMM.155-156.678 | 1660-9336 |
| Existence of nontrivial positive solutions to a semilinear elliptic system with variable coefficients | This paper studies the nontrivial positive solutions to a semilinear elliptic system with variable coefficients in the n dimensional Euclide space. By constructing a new variational space and using some linking theorems, this paper finally proves the existence of positive solution to a semilinear elliptic system. (2012) Trans Tech Publications. | | Article | Shao, Lin; Wang, Xuemei; Rusakova, Irene; Chen, Hui; Liu, Jiarui; Bennett, Joe; Larson, Larry; Jin, Jianyue; Van Der Heide; Chu, Wei-Kan |
| J. Appl. Phys. | 92 | 10 | 2002 | 5788 - 5792 | 10.1063/1.1513206 | 0021-8979 |
| Stability studies of ultrashallow junction formed by low energy boron implant and spike annealing | The stability of junctions formed by spike anneal remains a crucial issue for the device performance. In this study, 0.2 keV B implanted silicon was thermally spike annealed at 1100C. Samples were then furnace annealed under temperatures between 550 and 750C to study their stabilities. We have observed the anomalous diffusion of boron during the post-spike furnace annealing in nitrogen ambient. The anomalous behavior shows two features in the near-surface region and in the tail region. B diffusion in the tail region was transient, e.g., with an enhancement of 103×equilibrium at 700C for the first 60 s. In the near-surface region, a large number of B atoms move toward the native oxide/Si interface with a diffusion rate also transient and similar to that observed in the tail region. It is indicated that interstitials are generated due to spike annealing and will cause instability of the junction during the following thermal processes. 2002 American Institute of Physics. | | Article | Shao, Lin; Thompson, Phillip E.; Bleiler, Roger J.; Baumann, Scott; Wang, Xuemei; Chen, Hui; Liu, Jiarui; Chu, Wei-Kan |
| J. Appl. Phys. | 92 | 10 | 2002 | 5793 - 5797 | 10.1063/1.1513207 | 0021-8979 |
| Reduction of boride enhanced diffusion in MeV-implanted silicon | We demonstrated that implantation of MeV Si ions into a Si substrate can suppress boride-enhanced diffusion (BED) normally associated with a high B concentration layer. In this study, a molecular-beam-epitaxy grown Si layer with a B concentration of 1021/cm3 over a 10 nm region capped with 100 nm Si was used as a source of BED. A sequence of four B delta-doped layers with 100 nm Si spacers was grown prior to the source layer to monitor the diffusion. Half of the sample was implanted with 1 MeV Si ions at a dose of 1016/cm2, followed by annealing at 800, 900, 1000C for different periods of time. For control samples without the MeV Si implant, BED was observed with enhancements of around 40 while the MeV Si-implanted sample showed a reduced, yet nonvanishing, BED with an enhancement of around 8 after annealing at 800C for 1 h. Both BED and suppressed BED with MeV implant show transient behavior with decay after annealing for long periods of time. The effect of high energy implant on B diffusion from surface deposited B layer was also discussed. 2002 American Institute of Physics. | | Article | Shao, Lin; Wang, Xuemei; Liu, Jiarui; Bennett, Joe; Larsen, Larry; Chu, Wei-Kan |
| J. Appl. Phys. | 92 | 8 | 2002 | 4307 - 4311 | 10.1063/1.1505672 | 0021-8979 |
| Athermal annealing at room temperature and enhanced activation of low- energy boron implants with high-energy Si coimplantation | Interactions between shallow implanted boron and high-energy silicon implants have been investigated. Athermal annealing of implantation damage induced by low energy boron implants at room temperature was observed after coimplantation and such annealing effects were more obvious when the dosage of preimplanted Si was increased. Electrical measurements after rapid thermal annealing showed that the activation of B was greatly increased with the dosages of high-energy Si coimplantation. An enhancement of substitutional ratio of B was observed by aligned nuclear reaction analysis. | | Letter | Wang, ZeSong; Zhang, ZaoDi; Zhang, Rui; Wang, ShiXu; Fu, DeJun; Liu, JiaRui |
| Chin. Sci. Bull. | 57 | 27 | 2012 | 3556 - 3559 | 10.1007/s11434-012-5397-3 | 1861-9541 |
| An ultralow-energy negative cluster ion beam system and its application in preparation of few-layer graphene | We developed a cluster ion beam system that produces negative cluster beams of C1-C10 with ion current of 4. 5 nA-50 μA at extraction voltages ranging from 6 to 20 kV. The system uses the injector of a tandetron accelerator and was established by inserting an electrostatic scanner on its ion-optical line and modifying its Faraday cup into a substrate holder. Utilization of clusters enables ultrashallow ion implantation at energies as low as 600 eV/atom without deceleration. Small carbon clusters C2 and C4 were implanted into Ni/SiO2/Si substrates and following post-thermal treatment graphene was obtained. Raman spectroscopy showed characteristic 2D peaks with G-to-2D peak ratios revealing formation of 2-3 layers of graphene. The Raman data reveals clear effect of nonlinear cluster-surface interaction in ion beam synthesis of two-dimensional nanomaterials. | | Article | Luo; Liu; Wang; Luo; Xu |
| Laser Phys. | 22 | 1 | 2012 | 203 - 206 | 10.1134/S1054660X11230125 | 1555-6611 |
| Wide-band tunable passively Q-switched all-fiber ring laser based on nonlinear polarization rotation technique | A wide-band tunable passively Q-switched all-fiber ring laser based on nonlinear polarization rotation (NPR) technique is demonstrated. The NPR-induced intensity-dependent loss effect acts as an artificial saturable absorber, which was used to achieve the Q-switched operation with a low pump threshold of about 25 mW. Taking advantage of the intracavity birefringence-induced spectral filtering effect, the central wavelength of Q-switched pulse can be continuously tuned from 1543.4 to 1592.4 nm by simply rotating the PCs. | | Article | Wijesundera, Dharshana N.;Rajapaksa, Indrajith;Wang, Xeumei;Liu, Jia-Rui;Rusakova, Irene;Chu, Wei-Kan |
| J. Raman Spectrosc. | 44 | 7 | 2013 | 1014 - 1017 | 10.1002/jrs.4326 | 1097-4555 |
| Ion beam engineered nano silver silicon substrates for surface enhanced Raman spectroscopy | We demonstrate a method for engineering substrates for surface enhanced Raman spectroscopy (SERS) by Ag ion implantation in Si. The implantation dose and beam current density are chosen such that the Ag concentration in Si exceeds the solid solubility limit, causes aggregation of Ag and nucleates Ag nano particles. The embedded nano particles are then partially exposed by a wet etch process. Our measurements show that the so fabricated nano-composite substrates are very effective as stable and reproducible SERS substrates. Copyright 2013 John Wiley & Sons, Ltd. | | Article | Zhang; Wang; Zhang; Dai; Wang; Li; Zhou; Shang; He; Fu; Liu |
| Appl. Phys. Lett. | 102 | 19 | 2013 |
| 10.1063/1.4804982 | 0003-6951 |
| Direct graphene synthesis on SiO2/Si substrate by ion implantation | We present results of few-layer graphene synthesis directly on SiO 2/Si substrate by negative carbon ion implantation in Ni catalyst films on the top of SiO2/Si substrate. Negative carbon ions at 20 keV were implanted into Ni films with doses of (4-16) × 1015 cm-2. The implanted carbon atoms dissolved in Ni at an elevated temperature and diffused towards both sides of the Ni film. After annealing, graphene layers were observed on top of the Ni surface and on SiO2 beneath the Ni film. Formation of graphene layers directly on insulating substrates was achieved by etching the top Ni layer. | | Article | Shao, Lin; Chen, John; Zhang, Jianming; Tang; Patel, Sanjay; Liu, Jiarui; Wang, Xuemei; Chu, Wei-Kan |
| J. Appl. Phys. | 96 | 1 | 2004 | 919 - 921 | 10.1063/1.1756685 | 0021-8979 |
| Using point defect engineering to reduce the effects of energy nonmonochromaticity of B ion beams on shallow junction formation | Reducing the effects of energy nonmonochromaticity of B ion beams on shallow junction formation by using point defect engineering (PDE) was discussed. Boron implantation was performed using a high beam current, ultralow energy implanter. It was suggested PDE can reduce boron clustering and enhance boron activation. It was also suggested that shallower and sharper box-like boron junctions can be achieved by PDE with sub-ke V B implants with highly monoenergetic beams. | | Conference Paper | Shao, Lin; Thompson; Wang; Chen; Liu; Chu, Wei-Kan |
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| 2004 | 82 - 89 |
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| Stability of shallow junctions: Issue and solution | We have shown that p+/n junctions formed by ultra low energy B ion implantation and spike rapid thermal annealing (RTA) are not stable during subsequent thermal processes. Anomalous diffusion of boron during the post-RTA furnace annealing has been observed. Such instability was also observed for junctions formed by molecular beam epitaxy growth. Supersaturation of Si interstitials due to coupled boron diffusion is believed to cause the instability. Modeling with specific boundary condition gives a good account of the data over a range of annealing times. Furthermore, we have shown that the technique of point defect engineering with a MeV implantation can effectively stabilize junctions. | | Article | Wang, Xuemei; Liu, Jiarui; Lu, Xinming; Shao, Lin; Chen, Hui; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 215 | 1-2 | 2004 | 278 - 282 | 10.1016/S0168-583X(03)01790-7 | 0168-583X |
| Boron cluster ions from source of negative ions by cesium sputtering | One of the ion implantation challenges for shallow junction formation is the production of high beam current at very low energy. Implantation of boron-containing clusters, such as Bn, SiBn, GeB n and B10H14 is a potential solution for this problem. Due to the higher cluster ion energy for the lower partial energy of the boron atom, the space-charge limit to the transport of the boron-containing cluster ion beams can be reduced by a factor of M/m, where M and m are the masses of the cluster and the boron atom, respectively. For a cluster of n boron atoms, the total gain in the cluster beam transport is n × M/m. In this paper, we will present new data on the extraction of boron-containing clusters with a Source of Negative Ions by Cesium Sputtering. For some clusters, the ion beam current can be increased by 1 to 2 orders of magnitude by adjusting the source parameters. Our experience in the successful extraction of boron-containing clusters may be useful in the design of high current ion sources. | | Conference Paper | Shao, Lin; Thompson, Phillip E.; Van der Heide; Patel, Sanjay; Chen, Quak Y.; Wang, Xuemei; Chen, Hui; Liu, Jiarui; Chu, Wei-Kan |
| J Vac Sci Technol B. Microelectron Nanometer Struct | 22 | 1 | 2004 | 302 - 305 | 10.1116/1.1621887 | 1071-1023 |
| Ultrashallow junction formation by point defect engineering | The technique of point defect engineering (PDE) was investigated to control boride-enhanced diffusion (BED) in ultrashallow junction formation. The approach is based on high-energy ion bombardment with silicon that can spatially separate the distribution of intersitials and vacancies, with a vacancy-rich region formed near the surface region. It was shown that implantation of high energy (MeV) Si ions into a Si substrate can suppress BED. The PDE can also increase the stability of highly doped junction, retard boron diffusion to a rate much less than normal diffusion, sharpen the dopant profile and enhance boron activation. | | Conference Paper | Shao, Lin; Liu, Jiarui; Wang, Chong; Ma, Ki B.; Zhang, Jianming; Chen, John; Tang, Daniel; Patel, Sanjay; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 219-220 | 1-4 | 2004 | 303 - 306 | 10.1016/j.nimb.2004.01.073 | 0168-583X |
| Response function during oxygen sputter profiling for deconvolution of boron spatial distribution | We have studied the spatial distribution of a surface deposited boron layer by secondary ion mass spectrometry (SIMS) using oxygen beams of various incident energies. A boron layer around 0.4 nm thick was deposited by using electron-gun evaporation combined with liquid nitrogen cooling of the target. The SIMS boron profiles can be approximated closely by exponential-like distributions with decay lengths that are linear functions of the incident energy of the oxygen beam. Furthermore, our studies show that corrections to the depth and yield scales due to transient sputtering near the Si surface region must be considered for a plausible deconvolution of the original boron distribution. | | Conference Paper | Shao, Lin; Wang, Xuemei; Rusakova, Irene; Chen, Hui; Liu, Jiarui; Thompson, Phillip E.; Van der Heide; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 219-220 | 1-4 | 2004 | 938 - 941 | 10.1016/j.nimb.2004.01.192 | 0168-583X |
| Study on interfacial dislocations of Si substrate/epitaxial layer by defect trapping | A defect decoration technique has been developed to study evolution of interfacial dislocations. We have found that the interface of Si/Si layer, grown by molecular beam epitaxy, is a strong sink for self-interstitials during MeV bombardment at room temperature. Trapped Si interstitials at the interface were quantitatively measured by Rutherford backscattering spectrometry. The amount of trapped interstitials in the sample with various pre-bombardment annealing indicates a weak binding of stored Si atoms at interfacial dislocations. | | Conference Paper | Chu, Wei-Kan; Shao, Lin; Liu, Jiarui |
| Mater. Res. Soc. Symp. Proc. | 792 |
| 2003 | 297 - 300 | 10.1557/proc-792-r7.1 | 0272-9172 |
| Application of high energy ion beam on the control of boron diffusion | Anomalous diffusion of boron during annealing is a detriment on the fabrication of ultrashallow junction required by the next generation Si devices. This has driven the need to develop new doping methods. In the point defect engineering approach, high-energy ion bombardments inject vacancies near the surface region and create excessive interstitials near the end of projected range of incident ions. Such manipulation of point defects can retard boron diffusion and enhance activation of boron. We will review the current understanding of boron diffusion and our recent activities in point defect engineering. | | Article | Shao, Lin; Wang, Xuemei; Chen, Hui; Liu, Jiarui; Bennett, Joe; Larsen, Larry; Chu, Wei-Kan |
| Electrochem. Solid. State. Letters | 6 | 6 | 2003 | G82-G84 | 10.1149/1.1570631 | 1099-0062 |
| Stability of ultrashallow junction formed by low-energy boron implant and spike-annealing. Problem and solution | Dopant stabilization after high-temperature thermal spike annealing was investigated, 0.2 keV B implanted silicon wafers were thermally spike-annealed at 1100C, followed by furnace annealing between 550 and 750C to study their stabilities. We have observed the anomalous diffusion of boron during the post-spike furnace annealing in nitrogen ambient. It is indicated that p+/n junctions formed by ultralow energy B implant and spike annealing are not stable during subsequent thermal processes. By adding a megaelectronvolt (MeV) implantation after spike annealing, the B profile shows a negligible diffusion during the following furnace annealing at 750C. The concept of MeV implantation can be used as a method to overcome instability of the shallow junction. | | Article | Chen; Wang; Shao; Liu; Yen; Chu, Wei-kan |
| Nucl. Instrum. Methods Phys. Res. B. | 211 | 1 | 2003 | 1 - 6 | 10.1016/S0168-583X(03)01189-3 | 0168-583X |
| Cross-sections of 10B(α, p)13C nuclear reaction for boron analysis | The 10B(α, p)13C nuclear reaction shows great potential in boron depth profiling due to its large cross-section and a narrow resonance in the MeV energy range. Unfortunately, the existing cross-section data on this reaction are too rough for depth profiling. We present an accurate measurement of the cross-section of the (α, p) reaction on 10B using a boron thin film on a Si substrate, high-resolution detection and careful analysis of the proton spectra. Angular distributions of the cross-section at the resonant energy Er = 1512 keV are also presented. The sharp resonance at 1512 keV was used to measure the B depth distribution in a borophosphosilicate glass (BPSG) thin film. The boron concentration profiles are compared with SIMS measurement and are found in good agreement. | | Review | Shao, Lin; Liu, Jiarui; Chen, Quark Y.; Chu, Wei-Kan |
| Mater. Sci. Eng. R Rep. | 42 | 3-4 | 2003 | 65 - 114 | 10.1016/j.mser.2003.08.002 | 0927-796X |
| Boron diffusion in silicon: The anomalies and control by point defect engineering | The fabrication of ultra large-scale integrated (ULSI) circuits with ever shrinking feature size requires a continued reduction of diffusion lengths of dopants in Si. However, boron implants undergo an "anomalous" diffusion upon annealing, which is detrimental to the ultra-shallow junction formation. Over the last decade, boron transient diffusion has been much better understood. This implantation-induced transient-enhanced diffusion is known to be driven by the large supersaturation of self-interstitial silicon atoms emitted from the extended defects. The form and evolution of implantation-induced defects with respect to implant species, energy, dose, and annealing temperature have been systematically studied. The improved understanding has led to the development of new doping techniques, such as carbon co-implant, multiple step annealing and point defect engineering (PDE) using co-implantation of high-energy ions. In the PDE approach, high-energy ion bombardments inject vacancies near the surface region and create excessive interstitials near the end of projected range deep inside the substrate. Such manipulation of point defects can retard boron diffusion and enhance the activation of boron. The control of boron diffusion could be used to form ultra-shallow junctions for next generation Si device. In this article, we review the history and recent progress in PDE. | | Conference Paper | Lu, Xinming; Shao, Lin; Wang, Xuemei; Liu, Jiarui; Chu, Wei-Kan; Bennett, Joe; Larson, Larry; Ling, Peiching |
| J Vac Sci Technol B. Microelectron Nanometer Struct | 20 | 3 | 2002 | 992 - 994 | 10.1116/1.1479361 | 1071-1023 |
| Cluster-ion implantation: An approach to fabricate ultrashallow junctions in silicon | The formation of ultrashallow junctions of silicon by the cluster-ion implantation technique was demonstrated. The use of heavy atom-boron cluster ions effectively reduced the boron energy required for shallow-junction formation. SiB, SiB2 and GeB cluster ions were generated by a cesium sputtering ion source and produced the 2keV boron required for the low-energy ion implantation. Shallow junctions with energies of 6.88, 8.82 and 15 keV were obtained. The effects of a 550 C preannealing before a 1000C rapid thermal annealing procedure was also discussed. | | Conference Paper | Shao, Lin; Liu, Jiarui; Wang, Xuemei; Chen, Hui; Thompson, Phillip E.; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 206 |
| 2003 | 413 - 416 | 10.1016/S0168-583X(03)00777-8 | 0168-583X |
| Reduction of boride-enhanced diffusion by point defect engineering and its application for shallow junction formation | Point defect engineering using high energy ion bombardment can be used as a method to inject vacancies near the surface region with excessive interstitials created near the end of the projected range. We demonstrated that implantation of MeV Si ions into a Si substrate can suppress boride-enhanced diffusion normally associated with a high B concentration layer. The concept of boron diffusion control can be used as an approach to form ultra-shallow junction. | | Conference Paper | Wang, Chong; Seo, Hye-Won; Su, Chun-Jung; Wang, Yuh-Huah; Chen; Lu, Xinming; Liu; Johansen, Tom; Chu |
| Int. J. Mod. Phys. B | 15 | 24-25 | 2001 | 3357 - 3358 | 10.1142/S0217979201007762 | 0217-9792 |
| Magneto-optic imaging of proton-irradiated high Tc superconducting thin films: A revisit of Jc(T) functional and flux pinning enhancement | We have performed systematic quantitative measurements of the critical current density Jc(B,T) for YBCO thin films proton-irradiated to various dosages using the MOI technique. Results for external magnetic fields up to 400Oe and temperature ranging from 5 to 80K are presented for a 600nm thick YBCO film irradiated by proton up to a dosage of 1016cm-2 at 500 keV. While no significant differences were observed for T>50K, the Jc values consistently increased with the increasing external field for T<50K. | | Article | Wang; Chen; Shao; Liu; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 196 | 1-2 | 2002 | 100 - 104 | 10.1016/S0168-583X(02)01301-0 | 0168-583X |
| Non-linear effect of copper cluster ions induced damage in silicon | We have observed a strong non-linear effect in copper cluster ions induced damage in silicon. Copper cluster ions Cun (n=1,2,...,7) were extracted from a source of negative ions by cesium sputtering. P-type silicon wafers were irradiated with copper cluster ions at an atomic dosage range of 8 × 1012 to 1 × 1015 atoms/cm2 at the energy of 6 keV/atom. The quantitative characterization of the cluster ion induced damage was performed by Rutherford backscattering spectrometry/channeling analysis. Comparison with analytical overlapping model shows very good agreement. | | Article | Wang; Lu; Shao; Liu; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 196 | 1-2 | 2002 | 198 - 204 | 10.1016/S0168-583X(02)01302-2 | 0168-583X |
| Small cluster ions from source of negative ions by cesium sputtering | We investigated the delivery of small cluster ions using a source of negative ions by cesium sputtering (SNICS). The negative cluster ions of Bn, Cn, Sin, Con, Cun, Gen, Aun, GeBn and SiBn have been extracted by SNICS. Adequate beam current of some small clusters was obtained by changing several parameters for cluster ion yield. After a comprehensive study of the operation parameters, such as target material selection, target geometry, sputtering voltage and current, the small cluster ion current can be increased by several orders of magnitude, with little change on the monomer ion yield. | | Article | Shao, Lin; Liu; Thompson; Wang; Rusakova; Chen; Chu, Wei-Kan |
| Electrochem. Solid. State. Letters | 5 | 10 | 2002 | G93-G95 | 10.1149/1.1504903 | 1099-0062 |
| Point defect engineering and its application in shallow junction formation | Point defect engineering using high-energy ion bombardment can be used as a method to inject vacancies near the surface region with excessive interstitials created near the end of the projected range deep inside the substrate. We demonstrate that implantation of MeV Si ions into a Si substrate can suppress boride-enhanced diffusion normally associated with a high B concentration layer. B atoms from a surface-deposited boron layer experienced a suppressed diffusion during annealing if the Si substrate was preimplanted with MeV Si ions, and the retardation of B diffusion became more effective with higher dosages. The concept of boron diffusion control was used as an approach to form ultrashallow junctions. | | Article | Liu; Wang; Shao; Chen; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 197 | 1-2 | 2002 | 101 - 106 | 10.1016/S0168-583X(02)01357-5 | 0168-583X |
| Non-linear effect of gold cluster ion induced damage in silicon | We observed as much as 50% more damage for Au-cluster ion implantation in Si as compared with that of the Au monomer in the energy range of 6 keV/atom. This is contrary to the literature where the linear damage result was reported. In this experiment, small gold clusters Aun with n from 1 to 4 were used. Energy of 6 keV per Au atom was applied to bombard the Si single-crystal surface. The radiation damage was characterized by Rutherford backscattering spectrometry/channeling in the number of Si atom displacements per Au atom. We have also studied this non-linear effect in a wide range of fluences from 8 × 1012 to 1.2 × 1015 Au-atoms/cm2 and observed a fluence-dependent effect. At higher fluence, sputtering and overlapping of the damage will reduce the damage efficiency, therefore reducing the non-linear effect. This could be the reason that earlier publication did not observe the non-linear effect. | | Conference Paper | Shao, Lin; Lu, Xinming; Wang, Xuemei; Rusakova, Irene; Liu, Jiarui; Chu, Wei-Kan |
| J Vac Sci Technol B. Microelectron Nanometer Struct | 20 | 1 | 2002 | 419 - 421 | 10.1116/1.1424283 | 1071-1023 |
| Defect engineering: An approach on ultrashallow junction in silicon | Ultrashallow junction formation in silicon was demonstrated by thermal diffusion of surface deposited boron into an ion implantation irradiated silicon substrate. 10 nm thick boron layers were deposited onto an ion implantation irradiated substrate, by electron-gun deposition. Samples were annealed using rapid thermal processor under continuous nitrogen flow. Results indicated that the surface deposited boron experienced a suppressed diffusion during annealing if the Si substrate was preimplanted with 50 or 500 keV, 5×1014 cm-2 silicon ions. | | Article | Chou, Hsiung; Lin; Hsu; Chow; Hong; Chen; Liu; Tsai |
| J. Vac. Sci. Technol. A Vac. Surf. Films | 20 | 2 | 2002 | 441 - 446 | 10.1116/1.1450579 | 0734-2101 |
| Polishing effect of the plasma on the growth of YBa2Cu3O7-δ films by radio frequency sputtering | The polishing effect of the plasma on the growth of YBa2Cu3O7-δ films by radio frequency sputtering was discussed. It was observed that when the substrates were in the influence range of the plasma, the negative oxygen ions resputtered the mobile atoms on the surface of films back into the plasma. The results showed that when the separation distances and angle between the heater and the gun were in the suitable range, the negative oxygen ions provided a polishing effect which suppressed the growth of precipitates without slowing down the growth of grains, thereby yielding a smooth and precipitate free film. | | Conference Paper | Zhai; Chen; Liu; Chu |
| Mater. Res. Soc. Symp. Proc. | 636 |
| 2001 | D581-D585 |
| 0272-9172 |
| Nanofabrication of planar high temperature superconducting Josephson junctions using focused ion beam technology | Superconductor-normal metal-superconductor (SNS) high-Tc Josephson junctions have been fabricated on c-oriented YBa2Cu3O7-δ (YBCO) films. Focused ion beam (FIB) nano-structure modification (cutting of the film and local deposition of a metal) was used to form the junction with tungsten barrier. The junctions exhibit resistively shunted junction (RSJ) -like I-V characteristics. | | Article | Sharma; Venkatesan; Zhang; Liu; Chu; Chu |
| Phys. Rev. Lett. | 77 | 22 | 1996 | 4624 - 4627 | 10.1103/PhysRevLett.77.4624 | 0031-9007 |
| Evidence for large static and dynamic distortions in high Tc superconducting YBa2Cu3O7-δ crystals over a wide temperature range | Large deviations from the expected atomic thermal vibrational amplitude in Cu-O rows in a YBa2Cu3O7-δ (Tc = 92.5 K) crystal have been observed in a wide temperature range (300-30 K) by ion channeling. In contrast, Y-Ba as well as Cu-O rows in nonsuperconducting deoxygenated YBa2Cu3O6.2 specimens show a normal decrease in the atomic vibrational amplitude as the sample temperature is lowered. These anomalous results in the YBCO superconductor provide a clear indication of uncorrelated static and dynamic distortions associated with Cu-O rows. Possible implications of these structural changes are discussed. | | Article | Li, Yupu; Kilner; Liu; Chu; Wagner; Somekh |
| Appl. Phys. Lett. | 68 | 19 | 1996 | 2738 - 2740 | 10.1063/1.115582 | 0003-6951 |
| Secondary ion mass spectroscopy study of Au trapping and migration in the Au-irradiated YBa2Cu3O7-δ film | The range data and migration of Au in YBa2Cu3O7-δ film were studied with implanted 197Au (1.5 MeV 5×1015 Au+/cm2) as a tracer. The film was a c-axis oriented film, ∼750 nm thick, deposited by high-pressure planar dc sputtering on 〈100〉 LaAlO3. Analysis by secondary ion mass spectroscopy shows that the as-implanted Au concentration distribution is essentially Gaussian-like and the depth (Rp) of maximum Au concentration (∼1.2 wt%) is 201 nm. The projected range (Rp) and (Rp) are found to be in very good agreement with the simulated data by TRIM-95, whereas the measured ''straggle'' (ΔRp*) is about 20% larger than that by TRIM-95 simulation. It has also been found that the implanted 197Au starts to migrate within the film at a temperature between 650 and 700 C, which is much higher than that for the implanted 2H (∼175 C) and the implanted 18O (between 250 and 300C) in c-oriented YBa2Cu3O7-δ films. | | Article | Wilson; Liu; Romero-Borja; Chu, Wei-Kan |
| J. Mater. Res. | 14 | 11 | 1999 | 4431 - 4436 | 10.1557/JMR.1999.0600 | 0884-2914 |
| Study of hydrogen annealing of ultrahigh molecular weight polyethylene irradiated with high-energy protons | Ultrahigh molecular weight polyethylene, an important biomaterial for orthopedic implants, was irradiated with 2.6- and 3-MeV H+ ions at low doses from 5.7×1011 to 2.3×1014 ions/cm2. Fourier transform infrared spectroscopy showed that irradiation resulted in increased free radicals, carbon double bonds, and increased methyl and vinyl end groups. The free radicals resulted in poor polymer oxidative stability, as measured by increased carbonyl concentration. Hydrogen annealing after ion irradiation reacted with the free radicals generated during proton irradiation resulted in a 40-50% decrease in infrared absorption associated with carbonyl and prevented further oxidation. | | Conference Paper | Lu; Shao; Jin; Li; Rusakova; Chen; Liu; Chu; Ling |
| Mater. Res. Soc. Symp. Proc. | 610 |
| 2000 | B.4.5.1-B.4.5.5 |
| 0272-9172 |
| Ultra-shallow junction formation via GeB-ion implantation of Si | GeB- Cluster ions have been used to effectively produce 0.65-2KeV boron for low energy ion implantation. We have generated the GeB- cluster ions using the SNICS ion source (source of negative ion by cesium sputtering). Shallow junctions have been made by the GeB- cluster ions implanting into Si substrates at 15keV, 1×1015/cm2 and 5keV, 5×1014. The junction depth as small as 37nm has been achieved by rapid thermal annealing of the 5 keV sample at 1000C for 1 second. A two-step annealing was also performed to study the diffusion of B in the GeB- ion cluster implanted Si by annealing the 15 keV implanted sample at 550C/300sec+1000C/10sec. We found that the junction depth of the two-step annealed sample was only half of the one-step annealed sample. TEM (transmission electron microscopy) showed clear recrystallization of the amorphized layer with no observable residual defects. We briefly discussed the role of Ge in regards to reduction of the junction depth. | | Conference Paper | Shao; Lu; Jin; Li; Rusakova; Liu; Chu |
| Mater. Res. Soc. Symp. Proc. | 610 |
| 2000 | B6.8.1-B6.8.6 |
| 0272-9172 |
| Depth profiles of high-energy recoil implantation of boron into silicon | We have studied boron profiles by using the ion beam recoil implantation. A boron layer was first deposited onto Si, followed by irradiation with Si ions at various energies to knock the boron. Conventional belief is that the higher the implantation energy, the deeper the recoil profiles. While this is true for low-energy incident ions, we show here that the situation is reversed for incident Si ions of higher energy due to the fact that recoil probability at a given angle is a strong function of the energy of the primary projectile. Our experiments show that 500-keV high-energy recoil implantation produces a shallower B profile than lower-energy implantation such as 10 keV and 50 keV. The secondary-ion-mass-spectrometry (SIMS) analysis shows that the distribution of recoiled B atoms scattered by the energetic Si ions agrees with our calculation results. Sub-100 nm p+/n junctions have been realized with a 500-keV Si ion beam. | | Article | McCarten; Miller Jr.; Xu; Pirtle; Liu; Chu, Wei-Kan; Claycorab; Chu, Rambis K. |
| Physica. C. Supercond. | 341-348 | PART 3 | 2000 | 789 - 790 | 10.1016/S0921-4534(00)00694-8 | 0921-4534 |
| Zero-bias resistance anomalies in normal metal/charge-density wave interfaces | A number of reduced dimensional conductors, such as K0.3MoO3, NbSe3, and TaS3, exhibit collective charge density wave (CDW) transport. We report on the observation of zero-bias anomalies in the differential resistance of NbSe3 crystals near an interface between strongly pinned and weakly pinned regions of a CDW, where current is being converted from normal metallic to CDW current. We observe a dramatic drop in zero-bias resistance, suggesting a new phase transition, when the temperature is cooled below 44 K. | | Article | Li, Yupu; Liu; Cui, Xingtian; Qu; Chen; Chu, Wei-Kan |
| Appl. Phys. Lett. | 70 | 22 | 1997 | 3029 - 3031 | 10.1063/1.118739 | 0003-6951 |
| Doping silver into YBa2Cu3O7-δ films by 800 keV Ag+ implantation at room temperature and elevated temperatures | Thin films (∼0.43 and ∼0.95 μm thick) of YBa2Cu3O7-δ on (100) LaAlO3 substrates have been implanted with 800 keV Ag+ to a dose of 5×1014/cm2, at room temperature (i.e., the total range ≈ 0.4 μ and the damage level ≈ 3.1 displacements per atom) and at elevated temperatures (450, 650, and 780 C), followed by an in situ annealing schedule in flowing oxygen ambient. We have found that the implantation at room temperature amorphizes the implanted layer. In such a case, the implanted layer cannot regrow to the superconducting phase if there is no crystal seed remaining in the bottom of the film, whereas implantation at elevated temperatures plus an in situ annealing schedule, including a step at 870 C in flowing oxygen ambient, can maintain the crystal structure and superconductivity of the films. For the thicker film, we have found that after the implantation at 450 or 650 C and the in situ annealing, the total volume of the film has recovered to the superconducting 123 phase with a Tc = 89 K. | | Conference Paper | Joos; Van Der Heide; Liu; Christoffersen; Chu; Mims |
| Mater. Res. Soc. Symp. Proc. | 548 |
| 1999 | 605 - 610 |
| 0272-9172 |
| Surface oxygen exchange kinetics and oxygen diffusion rates in YSZ single crystals | Isotope exchange with C18O2 followed by depth profiling analysis was used to study surface exchange and bulk diffusion of oxygen in single crystal ((100) surface orientation) yttria-stabilized zirconia (YSZ) in the temperature range 250C - 350C. The depth profiles, which were obtained using 18O(ρ,α)15N nuclear reaction analysis (NRA) and secondary ion mass spectrometry (SIMS), reveal both the bulk oxygen diffusion coefficients (D) and surface exchange coefficients (k). Bulk oxygen diffusion coefficients are consistent with an extrapolation to lower temperature of previously published results with an activation energy of 114 kJ/mol (1.2 eV). The surface exchange rates, however, depend strongly on the gas exchange species. Much higher exchange rates are observed with C18O2 than with 18O2 (over four orders of magnitude when compared to an extrapolation to lower temperatures of previously published results) with a measured activation energy of 152 kJ/mol (1.6 eV). This faster surface exchange rate enabled measurable 18O tracer profiles to be generated at lower temperatures than previously reported, further contributing to the understanding of YSZ material properties and bringing to light a possible order/disorder transition similar to that previously observed at 650C. | | Article | Sharma; Ogale; Zhang; Liu; Chu; Veal, Boyed; Paullkas; Zheng; Venkatesan |
| Nature | 404 | 6779 | 2000 | 736 - 740 | 10.1038/35008018 | 0028-0836 |
| Phase transitions in the incoherent lattice fluctuations in YBa2Cu3O(7-δ) | The growing body of experimental evidence for the existence of complex textures of charges and spins in the high-temperature superconductors has drawn attention to the so-called 'stripe-phase' model as a possible basis for the mechanism of superconductivity in these materials. Such observations have until now been restricted to systems where the texture dynamics are slow or suppressed altogether, and do not include the important case of YBa2Cu3O(7- δ). It seems likely that the dynamic behaviour of stripes, which has been suggested to undergo several phase transitions as a function of temperature, should also be reflected in the lattice properties of the host materials, and this forms the motivation for our present experiments. Specifically, we use MeV helium ion channelling, an ultrafast real-space probe of atomic displacements (with sub-picometre resolution), to probe incoherent lattice fluctuations in YBa2Cu3O(7-δ) as a function of temperature and oxygen doping. We detect lattice fluctuations that are larger than the expected thermal vibration component, and which show anomalies characteristic of the phase transitions anticipated for a dynamic stripe phase. Comparison of our lattice results with single-particle-tunnelling and photoemission data highlights the importance of spin-charge separation phenomena in the copper oxide superconductors. | | Article | McCarten; Jones; Wu; Miller Jr.; Pirtle; Xu; Claycomb; Liu; Chu |
| J. Phy. IV JP | 9 | 10 | 1999 | Pr10-129-Pr10-132 |
| 1155-4339 |
| Phase slip scaling relationship for the 59 K and 143 K charge-density-waves in NbSe3 | Selective area irradiation was used to create irradiated/unmodified/irradiated CDW heterostructures with well-defined interfaces on a single NbSe3 crystal. The temperature dependence of the extra voltage required for carrier conversion (phase slip voltage, Vps0) is extracted from length dependent studies. We find that the temperature dependence of Vps0 for the 143 K and 59 KCDW transitions are identical if properly scaled by the transition temperature. The Vps0 temperature dependence is not thermally activated, but contains an upper and lower temperature branch. The crossover temperature for the two branches is 0.75 Tp. For the 59 K CDW we observe a zero-bias resistance anomaly near a single irradiated/unmodified interface. This anomaly abruptly changes with temperature near 44 K suggesting a qualitative change in the phase slip mechanism near 0.75 Tp. | | Article | Oladeji; Chow; Liu; Chu; Bustamante; Fredricksen; Schulte |
| Thin Solid Films | 359 | 2 | 2000 | 154 - 159 | 10.1016/S0040-6090(99)00747-6 | 0040-6090 |
| Comparative study of CdS thin films deposited by single, continuous, and multiple dip chemical processes | We have used Rutherford backscattering spectrometry (RBS), X-ray diffraction (XRD), Raman, and photoconductivity to characterize CdS thin films grown by single, continuous, and multiple dip chemical processes. XRD has further shown, without ambiguity, that grown CdS films, independent of the process, in an almost homogeneous reaction free basic aqueous bath have a zincblende crystal structure where reflections from (111), (200), (220), and (311) planes are clearly identified. RBS, Raman, and photoconductivity confirm the high stoichiometry and excellent structural properties with low optically active trap state density of single and continuous dip CdS films. However, they collectively suggest that multiple dip CdS films suffer from defects that act as carrier traps and lead to prolong photoconductivity decay in these films. | | Article | Liu; Li; Chen; Cui; Christoffersen; Jacobson; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 136-138 |
| 1998 | 1306 - 1311 | 10.1016/S0168-583X(97)00835-5 | 0168-583X |
| Depth resolution and dynamic range of 18O(p,α)15N depth profiling | This paper discusses an approach to get better depth resolution and the 2-3 μm dynamic range needed for diffusion studies of oxygen, using 18O(p,α)15N nuclear reaction analysis (NRA). This was achieved by optimizing the experimental parameters, and using fast electronics without the absorber in front of the detector. By energy analysis of the α-particles, a depth resolution of 170 to 300 A was obtained with the dynamic range varying from the surface to a depth of 3 μm. Problems in data analysis, i.e., the cross sections and energy straggling will be discussed. Examples in depth profiling of 18O-implanted SrTiO3 single crystals and Yttrium stabilized zirconia (YSZ) single crystals annealed in 18O at high temperature are presented. | | Article | Gapud; Aytug; Yoo; Xie; Kang; Gapud; Wu; Wu; Liang; Cui; Liu; Chu |
| Physica. C. Supercond. | 308 | 3-4 | 1998 | 264 - 278 | 10.1016/S0921-4534(98)00570-X | 0921-4534 |
| Lithium-doping-assisted growth of HgBa2Ca2Cu3O8+δ superconducting phase in bulks and thin films | The superconducting HgBa2Ca2Cu3O8+δ (Hg-1223) phase has been successfully formed at temperatures as low as 720C, by the addition of Li at a level of 0.1 to 0.4 per unit cell, thus effectively lowering the processing temperature by more than 100C. Data indicate that Li most likely forms a flux which catalyzes the reaction of constituents and the formation of superconducting domains at low temperatures. There are indications that the Li may also help improve the onset of superconductivity by locally perturbing the electronic structure as an interstitial. Applying the process to thin-film fabrication has successfully produced c-oriented film with 73% Hg-1223 phase purity at a processing temperature of 800C and 0.2 Li doping level. | | Article | Yan; Xie; Wu; Aytug; Gapud; Kang; Fang; He; Tidrow; Kirchner; Liu; Chu |
| Appl. Phys. Lett. | 73 | 20 | 1998 | 2989 - 2991 | 10.1063/1.122653 | 0003-6951 |
| High critical current density in epitaxial HgBa2CaCu2OX thin films | High quality superconducting HgBa2CaCu2Ox (Hg-1212) thin films have been reproducibly fabricated using cation-exchange method. The thin films have pure Hg-1212 phase and have smooth surface morphology. The superconducting transition temperatures of these films are in the range of 120-124 K. The critical current density Jc is up to 3.2×106A/cm2 at 77 K and drops only by a factor of 2 at 100 K and self field. At 110 K, a Jc of 7.8×105A/cm2 has been obtained. X-ray diffraction pole figures show that these films are epitaxially grown on LaAlO3(001) substrates, which is consistent with a χmin of 19% obtained using Rutherford backscattering/channeling analysis. | | Article | Miinea, Liliana; Suh, Seigi; Bott, Simon G.; Liu, Jia-Rui; Chu, Wei-Kan; Hoffman, David M. |
| J. Mater. Chem. | 9 | 4 | 1999 | 929 - 935 | 10.1039/a808460b | 0959-9428 |
| Synthesis of aluminium and gallium fluoroalkoxide compounds and the low pressure metal-organic chemical vapor deposition of gallium oxide films | Aluminium and gallium fluoroalkoxide complexes of formula M(OR(f))3(HNMe2) [M = Al or Ga; R(f)= CH(CF3)2, CMe2(CF3) or CMe(CF'3)2] were prepared by reacting the corresponding metal dimethylamide complexes with fluorinated alcohols. The dimethylamine adducts reacted with 4-dimethylaminopyridine to give M (OR(f))3 (4-Me2Npy) [M = Al or Ga; R(f)= CH(CF3)2, CMe2(CF'3) or CMe(CF3)'2]. Crystal structure analyses of Ga[OCH(CF3)2]3(4-Me2Npy), Ga[OCMe2(CF3)]3(4-Me2Npy) and Al[OCMe(CF3)2]3(4-Me2Npy) showed they have distorted tetrahedral geometries. Gallium oxide films were prepared from Ga[OCH(CF3)2]3(HNMe2) and air by low-pressure chemical vapor deposition at substrate temperatures of 250-450 C. Films deposited at 450 C had a composition of Ga2O3.1 by backscattering analysis, an optical band gap of 4.9 eV, and were > 90% transmittant in the 300-820 nm region. | | Article | Li, Yupu; Liu; Cui; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 134 | 1 | 1998 | 107 - 112 | 10.1016/S0168-583X(98)80039-6 | 0168-583X |
| RBS and ion channeling studies of Ag-doped YBa2Cu3O7-δ targets and films | The location of Ag in Ag-doped YBa2Cu3O7-δ (YBCO) films and other high-Tc materials (such as Ag-doped BiSr-CaCuO films and Ag-sheathed textured BiSrCaCuO wires) is a very important issue for improving high-Tc materials. In this work, laser ablated and DC magnetron sputtered YBCO films on (1 0 0) LaAlO3 and (1 0 0) SrTiO3 were prepared from sintered Ag-YBCO composite targets (nominally containing 5 wt% Ag) and studied by Rutherford Backscattering Spectrometry (RBS) and ion channeling techniques using 2.0 MeV 4He+ and 7Li+ beams. We have found that the Ag-YBCO targets contain about 3 wt% Ag and most of the retained Ag atoms form some small size Ag precipitates with a typical size smaller than a few microns. We have demonstrated that in very good single crystalline YBCO films, the percentage of retained Ag in substitutional sites can be estimated by ion channeling technique. For example, we have found that about 1.2 wt% Ag atoms remain in the laser ablated Ag-doped films prepared from the Ag-YBCO target and about two-thirds of the retained Ag atoms occupy substitutional sites. The sputtered films contain less retained Ag atoms since the deposition temperature is higher and deposition time is longer than those for laser ablated films. | | Article | Suh, Seigi; Hoffman, David M.; Atagi, Lauren M.; Smith, David C.; Liu, Jia-Rui; Chu, Wei-Kan |
| Chem. Mater. | 9 | 3 | 1997 | 730 - 735 | 10.1021/cm960423t | 0897-4756 |
| Precursor Oxidation State Control of Film Stoichiometry in the Metal-Organic Chemical Vapor Deposition of Tin Oxide Thin Films | A new tin(IV) hexafluoroisopropoxide complex and a related tin(II) compound were used as low-pressure chemical vapor deposition precursors to tin oxide thin films. The films were characterized by backscattering and elastic recoil spectrometries, Auger and UV - vis spectroscopies, and nuclear reaction analysis. Sn(OCH(CF3)2)4(HNMe2)2, a volatile solid (subl 70-75C at 0.06 Torr), was synthesized in high yield by reacting Sn(NMe2)4 with (CF3)2-CHOH. A crystal structure determination shows that it has an octahedral structure with trans-amine ligands. Low-pressure chemical vapor deposition using Sn(OCH(CF3)2)4-(HNMe2)2 and air as precursors gave fluorine-doped tin oxide films (O/Sn = 1.8-2.4; F/Sn = 0.005-0.026) at substrate temperatures of 200-450C. The films are highly transparent in the visible region (>85%) and have resistivities as low as 2.1 × 10-3 Ω cm. In contrast to the results obtained for the tin(IV) precursor, the tin(II) compound Sn(OCH(CF3)2)2-(HNMe2) in combination with air or water vapor gave nonconductive transparent films at substrate temperatures of 180-250C having composition SnO0.9-1.3F0.1-0.4. These film stoichiometries suggest that hydrolysis was the primary film-forming reaction and that the tin was not oxidized in the deposition process. | | Article | Li, Yupu; Liu; Cui; Cao; Qu; Chen; Chu; Chu |
| Physica. C. Supercond. | 282-287 | PART 2 | 1997 | 653 - 654 | 10.1016/S0921-4534(97)00474-7 | 0921-4534 |
| On the role of Ag in improved YBa2Cu3O7-δ flms | In the present paper, we report that (i) silver could also help in crystallization along the c-direction, as shown in high quality Ag-doped YBa2Cu3O7-δ (YBCO) films prepared by both laser ablation and DC Magnetron sputtering. In the case of the c-oriented films on (100) SrTiO3 and (100) LaAlO3 substrates in the near surface region, from ion channeling analysis, we obtained χmin=1.5% and χmin=3.5%, respectively, better than the undoped films; (ii) some Ag was found to re-evaporate during the film deposition and the percentage of retained Ag was dependent on the deposition techniques (mainly the deposition time and temperature). By RBS and ion channeling analyses we have found that about 1 wt.% Ag remained in the laser ablated Ag-doped film prepared from a 3 wt. % Ag-YBCO target, and (iii) at least some retained Ag occupied substitution positions. Jc (77K) measured by the SQUID magnetometer for the laser ablated Ag-doped film was found to be enhanced by a factor of 2 in comparison with the undoped film. The Jc enhancement in Ag doped films may not totally come from the improvement of the in-plane alignment. | | Article | Hoffman, David M.; Rangarajan, Sri Prakash; Athavale, Satish D.; Economou, Demetre J.; Liu, Jia-Rui; Zheng, Zongshuang; Chu, Wei-Kan |
| J. Vac. Sci. Technol. A Vac. Surf. Films | 14 | 2 | 1996 | 306 - 311 | 10.1116/1.579893 | 0734-2101 |
| Chemical vapor deposition of aluminum and gallium nitride thin films from metalorganic precursors | Nearly stoichiometric aluminum and gallium nitride thin films were prepared from hexakis(dimethylamido)dimetal complexes, M2[N(CH3)2]6 (M=Al,Ga), and ammonia at substrate temperatures as low as 200C by using low pressure thermal and plasma enhanced chemical vapor deposition (CVD). Both processes gave films that showed little or no carbon (<5 at. %) and no oxygen (<few at. %) contamination, but in all cases there was hydrogen incorporation. The films were highly transparent in the ultraviolet and visible regions. The barrier properties of the aluminum nitride films in a Si/AlN/Au metallization scheme were examined by using backscattering spectrometry. The growth rate of the aluminum nitride films was as high as 1300 A /min. Overall, the results suggest that M2[N(CH3)2]6 (M=Al,Ga) are promising precursors for low-temperature/ low-pressure thermal and plasma-enhanced CVD of group III nitride thin films. | | Article | Chu; Li; Liu; Wu; Tidrow; Toyoda; Matsuo; Yamada |
| Appl. Phys. Lett. | 72 | 2 | 1998 | 246 - 248 | 10.1063/1.120699 | 0003-6951 |
| Smoothing of YBa2Cu3O7-δ films by ion cluster beam bombardment | A method to planarize the surface of a YBa2Cu3O7-δ HTS film down to a smoothness with a standard deviation of 1 nm or better is described. The method includes first smoothing the high-temperature superconductor (HTS) surface by ion cluster beam bombardment, followed by annealing in oxygen ambient to regrow the damaged surface layer. Additional YBCO layers can be grown epitaxially on the treated surface, even without removing the top surface layer, which contained some residual damage after annealing. This method can be integrated into HTS circuit fabrication as a key step of planarization. | | Article | Sharma; Venkatesan; Zhang; Liu; Chu; Chu |
| Phys. Rev. Lett. | 77 | 22 | 1996 | 4624 - 4627 | 10.1103/PhysRevLett.77.4624 | 0031-9007 |
| Evidence for large static and dynamic distortions in high Tc superconducting YBa2Cu3O7-δ crystals over a wide temperature range | The ion channeling technique, which provides a direct real space probe of displacements as small as 1 picometer, is used to investigate the phonon behavior and other atomic displacements related to static or dynamic distortion in YBa2Cu3O7-δ. It is shown that the channeling data provide direct evidence of static and dynamic distortions associated with Cu-O rows spread over a wide temperature range (300-33 K) in YBa2Cu3O6.98. The lattice disorder seems to be more at 300 K, and, as the temperature is lowered, the solid changes to more ordered states with transitions around 180 K and across Tc = 92.5 K. Below Tc no measurable change in u is observed, and the material seems to be in a highly ordered state. | | Article | Ignatiev; Zhong; Chou; Zhang; Liu; Chu |
| Appl. Phys. Lett. | 70 | 11 | 1997 | 1474 - 1476 | 10.1063/1.118566 | 0003-6951 |
| Large Jc enhancement by ion irradiation for thick YBa2Cu3O7-δ films prepared by photoassisted metallorganic chemical vapor deposition | Thick YBCO films grown by photoassisted MOCVD at very high growth rates have been shown to possess too few pinning centers in the bulk of the films to allow for high Jc behavior. In irradiation of a 4.5 μm thick film introduced point pinning sites that resulted in the increase of the Jc of the thick film by a factor of approx. 17 at 77 K. This ion-irradiation results indicates that the cause of the Jc degradation with increased film thickness observed for thick YBCO films is due to a high crystalline quality for the thick films. | | Article | Liu; Zheng; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 108 | 1-2 | 1996 | 1 - 6 | 10.1016/0168-583X(95)00870-5 | 0168-583X |
| (α, α) cross section on 11B for α-energies between 1.0 and 5.3 MeV | Cross sections for θlab = 165 of He-ion backscattering on 11B in the 1.0-5.3 MeV energy range were measured. Self-supported films of 500 A from enriched 11B were used as targets. A new resonance at 3.87 MeV was observed and the resonances at 4.19 and 4.25 MeV were resolved. Angular distributions were measured at useful resonance energies of 2.62, 3.69 and 3.87 MeV for ion beam analysis. The cross sections are presented in graphic and tabular forms with ±2% uncertainty in the relative cross section. | | Article | Liu, Jiarui; Zheng, Zongshuang; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 108 | 3 | 1996 | 247 - 250 | 10.1016/0168-583X(95)01064-5 | 0168-583X |
| Cross section for non-Rutherford backscattering of α on Be | Be is an important element in fusion and fission reactor technology and in X-ray optical components. Non-Rutherford backscattering is desirable when the stoichiometry and depth profile of Be and other heavy elements have to be measured simultaneously. Cross sections for θlab = 165 of He-ion backscattering on 9Be in the 0.88-5.3 MeV energy range were measured. Self-supported films of 15 μg/cm2 Be were used as targets. The measured resonance at 5.05 MeV shows a cross section 47 times as large as the Rutherford cross section. The relative cross sections are presented in graphic and tabular forms with a typical ±2.7% uncertainty. | | Article | Liu, Jiarui; Zheng, Zongshuang; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 118 | 1-4 | 1996 | 24 - 28 | 10.1016/0168-583X(95)01122-6 | 0168-583X |
| Stopping cross sections of C, A1, and Si for 7Li ions | While the advantages of using Li ion in RBS have been well known since the 1970s, application of Li ions in ion beam analysis is limited by the uncertainty in stopping power for Li ions and the technical problems with Li ion beams. All the systematic models established before 1993 fail seriously for all materials studied for energies below about 3.5-7.0 MeV, which is a good energy range for ion beam analysis. We present recent measurements on the stopping power of C, Al and Si for Li ions over the energy range from 1 to 7 MeV. The measurements were performed in transmission geometry with thin films deposited on part of the surface-barrier detector. Comparisons with previous results and different systematics are discussed. | | Article | Zheng; Liu; Cui; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 118 | 1-4 | 1996 | 214 - 218 | 10.1016/0168-583X(95)01073-4 | 0168-583X |
| Cross sections for light element analysis by non-Rutherford scattering | The non-Rutherford cross sections of light elements, from Be to F, for θlab = 165 are reviewed. New results for cross section measurements of Be, B and other light elements at θlab = 165 in the energy range of 1.0-5.3 MeV are presented. Non-Rutherford backscattering for light elements and Rutherford backscattering for heavy elements were used to measure stoichiometries, depth profiles and light element contaminants in thin films of different compounds. The suitable energy range of the α-particles used for major light elements analysis is discussed. In the 3-10 MeV energy range, significant light element sensitivity enhancements were observed, while the heavy elements showed classical Rutherford behavior. | | Article | Qu; Liu; Chen; Cui; Chu |
| Nucl. Instrum. Methods Phys. Res. B. | 118 | 1-4 | 1996 | 684 - 687 | 10.1016/0168-583X(95)01175-7 | 0168-583X |
| Channeling analyses of epitaxially grown YB2C3O7-x thin film | The structure features of YBCO {110}-films on (110) SrTiO3 substrate were studied by 3.05 MeV He2+ and 6 MeV Li3+ ion channeling measurement. Li3+ ion was used to enhance the mass resolution of Ba, Y and Cu. Angular scan along the [110] directions reflected a misorientation between the film and the substrate. A sample consisting of three distinctive layers deposited under three different conditions were used to study the relationships between deposition conditions and crystallographic orientation. The angle of misorientation is consistent with a tilting in compensating for the lattice parameter difference between the substrate and the YBCO film. | | Article | Chu; Liu |
| Mater. Chem. Phys. | 46 | 2-3 | 1996 | 183 - 188 | 10.1016/S0254-0584(97)80012-0 | 0254-0584 |
| Rutherford backscattering spectrometry: Reminiscences and progresses | This paper documents a few historical events important to the development of Rutherford backscattering spectrometry (RBS). The classical experiment of Geiger and the atomic model and theoretical understanding of Rutherford on alpha-scattering are fundamental to the backscattering technique. The rapid growth of atomic and nuclear physics from the 1920s to the 1960s with the development of tools and methods such as accelerators and solid state detectors all contributed to improvements in and proliferation of RBS applications. Research in semiconductors and in thin-film areas especially benefited from the development of RBS. Recent trends to extend RBS into a broader region of energies and a broader selection of projectiles will also be discussed. | | Article | Miller Jr., John H.; Zou, Zhongji; Cho, Hsiao-Mei; Liu, Jiarui; Zheng, Zong-Shuang; Chu, Wei-Kan |
| J. Low Temp. Phys. | 105 | 3-4 | 1996 | 527 - 532 | 10.1007/BF00768439 | 0022-2291 |
| Phase sensitive measurements of the pairing state symmetries of cuprate superconductors using tricrystal microbridges | Measurements of the field-modulated critical currents of cuprate thin film microbridges on tricrystal substrates are reported. Two central peaks of equal height are observed in the field-dependent critical currents of YBCO tricrystal microbridges. However, the critical current is nonvanishing at zero field for YBCO, consistent with an orthorhombically distorted d-wave order parameter. An ion-irradiated YBCO tricrystal microbridge has also been measured, and has been found to exhibit more ideal dx2-y2-like behavior with increasing irradiation dosage. | | Conference Paper | Hoffman; Atagi; Chu; Liu; Zheng; Rubiano; Springer; Smith |
| Mater. Res. Soc. Symp. Proc. | 343 |
| 1994 | 523 - 528 |
| 0272-9172 |
| Low temperature atmospheric pressure chemical vapor deposition of group 14 oxide films | Depositions of high quality SiO2 and SnO2 films from the reaction of homoleptic amido precursors M(NMe2)4 (M = Si, Sn) and oxygen were carried out in an atmospheric pressure chemical vapor deposition reactor. The films were deposited on silicon, glass and quartz substrates at temperatures of 250 to 450 C. The silicon dioxide films are stoichiometric (O/Si = 2.0) with less than 0.2 atom % C and 0.3 atom % N and have hydrogen contents of 9±5 atom %. They are deposited with growth rates from 380 to 900 angstroms/min. The refractive indexes of the SiO2 films are 1.46, and infrared spectra show a possible Si-OH peak at 950 cm-1. X-Ray diffraction studies reveal that the SiO2 film deposited at 350 C is amorphous. The tin oxide films are stoichiometric (O/Sn = 2.0) and contain less than 0.8 atom % carbon, and 0.3 atom % N. No hydrogen was detected by elastic recoil spectroscopy. The band gap for the SnO2 films, as estimated from transmission spectra, is 3.9 eV. The resistivities of the tin oxide films are in the range 10-2 to 10-3 Ω cm and do not vary significantly with deposition temperature. The tin oxide film deposited at 350 C is crystalline cassitterite with some (101) orientation. | | Conference Paper | Cui; Zhang; Chen; Romero-Borja; Liu; Zheng; Pan; Wood; Chu |
| Mater. Res. Soc. Symp. Proc. | 339 |
| 1994 | 515 - 520 |
| 0272-9172 |
| Deposition and characterization of CNx films | CNx films with x around 1.0 have been made by inverted cylindrical DC magnetron sputtering. RBS, XPS, IR spectroscopy, ERD and SEM were used to characterize the composition and bonding properties of the films, while X-ray diffraction was used for crystal structure determination. XPS data indicated the existence of the tetrahedral C3N4 phase in the CNx films, which was consistent with the C-N single bond suggested by IR spectra. The annealing effect on Cnx films will also be discussed. | | Article | Hoffman; Rangarajan; Athavale; Deshmukh; Economou; Liu; Zheng; Chu |
| J. Mater. Res. | 9 | 12 | 1994 | 3019 - 3021 | 10.1557/JMR.1994.3019 | 0884-2914 |
| Plasma enhanced chemical vapor deposition of silicon nitride films from a metal-organic precursor | Silicon nitride films are grown by plasma enhanced chemical vapor deposition from tetrakis(dimethylamido)silicon, Si(NMe2)4, and ammonia precursors at substrate temperatures of 200-400 C. Backscattering spectrometry shows that the films are close to stoichiometric. Depth profiling by Auger electron spectroscopy shows uniform composition and no oxygen or carbon contamination in the bulk. The films are featureless by scanning electron microscopy under 100,000X magnification. | | Conference Paper | Hoffman; Rangarajan; Athavale; Economou; Liu; Zheng; Chu |
| Mater. Res. Soc. Symp. Proc. | 335 |
| 1994 | 3 - 7 |
| 0272-9172 |
| Plasma enhanced metal-organic chemical vapor deposition of germanium nitride thin films | Amorphous germanium nitride thin films are prepared by plasma enhanced chemical vapor deposition from tetrakis(dimethylamido) germanium, Ge(NMe2)4, and an ammonia plasma at substrate temperatures as low as 190C with growth rates >250 A/min. N/Ge ratios in the films are 1.3 and the hydrogen contents are 13 atom %. The hydrogen is present primarily as N-H. The refractive indexes are close to the bulk value of 2.1, and the band gap, estimated from transmission spectra, is 4.8 eV. | | Article | Cross; Liu; Giannone |
| Nucl. Fusion | 23 | 6 | 1983 | 791 - 797 | 10.1088/0029-5515/23/6/006 | 0029-5515 |
| EFFECTS OF DISCHARGE CLEANING ON THE PRODUCTION OF RUNAWAY ELECTRONS IN TORTUS TOKAMAK. | Experimental results are presented on the production of runaway electrons as a function of wall cleanliness in the TORTUS tokamak. When the walls are clean, the production rate decreases as the filling pressure increases. When the walls are contaminated by oxygen, the production rate can increase when the filling pressure is increased, owing to the production of water vapor during tokamak discharges. These results resolve the differences reported in the literature on the production of runaways as a function of filling pressure. It is also observed that the runaway electron instability seen in other devices is suppressed when the walls are discharge-cleaned. | | Article | Yin; Wu; Zhang; Liu; Zhu |
| Pan Tao Ti Hsueh Pao. | 10 | 1 | 1989 | 12 - 17 |
| 0253-4177 |
| Ion channeling analysis of In0.25Ga0.75As/GaAs strained heterojunction | The structure of In0.25Ga0.75As/GaAs strained heterojunction is investigated by means of Li ion beam analysis. Channeling and angular scan measurements suggest that lattice strain occurs in the interface because of the lattice mismatch between the lattice constants of In0.25Ga0.75As and GaAs. There is an expansion and contraction of the equilibrium lattice constant of about 0.04 angstrom in the interface; these stresses cause tetragonal distortions of 0.9. Abnormally high dechanneling is observed due to the presence of this lattice strain. Lattice-defects in the epitaxial layer also give rise to a significant dechanneling. | | Article | Tan; Xia; Yang; Sun; Liu; Zheng; Zhu |
| Nucl. Instrum. Methods Phys. Res. B. | B42 | 1 | 1989 | 1 - 6 | 10.1016/0168-583X(89)90002-5 | 0168-583X |
| Depth profiles of implanted 18F, 79Br, and 132Xe in silicon in the energy range 85-600 keV | The RBS technique and 19F(p, αγ)16O resonance nuclear reaction at 872.1 keV, with Γ=4.2 keV, were used to measure the depth profiles of implanted 79Br, 132Xe and 19F in silicon samples. A special convolution procedure was used to extract the depth profiles from the RBS spectra and the experimental excitation yield curves. The range parameters, Rp and ΔRp obtained in this experiment were compared with theoretical calculations. | | Article | Lu; Ban; Liu; Liu; Zheng; Zhang |
| Nucl. instrum. methods phys. res. | 272 | 3 | 1988 | 909 - 912 | 10.1016/0168-9002(88)90779-6 | 0167-5087 |
| DSA measurement using heavy ion reactions on the small tandem accelerator | The lifetimes of the 7.12 Mev level in 16O and the 4.44 Mev level in 12C have been measured using the Doppler shift attenuation method at a small accelerator. The reversed nuclear reactions 1H(19F, α)16O* and 1H(11B, γ)12C* were used. | | Article | Li; Wang; Chen; Liu; Zhang; Qiu |
| Vacuum | 40 | 3 | 1990 | 281 - 284 | 10.1016/0042-207X(90)90044-Y | 0042-207X |
| Temperature effect of ion beam mixing at Au--Si[111] interfaces | Ar ion beam induced mixing at Au-Si[111] interfaces has been studied as a function of the temperature from 77 up to 573 K. The temperature dependence of intermixed Si atoms is different from the temperature dependence in the other systems such as Ni-Si, Mo-Si, Co-Si, Cr-Si and Nb-Si. The temperature affects the unformity and phase structure of the mixed layers. Amorphous and the metastable crystalline phases with a composition close to Au49Si51 (approximately AuSi) layers have been obtained. There is an amorphous (damaged) Si layer behind the mixed layer as seen by cross-sectional transmission electron microscopy. | | Article | Xiao; Yin; Zhang; Fan; Liu; Ding; Zhou; Zhu |
| Pan Tao Ti Hsueh Pao. | 11 | 11 | 1990 | 866 - 870 |
| 0253-4177 |
| Crystalline quality study of MBE GaAs-on-Si through high energy ion-implantation and subsequent annealing | 4.2MeV 7Li channeling techniques and laser Raman scattering spectrometry have been utilized to study the regrowth of MBE-GaAs films on Si substrates by MeV Si+ implantation and subsequent rapid infrared thermal annealing. Complete regrowth has been obtained when a buried amorphous layer was formed at the GaAs/Si interface and annealed at 850C for 15s. Crystalline disorder is greatly reduced in the recrystallized layers especially at the interface. When Si+ implantation dose exceeds a certain critical value, which leads to severe local nonstoichiometry, incomplete regrowth occurs. The results of Raman scattering show that the ratio of TO/LO decreases significantly after annealing. | | Article | Yang; Mao; Chen; Liu; Yang; Xu |
| Pan Tao Ti Hsueh Pao. | 10 | 11 | 1989 | 846 - 852 |
| 0253-4177 |
| Ion-induced interface reaction between Si and rare-earth-metal Ce and the formation of silicide | The mixing kinetics and silicide formation were characterized for Ce/Si〈100〉 bilayer samples by ion beam mixing. The implanted ion was 150 keV Ar+, and the irradiation temperatures ranged from LNT to 300C. The silicide thus formed was CeSi2 with a centered tetragonal structure. The thickness is proportional to the square root of the ion dose indicating that its growth is diffusion limited. Comparisons of the Ce/Si system with near-noble metal/Si systems and refractory metal/Si systems revealed that in the formation sequence of silicides, Ce/Si system is quite similar to refractory metal/Si systems, but in the mixing kinetics of the silicides, it is similar to near-noble metal/Si systems. | | Article | Song; Xie; Pan; Lei; Liu; Yang; Zhang; Liu; Wu; Xi; Din; Xu |
| Hongwai Yanjiu. A-ji. | 7 | 5-6 | 1988 | 339 - 342 |
| 0258-7114 |
| Investigation on the valence state of copper in YBa2Cu3Ox by H2+ beam spectra | The H2+ beam spectra of high Tc YBa2Cu3Ox (YBCO) and the nominal compounds of YBa2Ag3Ox, YBa2Cu1.5Ag1.5Ox are measured at room temperature and liquid nitrogen temperature, respectively. Comparison of H2+2 beam spectrum of YBCO with those of YBa2Ag3Ox and YBa2Cu1.5Ag1.5Ox indicates that the emission bands of YBCO can be attributed to the transition between the energy levels of the copper ions. On the basis of spectra assignment the valence state of copper in YBCO is discussed. | | Article | Yang; Chen; Liu; Yang |
| Appl. Surf. Sci. | 38 | 1-4 | 1989 | 226 - 234 | 10.1016/0169-4332(89)90543-6 | 0169-4332 |
| Comparison between the reaction of La-Si limited and unlimited supply systems | The authors discussed the reaction and phase formation process of La/Si bilayers (unlimited supply systems) and multilayers (limited supply systems). The specimens were bombarded with Ar+ ions of 150 keV energy and fluences in the 5 × 1014-1 × 1017 cm-2 range. Before and after the reactions all samples were analyzed by RBS, TEM, electron diffraction and X-ray diffraction. The different reaction mechanisms for unlimited and limited supply systems have been revealed. In unlimited supply systems, the reaction is governed by the diffusion fluxes of various elements to the interface. In limited supply systems, the reaction has a characteristic of collective movement. | | Article | Wang; Li; Liu; Zhang; Ma; Zhu; Qiu; Xu |
| J. Nucl. Mater. | 169 | 1 | 1989 | 167 - 176 | 10.1016/0022-3115(89)90532-1 | 0022-3115 |
| Study of helium trapping, bubble structures and helium migration in type 316L stainless steel under helium implantation | Type 316L stainless steel was irradiated with 70-170 keV He+ to a dose of 1015-1×1018 ions cm-2 at 77-673 K. Post-irradiation annealing was carried out up to 1323 K. 2.5 MeV enhanced proton backscattering, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and conversion electron Moessbauer spectrometry (CEMS) are used to investigate the He trapping, bubble structures and the He release. | | Article | Liu; Zhang |
| Vacuum | 39 | 2-4 | 1989 | 83 - 86 | 10.1016/0042-207X(89)90166-8 | 0042-207X |
| Proton channeling effect of α-LilO3 single crystal | The channeling effect measurements of α-LilO3 single crystals have been performed by proton beams. The angular width Y 1/2 and the minimum yield Xmin of α-LilO3 axial channeling parameters along 〈001〉 axis have been measured by backscattered protons and the α-particle from 7Li(p,α)4He reaction. The electrostatic field effect of the crystal and its ionic conducting phenomena have been studied by these combined channeling effect measurements. Radiation damage has also been studied. | | Article | Liu; Zhu; Feng; Li |
| Vacuum | 39 | 2-4 | 1989 | 121 - 122 | 10.1016/0042-207X(89)90175-9 | 0042-207X |
| Elastic recoil detection by C ions for hydrogen profiling in solids | The depth profiling of hydrogen in solids has been performed by elastic recoil detection (ERD) with multicharged C ions at a small 1.7 MV tandem accelerator. Both experimental and theoretical analyses show a depth resolution of about 15-25 nm in the near surface region of solids. Optimization of the experimental parameters such as scattering geometry and incident beam energy has been performed by computer simulation. | | Article | Lu; Xie; Liu; Zheng |
| Vacuum | 39 | 2-4 | 1989 | 123 - 124 | 10.1016/0042-207X(89)90176-0 | 0042-207X |
| Depth profile of 18O at the titanium surfaces using the nuclear reaction 18O(p,α)15N | The 18O (p, α)15N nuclear reaction was used to measure the depth profile of 18O within the near-surface region of titanium. The measurements were performed using a 2 × 1.7 MV tandem accelerator. To reduce the depth resolution value Δx, the target was tilted. A good depth resolution Δx approximately 30 nm within the surface ( ≤ 200 nm) of titanium was obtained. The Fourier-transformation method was used in the data processing. | | Article | Zhu; Liu; Zhang; Yin |
| Vacuum | 39 | 2-4 | 1989 | 151 - 152 | 10.1016/0042-207X(89)90184-X | 0042-207X |
| MeV He microbeam analysis of a semiconductor integrated circuit | An MeV He+ microbeam has been used to analyse a microscale semiconductor structure. The 2 MeV He+ ion beam is limited to 25 μm diameter by a set of diaphragms and is further focused by a quadrupole quadruplet to 3 μm diameter. The incident beam current on the sample is about 0.3 nA. The Rutherford backscattering (RBS) technique is applied to the measurement of the composition and depth profile in the near-surface region of a semiconductor integrated circuit. | | Article | Yang; Mao; Chen; Liu; Yang; Gao; Wang |
| Vacuum | 39 | 2-4 | 1989 | 191 - 193 | 10.1016/0042-207X(89)90193-0 | 0042-207X |
| Investigation of ion beam induced phase transformation in Ni/Si, Nb/Si, Mo/Si and Ti/Si systems | The ion-induced intermixing of atoms between a thin metal film (Ni, Nb, Mo and Ti) and its silicon substrate was investigated. With a dose ranging from 5 × 1014 to 5 × 1016 Xe2+ cm-2 at an implantation temperature from LN2T to 400C, many crystal silicide phases were formed. Differences from predicted behavior have been formed. At high ion dosages, the sequence of the phase transformation is influenced. Some possible explanations are given. | | Article | Gao; Li; Wang; Liu |
| Vacuum | 39 | 2-4 | 1989 | 259 - 261 | 10.1016/0042-207X(89)90212-1 | 0042-207X |
| Effect of temperature on ion beam mixing of Mo films on Si substrates | The atomic mixing of Mo/Si samples irradiated by 170 keV Ar+ or Xe2+ ions has been investigated by backscattering spectrometry. The Mo films of 550 angstrom in thickness deposited on (111) Si substrates were irradiated at temperatures from -196 up to 350C with different beam fluxes and different doses. The silicides of both MoSi2 and Mo5Si3 were observed at 150 and 250C, but only MoSi2 was observed at 350C. These results suggest that the radiation induced reaction at Mo/Si interfaces at high temperature is dominated by the interstitial migration of Si atoms in the intro-cascade regions, rather than long range migrations of defects and thermal-spike effects. | | Article | Li; Wang; Zhang; Ma; Liu; Zhu; Yang |
| Vacuum | 39 | 2-4 | 1989 | 267 - 269 | 10.1016/0042-207X(89)90214-5 | 0042-207X |
| Influence of temperature on He-implanted stainless steel | Helium ion implantation (30-170 keV) into SS 316L at doses of 1014-5 × 1017 cm-2 at temperatures of 77-673 K was investigated with enhanced proton backscattering, TEM and microhardness measurement. The influence of temperature on He trapping, He bubble lattice formation, bubble growth and coalescence, and microhardness was studied. | | Article | Xia; Tan; Yang; Sun; Liu; Zheng; Zhu |
| Vacuum | 39 | 2-4 | 1989 | 347 - 349 | 10.1016/0042-207X(89)90238-8 | 0042-207X |
| Electronic stopping powers derived from range measurements for ions at low velocity | Electronic stopping cross sections for 19F+ in Pb1-xSnxTe and 19F+, 40Ar+, 75As+, 79Br+ and 132Xe+ in silicon were obtained by range measurements. Depth profiles of F in Pb1-xSnxTe and Si were measured by 19F(p, αγ)16O resonance nuclear reaction and those of Ar, As, Br and Xe were determined by RBS. In order to obtain the true range distribution from the measured NRA excitation curves or RBS spectra, a deconvolution program was developed using a reference function, the Edgeworth distribution function, and parameter optimization process. By forcing a fit between the experimentally determined projected range and that calculated with the range statistics program the total stopping power was obtained. After subtracting the nuclear stopping power the electronic stopping power was derived. The electronic stopping power can be described by a four-parameter formula. | | Article | Lu; Xie; Zheng; Jiang; Liu |
| Nucl. Instrum. Methods Phys. Res. B. | B43 | 4 | 1989 | 565 - 569 | 10.1016/0168-583X(89)90407-2 | 0168-583X |
| New method for profiling boron | By studying the relative excitation curve of 11B(p, α0)8Be, we have found that there is a wide plateau (approximately 100 keV) near the Ep = 2.62 MeV peak, which can be used to profile boron. A brief comparison between the new method and that of the 11B(p, α1)8Be reaction is given. | | Article | Mou; Wang; Yin; Zhang; Liu |
| Pan Tao Ti Hsueh Pao. | 11 | 7 | 1990 | 533 - 538 |
| 0253-4177 |
| Formation of La, Ce and Nd rare earth metal silicides on silicon | Auger Electron Spectroscopy, X-Ray Diffraction and Rutherford Backscattering Spectrometry are used to investigate the formation of La, Ce, and Nd rare earth metal silicides from thermal and ion beam induced reaction between Si and rare earth metals. Metal-rich silicides, monosilicides, disilicides are formed at different growth conditions, such as annealing temperature, implantation dose, etc. The contamination of oxygen not only inhibits the formation of silicides, but also to some extent determines the silicide phases and the quality of thin films. The prominent influence of substrate temperature and coating overlayer to prevent oxidation on roughness, uniformity, and quality of silicide thin film is also discussed. | | Article | Xia Yueyuan; Tan Chunyu; Yang Hong; Hu Xierong; Chen Lixin; Wang Yihua; Sun Xiufang; Zheng Zongshuang; Zhang Qichu; Zhu Peiran; Liu Jiarui |
| Pan Tao Ti Hsueh Pao. | 9 | 1 | 1988 | 74 - 81 |
| 0253-4177 |
| STUDIES OF DEPTH PROFILES OF FLUORINE IN 19F + ION IMPLANTED Pb1 - xSnxTe, CdTe AND Si. | The **1**9F(P, alpha gamma )**1**6D resonance nuclear reaction at E//R equals 872. 1 keV, with width GAMMA equals 4. 2 keV, is used to measure the fluorine depth profiles in **1**9F** plus ion implanted Pb//1// minus //xSn//xTe, CdTe and Si samples. Deconvoluting the experimental excitation curves by use of a reference function and parameter optimization procedure, the fluorine depth profiles are obtained, while the projected range distribution parameters, R//p, DELTA R//p and SK for **1**9F** plus ion implantation in Pb//1// minus //xSn//xTe, CdTe and Si are determined. These range distribution parameters are also calculated theoretically. The comparison between the experimental and theoretical results shows that the experimental R//p, and DELTA R//p agree well with the theoretical values. The possibility of studying the stopping powers of heavy ions at low velocities in solids by using resonance nuclear reaction technique is discussed. | | Article | Liu; Zhang |
| Solid State Commun. | 63 | 4 | 1987 | 307 - 310 | 10.1016/0038-1098(87)90914-8 | 0038-1098 |
| COMBINED CHANNELING STUDY OF alpha -LiIO3 CRYSTAL IN AN ELECTROSTATIC FIELD. | The combined channeling backscattering and channeling nuclear reaction analysis of the alpha -LiIO//3 monocrystal in an electrostatic field has been performed by proton beam at different energies to identify the behavior of Li and I ions in the crystal. The thickness of the crystal was about 2 mm and has been cut perpendicular to C-direction. The channeling parameters like half angular width and minimum yield of LT AN BR 001 RT AN BR axial channeling have been measured precisely and the channeling behavior of different ions in the crystal has been observed and measured quantitatively first time. The ionic dc conductivity can be calculated from the surface peak of the aligned channeling spectrum directly. | | Article | Zongshuang Zheng; Zhang Qichu; Zhang Houxian; Liu Jiarui; Lu Xiting; Lao Fei; Jiang Dongxing; Liu Hongtao |
| Solid State Commun. | 62 | 3 | 1987 | 177 - 179 | 10.1016/0038-1098(87)90186-4 | 0038-1098 |
| HYDROGEN PROFILING IN SOLIDS BY RESONANCE NUCLEAR REACTIONS. | Hydrogen profiling by resonance nuclear reactions of 1H(19F, a gamma )160 and 1H(7Li, gamma )8Be with the resonance energy of 6. 42 and 3. 07 mev, respectively, with good depth resolution has been performed. The measurements have been carried out at a small tandem accelerator of 2 multiplied by 1. 7 mv with multicharged ion beams. The comparison of these two reactions and a number of applications to amorphous silicon (a-Si) and multilayer solid samples are presented. | | Article | Lei; Liu; Pan |
| Nucl. Instrum. Methods Phys. Res. B. | B34 | 2 | 1988 | 169 - 172 | 10.1016/0168-583X(88)90740-9 | 0168-583X |
| ONE ELECTRON CAPTURE INTO EXCITED STATES AND TARGET ATOM EXCITATION IN He plus COLLISONS WITH Ar. | One-electron capture and direct excitation in collisions between He** plus and Ar in the ion energy range 70-150keV is discussed. The emission cross section of the triplet HeI states for the He** plus -Ar collision system is much larger than that for the He** plus -Ne collision system at low ion energies. A qualitative explanation for this difference is given. |
| Guo; Liu |
| Nucl. Instrum. Methods Phys. Res. B. | B16 | 4-5 | 1986 | 317 - 320 | 10.1016/0168-583X(86)90090-X | 0168-583X |
| WAKE EFFECTS ON CHARGED PARTICLE STOPPING IN SOLIDS. | The wake effect on stopping is considered in the high velocity region using Bethe theory. The dependence of the scattering cross section for different energy transfer on the wake is shown by introducing a wake charge density and it is found that the wake is important. The calculation gives an explanation of the difference of stopping in the gas state and the solid state. | | Article | Yang; Liu |
| Nucl. Instrum. Methods Phys. Res. B. | B24-25 | pt 2 Apr III | 1986 | 791 - 792 | 10.1016/S0168-583X(87)80248-3 | 0168-583X |
| LOW ENERGY ION IMPLANTER FOR NEGATIVE AND POSITIVE IONS. | A low energy ion implanter for the energy range 100 eV-60 keV has been designed, manufactured and tested in the ion beam laboratory of the Institute of Physics. The system consists of a 30 kV extraction system, an analyzing magnet, a deceleration or acceleration system of changeable voltage from 0 up to 30 kV, and electrostatic scanning system and a UHV target chamber. Three different ion sources can be used at the ion implanter: a Penning ion source, a hollow cathode ion source and negative sputtering ion source. The system has been designed for ion beam materials modification, surface analysis and atomic-molecular physics research. | | Article | Lenoir; Liu; Church |
| Nucl. Instrum. Methods Phys. Res. B. | B24-25 | pt 1 Apr III | 1986 | 312 - 315 | 10.1016/0168-583X(87)90650-1 | 0168-583X |
| ORIENTATION ARISING FROM GRAZING COLLISIONS OF ARGON IONS WITH A COPPER TARGET. | The orientation of S, P, D, and F states of 20-100 kev argon ions by grazing collision with a polished copper target was studied. A general increase in the relative circular polarization of the emitted light with ion velocity was found, with larger magnitudes of circular polarization for D and F sttes than for S and P states. Alignment tensor parameters were found to be significant in the interpretation of the orientation data. | | Article | Yin; Zhang; Gu; Xu; Liu; Zhang; Li |
| Pan Tao Ti Hsueh Pao. | 8 | 3 | 1987 | 308 - 311 |
| 0253-4177 |
| INFRARED TRANSIENT ANNEALING OF LEAD IMPLANTED SILICON. | The backscattering-channeling effect has been used to determine the lattice disorder and distribution of Pb implanted in Si followed by infrared transient annealing. The results suggest that in the high implant concentration region, Pb precipitates and high local stress may sufficiently retard the rate of epitaxial regrowth. As epitaxial growth has ceased, a polycrystalline structure surface layer results and the grain boundaries offer preferential diffusion paths towards the surface, thus a redistribution of Pb takes place. | | Article | Xia; Tan; Zheng; Zhang; Zhu; Liu; Yang; Hu; Chen |
| J. Phys. Chem. Solids | 48 | 8 | 1987 | 697 - 699 | 10.1016/0022-3697(87)90061-8 | 0022-3697 |
| DEPTH PROFILES OF FLUORINE IN 19F + ION-IMPLANTED Pb1 - xSnxTe AND CdTe. | The F19(p, ag)16O resonance nuclear reaction at 872.1keV, with Γ=4.2keV was used to measure the depth profiles of fluorine in F19+ -implanted Pb_(1-x) Sn_x Te and CdTe samples. A deconvolution procedure was performed to extract the depth profiles from the experimental excitation yield curves. The range parameters, R_p,ΔR_p and SK, obtained in this experiment were compared with theoretical calculations. | | Conference Paper | Sun, Da Wei; Liu, Jia Rui |
|
| 345 |
| 2013 | 85 - 88 | 10.4028/www.scientific.net/AMM.345.85 | 1662-7482 |
| Study on the correspondence of hamiltonian flows and functions of brake hamiltonian system based on mechanical mechanics | This paper studies the Hamiltonian flows and functions of the brake Hamiltonian dynamical system. By the properties of the brake Hamiltonian system and the transformation law of Hamiltonian diffeomorphisms, this paper proves the correspondence of the Hamiltonian flows and the symmetrical Hamiltonian functions under some conditions. (2013) Trans Tech Publications, Switzerland. | | Conference Paper | Chu; Liu; Lu; Shao; Wang; Ling |
| Nucl. Instrum. Methods Phys. Res. B. | 190 | 1-4 | 2002 | 34 - 39 | 10.1016/S0168-583X(01)01271-X | 0168-583X |
| The point defect engineering approaches for ultra-shallow boron junction formation in silicon | When high energy heavy ions bombard a single crystal, such as MeV Si implantation in Si, the surface region becomes vacancy-rich, while interstitials are mostly distributed near the range of the implants. We have demonstrated that vacancy retards while interstitial enhances boron thermal diffusion in silicon. In this paper we will show experimental results on the modification of boron diffusivity by point defect engineering, and its application in ultra-shallow junction (10 nm) formation. In this paper, we will also show cluster ion, such as GeB and SiB, implantation in silicon, and two-stage annealing in forming ultra shallow junction in Si. RBS, channeling, nuclear reaction, and secondary ion mass spectrometry are used for this studies. | | Conference Paper | Liu, Jiarui; Lu, Xinming; Wang, Xuemei; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 190 | 1-4 | 2002 | 107 - 111 | 10.1016/S0168-583X(01)01272-1 | 0168-583X |
| Cross-sections of 11B(p,α)8Be reaction for boron analysis | Nuclear reaction, 11B(p,α)8Be, shows great potentials in boron characterization of materials due to its large cross-section at the broad resonance at 660 keV. Unfortunately, the existing cross-section data on this reaction show errors of up to 30% and inconsistency as high as 50%. All previously published cross-sections of this reaction were based on assumptions or on more or less arbitrary convention. We present an accurate measurement of the cross-sections of nuclear reaction 11B(p,α1)8Be * using self-supported 11B foil target, high resolution detection and careful analysis of the α-spectra. An accurate cross-section with α1 was obtained with careful spectrum stripping of α1 from the α12 continuum. Cross-section with α1 + α12 under more definite and realistic convention is also given for practical applications. Cross-sections are given in graphical form for θlab = 150. | | Conference Paper | Liu, Jiarui; Wang, Xuemei; Shao, Lin; Lu, Xinming; Chu, Wei-Kan |
| Nucl. Instrum. Methods Phys. Res. B. | 190 | 1-4 | 2002 | 787 - 791 | 10.1016/S0168-583X(01)01305-2 | 0168-583X |
| Non-linear effect on radiation damage of silicon by cluster ion bombardment | Due to the spatial and temporal close proximity of cluster ion bombardment on Silicon, radiation damage of Si due to cluster ions cannot be extrapolated from that of atomic ions. In this paper we overview our recent observations of radiation damage in Si by clusters of C and Au aggregates of up to 10 atoms and 4 atoms respectively. Quantification of damage is made by RBS/channeling. We observed hyper linear radiation damage depending on cluster size. We developed a theoretical interpretation of this observation using a collision cascade overlapping model. | | Article | Zhang; Wang; Zhang; Wu; Fu; Liu |
| Nucl. Instrum. Methods Phys. Res. B. | 307 |
| 2013 | 260 - 264 | 10.1016/j.nimb.2012.11.075 | 0168-583X |
| Improvement of graphene quality synthesized by cluster ion implantation | Graphene was prepared by negative C4 cluster ion implantation at 5 keV/atom followed by vacuum thermal annealing and cooling. The surface morphology and structure of samples were studied by scanning electron microscopy, atomic force microscopy, and Raman spectroscopy. Improvement of the grapheme quality was realized by optimization of the post thermal processes. 1-2 layer graphene was obtained with I2D/IG ratio of 1.43 and ID/IG ratio of 0.07 at the implantation dose of 12 × 1015 atoms/cm2 and annealed at 900 C followed by cooling at 20 C/min. | | Article | Wang; Zhang; Zhang; Huang; Liu; Fu; Liu |
| Nucl. Instrum. Methods Phys. Res. B. | 307 |
| 2013 | 40 - 42 | 10.1016/j.nimb.2013.01.083 | 0168-583X |
| Raman spectroscopy of few-layer graphene prepared by C2-C 6 cluster ion implantation | Few-layer graphene has been prepared on 300 nm-thick Ni films by C 2-C6 cluster ion implantation at 20 keV/cluster. Raman spectroscopy reveals significant influence of the number of atoms in the cluster, the implantation dose, and thermal treatment on the structure of the graphene layers. In particular, the graphene samples exhibit a sharp G peak at 1584 cm-1 and 2D peaks at 2711-2717 cm-1. The IG/ I 2D ratios higher than 1.70 and IG/ID ratio as high as 1.95 confirm that graphene sheets with low density of defects have been synthesized with much improved quality by ion implantation with larger clusters of C4-C6. | | Conference Paper | Sun, Da Wei; Liu, Jia Rui |
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| 394 |
| 2013 | 92 - 95 | 10.4028/www.scientific.net/AMM.394.92 | 1662-7482 |
| Study on the periodic solutions to a superquadratic discrete hamiltonian system based on mechanics | This paper studies the periodic solutions to a superquadratic second-oder discrete type Hamiltonian system in the n dimensional Euclide space. By the variational methods and some discrete computional techniques, this paper proves the existence of solution to a new type discrete Hamiltonian system. (2013) Trans Tech Publications, Switzerland. | | Article | Xu, Jinxia; Chen, Chi; Xiao, Xiangheng; Liao, Lei; Miao, Ling; Wu, Wei; Mei, Fei; Stepanov, Andrey L.; Cai, Guangxu; Liu, Yong; Dai, Zhigao; Ren, Feng; Jiang, Changzhong; Liu, Jiarui |
| J. Appl. Phys. | 115 | 14 | 2014 |
| 10.1063/1.4871192 | 0021-8979 |
| Synergistic effect of V/N codoping by ion implantation on the electronic and optical properties of TiO2 | Performance of the material depends directly on the electronic and energy band structure, to improve the photoactivity of TiO2 and decrease carrier recombination centers induced by monodoping, the TiO2 thin film has been modified with V and N codopants by ion implantation for tailing and controlling the electronic structure and energy band structure. Compared to monodopant, codopants of V and N exhibit a synergistic effect in the photoactivity enhancement of TiO2. X-ray photoelectron spectroscopy (XPS) studies demonstrate that the implanted V and N ions are introduced into the lattice of TiO2 through V and N substituting Ti and O, respectively. The electronic structure of V/N codoped TiO2 was calculated by First-principles calculations based on density-functional theory, the results show the band edges of TiO2 can be tailored by V and N codopants. UV-vis spectra consistently show the absorption edge of V/N codoped TiO2 film is widen to visible light region. More importantly, the photoactivity of TiO2 film has been significantly improved after V/N codoping. The enhanced photocatalytic performance is believed to be due to the V and N codopants induced synergistic effect that not only enhances the absorption of visible light but also promotes the separation of photogenerated electrons and holes in TiO2. Besides, there exists an optimum for V/N ions implantation fluence. The capability of improving TiO2 photoactivity by V/N codoping could open up new opportunities in the development of highly efficient photocatalysts and photoelectrodes for solar energy and environmental applications. | | Article | Ding, Xu; Liu, Jiarui; Shang, Yongheng; Wang, Zhiyu; Wang, Liping; Huang, Zhengliang; Yu, Faxin; Liu, Dongdong |
| Meas. J. Int. Meas. Confed. | 65 |
| 2015 | 220 - 226 | 10.1016/j.measurement.2015.01.007 | 0263-2241 |
| Design and auto-screening of a K-Band GaAs MMIC multi-function power amplifier | This paper introduces the design and auto-screening of a K-band multi-function power amplifier (MFPA). The proposed MFPA is fabricated using 0.25 μm GaAs pHEMT technology and has a center operation frequency at 22.5 GHz with 1 GHz bandwidth. It consists of three ports: Transmission port, Receiving port and Common port. The transmission channel which starts from Transmission port and ends at Common port provides a linear gain greater than 21 dB, a 19 dB power gain and over 40% power added efficiency (PAE) at 2 dB compress point with 0 dBm input power. The receiving channel, from Common port to Receiving port, has an insertion loss of less than 1.3 dB. The isolation between the transmission channel and the receiving channel is better than 20 dBc. A piece of auto-screening software is presented here as well to characterize and screen the designed MFPA which is able to accelerate the test three times faster. | | Article | Zhang; Li; Zhang; Wang; Zhou; Wang; Li; Liu; Fu |
| Nucl. Instrum. Methods Phys. Res. B. | 356-357 |
| 2015 | 99 - 102 | 10.1016/j.nimb.2015.04.067 | 0168-583X |
| Graphene synthesis on SiC: Reduced graphitization temperature by C-cluster and Ar-ion implantation | Thermal decomposition of SiC is a promising method for high quality production of wafer-scale graphene layers, when the high decomposition temperature of SiC is substantially reduced. The high decomposition temperature of SiC around 1400 C is a technical obstacle. In this work, we report on graphene synthesis on 6H-SiC with reduced graphitization temperature via ion implantation. When energetic Ar, C1 and C6-cluster ions implanted into 6H-SiC substrates, some of the Si-C bonds have been broken due to the electronic and nuclear collisions. Owing to the radiation damage induced bond breaking and the implanted C atoms as an additional C source the graphitization temperature was reduced by up to 200 C. | | Article | Dehdashti, Shahram; Li, Rujiang; Liu, Jiarui; Yu, Faxin; Chen, Hongsheng |
| AIP Adv. | 5 | 6 | 2015 |
| 10.1063/1.4923325 | 2158-3226 |
| Realization of non-linear coherent states by photonic lattices | In this paper, first, by introducing Holstein-Primakoff representation of α-deformed algebra, we achieve the associated non-linear coherent states, including su(2) and su(1, 1) coherent states. Second, by using waveguide lattices with specific coupling coefficients between neighbouring channels, we generate these non-linear coherent states. In the case of positive values of α, we indicate that the Hilbert size space is finite; therefore, we construct this coherent state with finite channels of waveguide lattices. Finally, we study the field distribution behaviours of these coherent states, by using Mandel Q parameter. | | Conference Paper | Liu, Chunye; Miao, Yanqing; Guo, Yihui; An, Yinjuan; Li, Yunfang; Liu, Huanhuan; Chen, Jia; Liu, Jiarui; Dai, Huibin |
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| 19 |
| 2014 | 509 - 516 | 10.2495/MEB140641 | 1743-3525 |
| Chiral drugs separation by a new antibioticsbased chiral stationary phase | A new chiral stationary phase (CSP) was prepared by bonding streptomycin to silica gel through a glutaraldehyde spacer. First, Ɣ-Aminopropyl trimethoxy silane was bonded to the surface of silica gel, and linked with glutaraldehyde through the amino group. Second, streptomycin reacted with the other aldehyde group of glutaraldehyde by its primary amino-group. Fourier-transform infrared (FI-IR) spectrometer, scanning electron microscope, and elemental analysis indicate that streptomycin was successfully introduced to the surface of silica gel through nucleophilic addition and elimination reactions. The new CSP was applied to the resolution of four kinds of drugs under normal phase conditions, such as isoprenaline hydrochloride, nifedipine, ibuprofen and mandelic acid, which were all fully resolved within 6 min. The results indicate that the new CSP has excellent enantioselectivity for the separation of enantiomers of acid chiral drugs, the mechanism of chiral resolution was also discussed. | | Conference Paper | Chu, Wei-Kan; Shao, Lin; Liu; Thompson; Wang; Chen |
| Proc. Int. Conf. Ion Implantation Technol. | 22-27-September-2002 |
| 2002 | 48 - 51 | 10.1109/IIT.2002.1257935 | 00001 |
| Ultra-shallow junction formation by Point Defect Engineering | Point Defect Engineering (PDE) using high-energy ion bombardment can be used as a method to inject vacancies near the surface region with excessive interstitials created near the end of the projected range deep inside the substrate. We demonstrate that PDE not only suppresses transient enhanced diffusion of B in Si caused by implantation-induced defects, but also suppresses boride-enhanced diffusion normally associated with a high B concentration layer. With PDE, we can retard B diffusion, sharpen boron profile and increase B activation. An enhancement of substitutional ratio of B was observed by aligned nuclear reaction analysis. By drive-in diffusion of B from a surface deposited layer, the concept of boron diffusion control was used as an approach to form sub-10 nm ultrashallow junctions in Si. | | Conference Paper | Zagozdzon-Wosik; Shao; Menon; Arroyo-Castelazo; Rusakova; Wang; Van Der Heide; Liu; Chu; Bennet |
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| 2001 | 82 - 86 | 10.1109/RTP.2001.1013748 |
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| Device and material issues related to integration of junctions with contacts in deep 0.1 μm MOSFETs | We address issues of process integration for source and drain (S/D) regions, which include formation of junctions and contacts for future scaled down MOSFETs. Computer simulation using Silvaco and material studies, were used to consider constraints originating in these regions and associated with both device operation and fabrication. In simulations, we focused on the role of doping profiles in the S/D regions on current drivability while devices are being scaled down to the sub. 0.1 μm range. Fabrication and material analysis were oriented on shallow and heavy doped junctions produced using boride layers (TiB2), which also acted as a contact material. High thermal stability of the stochiometric diboride ensures significantly restricted dopant outdiffusion to silicon during Rapid Thermal Processing. That should allow for high surface concentrations required for small contact and series resistance. Ohmic contacts are obtained for p-type wafers after annealing, while for n-type wafers, well defined non-leaky p-n diodes are formed. Techniques used in material studies (RBS, XPS and SIMS) did not reveal convincing dopant outdiffusion or significant changes in composition of the films. | | Article | Su, Meng-Yao; Chen, Xu-Bin; Qiu, Jin-Peng; Wang, Zhi-Yu; Liu, Jia-Rui; Chen, Hua; Shang, Yong-Heng; Liu, Dong-Dong; Yu, Fa-Xin |
| Zhejiang Daxue Xuebao (Gongxue Ban) | 50 | 4 | 2016 | 792 - 798 | 10.3785/j.issn.1008-973X.2016.04.026 | 1008-973X |
| Design of highly reliable single-event-upset hardened shift register | A design of highly reliable shift register which can efficiently fight against the single event upset (SEU) to improve reliability and SEU tolerance of traditional shift register was presented. Bilateral resetting, bit-line segregation and tri-mode redundancy technologies were applied based on TSMC 0.18 μm 1.8 V 1P5M process in order to design bilateral resetting power on reset (POR) and SEU hardened dual interlocked storage cell (DICE) circuits. The SEU hardening performance of traditional shift register was completely enhanced at both aspects of schematic and layout. Transient current pulses with different linear energy transfer (LET) were injected in sensitive nodes of circuits in order to emulate the single event effects. Simulations were performed to verify the SEU tolerance of designed shift register by introducing Spectre simulator, BSIM3v3 physical model and theoretical analysis of transient circuits. The simulation results show that the proposed bilateral POR and SEU hardened DICE do not upset even when LET reaches 100 MeV·cm2/mg. Compared with traditional shift register, the presented shift register shows great improvement of SEU tolerance as well as high reliability and radiation tolerance, which can be applied for the design of CMOS chips in the field of aerospace. | | Article | Liu, Jia-Rui; Zhao, Wei; Zhang, Hua; Yu, Xiao-Ming |
| Reneng Dongli Gongcheng. | 31 | 5 | 2016 | 7 - 15 | 10.16146/j.cnki.rndlgc.2016.05.002 | 1001-2060 |
| Simulation and optimization of the flow distribution characteristics of the plate side of a plate and shell type heat exchanger | With the plate side of a plate and shell type heat exchanger serving as the object of study, established was a geometrical model and performed also was a numerical simulation. On this basis, the flow distribution characteristics in a U-shaped and Z-shaped inlet and outlet arrangement were analyzed and compared and through calculating the heat transfer efficiency and comparing the pressure drops, the influence of the flow distribution characteristics on the heat transfer efficiency and the pressure drops was analyzed. The simulation and analytic results show that a serious flow distribution non-uniform phenomenon appears in various flow passages in the plate side and results in a decline of the heat transfer efficiency, and at the same time, leads to an increase of the pressure drops. In such a case, the overall performance of the U-shaped arrangement is better than that of the Z-shaped arrangement. Through comparing the flow distribution in different combinations of various inlet and outlet diameters, the flow distribution of the U-shaped arrangement was optimized, thus improving the uniformity of the flow distribution and enhancing the performance of the heat exchanger. The optimization and analytic results show that when a combination of the inlet diameter of 20 mm and the outlet diameter of 23 mm is adopted, the best comprehensive effectiveness will result, therefore, enhancing the heat transfer efficiency and reducing the pressure drop by a large margin at the same time of improving the uniformity of the flow distribution in the heat exchanger. | | Article | Jiang, Hui-Qiang; Chen, Xu-Bin; Mo, Jiong-Jiong; Wang, Zhi-Yu; Liu, Jia-Rui; Chen, Hua; Yu, Fa-Xin |
| Tien Tzu Hsueh Pao. | 45 | 4 | 2017 | 944 - 949 | 10.3969/j.issn.0372-2112.2017.04.025 | 0372-2112 |
| CMOS Digital Temperature Sensor with Self-Correcting Technique | A CMOS temperature sensor with digital output is presented, and a new self-correcting technique is proposed to solve the problem of poor consistency and low yield caused by process variations. By applying the self-correcting technique, the change of the reference voltage in the temperature sensor kernel module is effectively suppressed and the consistency among chips is obviously improved. In this paper, the reference voltage module is simulated with different process corners. By comparing the maximum deviation of the reference voltages in the open and close states of the self-correcting module, the effectiveness of self-correcting technique is validated. The complete design is fabricated in the CSMCB5212 0.5 μm CMOS process, providing an SPI digital interface with 10-bit output data. In the temperature range from -35℃ to 105℃, the inaccuracy of experiment results is merely ±1℃, and the overall power consumption is less than 0.6 mW. | | Conference Paper | Wang, Xiaofeng; Wang, Zhiyu; Li, Haoming; Tian, Rongqian; Liu, Jiarui; Yu, Faxin |
| Inf. MIDEM | 47 | 4 | 2017 | 247 - 253 |
| 0352-9045 |
| An Improved Low Phase Noise LC-VCO with Wide Frequency Tuning Range Used in CPPLL | Based on TSMC 0.18μm CMOS process, a complementary cross-coupled differential LC voltage controlled oscillator (LC-VCO) used in charge pump phase-locked loop (CPPLL) frequency synthesizer for satellite receiver with low phase noise and wide frequency tuning range is designed and implemented. The VCO adopts self-bias structure to remove flicker noise produced by tail current. Programmable LC tanks are introduced at the common source of cross-couple transistors to eliminate second harmonics of resonant frequency. Distributed biasing is applied for a wider linear tuning range. An optimized switch is proposed to lower on-resistance. The measured results show that the VCO exhibits a 53.8% tuning range from 1.02GHz to 1.77GHz. From the carrier frequency of 1.4 GHz, the phase noise of the VCO can reach -131.2 dBc/Hz at 1MHz offset. The core circuit consumes 7.7mA with 1.8V supply voltage. | | Article | Ding, Xu; Wang, Zhiyu; Liu, Jiarui; Zhou, Min; Chen, Wei; Chen, Hua; Mo, Jiongjiong; Yu, Faxin |
| Electronics (Switzerland) | 7 | 5 | 2018 |
| 10.3390/electronics7050057 | 2079-9292 |
| All-in-one wafer-level solution for MMIC automatic testing | In this paper, we present an all-in-one wafer-level solution for MMIC (monolithic microwave integrated circuit) automatic testing. The OSL (open short load) two tier de-embedding, the calibration verification model, the accurate PAE (power added efficiency) testing, and the optimized vector cold source NF (noise figure) measurement techniques are integrated in this solution to improve the measurement accuracy. A dual-core topology formed by an IPC (industrial personal computer) and a VNA (vector network analyzer), and an automatic test software based on a three-level driver architecture, are applied to enhance the test efficiency. The benefit from this solution is that all the data of a MMIC can be achieved in only one contact, which shows state-of-the-art accuracy and efficiency. | | Article | Wang, Gang; Chen, Wei; Liu, Jiarui; Mo, Jiongjiong; Chen, Hua; Wang, Zhiyu; Yu, Faxin |
| IEICE Electron. Express | 15 | 10 | 2018 |
| 10.1587/elex.15.20180317 | 1349-2543 |
| Design of a broadband Ka-band MMIC LNA using deep negative feedback loop | In this paper, we present a broadband Ka-band LNA using 0.15-µm GaAs pseudomorphic high electron mobility transistor (pHEMT) process. By using bandwidth enhancement techniques and deep negative feedback technology, the LNA achieves relatively broadband performances. The LNA attains 20 dB small signal gain from 25 to 40 GHz and shows a measured noise figure of 2.8 dB from 25 to 40 GHz with 230-mW dc power consumption. The input and output return loss of the LNA is less than 8 dB, which is competitive compared with other published Ka-band LNAs. The size of the chip is 2.5 mm × 1.2 mm. | | Article | Wang, Gang; Liu, Jiarui; Xu, Shiyi; Mo, Jiongjiong; Wang, Zhiyu; Yu, Faxin |
| Inf. MIDEM | 48 | 2 | 2018 | 115 - 120 |
| 0352-9045 |
| The design of broadband LNA with active biasing based on negative technique | In this paper, we present a broadband LNA based on an improved negative feedback design. With the adjustment of the negative feedback inside the chip, the LNA achieves a planarized gain and an optimized operating bandwidth from 0.2 GHz to 4 GHz. To guarantee the good performance stability under severe environments, an active biasing is used inside the chip. As a result, effective compensations for the fluctuation of the supply voltage and the temperature variation are achieved. The LNA chip uses GaAs pHEMT at 0.25-μm technology node and SIP package technique. This broadband LNA shows good performances, including gain of about 15 dB, gain flatness of less than 1dB, and noise figure of less than 1.5 dB. The packaged size of this broadband LNA is 3 mmX3 mmX1 mm. | | Article | Luo, Wei; Sun, Feng-Long; Liu, Jia-Rui; Hou, Jun-Wu; Wang, Ben-Gan; Huang, Xiao-Ping |
| Guang Pu Xue Yu Guang Pu Fen Xi. | 38 | 6 | 2018 | 1982 - 1986 | 10.3964/j.issn.1000-0593(2018)06-1982-05 | 1000-0593 |
| Matrix Measurement of Glucose Concentration Based on Surface Plasmon Resonance Sensor | An angle scanning prism-based SPR sensor system is proposed in this paper. With the structure of reflex parallel light path, the system has been simplified, which mainly consists of light source, CCD sensor, parallel light path structure, rotation and temperature control module. With the motor scanning incidence angle and temperature control, an effective measurement of glucose refractive index (RI) mass concentration property can be achieved. Moreover, a theoretical model has been established to explain the existence of a sensitivity matrix, which enables both the RI and temperature to be measured and obtained from proof-of-concept experiment. This approach paves a way for conventional SPR-based sensors to discriminate between RI-induced and temperature-induced SPR changes and provides a reference for the correction of temperature interference. | | Patent | Wei-Kan Chu , Jiarui Liu | THE UNIVERSITY OF HOUSTON SYSTEM |
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| 1996 |
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| US6493411
JP3327548B2
US06493411B1
DE69224064T2
AU667677B2
CA2112567A1
EP0593607B1
WO1993001602A1 | Method for producing formed bodies of high temperature superconductors having high critical currents | Thermal neutron irradiation of superconducting body compositions into which Li or B has been incorporated as a unit cell external or internal dopant introduces by the nuclear reaction of the dopant pinning centers which substantially improve the critical current density of the body. | | Patent | Wei-Kan Chu , Lin Shao , Xinming Lu , Jiarui Liu , Xuemei Wang | CHU INVENTORS |
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| 2004 |
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| US6812523
US07105427B1 | Semiconductor wafer with ultra thin doping level formed by defect engineering | Vacancies and dopant ions are introduced near the surface of a semiconductor wafer. The dopant ions which diffuse by an interstitialcy mechanism have diffusivity greatly reduced, which leads to a very low resistivity doped region and a very shallow junction. | | Patent | 朱唯幹 , 刘家瑞 | THE UNIVERSITY OF HOUSTON SYSTEM |
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| 2006 |
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| WO2008/30212
CN101512329A
JP2009500644A
US20100193685A1
KR1020080045673A
EP1925000A4 | MINIATURE NEUTRON GENERATOR FOR ACTIVE NUCLEAR MATERIALS DETECTION | This miniature neutron generator is for active detection of highly enriched uranium using a movable detection system. It is a small size, lightweight, low power consumption neutron generator with ease of operation and maintenance. The detector is based on a simplified ion source and ion transport system. | | Patent | CHU WEI-KAN , SHAO LIN , LIU JIARUI | THE UNIVERSITY OF HOUSTON SYSTEM |
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| 2003 |
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| WO2004/10470
AU2003281663A1
US06835626B2
US20050260836A1
US20040018703A1
WO2004010470A2 | METHOD TO OVERCOME INSTABILITY OF ULTRA-SHALLOW SEMICONDUCTOR JUNCTIONS | A method of forming a stable unction on a microelectronic structure on a semiconductor wafer having a silicon surface layer on a substrate includes the following steps: implanting dopant ions into the surface layer; cleaning and oxidizing the surface layer, and twice annealing the wafer to recover a damaged silicon crystal structure of the surface layer resulting from the low energy ion implantation. The first annealing process uses a temperature range of 800C to 1200C for a duration from about a fraction of a second to less than about 1000 seconds, with a ramp-up rate of about 50C/second to about 1000C/second. The second annealing process uses a temperature range of 400C to 650C for a time period of from about 1 second to about 10 hours, and more preferably, from about 60 seconds to about 1 hour. Both annealing processes include cooling processes. |
| Document Type | Authors | Current Patent Assignee | Journal Title (Short) | (Series) Volume | Number | Publication Year | Page | DOI | ISSN | Patent Number | Title | Abstract | | Conference Paper | Cheng, Ying; Zhang, Yue; Lv, Lin; Liu, Jiarui; Tao, Fei; Zhang, Lin |
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| 2012 | 320 - 325 | 10.1109/INDIN.2012.6301212 | 1935-4576 |
| Analysis of cloud service transaction in cloud manufacturing | The new networked manufacturing mode, cloud manufacturing (CMfg), is provided with a new operation and transaction mode. To support the research, development and application of the mode and service platform of CMfg, manufacturing resource and capability cloud service transaction (CST) of the tripartite users (i.e., provider, operator and consumer) is described briefly, and the detailed transaction flow is provided. With the characteristics of different cloud services (CSs), considering the multi-layer of logistics, information flow and capital flow, the transactions on hardware-class, software-class, product-class and capability-class CSs are analyzed respectively. Finally, the important and difficult problems urgently to be solved in the whole CST process are pointed out. | | Article | Liu, Jia-Rui; Guo, Shi-Ze; Lu, Zhe-Ming; Yu, Fa-Xin; Li, Hui |
| IEICE Trans. Inf. Syst. | E96-D | 3 | 2013 | 727 - 730 | 10.1587/transinf.E96.D.727 | 0916-8532 |
| An approximate flow betweenness centrality measure for complex network | In complex network analysis, there are various measures to characterize the centrality of each node within a graph, which determines the relative importance of each node. The more centrality a node has in a network, the more significance it has in the spread of infection. As one of the important extensions to shortest-path based betweenness centrality, the flow betweenness centrality is defined as the degree to which each node contributes to the sum of maximum flows between all pairs of nodes. One of the drawbacks of the flow betweenness centrality is that its time complexity is somewhat high. This Letter proposes an approximate method to calculate the flow betweenness centrality and provides experimental results as evidence. Copyright | | Article | Wang, Zhongyuan; Shang, Yongheng; Liu, Jiarui; Wu, Xidong |
| Meas. J. Int. Meas. Confed. | 46 | 1 | 2013 | 402 - 410 | 10.1016/j.measurement.2012.07.015 | 0263-2241 |
| A LabVIEW based automatic test system for sieving chips | The present trend for Complementary Metal Oxide Semiconductor (CMOS) chip designs is smaller in size and power consumption with multifunction. This results the difficulty for the testing engineer, especially for small amount production without an automatic probe station, to complete such task. In order to reduce the workload of the engineer, improve the testing efficiency and accuracy, a LabVIEW based automatic test system for such CMOS chip has been designed in this paper. The details of the overall system which includes the setup of the testing by using a PXI (PCI extensions for instrumentation) system with Data Acquisition (DAQ) and Source Measure Units (SMUs) module, and the LabVIEW based automatic testing program has been introduced in this paper. The testing results have shown that this system is able to improve the testing efficiency with great accuracy, at the same time to evaluate the testing results in real-time. Due to the software is built on different modules, and it is therefore easy to be extended for different applications. | | Article | Huang; Ye; Xu; Liu; Qu |
| Shengwu Yixue Gongchengxue Zazhi/J. Biomed. Eng. | 17 | 1 | 2000 | 63 - 65 |
| 1001-5515 |
| Effects of extremely low frequency weak magnetic fields on the intracellular free calcium concentration in PC-12 tumor cells | In this study the effects of the extremely low frequency (ELF) magnetic fields on intracellular Ca2+ concentration ([Ca2+]i) of rat chromaffinoma PC-12 cells were examined by using a digital fluorescence image microscopy system. A 50 Hz, 100 μT sinusoidal ELF magnetic field increased [Ca2+]i to a marked level, whereas a static field or a field of higher frequency (2000 Hz) did not cause a [Ca2+]i increase. The magnetic field-induced [Ca2+]i rise was partly due to an influx of extracellular Ca2+ and partly due to the release of intracellular Ca2+ pool. It seemed likely that the Ca2+ transport ability of the cell membranes was increased by the 50 Hz magnetic field. | | Conference Paper | Wilson; Liu; Romero-Borja; Chu |
| Mater. Res. Soc. Symp. Proc. | 396 |
| 1996 | 311 - 316 |
| 0272-9172 |
| Proton modification of ultra high molecular weight polyethylene to promote crosslinking for enhanced chemical and physical properties | Crosslinking onset was investigated for ultra high molecular weight polyethylene(UHMW-PE) implanted with 2.6 MeV H+ ions at low doses from 6×1011-3×1013 ions/cm2. Crosslinking in the near surface region(20-40μm) was determined from gel permeation chromatography(GPC) of 1,2,4 trichlorobenzene sol fractions and increased with dose. Fourier transform infrared spectroscopy(FTIR) showed irradiation resulted in increased free radicals confirmed from increased carbonyl groups. Hydrogen annealing after ion implantation resulted in 38-49% decrease in FTIR peak associated with carbonyl. | | Article | Zheng; Liu; Cui; Chu; Rangarajan; Hoffman |
| J. Mater. Res. | 10 | 12 | 1995 | 3124 - 3128 | 10.1557/JMR.1995.3124 | 0884-2914 |
| Analysis of nitride films on silicon substrates by ion beam methods | The simultaneous determination of light element contamination levels and accurate nitrogen-to-metal ratios in nitride thin films deposited on silicon substrates is demonstrated by using α-particle beam energies in the range 3-4 MeV. In this energy range, significant light element sensitivity enhancements are observed, while the heavy elements show classical Rutherford behavior. The use of resonance scattering at different resonance energies is shown to be the method of choice for analyzing BN films on silicon. Also, a technique is suggested for analyzing very thin films in which an aluminum foil substrate and buffer layer are used to enhance sensitivities. | | Conference Paper | Sun, Dawei; Liu, Jiarui |
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| 208 LNEE |
| 2013 | 351 - 357 | 10.1007/978-1-4471-4796-1_45 | 1876-1119 |
| New techniques to improve mathematical education in local engineering universities | This paper analyzes the mathematical education in local engineering universities of China. Some possible reasons are given to explain the difficulties in mathematical teaching and learning. By using morden technologies, emphasizing the fundamental principles and demonstrating the applications of mathematics from various problems in many subjects of engineering, this paper proposed some methods and examples to improve the mathematical education. | | Conference Paper | Sun, Da Wei; Liu, Jia Rui |
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| 415 |
| 2013 | 515 - 518 | 10.4028/www.scientific.net/AMM.415.515 | 1662-7482 |
| On the hamiltonian flow of brake hamiltonian system | This paper studies the Hamiltonian flow of the brake Hamiltonian dynamical system on the symmetrical symplectic manifold. By using the transformation law of Hamiltonian diffeomorphisms and the Hamiltonian vectors, this paper describes the characteristics of the Hamiltonian flows and proves that the Hamiltonian flows are invariant under some transformations. (2013) Trans Tech Publications, Switzerland. | | Article | Dawei, Sun; Jiarui, Liu |
| J. Chem. Pharm. Res. | 6 | 7 | 2014 | 1284 - 1290 |
| 0975-7384 |
| Variational analysis of some questions in dynamical system and biological system | This paper studies the variational problems of some dynamical system. By using the methods of Euler equation and Legendre conditions and some computional techniques in mechanics and differential equations, this paper computes the extrema of some systems and discuss some future applications in symplectic dynamical systems and biological mathematical problems. | | Conference Paper | Liu, Chunye; Miao, Yanqing; Guo, Yihui; An, Yinjuan; Li, Yunfang; Liu, Huanhuan; Chen, Jia; Liu, Jiarui; Dai, Huibin |
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| 19 |
| 2014 | 509 - 516 | 10.2495/MEB140641 | 1743-3525 |
| Chiral drugs separation by a new antibioticsbased chiral stationary phase | A new chiral stationary phase (CSP) was prepared by bonding streptomycin to silica gel through a glutaraldehyde spacer. First, -Aminopropyl trimethoxy silane was bonded to the surface of silica gel, and linked with glutaraldehyde through the amino group. Second, streptomycin reacted with the other aldehyde group of glutaraldehyde by its primary amino-group. Fourier-transform infrared (FI-IR) spectrometer, scanning electron microscope, and elemental analysis indicate that streptomycin was successfully introduced to the surface of silica gel through nucleophilic addition and elimination reactions. The new CSP was applied to the resolution of four kinds of drugs under normal phase conditions, such as isoprenaline hydrochloride, nifedipine, ibuprofen and mandelic acid, which were all fully resolved within 6 min. The results indicate that the new CSP has excellent enantioselectivity for the separation of enantiomers of acid chiral drugs, the mechanism of chiral resolution was also discussed. | | Article | Liu, Jiarui; Zhao, Wei; Huang, Xiaodong; Zhang, Hua; Yu, Xiaoming |
| Dongli Gongcheng Xuebao/Jr. Chi. Soc. Pr. Eng. | 35 | 6 | 2015 | 469 - 475 |
| 1674-7607 |
| Analysis and experimental study on heat transfer formula for plate and shell heat exchangers | Experimental studies were conducted to the heat transfer formula for plate and shell heat exchanger (PSHE), based on the assumption that the plate and shell heat exchanger is a special kind of plate heat exchanger. By analyzing and comparing the applicability of different research methods, such as wall temperature determination method, equal Reynolds number method, Wilson graphical method and equal velocity method, the equal velocity method was finally selected in the experimental study, with which test and verification experiment were respectively performed. In the test experiment, both the inlet and outlet flow rate were controlled to be the same, while in the verification experiment, the flow rate in hot side was kept constant, but that in cold side was changed. The data thus obtained were used to fit the heat transfer formula and calculate the error of heat transfer coefficient. Results show that the relative error of heat transfer coefficient is less than 5%, indicating the heat transfer formula is available, and the study method for heat transfer in plate heat exchanger may serve as a reference for plate and shell heat exchanger. | | Article | Liu, Jiarui; Zhao, Wei; Huang, Xiaodong; Zhang, Hua; Yu, Xiaoming |
| Dongli Gongcheng Xuebao/Jr. Chi. Soc. Pr. Eng. | 35 | 11 | 2015 | 893 - 900 |
| 1674-7607 |
| Experimental analysis on heat transfer correlation of plate-shell heat exchangers | To solve the heat transfer correlation of a plate-shell heat exchanger (PSHE), experimental study was made on the basis of relevant research results of plate heater exchanger (PHE) using equal velocity method. Keeping the flow rate of both cold and hot fluid to be constant, experimental tests were conducted to a 1/1 process PSHE, of which the results were compared and analyzed. Results show that the heat transfer correlation obtained by fitting the empirical value of PHE varies at different qualitative temperatures; the unknown parameters in heat transfer correlation of PSHE are all definite values, i. e. coefficient 0.182 5, Reynolds number index 0.75 and Prandtl number index 0.34; the heat transfer correlation of PSHE is unrelated to the flow processes at plate side, unrelated to the flow processes 1 and 2 at shell side, but is coefficient-related to the flow processes 3 and 4 at shell side, and the coefficients of processes 3 and 4 are 0.82 and 0.68 times of the process 1. | | Article | Liu, Jia-Rui; Zhao, Wei; Huang, Xiao-Dong; Zhang, Hua |
| Reneng Dongli Gongcheng. | 31 | 3 | 2016 | 1 - 8 | 10.16146/j.cnki.rndlgc.2016.03.001 | 1001-2060 |
| Research development on guide groove type plate and shell heat exchanger | As one kind of new-pattern and high-efficiency heat transfer equipment, the plate and shell heat exchanger (PSHE) has the broad application prospects in industry. Taking the guide groove type PSHE as the object, based on the domestic and international research achievements, the paper discusses in detail the structure and the working principle of PSHE, the selection of process composition on plate side and shell side as well as the relevant theories of the heat transfer calculation and pressure drop calculation. The paper also presents the detailed steps and relevant formula on the thermodynamic calculation and points out the problems which shall be noted during the period of the design and calculation for PSHE, such as the plate model selection, the choice of the fouling factor value, the control of errors and so on. In addition, the paper describes the performance test method of PSHE as well as the solving method of the heat transfer criterion equation, summaries the influences of plate structure parameters on flow and heat transfer and analyzes the phenomenon of the flow maldistribution at the inlet of the shell side. Finally, the paper forecasts the development prospects of PSHE and indicates the integrated design, complete-set assembly, and central intellective control will become the key development direction for PSHE. | | Article | Qiu, Jinpeng; Liu, Tong; Chen, Xubin; Shang, Yongheng; Mo, Jiongjiong; Wang, Zhiyu; Chen, Hua; Liu, Jiarui; Lv, Jingjing; Yu, Faxin |
| J. Electr. Comput. Eng. | 2017 |
| 2017 |
| 10.1155/2017/1658695 | 2090-0155 |
| A New Digital to Analog Converter Based on Low-Offset Bandgap Reference | This paper presents a new 12-bit digital to analog converter (DAC) circuit based on a low-offset bandgap reference (BGR) circuit with two cascade transistor structure and two self-contained feedback low-offset operational amplifiers to reduce the effects of offset operational amplifier voltage effect on the reference voltage, PMOS current-mirror mismatch, and its channel modulation. A Start-Up circuit with self-bias current architecture and multipoint voltage monitoring is employed to keep the BGR circuit working properly. Finally, a dual-resistor ladder DAC-Core circuit is used to generate an accuracy DAC output signal to the buffer operational amplifier. The proposed circuit was fabricated in CSMC 0.5 μm 5 V 1P4M process. The measured differential nonlinearity (DNL) of the output voltages is less than 0.45 LSB and integral nonlinearity (INL) less than 1.5 LSB at room temperature, consuming only 3.5 mW from a 5 V supply voltage. The DNL and INL at -55C and 125C are presented as well together with the discussion of possibility of improving the DNL and INL accuracy in future design. | | Conference Paper | Luo, Bin; Liu, Jiarui; Li, Junlan; Liang, Haibo |
| MATEC Web Conf. | 100 |
| 2017 |
| 10.1051/matecconf/201710003007 | 2274-7214 |
| The design and implementation of the remote centralized-monitoring system of well-control equipment based on RFID technique | At present, in domestic for the management of well control equipment continue to the traditional way of nameplates identifies and paper-based registration, there are many issues like the separation of data information of device, easy lose, difficult query, confused management and many other problems, which will make the problem device into the well field, and then resulting in well control runaway drilling accident. To solve the above problems, this paper put forward to the integrated remote centralized-monitoring management mode of the well-control equipment. Taking the advantages of IOT technology, adopting the RFID technology, and combining with the remote transmission, this paper designs the remote centralized-monitoring system of well-control equipment based on RFID, which realizes the intelligent management of well-control equipment and meets the actual demand of the well-control equipment safe use and timely scheduling, and it has the ability of field application. | | Review | Li, Si-Rong; Huang, Yen-Chun; Liu, Jia-Rui; Wang, Er-Kang; Wei, Hui |
| Prog. Biochem. Biophys. | 45 | 2 | 2018 | 129 - 147 | 10.16476/j.pibb.2017.0469 | 1000-3282 |
| Nanozymes in analytical chemistry: From in vitro detection to live bioassays | Nanozymes, the catalytic nanomaterials w ith enzyme-like properties, have attracted enormous interests in recent years. They have been used for wide range applications from biosensing and bioimaging to therapeutics and environmental protection. In this review, we highlighted the recent progress of nanozymes in analytical applications. We first discussed the in vitro applications, which covered the detection of bioactive small molecules, nucleic acids, protein biomarkers, cells, etc. We then discussed the in vivo applications, which included the monitoring of bioactive small molecules in live brains and tumor tissues, the study of drug efficacy, and the investigation of drug and nanozyme metabolism, etc. Finally, we concluded the potential challenges of nanozymes when applying to analytical chemistry and prospected future directions. | | Article | Liu, Jiarui; Izon, Gareth; Wang, Jiasheng; Antler, Gilad; Wang, Zhou; Zhao, Jie; Egger, Matthias |
| Biogeosciences | 15 | 20 | 2018 | 6329 - 6348 | 10.5194/bg-15-6329-2018 | 1726-4189 |
| Vivianite formation in methane-rich deep-sea sediments from the South China Sea | Phosphorus is often invoked as the ultimate limiting nutrient, modulating primary productivity on geological timescales. Consequently, along with nitrogen, phosphorus bioavailability exerts a fundamental control on organic carbon production, linking all the biogeochemical cycles across the Earth system. Unlike nitrogen that can be microbially fixed from an essentially infinite atmospheric reservoir, phosphorus availability is dictated by the interplay between its sources and sinks. While authigenic apatite formation has received considerable attention as the dominant sedimentary phosphorus sink, the quantitative importance of reduced iron-phosphate minerals, such as vivianite, has only recently been acknowledged, and their importance remains underexplored. Combining microscopic and spectroscopic analyses of handpicked mineral aggregates with sediment geochemical profiles, we characterize the distribution and mineralogy of iron-phosphate minerals present in methane-rich sediments recovered from the northern South China Sea. Here, we demonstrate that vivianite authigenesis is pervasive in the iron-oxide-rich sediments below the sulfate-methane transition zone (SMTZ). We hypothesize that the downward migration of the SMTZ concentrated vivianite formation below the current SMTZ. Our observations support recent findings from non-steady-state post-glacial sedimentary successions, suggesting that iron reduction below the SMTZ, probably driven by iron-mediated anaerobic oxidation of methane (Fe-AOM), is coupled to phosphorus cycling on a much greater spatial scale than previously assumed. Calculations reveal that vivianite acts as an important burial phase for both iron and phosphorus below the SMTZ, sequestering approximately half of the total reactive iron pool. By extension, sedimentary vivianite formation could serve as a mineralogical marker of Fe-AOM, signalling low-sulfate availability against methanogenic and ferruginous backdrop. Given that similar conditions were likely present throughout vast swathes of Earth's history, it is possible that Fe-AOM and vivianite authigenesis may have modulated methane and phosphorus availability on the early Earth, as well as during later periods of expanded marine oxygen deficiency. A better understanding of vivianite authigenesis, therefore, is fundamental to test long-standing hypotheses linking climate, atmospheric chemistry and the evolution of the biosphere. | | Chapter | Liu, Jiarui; Yang, Xiaoning; Yu, Siwang; Zheng, Ruimao |
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| 1090 |
| 2018 | 123 - 144 | 10.1007/978-981-13-1286-1_7 | 2214-8019 |
| The leptin signaling | Leptin plays a critical role in the regulation of energy balance and metabolic homeostasis. Impairment of leptin signaling is closely involved in the pathogenesis of obesity and metabolic diseases, including diabetes, cardiovascular disease, etc. Leptin initiates its intracellular signaling in the leptin-receptor-expressing neurons in the central nervous system to exert physiological function, thereby leading to a suppression of appetite, a reduction of food intake, a promotion of mitochondrial oxidation, an enhancement of thermogenesis, and a decrease in body weight. In this review, the studies on leptin neural and cellular pathways are summarized with an emphasis on the progress made during the last 10 years, for better understanding the molecular mechanism of obesity and other metabolic diseases. | | Chapter | Liu, Jiarui; Yang, Xiaoning; Yu, Siwang; Zheng, Ruimao |
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| 1090 |
| 2018 | 145 - 163 | 10.1007/978-981-13-1286-1_8 | 2214-8019 |
| The leptin resistance | Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid metabolism. The pathologically increased circulating leptin is a biomarker of leptin resistance, which is common in obese individuals. Leptin resistance is defined by a reduced sensitivity or a failure in response of the brain to leptin, showing a decrease in the ability of leptin to suppress appetite or enhance energy expenditure, which causes an increased food intake and finally leads to overweight, obesity, cardiovascular diseases, and other metabolic disorders. Leptin resistance is a challenge for clinical treatment or drug discovery of obesity. Until recently, emerging evidence has been showing novel mechanisms of the leptin resistance. Here, we summarized the advances and controversy of leptin resistance and associated diseases, for better understanding the physiology and pathophysiology of leptin as well as the new strategies for treating obesity and metabolic disorders. |
| Document Type | Authors | Current Patent Assignee | Journal Title (Short) | (Series) Volume | Number | Publication Year | Page | DOI | ISSN | Patent Number | Title | Abstract | | Article | Xuwei, Deng; Min, Qi; ren, Ren; Jiarui, Liu; Xiaoxue, Sun; Ping, Xie; Jun, Chen |
| Chemosphere | 218 |
| 2019 | 569 - 576 | 10.1016/j.chemosphere.2018.11.121 | 1879-1298 |
| The relationships between odors and environmental factors at bloom and non-bloom area in Lake Taihu, China | Lake Taihu has been experiencing taste and odor (T&O) events recently. And for the purpose of seeking the environmental factors having great influences on T&O compounds and supplying theory information for preventing the occurrence of T&O problems, Redundance analysis (RDA) was conducted for the dissolved and particle-bound forms of T&O compounds. And the whole lake was divided into the blooming and non-blooming areas. Results indicated that environmental factors, including biotic and abiotic factors, made great contributions to the variation of T&O compounds in Lake Taihu. The key biotic factors included Microcystis, Oscillatoria and chlorophyll-a. Microcystis made great contribution of these compounds in the blooming area and had close relationship with those particulate forms of odorants in Taihu. Oscillatoria made great and absolute contribution to odorants in the non-blooming area. Chlorophyll-a influenced greatly the odorants in the blooming area and had significant relationship with the particle-bound fractions in the whole lake. Dissolved oxygen and water temperature were the dominant abiotic factors with large contributions. | | Article | Xie, Peng; Xue, Mantian; Wen, Yu; Li, Xiaofeng; Wang, Xinyu; Yin, Haoyi; Du, Chengze; Liu, Jiarui; Liu, Jianhua |
| Mod. Phys. Lett. B | 33 | 5 | 2019 |
| 10.1142/S0217984919500532 | 0217-9849 |
| Unveiling electrically tunable characteristics of second-order dispersion in graphene-silicon nitride waveguides | In this paper, we proposed a graphene-silicon nitride (GSN) waveguide model, which was unveiled to unveil its second-order dispersion (SOD) characteristics. The influences of the different thicknesses of graphene layer and the different heights from graphene to the core material of silicon nitride on SOD were investigated in detail. The tunability of SOD via controlling the bias voltage applied to the graphene layer was demonstrated and a 50 nm wavelength tuning was achieved with a small perturbation in voltage while keeping the geometric structure of the waveguide unchanged. Moreover, a flat SOD curve of the GSN waveguide was obtained with a large bandwidth of 700 nm between the two zero-dispersion wavelengths (ZDWs). These results provided significant insights for potential applications of graphene-related optoelectronic devices, integrated optics, and optical communications. | | Article | Zhuang, Guang-Chao; Montgomery, Andrew; Samarkin, Vladimir A.; Song, Min; Liu, Jiarui; Schubotz, Florence; Teske, Andreas; Hinrichs, Kai-Uwe; Joye, Samantha B. |
| Geophys. Res. Lett. | 46 | 5 | 2019 | 2637 - 2646 | 10.1029/2018GL081284 | 1944-8007 |
| Generation and Utilization of Volatile Fatty Acids and Alcohols in Hydrothermally Altered Sediments in the Guaymas Basin, Gulf of California | Volatile fatty acids (VFAs) and alcohols are key intermediates of anaerobic carbon metabolism, yet their biogeochemical cycling remains poorly constrained in hydrothermal systems. We investigated the abundance, stable carbon isotopic composition, and metabolic cycling of VFAs and alcohols to elucidate their generation and utilization pathways in hydrothermally influenced sediments (4 C to 90 C) from the Guaymas Basin. Acetate (up to 229 μM) and methanol (up to 37 μM) were abundant in porewaters. The δ13C values of acetate varied between −35.6‰ and −18.1‰. Carbon isotopic signatures, thermodynamic predictions, and experimental incubations suggested biological sources such as fermentation and acetogenesis for acetate. Acetate and methanol were predominantly consumed by nonmethanogenic processes (e.g., sulfate reduction), as reflected in high oxidation rates versus low methanogenesis rates, and further evidenced through inhibition experiments with molybdate. These results reveal an important role for VFAs and alcohols as energy sources for diverse chemoheterotrophs in organic-rich hydrothermally influenced sediments. | | Article | Li, Haoming; Shen, Yupeng; Wang, Tengjia; Liu, Jiarui |
| Microelectron. j. | 85 |
| 2019 | 135 - 143 | 10.1016/j.mejo.2019.02.007 | 0959-8324 |
| A 210fs RMS jitter 187.5 MHz-3GHz fractional-N frequency synthesizer with quantization noise suppression techniques and chopping differential charge pump for SDR applications | This paper proposes a low noise fractional-N frequency synthesizer with quantization noise suppression techniques and a chopping differential charge pump. A level-shift-less phase frequency detector and a chopping differential charge pump are proposed to improve matching performance and suppress in-band phase noise of the frequency synthesizer. The combination of a 4/4.5 divider and a notch filter enable the design of an efficient system to suppress quantization noise and improve in-band and out-band phase noise by 3 dB and 6 dB, respectively. With all these techniques, the frequency synthesizer is implemented in a standard 65 nm CMOS process, achieving 210fs root mean square jitter and less than −70dBc reference spur with operating range from 187.5 MHz to 3 GHz. | | Article | Liu, Jiarui; Xia, Qing; Li, Shuai; Hao, Aimin; Qin, Hong |
| Comput. Aided Geom. Des. | 71 |
| 2019 | 63 - 76 | 10.1016/j.cagd.2019.04.017 | 0167-8396 |
| Quantitative and flexible 3D shape dataset augmentation via latent space embedding and deformation learning | Deep learning techniques for geometric processing have been gaining popularity in recent years, various deep models (i.e., deep learning methods based on neural networks) are developed with enhanced performance and functionality in conventional geometric tasks such as shape classification, segmentation, and recognition. Yet, deep models would rely on large datasets for the training and testing purpose, which are generally lacking as 3D shape geometry could not be easily acquired and/or reconstructed. In this paper, we propose a new 3D shape dataset augmentation method by learning the deformation between shapes in a highly reduced latent space while affording interactive control of shape generation. Specifically, we model each shape using a concise skeleton-based representation, and then we apply Gaussian Process Latent Variable Model (GPLVM) to embed all shape skeletons into a low-dimensional latent space, where new skeletons could be generated with diverse kinds of flexible control and/or quantitative guidance. A second network that learns the displacement between shapes can be employed to produce new 3D shape from newly-generated skeletons. Compared with popular computer vision techniques, our new generative method could overcome remaining challenges of 3D shape augmentation with new characteristics. Specifically, our new method is capable of transforming 3D shapes in a more liberal way, preserving their geometric properties at a semantic level, and creating new shape with ease and flexible control. Extensive experiments have exhibited the capability and flexibility of our new method in generating new shapes using only few samples. Our shape augmentation is an effective way to simultaneously improve the shape creation capability and the shape extrapolation accuracy, and it is also of immediate benefit to almost all deep learning tasks in geometric modeling and processing. | | Article | Shen, Yupeng; Li, Haoming; Chen, Xubin; Liu, Jiarui; Chen, Hua |
| IEICE Electron. Express | 16 | 4 | 2019 | 1 - 7 | 10.1587/elex.16.20181089 | 1349-2543 |
| A 0.07-3GHz wideband front-end for SDR receiver with 2.3dB NF and 12dBm IIP3 in 65nm CMOS | This paper presents a wideband (0.07-3 GHz) receiver front-end realized in 65 nm CMOS technology for mobile Software-Defined Radio (SDR) applications. A more power-efficient wideband common-gate lownoise amplifier (LNA) featuring a common-source path for noise-canceling is proposed to trade-off linearity and noise figure (NF). A current commutating down conversion passive mixer with transimpedance amplifier is applied to achieve low flicker noise and high linearity with low supply voltage. Measurements show that the front-end achieves conversion gain higher than 42 dB. The measured NF ranges from 2.28 to 3.68 dB in the covered frequency range and IIP3 varies from 9 to 12dBm versus different frequencies. The front-end occupies an active area of 0.8mm2 and consumes a power of 40mW from 1.2V supply voltage. | | Article | Liang, Yi; Zhang, Han; Tan, Xin; Liu, Jiarui; Qin, Chunhong; Zeng, Hui; Zheng, Yanting; Liu, Yujie; Chen, Jingxian; Leng, Xi; Qiu, Shijun; Shen, Dinggang |
| Front. Neurosci. | 13 | FEB | 2019 |
| 10.3389/fnins.2019.00063 | 1662-4548 |
| Local diffusion homogeneity provides supplementary information in T2DM-related Wm microstructural abnormality detection | Objectives: We aimed to investigate whether an inter-voxel diffusivity metric (local diffusion homogeneity, LDH), can provide supplementary information to traditional intra-voxel metrics (i.e., fractional anisotropy, FA) in white matter (WM) abnormality detection for type 2 diabetes mellitus (T2DM). Methods: Diffusion tensor imaging was acquired from 34 T2DM patients and 32 healthy controls. Voxel-based group-difference comparisons based on LDH and FA, as well as the association between the diffusion metrics and T2DM risk factors [i.e., body mass index (BMI) and systolic blood pressure (SBP)], were conducted, with age, gender and education level controlled. Results: Compared to the controls, T2DM patients had higher LDH in the pons and left temporal pole, as well as lower FA in the left superior corona radiation (p < 0.05, corrected). In T2DM, there were several overlapping WM areas associated with BMI as revealed by both LDH and FA, including right temporal lobe and left inferior parietal lobe; but the unique areas revealed only by using LDH included left inferior temporal lobe, right supramarginal gyrus, left pre- and post-central gyrus (at the semiovale center), and right superior radiation. Overlapping WM areas that associated with SBP were found with both LDH and FA, including right temporal pole, bilateral orbitofrontal area (rectus gyrus), the media cingulum bundle, and the right cerebellum crus I. However, the unique areas revealed only by LDH included right inferior temporal lobe, right inferior occipital lobe, and splenium of corpus callosum. Conclusion: Inter- and intra-voxel diffusivity metrics may have different sensitivity in the detection of T2DM-related WM abnormality. We suggested that LDH could provide supplementary information and reveal additional underlying brain changes due to diabetes. | | Article | Xie, Peng; Wen, Yu; Yang, Wenqiang; Wan, Zishen; Liu, Jiarui; Wang, Xinyu; Da, Siqi; Wang, Yishan |
| Mod. Phys. Lett. B | 33 | 17 | 2019 |
| 10.1142/S0217984919501872 | 0217-9849 |
| Tunable gallium nitride-based devices for ultrafast signal processing | In this paper, we propose a micro-ring resonator model based on gallium nitride (GaN) and graphene, which exhibits tunable properties of nonlinearity. It provides a great bandwidth covering from visible to telecommunication band. Especially, based on the characteristic of GaN, it has unique advantages in shorter wavelength, which is used for demonstrating the ultrafast signal processing including wavelength conversion, temporal amplification and pulse compression. Moreover, the tunable signal processing is achieved via the method of applying additional bias voltage to graphene without changing the geometric dimension of the device. These results have significant potential applications of nonlinear optics and optical communications. | | Article | Xia, Qing; Chen, Chengju; Liu, Jiarui; Li, Shuai; Hao, Aimin; Qin, Hong |
| Comput. Graph. | 82 |
| 2019 | 129 - 139 | 10.1016/j.cag.2019.05.014 | 0097-8493 |
| Efficient 4D shape completion from sparse samples via cubic spline fitting in linear rotation-invariant space | Computer animation is frequently produced via interpolating a few sparse samples created by artists or reverse-engineered from physical prototypes, however, existing interpolation techniques fall short in efficiently generating a smooth 4D shape sequence from sparse samples. In this paper, we extend traditional curve fitting technique to 4D shape completion in shape space with novel technical components. In particular, we seek a smooth 4D shape sequence by minimizing the total shape distortion along the sequence trajectory. After embedding the shapes into a linear rotation-invariant feature space, the complex global minimization of shape distortion in shape space can be converted into simple cubic spline fitting problems in feature domains, which can be solved analytically. With cubic splines, we can not only handle in-between shapes interpolation, but also perform extrapolation towards more exciting results. To further improve the computational efficiency, we devise a hierarchical framework, in which the shape space is decomposed into high-frequency and low-frequency domains, the interpolation is only operated on the low-frequency domain, while the high-frequency details are enabled via deformation transfer techniques. We have conducted extensive experiments and comprehensive evaluations that showcase many attractive advantages of our novel method, including smooth interpolation between shapes, plausible extrapolation outside conventional shape domain, robustness under large deformations, and interactive performance for complicated shapes with high-quality details. | | Article | Liu, Jiarui; Wang, Yingli; Liu, Fangming; Cheng, Fangyi; Chen, Jun |
| J. Energy Chem. | 42 |
| 2020 | 1 - 4 | 10.1016/j.jechem.2019.05.017 | 2095-4956 |
| Improving metallic lithium anode with NaPF6 additive in LiPF6-carbonate electrolyte | A facile, efficient strategy to stabilize the Li anode of a battery involves introducing NaPF6 additive into the LiPF6-carbonate electrolyte. In the mixed ethylene carbonate and diethyl carbonate solvents, the addition of dilute NaPF6 modulates the plating/stripping behaviors of Li+/Li. Electrochemical, structural, and morphological studies suggest that the benefits of Na addition arise from the sluggish dynamics of Na+/Na due to charge transfer, ionic mobility and modified desolvation energy. Remarkably, a for- mulated electrolyte (1.0 M LiPF6 + 0.02 M NaPF6) results in a stable discharge/charge potential of lithium anode and a smooth deposition layer over 800 hr. | | Article | Xie, Peng; Wen, Yu; Wan, Zishen; Wang, Xinyu; Liu, Jiarui; Yang, Wenqiang; Li, Xiaofeng; Wang, Yishan |
| Jpn. J. Appl. Phys. | 58 | 5 | 2019 |
| 10.7567/1347-4065/ab0c52 | 1347-4065 |
| Electrically tunable temporal imaging in a graphene-based waveguide | We propose an electrically tunable temporal imaging system (TIS) based on four-wave mixing in a dispersion engineered graphene-based waveguide, which could realize a magnification factor of 1000× for a signal consisting of two 100-fs-wide pulses separated by 500 fs and a large working bandwidth of about 700 nm. The TIS was analyzed by solving the couple-mode equations in detail. It was demonstrated that the working wavelength range could be tuned via a small disturbed bias voltage applied to the graphene layer without changing the geometric structure of the waveguide. These results provide attractive insights for potential applications in integrated optics and optical communications. | | Article | Liu, Jiarui; Lu, Wei; Liu, Ke; Huang, Xinchao; Lin, Cong; Liu, Xianjin |
| Yingyong Kexue Xuebao. | 37 | 3 | 2019 | 419 - 426 | 10.3969/j.issn.0255-8297.2019.03.012 | 0255-8297 |
| Copy-Move Forgery Detection Based on Super Pixel Segmentation | A clustering method to detect the copy-move area based on the results of superpixel segmentation is proposed. Different from the traditional K-means clustering method, the proposed clustering method is to place random seeds in the image and segment the region by using super-pixel segmentation method, and then obtain the regions containing pre-matched feature points. In this algorithm, the number of matched feature points in each region is used as a criterion to determine whether the matched feature points in the region are effective feature points. When the number of matching points reaches a certain threshold, the points in the sub-regions are clustered into one group, so that the clustering results are closer to the image content and in accordance with the actual situation. Experiments show that the proposed method based on super-pixel segmentation is more effective than the traditional SIFT method. | | Article | Chen, Xubin; Li, Xuan; Shen, Yupeng; Liu, Jiarui; Chen, Hua |
| IEICE Electron. Express | 16 | 11 | 2019 | 1 - 5 | 10.1587/elex.16.20190197 | 1349-2543 |
| Letter a 14 bit 500 MS/s SHA-less pipelined ADC with a highly linear input buffer and power-efficient supply voltage domain arrangement in 40 nm CMOS | In this paper, a 14 bit 500 MS/s SHA-less pipelined Analog-to-Digital Converter (ADC) realized in 40 nm CMOS technology is presented. A 2.5 V powered buffer that exhibits a comprehensive bootstrap architecture is proposed to achieve the trade-off between linearity and power consumption. Besides, the high-voltage-thin-oxide-device design is incorporated to further improve the linearity. In the meantime, an improved supply voltage domain arrangement is proposed to achieve a single power design and improve structural power efficiency. The measured Signal-to-Noise-and-Distortion-Ratio (SNDR) and Spurious-Free-Dynam-ic-Range (SFDR) are 71 dB and 79 dBc at 120.2 MHz input signal under 500 MS/s. The ADC occupies an active area of 0.4 mm2 and consumes a total power of 300 mW. | | Article | Zhao, Xiaoyu;Xie, Zongwu;Yang, Haitao;Liu, Jiarui |
| Robotica | 38 | 4 | 2020 | 652 - 668 | 10.1017/S0263574719000924 | 1469-8668 |
| Minimum Base Disturbance Control of Free-Floating Space Robot during Visual Servoing Pre-capturing Process | During visual servoing space activities, the attitude of free-floating space robot may be disturbed due to dynamics coupling between the satellite base and the manipulator. And the disturbance may cause communication interruption between space robot and control center on earth. However, it often happens that the redundancy of manipulator is not enough to fully eliminate this disturbance. In this paper, a method named off-line optimizing visual servoing algorithm is innovatively proposed to minimize the base disturbance during the visual servoing process where the degrees-of-freedom of the manipulator is not enough for a zero-reaction control. Based on the characteristic of visual servoing process and the robot system modeling, the optimal control method is applied to achieve the optimization, and a pose planning method is presented to achieve a second-order continuity of quaternion getting rid of the interruption caused by ambiguity. Then simulations are carried out to verify the method, and the results show that the robot is controlled with optimized results during visual servoing process and the joint trajectories are smooth. | | Article | Xie, Peng; Liu, Jiarui; Wen, Yu; Wan, Zishen; Wang, Yishan |
| Mod. Phys. Lett. B | 33 | 21 | 2019 |
| 10.1142/S0217984919502415 | 0217-9849 |
| Influences of second-order and third-order dispersion on spectral properties of mid-infrared wavelength conversion in silicon nitride waveguides | The influences of second-order dispersion (SOD) and third-order dispersion (TOD) on spectral properties of wavelength conversion based on FWM at mid-infrared region (mid-IR) are theoretically investigated in a silicon nitride waveguide. It is found that the SOD and TOD can affect the frequency shift and temporal profiles of idler pulses. Moreover, the temporal and frequency spectrum of output signal are also discussed with different SODs and TODs. Meanwhile, the numerical simulation results imply that the efficiency of FWM process will be reduced and the wavelength range of phase-match will be shifted due to the change of SOD or TOD. | | Article | Yu, Jia; Chen, Jun; Deng, Xuwei; Wu, Zhixu; Yu, Zuoming; Xu, Jun; Su, Haojie; Liu, Jiarui; Wang, Li; Wu, Yao; Xie, Ping |
| Water | 11 | 7 | 2019 |
| 10.3390/w11071429 | 2073-4441 |
| Trophic patterns of bighead carp and silver carp follow the seasonality of resource availability | The influence of seasonality of the aquatic environment on food web has been notoriously understudied in empirical ecology. In this study, we focus on seasonal changes in one key attribute of a food web, the trophic level. We determine whether seasonal variations of fish trophic levels could be indicated by the change in food resources. Silver carp (Hypophthalmichthys molitrix) and bighead carp (H. nobilis) were used to explore the responses of trophic levels of the filter-feeding fish to seasonal variations of food resources. Combined stable isotopic analysis and dietary analysis revealed that filter-feeding fish tended to have a higher trophic level in spring (May) and autumn (September and October). This may result from the abundant density of food resources (zooplankton and phytoplankton) and fish flexible foraging strategy, as we predicted that the trophic level follows the seasonality of food availability. Pearson' correlation analysis and a structural equation model showed that seasonal variation of total phosphorus and water temperature could indirectly affect trophic levels of silver carp and bighead carp by mediating the abundance of phytoplankton and zooplankton directly and indirectly along the food chain. According to these findings, the seasonal variation of food resources could be an important indicator of the temporal dynamics of the food web trophic pattern in freshwater ecosystems. | | Article | Feng, Ran; Liu, Jiarui |
| Eng. Struct. | 199 |
| 2019 |
| 10.1016/j.engstruct.2019.109591 | 1873-7323 |
| Numerical investigation and design of perforated aluminium alloy SHS and RHS columns | This paper describes a numerical investigation on perforated aluminium alloy square and rectangular hollow section (SHS and RHS) columns by the finite-element analysis (FEA). The non-linear finite-element model (FEM) was developed by considering both geometric and material non-linearities. The initial local and overall geometric imperfections of aluminium alloy columns were incorporated in the FEM. The non-linear FEM was verified against the corresponding experimental results, which was further used for an extensive parametric study that consisted of 594 specimens with different cross-section dimensions, overall lengths, as well as diameters, numbers and locations of circular openings. The ultimate strengths of the columns obtained from FEA were employed to evaluate the current design specifications for aluminium alloy and cold-formed steel structures. It is demonstrated that American Specification (AA) and limit state design (LSD) in Australian/New Zealand Standard (AS/NZS) are somewhat unconservative, whereas allowable stress design (ASD) in Australian/New Zealand Standard (AS/NZS) and Chinese Code are quite conservative, while European Code (EC9) is generally appropriate for imperforated aluminium alloy columns. In addition, North American Specification (NAS) and direct strength method (DSM) for cold-formed steel structural members with openings are quite conservative for aluminium alloy columns with circular openings. The design equations proposed based on the design rules of EC9 were verified to be accurate for perforated aluminium alloy SHS and RHS columns under axial compression. | | Article | Zhang, Ya-Yun; Liu, Jia-Rui; Wang, Zhi-Yu; Mo, Jiong-Jiong; Yu, Fa-Xin |
| Zhejiang Daxue Xuebao (Gongxue Ban) | 53 | 10 | 2019 | 2034 - 2040 | 10.3785/j.issn.1008-973X.2020.10.021 | 1008-973X |
| Implementation of direct digital frequency synthesizer based on three-step rotation coordinate rotation digital computer algorithm | A high precision and low output delay coordinate rotation digital computer (CORDIC) algorithm based on three-step rotation mechanism was proposed. The operation of the residual rotation angle was avoided by binary to bipolar recoding of the input angle, the number of iterations was compressed by three-step rotation mechanism, and the number of iterations and output delay were reduced by combining with merging iteration technique. The three-step rotation CORDIC algorithm and pipeline iterative algorithm were implemented by taking 16-bit output bit-width as an example. The simulation results show that the three-step rotation CORDIC algorithm improves the output accuracy, reduces the input-output delay by 75%, and reduces the hardware overhead by 29.2% compared with the pipeline iterative algorithm. The direct digital frequency synthesizer (DDFS) with a phase accumulator of 24 bits bit-width was implemented based on the three-step rotation CORDIC algorithm, and the multi-input adder was optimized with the addition tree structure in order to improve the circuit frequency. The simulation results showed that the maximum amplitude error of the algorithm was 8.24 × 10-6, and the output delay was 38.5 ns. | | Conference Paper | Wang, Xin; Xu, Jiabing; Shi, Wei; Liu, Jiarui |
|
| 1325 | 1 | 2019 |
| 10.1088/1742-6596/1325/1/012089 | 1742-6596 |
| OGRU: An Optimized Gated Recurrent Unit Neural Network | Due to the structural problem, the traditional neural network models are prone to problems such as gradient explosion and over-fitting, while the deep GRU neural network model has low update efficiency and poor information processing capability among multiple hidden layers. Based on this, this paper proposes an optimized gated recurrent unit(OGRU) neural network.The OGRU neural network model proposed in this paper improves information processing capability and learning efficiency by optimizing the unit structure and learning mechanism of GRU, and avoids the update gate being interfered by the current forgetting information. The experiment uses Tensorflow framework to establish prediction models for LSTM neural network, GRU neural network and OGRU neural network respectively, and compare the prediction accuracy. The results show that the OGRU model has the highest learning efficiency and better prediction accuracy. | | Article | Wang, Ke; Sun, Xiaopeng; Li, Yongzheng; Wei, Pengyu; Liu, Jiarui; Bian, Chao; Zhang, Shixing; Huang, Xiangyu |
| Int. J. Mod. Phys. B | 34 | 1-3 | 2020 |
| 10.1142/S0217979220400330 | 1793-6578 |
| Dwell-fatigue crack growth mechanisms of titanium alloy Ti-6Al-4V at room-temperature | Ti-6Al-4V alloy is widely used for the deep-sea manned submersible. In addition to the normal cyclic loading, the manned cabin will experience a period of dwell time in each cycle during their service life. In this research, the fatigue and dwell-fatigue crack growth behavior of Ti-6Al-4V alloy under different dwell time were studied experimentally. The mechanism of dwell-fatigue crack growth was investigated. The acceleration phenomenon of the dwell-fatigue crack growth can be directly observed in the experiment. The relationship between the crack length and the dwell time was captured under different ?K within one cycle. The results presented that there is a saturation time for the dwell-fatigue crack growth. A prediction model is proposed to predict the dwell-fatigue crack growth behavior considering the effects of dwell time. | | Conference Paper | Liu, Jiarui; Wu, Xianyu |
|
| 688 | 4 | 2019 |
| 10.1088/1757-899X/688/4/044040 | 1757-899X |
| Research of emergency feeder bus scheme for urban rail transit under unexpected incident | Because of rail transit's fixed track, once the normal operation is interrupted due to unexpected events, a large number of passengers will be detained. The application of scheme for emergency feeder bus which include not only bus dispatching, but also the scheme of bus line operation is an efficient way to evacuate detained passenger when the rail transit is held up. To solve the problem of emergency feeder bus, it is suggested that the scheme of the bus dispatching and bus route layout be proposed on the basis of determining the affected passenger flow and analyzing the selection behavior of passengers. Based on the bus emergency reserve point, the transfer algorithm is proposed. An emergency bus route layout model is established, in which passengers who do not choose emergency bus connections are excluded, and corresponding connection schemes are designed. Finally, an example is given, and the result shows that considering passenger choice behavior will save scheduling cost, and the emergency bus transfer plan considering passenger choice behavior has certain practical significance. | | Article | Oita, Azusa; Wirasenjaya, Farah; Liu, Jiarui; Webeck, Elizabeth; Matsubae, Kazuyo |
| Resour. Conserv. Recycl. | 157 |
| 2020 |
| 10.1016/j.resconrec.2020.104752 | 1879-0658 |
| Trends in the food nitrogen and phosphorus footprints for Asia's giants: China, India, and Japan | Substantial losses of nitrogen (N) and phosphorus (P) to the environment occur during food production. These emissions of reactive N (Nr) and P have adverse effects on the environment. The life cycle emissions of Nr and P due to resource consumption can be quantified using N and P footprints. In this study, a common framework developed for the purpose of making comparisons was used to examine the food N and P footprints of China, India, and Japan from 1961 to 2013. The footprints increased significantly in China after 1976 (5.4–19.3 kg-N capita−1 yr−1 and 1.20–4.77 kg-P capita−1 yr−1 in 1976–2013) with the higher consumption of meat and vegetables. In India, an increase in milk and vegetable consumption resulted in a gradual increase in the footprints since 1976 (8.5–11.4 kg-N capita−1 yr−1, 0.99–1.6 kg-P capita−1 yr−1 in 1976–2013). In Japan, the footprints increased until 1993 (12.2–28.3 kg-N capita−1 yr−1, 2.59–8.43 kg-P capita−1 yr−1 in 1961–1993) before declining (21.8 kg-N capita−1 yr−1, 6.05 kg-P capita−1 yr−1 in 2013), with a constant increase in meat consumption, a decrease in cereals, and improvements in nutrient use efficiency. The N footprint tends to be more sensitive to the consumption of meat, milk, oil crops, fish, and seafood, and the P footprint tends to be more sensitive to vegetables. By analysing the Asian giants, the key food items to target to reduce the footprints are identified. If the per-capita average footprints in high and middle income countries were the same as that in Japan in 1993, the global food N and P footprints would increase by factors of 1.18–1.89 by 2030. The use of these results with other advances in agriculture practices has the potential to improve nutrient use efficiency and to promote more efficiently-produced food. | | Article | Liu, Jiarui; Pellerin, André; Izon, Gareth; Wang, Jiasheng; Antler, Gilad; Liang, Jinqiang; Su, Pibo; Jørgensen, Bo Barker; Ono, Shuhei |
| Earth Plan. Sci. Lett. | 536 |
| 2020 |
| 10.1016/j.epsl.2020.116165 | 0012-821X |
| The multiple sulphur isotope fingerprint of a sub-seafloor oxidative sulphur cycle driven by iron | Oxidative sulphur cycling is pervasive in marine sediments, replenishing the oxidised sulphur reservoir via re-oxidation of sulphide. An active, yet cryptic, sulphur cycle has been proposed to operate at depth beneath the sulphate-methane transition (SMT), fuelled by simultaneous sulphide oxidation and sulphate reduction under low-sulphate conditions. The existence of a cryptic sulphur cycle, however, is centred on porewater and genetic data that have little, to no, preservation potential, and thus are rarely accessible from the geological record. The absence of a suitable archive has hindered our ability to reconstruct the operation and importance of the cryptic sulphur cycle through space and time. To overcome this obstacle, and to develop a better understanding of the oxidative sulphur cycle in the deep biosphere, we have determined the abundance and triple sulphur isotope composition (Δ33S and δ34S) of both elemental sulphur and pyrite extracted from sediments recovered from the methane prone Taixinan Basin, South China Sea. Here, multiple sulphur isotope systematics of pyrite clearly reveal a tiering, with organoclastic sulphate reduction succumbing to sulphate-driven anaerobic oxidation of methane at depth. Importantly, a negative Δ33S-δ34S correlation was found at the periphery of the SMT that requires repeated and sustained iron-driven sulphide oxidation with concomitant disproportionation of the elemental sulphur product. We conclude that minor sulphur isotopes may provide a unique lens to resolve the cryptic sulphur cycle, allowing the importance of the deep biosphere to be evaluated over geological timescales. In turn, a better understanding of the cryptic sulphur cycle remains central to testing hypotheses linking major elemental cycles and diverse microbial activities that persist under the energy-limited conditions that typify the deep biosphere. | | Article | Liu, Yujie; Chen, Yaoping; Liang, Xinyu; Li, Danian; Zheng, Yanting; Zhang, Hanyue; Cui, Ying; Chen, Jingxian; Liu, Jiarui; Qiu, Shijun |
| Front. Neurol. | 11 |
| 2020 |
| 10.3389/fneur.2020.00272 | 1664-2295 |
| Altered Resting-State Functional Connectivity of Multiple Networks and Disrupted Correlation With Executive Function in Major Depressive Disorder | Background: Major depressive disorder (MDD) is one of the most common and costly psychiatric disorders. In addition to significant changes in mood, MDD patients face an increased risk of developing cognitive dysfunction. It is important to gain an improved understanding of cognitive impairments and find a biomarker for cognitive impairment diagnosis in MDD. Methods: One hundred MDD patients and 100 normal controls (NCs) completed resting-state fMRI (rs-fMRI) scan, in which 34 MDD patients and 34 NCs had scores in multiple cognitive domains (executive function, verbal fluency, and processing speed). Twenty-seven regions of interest from the default mode network (DMN), central executive network (CEN), salience network (SN), and limbic system (LS) were selected as seeds for functional connectivity (FC) analyses with the voxels in the whole brain. Finally, partial correlations were conducted for cognitive domain scores and FCs with significant differences between the MDD and NC groups. Results: Significant FC differences between groups were identified among the seeds and clusters in the DMN, CEN, LS, visual network, somatomotor network, ventral attention network, and dorsal attention network. In the MDD patients, the magnitude of the Stroop interference effect was positively correlated with the illness duration, and the illness duration was negatively correlated with the FC between the right ventral hippocampal gyrus and the left inferior frontal gyrus. However, the correlation between the Stroop interference effect and the FC of the right anterior prefrontal cortex with the left cerebellum_4_5 was disrupted in these patients. Conclusions: The MDD patients have altered FCs among multiple brain networks and a disrupted correlation between the FC of prefrontal cortex and executive function. The disrupted correlation could present before the symptoms develop and may be the core process in the development of executive function impairment. | | Article | Wei, Pengyu; Li, Hongliang; Liu, Jiarui; Li, Shengpeng; Zhang, Yilong; Zhu, Qiang; Lei, Yucheng |
| J. Manuf. Processes | 56 |
| 2020 | 417 - 427 | 10.1016/j.jmapro.2020.05.006 | 1526-6125 |
| The effect of water environment on microstructural characteristics, compositional heterogeneity and microhardness distribution of 16Mn/304L dissimilar welded joints | Dissimilar joint between low alloy steel 16Mn and 304L austenitic stainless steel was welded in the air and under water with two different flux-cored wires: commercially obtained ER308 filler and specially developed nickel-based tubular wire. For microstructure comparison, dissimilar welded joints in the air and under water were acquired at the same welding procedures. The effect of water environment on microstructure, alloying elements distribution and microhardness profiles of dissimilar welded joints was discussed. The results show that typeⅡ boundary existed between austenitic weld metal and ferritic base metal in underwater welds similar to that in the air welds. The underwater Ni-based welds had a lower dendritic spacing than air welds. The amount of delta-ferrite present in underwater welds with ER308 filler was more than that in air welds because of the higher cooling rate in water environment. Major alloying elements were non-uniformly distributed along the austenitic weld metal/16Mn interface. Macroscopic composition gradients did not tend to form in air welds because of high heat input. Maximum microhardness value of 470 HV in wet welded joints was found in coarse-grained heat affected zone instead of transition zone. The transition zone at 16Mn side of underwater austenitic stainless steel welded joints exhibited high microhardness of 330 HV, which was strongly diluted by ferritic base metal. | | Article | Chang, Yicong; Yuan, Liang; Liu, Jiarui; Muhammad, Ishfaq; Cao, Chuanbao; Shi, Chenxi; Zhang, Yuanyuan; Li, Rui; Li, Changwen; Liu, Fangping |
| Vet. Res. | 51 | 1 | 2020 |
| 10.1186/s13567-020-00796-8 | 1297-9716 |
| Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4/NF-κB signalling pathway | Lipopolysaccharide (LPS) as a major component of Escherichia coli cell wall can cause inflammation and cell death. Dihydromyricetin (ampelopsin, DHM) is a natural flavonoid compound with anti-inflammatory, anti-oxidant and anti-bacterial effects. The preventive effects of DHM against ileum injury remain unclear. Here, we explored the protective role of DHM against LPS-induced ileum injury in chickens. In this study, DHM significantly attenuated LPS-induced alteration in diamine oxidase, malondialdehyde, reduced glutathione, glutathione peroxidase and superoxide dismutase levels in chicken plasma and ileum. Histology evaluation showed that the structure of blood vessels in ileum was seriously fragmented and presence of necrotic tissue in the lumen in the LPS group. Scanning electron microscopic observation revealed that the surface of the villi was rough and uneven, the structure was chaotic, and the normal finger shape was lost in the LPS group. In contrast, 0.05% and 0.1% DHM treatment partially alleviated the abnormal morphology. Additionally, DHM maintained the barrier function by restoring the protein expression of occludin, claudin-1 and zonula occludens protein-1. DHM inhibited apoptosis through the reduction of the expression of bax and caspase-3 and restored the expression of bcl-2. Importantly, DHM could reduce ileum NLR family pyrin domain-containing 3 (NLRP3), caspase-1, interleukin (IL)-1β and IL-18 expression to protect tissues from pyroptosis and inhibited toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signalling pathway. In summary, DHM attenuated the ileum mucosal damage, oxidative stress and apoptosis, maintained barrier function, inhibited NLRP3 inflammasome and TLR4/NF-κB signalling pathway activation triggered by Escherichia coli LPS. | | Article | Xu, Haojie; Liu, Jiarui; Wang, Zhiyu; Zhou, Min; Mo, Jiongjiong; Yu, Faxin |
| Electronics (Switzerland) | 9 | 6 | 2020 | 1 - 15 | 10.3390/electronics9061032 | 2079-9292 |
| An area‐efficient and programmable 4 × 25‐to‐28.9 gb/s optical receiver with dcoc in 0.13 μm sige bicmos | In this paper, we present an area‐efficient noise‐optimized programmable 4 × 25‐to‐28.9 Gb/s optical receiver. Both high‐ and low‐power modes are available for the receiver to meet different requirements. Emitter degeneration provides the input transimpedance amplifier (TIA) stage with improved stability. The noise of the TIA with emitter degeneration is analyzed, and an improved noise optimization method for the TIA is proposed. A sink current source with emitter degeneration in a DC offset cancellation (DCOC) loop reduces the noise introduced by the DCOC circuit. Moreover, with parasitic capacitor utilization in the DCOC loop and capacitive emitter degeneration in the variable‐gain amplifier (VGA) stage, the chip area is minimized. Fabricated in a 0.13 μm SiGe BiCMOS technology, the receiver achieved a small area of 0.54 mm2 per lane. The measured bit error rate (BER) is 10−12 with input signal varying from 110 μApp to 1150 μApp. The one‐lane power dissipation values in the low‐power and high‐power modes are 84.97 mW and 123.75 mW, respectively. | | Article | Liu, Jiarui; Pellerin, André; Antler, Gilad; Kasten, Sabine; Findlay, Alyssa J.; Dohrmann, Ingrid; Røy, Hans; Turchyn, Alexandra V.; Jørgensen, Bo Barker |
| Geochim. Cosmochim. Acta | 284 |
| 2020 | 43 - 60 | 10.1016/j.gca.2020.06.003 | 0016-7037 |
| Early diagenesis of iron and sulfur in Bornholm Basin sediments: The role of near-surface pyrite formation | Pyrite formation in marine sedimentary environments plays a key role in the global biogeochemical cycles of carbon, sulfur and iron, regulating Earth's surface redox balance over geological time scales. The sulfur isotopic composition of pyrite is one of the major geochemical tools for investigating early diagenetic processes in modern marine sediments and substantive changes to the Earth's surface environment in ancient sedimentary rocks. We studied sulfur–iron diagenesis and the sulfur isotopic evolution in sediments of the Bornholm Basin, southwestern Baltic Sea, to track the formation of pyrite in the near-surface sediments. Pyrite accumulation is observed with depth over the uppermost 100 cm before the extent of pyritization of the highly reactive iron pool (Fepy/FeHR) stays constant at ca. 0.9, suggesting that the use of a single iron-speciation parameter as a proxy for anoxic and sulfidic conditions needs to be supported by other independent indicators in sedimentary records. Stable sulfur isotopic analysis demonstrates that the bulk pools of elemental sulfur and iron monosulfide do not exchange isotopes completely with aqueous sulfide. We suggest that the reactions with polysulfide and aqueous sulfide are probably restricted to the surface of the solid-phase sulfur and iron-sulfur aggregates. Although pyrite is growing throughout the uppermost sediment column, the pyrite at depth has a sulfur isotopic composition similar to that of pyrite formed near the sediment surface. To understand the isotopic discrepancy between pyrite and aqueous sulfide in the deeper sediments, we developed a simple diagenetic model, which reproduces the observed sulfur isotopic composition of pyrite well. Our results suggest that much of the pyrite is rapidly formed near the sediment–water interface, and its δ34S is not as influenced by the 34S-enriched pool of aqueous sulfide in the deeper part of the sediment, allowing 32S-enriched pyrite to be preserved in deeper sediments. This near-surface diagenesis and the associated isotopic pattern are possibly of relevance for many marine sediments with high organic matter content, and high aqueous sulfide but low reactive iron availability. Moreover, our sulfur isotopic data demonstrate that extremely slow pyritization is ongoing in the deep lacustrine clay sediments. These results have implications for the interpretation of sulfur–iron geochemical data in both modern and ancient settings as well as for improving reconstructions of ancient depositional environments and a better understanding of the marine sulfur cycle throughout Earth's history. | | Letter | Li, Qingwen; Wang, Weijia; Zhuang, Jiayi; Zhang, Jiao; Liu, Jiarui; Chen, Yongfeng |
| Dermatol. Ther. | 33 | 6 | 2020 |
| 10.1111/dth.13876 | 1529-8019 |
| Improvements in two subtypes of porokeratosis by superficial X-ray radiotherapy |
| | Article | Wang, Tengjia; Zhou, Min; Liu, Jiarui; Wang, Zhiyu; Mo, Jiongjiong; Chen, Hua; Yu, Faxin |
| IEICE Electron. Express | 17 | 11 | 2020 |
| 10.1587/ELEX.17.20200160 | 1349-2543 |
| A highly linear 10 Gb/s MOS current mode logic driver with large output voltage swing based on an active inductor | This letter proposes a MOS-current-mode-logic (MCML) driver with an active inductor structure to provide large voltage swing with linear response. This design is implemented in 45 nm CMOS with 1.2V supply. Compared with conventional active-inductor-based circuits, this topology enlarges the available single-ended output voltage swing from less than 350 mV to 600 mV. The MCML driver occupies a chip area of 0.0264 mm2. Operating at 10 Gb/s over a channel with 3.5 dB loss at 5 GHz, the eye height is measured as 351 mV with 600 mV single-ended voltage swing, and the peak-to-peak jitter is 14.9 ps (0.149 UI). | | Article | Yuan, Yu-Wen; Zhao, Wei; Liu, Jia-Rui; Liu, Ye-Feng |
| Reneng Dongli Gongcheng. | 35 | 4 | 2020 | 135 - 145 | 10.16146/j.cnki.rndlgc.2020.04.019 | 1001-2060 |
| Numerical Simulation and Optimization on Fluid Flow Distribution Performance of Multi-passes Plate and Shell Heat Exchanger | A geometric model of multi-passes plate and shell heat exchanger (PSHE) is established,and the numerical simulations are performed.The deviations and the relative standard deviation of the mass flow are calculated,and the fluid flow distribution performances of plate-side and shell-side are analyzed.The influences of fluid flow distribution performance on heat transfer efficiency and pressure drop are concluded.Enlarging the inlet groove diameter and changing the angle of inlet pipeline can optimize the performance of plate-side,and installing double inlets and adding a baffle can optimize that of shell-side.Results indicate that there are always uneven fluid flow distribution on both plate-side and shell-side,and the plate-side is more seriously.Moreover,the uneven fluid flow distribution increases with the increase of flow rate and passes,and it also leads to the descending of heat transfer efficiency,6percent-14percent for and 2percent-5percent for shell-side,and widely increases the pressure drop.The method of enlarging the inlet groove diameter and changing the angle of inlet pipeline of plate-side can improve the impact of the uneven fluid flow distribution but has limited effect.The method of installing double inlets has a great performance while the method of adding a baffle can drop the uneven fluid flow distribution but leads to the increase of pressure drop. | | Article | Feng, Ran; Liu, Jiarui; Chen, Zhenming; Roy, Krishanu; Chen, Boshan; Lim, James B.P. |
| Eng. Struct. | 225 |
| 2020 |
| 10.1016/j.engstruct.2020.111278 | 1873-7323 |
| Numerical investigation and design rules for flexural capacities of H-section high-strength steel beams with and without web openings | This paper presents a finite-element (FE) investigation on the flexural capacities of H-section high-strength steel beams with web openings. A non-linear finite-element model (FEM) was developed for H-section high-strength steel beams with web openings, which included initial geometric imperfections. The FEMs were validated against the test results available in the literature for H-section high-strength steel beams with web openings. The validated FEMs were then used to conduct a parametric study comprising 180 FEMs to investigate the effects of different cross-sections, the opening diameter, the number of opening and the type of loadings on flexural capacities of H-section high-strength steel beams. The flexural capacities predicted from the finite-element analysis (FEA) were also used to study the performance of the current design guidelines for steel structures. A comparison of numerical strengths and design strengths found that the American National Standard (AISC) is over-conservative by as much as 61percent, whereas the North American Specification (NAS) and Chinese Code (CC) are conservative by 34percent on average, when predicting the flexural capacities of H-section high-strength steel beams with web openings. In addition, the Steel Design Guide Series 2 (SDGS-2) and Continuous Strength Method (CSM) for cold-formed steel (CFS) members with openings are generally appropriate for H-section high-strength steel beams with web openings subjected to flexural failure. Moreover, the design rules from Direct Strength Method (DSM) were found to be over-conservative by around 40percent. Accordingly, this paper proposes modified design equations over the existing design rules of SDGS-2. The proposed design equations have predicted closely the flexural capacities of H-section high-strength steel beams with web openings, being only 1percent conservative to the FEA strengths. | | Article | Liu, Ye; Liu, Jiarui; Yu, Jianlin |
| Int. J. Refrig. | 119 |
| 2020 | 268 - 275 | 10.1016/j.ijrefrig.2020.08.002 | 0140-7007 |
| Theoretical analysis on a novel two-stage compression transcritical CO2 dual-evaporator refrigeration cycle with an ejector | This paper proposes a novel two-stage compression transcritical CO2 dual-evaporator refrigeration cycle with an ejector. The ejector and flash tank introduced in the novel system is used to reduce the flashed vapor flowing through the low-temperature evaporator and thus reduce the input power of the low-temperature compressor, rather than traditionally reducing the compressor input power by lifting the compressor suction pressure. Thermodynamic analysis results indicate that under all given operating conditions, the performances of novel system are better than those of conventional system. Compared with the conventional system, the COP and exergy efficiency of the novel system under a typical operating condition is increased by 19.6percent and 15.9percent respectively, and the discharge temperature of high-temperature compressor in the novel system is reduced by 10.5 °C. In addition, the optimum gas cooler pressure of the novel system is 10.3 MPa, which is lower than that of the conventional system. Moreover, exergy analysis results display that the overall exergy destruction in all expansion devices for both systems accounts for the largest part of the total exergy destruction, but its proportion of the novel system is smaller than that of the conventional system. | | Article | Liu, Jiarui; Wang, Xin |
| J. Cell. Biochem. | 120 | 12 | 2019 | 19220 - 19228 | 10.1002/jcb.29241 | 0730-2312 |
| Focus on exosomes-From pathogenic mechanisms to the potential clinical application value in lymphoma | Exosomes are highly specialized and functional bilayer membranous particles. They have been considered as vehicles for transporting and delivering a large number of proteins, lipids, and nucleic acids (gene, noncoding RNA, DNA) from parental to recipient cells. In hematological malignancies, exosomes are involved in the tumorigenesis, including producing growth factors, hindering antitumor immunoreaction, promote inflammation, angiogenesis, and hypercoagulation. With the deepening of understanding, exosomes have ignited great interests and ever-increasing efforts into the therapeutic application among scientists, such as biomarkers, therapeutic target, drug delivery system, and vaccines. Here, we discuss the most recent studies on the functions and the emerging therapeutic applications of exosomes in lymphoma. | | Article | Hu, Hong-Yu; Liu, Jia-Rui; Gao, Fei; Gao, Zhen-Hai; Mei, Xing-Tai; Yang, Guang |
| Zongguo. Gonglu Xuebao. | 33 | 8 | 2020 | 195 - 203 | 10.19721/j.cnki.1001-7372.2020.08.019 | 1001-7372 |
| Driver Identification Based on 1-D Convolutional Neural Networks | Currently, the intelligent connected vehicle (ICV) is the most promising direction in the era of intelligent industry. As an important mode of modern mobility, ICVs increasingly emphasize individualized needs in the process of design and development. This paper proposes a general deep-learning framework for driver identification, relying on onboard CAN-bus driving data. First, naturalistic driving data of 20 drivers were collected under a fixed testing route with different road types and different traffic conditions. Second, data resampling was performed on nine types of CAN signal driving data to construct the data sample set. A one-dimensional convolutional neural network driver-identification framework was built, consisting of the convolutional layers, pooling layers, a fully connected layer, and a SoftMax layer. The Adam algorithm, L2 regularization, Dropout, and mini-batch gradient descent were utilized to improve the accuracy and increase the speed of the training process. The convolution kernel ratios, number of convolution kernels, number of convolution layers, and the size of the fully connected layer nodes were optimized by discussing their influences on the model accuracy. Further, the algorithm was compared with traditional machine-learning methods such as K-nearest neighbor, support vector machine, multi-layer perceptron, and another deep-learning algorithm long short-term memory. The effects of sample time window size, sample data overlap, and number of drivers on the model identification results were discussed. For a sample time window size of 1 s and an overlap of 80%, the evaluation index Macro F1 score reaches 99.1% with the identification of 20 drivers. The results show that the model performance is significantly better than other comparative model algorithms, and it is stable and robust for driver identification. | | Article | Mei, Yuan; Ye, Deng-pan; Jiang, Shun-zhi; Liu, Jia-rui |
| IETE Tech. Rev. | 38 | 1 | 2021 | 184 - 194 | 10.1080/02564602.2020.1824623 | 0256-4602 |
| A Particular Character Speech Synthesis System Based on Deep Learning | The speech synthesis system of a particular character is a TTS (text-to-speech) synthetic system, which can obtain voice with the specific speaker’s voice characteristics. The traditional method, based on machine learning, requires a great amount of training samples and large iterations. In this paper, we proposed a novel TTS system based on fully convolutional neural networks and attention mechanism. The system can be trained start from scratch with random initialization and realize end-to-end output. By adding the attention layer and the loss of attention, it can better adapt to the features of the pronunciation, intonation and accent of a specific speaker. Experimental results show that our speech synthesis framework demonstrates a stronger model performance by synthesizing higher quality forged specific character audio with a smaller training set and lesser iterations. | | Chapter | Wang, Lin; Yan, De; Song, Shuzhi; Liu, Jiarui |
|
| 48 |
| 2020 | 139 - 144 | 10.1016/B978-0-12-823377-1.50024-0 | 1570-7946 |
| An Optimal Design of Expansion-contraction Microchannel Based on Blockage Analysis | MicroChannel blockage is a common problem in microreactor applications. The principle of inertial aggregation in microchannel is used to analyze the formation of secondary flow and the wall effect of blockage. A heterogeneous microchannel structure combined with expansion and contraction is designed to achieve separation of blockage and solution. Finally, the designed microchannel is compared with the straight tube microchannel which has the same volume by CFD simulations, and the blockage distribution in the microchannel of the expansion-contraction structure is 340% larger than that of the straight tube structure, and the blockages are effectively collected in a predetermined separation position. | | Article | Peng, Xiaoye;Wang, Zhiyu;Mo, Jiongjiong;Wang, Chenge;Liu, Jiarui;Yu, Faxin |
| Electronics (Switzerland) | 9 | 11 | 2020 |
| 10.3390/electronics9111868 | 2079-9292 |
| A blind calibration model for i/q imbalances of wideband zero-if receivers | Frequency-dependent I/Q imbalance and frequency-independent I/Q imbalance are the major impairments in wideband zero-IF receivers, and they both cannot be ignored. In this paper, a blind calibration model is designed for compensating these I/Q imbalances. In order to accurately estimate the imbalance parameters with low cost, a classification rule is proposed according to the frequency-domain statistical characteristics of the received signal. The calibration points in the frequency-domain are divided into two groups. Then, the amplitude imbalance and the frequency-dependent phase imbalance are derived from the group of signal points and, separately, the frequency-independent phase imbalance is calculated from the group of noise points. In the derivation of the frequency-dependent phase imbalance, a general fitting model suitable for all signal points is proposed, which does not require special calculations for either DC point or fs /2 point. Then, a finite impulse response (FIR) real-valued filter is designed to correct the impairments of received signal. The performances of the proposed calibration model are evaluated through both simulations and experiments. The simulation results show the image rejection ratio (IRR) improvement to around 35–45 dBc at high signal-to-noise ratio (SNR). Based on the mismatched data of the ADRV9009 evaluation board, the experimental results exhibit the IRR improvement of both multi-tone and wideband signals to about 30 dBc. | | Article | Sun, Jing-Yu; Zhang, Quan-Zhi; Liu, Jia-Rui; Song, Yuan-Hong; Wang, You-Nian |
| Plasma Sources Sci. Technol. | 29 | 11 | 2020 |
| 10.1088/1361-6595/abad55 | 0963-0252 |
| Electrical asymmetry effect in inhomogeneously magnetized capacitively coupled plasmas | The electrical asymmetry effect combined with the magnetic asymmetry effect in a geometrically symmetric argon discharge is investigated using a one-dimensional particle-in-cell simulation with a Monte Carlo collision model. Both the asymmetry effects can induce an asymmetric plasma response with a consequent dc self-bias. It is found that these two asymmetry effects work independently of each other to some extent, which greatly enhances the flexibility for controlling the ion properties of interest, e.g. ion flux Γi and mean ion energy Ei at electrodes on the weak magnetic field side. On one hand, Γi can be modulated by tuning the gradient of the magnetic field, while the angle distribution on electrodes remains approximately unaffected for a fixed phase angle θ on the weak magnetic field side with a small shift in ion energy peak. On the other hand, Ei can be modulated by adjusting θ, while Γi only slightly fluctuates at a fixed gradient of magnetic field. Besides, the confinement effect of magnetic field on electron motion induces enhanced ionization rate and plasma density near the sheath edge on the strong magnetic field side. | | Article | Wu, Ke-Ke; Shen, Yu-Peng; Liu, Jia-Rui; Wang, Zhi-Yu; Mo, Jiong-Jiong; Yu, Fa-Xin |
| Tien Tzu Hsueh Pao. | 48 | 11 | 2020 | 2242 - 2249 | 10.3969/j.issn.0372-2112.2020.11.021 | 0372-2112 |
| A 1.8-Vpp 250-MS/s Pipelined ADC With Low Harmonic Distortion | This paper presents a 250-MS/s pipelined ADC with 1.8-Vpp full scale and low harmonic distortion implemented in 40nm CMOS.To reduce the large distortion of the conventional source follower when it drives a large sampling capacitor at a large swing, an improved current injection technique and a drain voltage bootstrapping technique were employed.Switches used for sampling and charge transfer in the ADC were implemented with thin-oxide devices to reduce the parasitic capacitance and charge injection.Moreover, on-chip LDOs were applied to provide safe supply voltages for these switches to protect thin-oxide devices from reliability problems.Test results show that with a 10.1MHz input, the ADC achieves the signal-to-noise and distortion (SNDR) of 68.3dB, the spurious free dynamic range (SFDR) of 76.4dBc and the total harmonic distortion (THD) of -75.1dBc at -1dBFS, and it achieves 68.3dB SNDR, 80.1dBc SFDR and -78.6dBc THD at -1.57dBFS. | | Article | Liu, Jiarui; Liu, Ye; Yan, Gang; Yu, Jianlin |
| Int. J. Refrig. | 122 |
| 2021 | 181 - 191 | 10.1016/j.ijrefrig.2020.11.009 | 0140-7007 |
| Theoretical study on a modified single‐stage autocascade refrigeration cycle with auxiliary phase separator | In order to improve the cycle performance of a conventional single-stage autocascade refrigeration cycle (ARC), an auxiliary separator is considered to be introduced. In the modified autocascade refrigeration cycle (MARC), the auxiliary separator located after an expansion device is used to further collect the vapor enriched with low-boiling components. In this case, the MARC enables to improve the cycle performances by utilizing more zeotropic mixture enriched with the low-boiling components to realize a higher evaporation pressure at the given evaporation temperature in the evaporator of the cycle. The performances of the MARC and ARC are compared utilizing energy, exergy and exergo-economic analysis methods, and several important parameters are also discussed in detail. The results indicate that the MARC using zeotropic mixture R290/R170 is feasible and there are obvious improvements in terms of the COP, volumetric refrigeration capacity and exergy efficiency. It is found that compared to the ARC, the COP improvement of MARC can reach up to 16.1%. The exergy efficiency of MARC is increased by 10.23% and the overall cost rate of MARC is decreased by 2.51% under a typical operating condition. In addition, the COP of MARC has a maximum value at given conditions when the mass fraction of R290 at the compressor inlet is around 0.3. In general, the performance characteristics of the proposed cycle demonstrate its potential applications in low-temperature freezers. | | Article | Zhao, Kai; Su, Zi-Xuan; Liu, Jia-Rui; Liu, Yong-Xin; Zhang, Yu-Ru; Schulze, Julian; Song, Yuan-Hong; Wang, You-Nian |
| Plasma Sources Sci. Technol. | 29 | 12 | 2020 |
| 10.1088/1361-6595/abc6f7 | 0963-0252 |
| Suppression of nonlinear standing wave excitation via the electrical asymmetry effect | The electrical asymmetry effect (EAE) enables separate control of the ion flux and the mean ion energy in capacitively coupled plasmas (CCP). While a variety of plasma processing applications benefit from this, large-area, very-high-frequency CCPs still suffer from lateral nonuniformities caused by electromagnetic standing wave effects (SWE). Many of such plasma sources are geometrically asymmetric and are operated at low pressure so that high frequency nonlinear plasma series resonance (PSR) oscillations of the RF current are self-excited. These PSR oscillations lead to the presence of short wavelength electromagnetic waves and a more pronounced SWE. In this work, we investigate the influence of the EAE on the nonlinear standing wave excitation in a geometrically asymmetric, low pressure capacitively coupled argon plasma driven by two consecutive harmonics (30 MHz and 60 MHz) with an adjustable phase shift, θ. We use a hairpin probe to determine the radial distribution of the electron density in combination with a high-frequency B-dot probe to measure the radial distribution of the harmonic magnetic field, which in turn is used to calculate the harmonic current density based on Ampere's law. Our experimental results show that the asymmetry of the discharge can be reduced electrically via the EAE. In this way the self-excitation of high frequency PSR oscillations can be attenuated. By tuning θ, it is, therefore, possible to switch on and off the nonlinear standing wave excitation caused by the PSR and, accordingly, the plasma uniformity can be optimized. | | Article | Sang, Tan; Yang, Juan; Liu, Jiarui; Han, Yang; Li, Ying; Zhou, Xiangxiang; Wang, Xin |
| Cancer Gene Ther. | 28 | 10-11 | 2021 | 1125 - 1135 | 10.1038/s41417-020-00258-5 | 1476-5500 |
| AMOT suppresses tumor progression via regulating DNA damage response signaling in diffuse large B-cell lymphoma | Angiomotin (AMOT) is a membrane protein that is aberrantly expressed in a variety of solid tumors. Accumulating evidence support that AMOT is involved in the pathological processes of tumor proliferation, apoptosis, and invasion. However, the potential role of AMOT in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) remains elusive. In the present study, we investigated the expression level and biological function of AMOT in DLBCL. AMOT expression was significantly reduced in DLBCL biopsy section, and low AMOT expression was associated with poor clinical prognosis. Overexpression of AMOT by lentivirus in human DLBCL cells induced cell viability inhibition concomitant with an increased percentage of cells in G1 phase and decreased percentage in S phase. Moreover, AMOT upregulation increased the sensitivity of DLBCL cells to doxorubicin. Furthermore, overexpression of AMOT led to reduced activation of key kinases for the DNA damage response (DDR). The above results indicated that AMOT acts as a tumor suppressor via inhibition of the DDR, thus reducing the viability while increasing the chemosensitivity in DLBCL. In summary, AMOT may be a novel potential target for DLBCL therapeutic intervention. | | Article | Wang, Yuan-Jie; Liu, Jia-Rui; Liu, Yong |
| Medicine | 98 | 35 | 2019 |
| 10.1097/MD.0000000000016703 | 0025-7974 |
| Safety issues related to the electronic crossmatching of blood in mainland China: A prospective cohort study involving cross-matching of 40,228 blood samples | Although the electronic cross-matching of blood has been widely applied in some developed countries and regions, concern over the risk of undetected red blood cell (RBC) antibodies has limited its application in mainland China. This study was performed to explore the missed detection rate of RBC antibodies in a Chinese population from 2011 to 2016. If the results of 2 consecutive tests of ABO/RhD blood group identification were consistent and antibody screening results were negative, electronic cross-matching of the blood was performed. In addition, traditional serological cross-matching of blood (polybrene method) and a parallel experiment for electronic cross-matching of blood were performed to analyze the missed detection of unexpected RBC antibodies in blood donors and recipients. Using the polybrene method, 40,228 blood samples were tested by parallel traditional serological cross-matching of blood; among these samples, blood compatibility was found in 40,222 cases, primary incompatibility (incompatibility of the donor’s erythrocytes with the recipient’s serum) was found in 6 cases, and no secondary incompatibility was found. Identification of antibody specificity was performed using panel cells, and all unexpected RBC antibodies were confirmed as anti-Mur alloantibodies in the MNS system. Further improvements in the erythrocyte antigenic spectrum, especially the Mur antigen in Asian populations, are expected to ensure the safety of implementing electronic cross-matching in China. | | Article | Chang, Yicong; He, Jingshan; Ma, Bingke; Ishfaq, Muhammad; Wang, Jiaqi; Zhang, Ruichen; Yuan, Liang; Liu, Jiarui; Li, Changwen; Liu, Fangping |
| Mol. Cell. Toxicol. | 17 | 2 | 2021 | 161 - 168 | 10.1007/s13273-021-00119-8 | 2092-8467 |
| Prevention of acetaminophen-induced hepatocyte injury: JNK inhibition and GSTA1 involvement | Background: Glutathione S-transferase A1 (GSTA1) is a detoxification enzyme and a sensitive marker for hepatotoxicity. We investigated the effects of JNK inhibition on different degrees of Acetaminophen (APAP)-induced hepatocyte injury and GSTA1 expression. Objective: This study aimed to investigate the role of JNK signaling pathway in APAP-induced different degrees of hepatocyte injury and its correlation with GSTA1 by inhibiting the phosphorylation of JNK by SP600125. Results: 6 and 8 mM APAP induced different degrees of hepatocyte injury and apoptosis, both activated JNK signaling pathway. In contrast, JNK inhibitor significantly reduced activation of JNK and c-JUN on exposure to APAP. Meanwhile, the levels of hepatocyte injury, oxidative stress, and apoptosis obviously decreased. Importantly, GSTA1 expression was significantly increased by JNK inhibition. Conclusions: JNK inhibition attenuates APAP-induced hepatocyte injury and oxidative stress and increases GSTA1 expression. Furthermore, GSTA1 may be involved in this signaling pathway for detoxification. | | Conference Paper | Liu, Jiarui; Cui, Xian |
|
| 233 |
| 2021 |
| 10.1051/e3sconf/202123303007 | 2555-0403 |
| Research on flexural performance of damaged RC beams strengthened by FPR plates | Combining two technologies of pasting fiber reinforced composite board (FRP) and externally reinforced steel plate concrete structure, fiber-reinforced composite material and steel plate composite reinforced concrete structure technology can effectively improve the stress performance of concrete reinforced structure. To explore the effect of the new technology steel plate anchoring FRP slab concrete beams and the effect of different damage levels on the reinforcement effect, in this paper, the author made 3 FRP reinforced beams with damage rates of 20%, 40%, and 60%, 1 RC beam with FRP plate only and an ordinary RC beam to analyze the reinforcement effect of the new process steel plate anchored FRP plate and the bearing capacity and plastic performance of the reinforced beam with different damage rates. The results show that the new technology steel plate anchoring FRP plate reinforcement technology can effectively prevent the occurrence of early peeling failure, improve the ductility and bearing capacity of the reinforced beam, and significantly increase the utilization rate of the FRP plate; as the damage rate increases, the ultimate bearing capacity of the reinforced beam increases, but the ductility is significantly reduced. | | Conference Paper | Liu, Jiarui; Hu, Ruofei; Hu, Hongyu |
| SAE Techni. Paper. | 2020-January |
| 2020 |
| 10.4271/2020-01-5107 | 0148-7191 |
| A Hybrid Classification of Driver's Style and Skill Using Fully-Connected Deep Neural Networks | Driving style and skill classification are of great significance in human-oriented advanced driver-assistance system (ADAS) development. In this paper, we propose Fully-Connected Deep Neural Networks (FC-DNN) to classify drivers' styles and skills with naturalistic driving data. Followed by the data collection and pre-processing, FC-DNN with a series of deep learning optimization algorithms are applied. In the experimental part, the proposed model is validated and compared with other commonly used supervised learning methods including the k-nearest neighbors (KNN), support vector machine (SVM), decision tree (DT), random forest (RF), and multilayer perceptron (MLP). The results show that the proposed model has a higher Macro F1 score than other methods. In addition, we discussed the effect of different time window sizes on experimental results. The results show that the driving information of 1s can improve the final evaluation score of the model. In order to get a relatively low computation cost, we use principal component analysis (PCA) to reduce input data dimensions, which also made the model achieve a good performance. | | Article | Hu, Hongyu; Liu, Jiarui; Gao, Zhenhai; Wang, Pin |
| IET Intel. Transport Syst. | 14 | 13 | 2020 | 1799 - 1809 | 10.1049/iet-its.2020.0105 | 1751-956X |
| Driver identification using 1d convolutional neural networks with vehicular can signals | This study proposes a deep learning framework for driver identity identification by extracting information from the vehicular controller area network (CAN) bus signals. First, naturalistic driving data of 20 drivers were collected under a fixed testing route with different road types and different traffic conditions. Then, a one-dimensional convolutional neural network was constructed for driver identification, which consists of two convolutional-pooling layers, a fully connected layer, and a SoftMax layer. Model optimisation algorithms were applied to improve accuracy and speed up the training process. Also, the model parameters were optimised by evaluating their influences on the model results. Furthermore, the performance of the proposed algorithm was compared with that of the K-nearest neighbour, support vector machine, multi-layer perceptron, and long shortterm memory model. The authors used the Macro F1 score as an evaluation criterion and the identification score of the authors' proposed model reaches 99.10% under 20 testing subjects where the data time window size is one second and the sample data overlap is 80%. The results show that the model's performance is significantly better than the other algorithms, which can effectively identify driver identities with stability and robustness. | | Article | Lyu, Qiyue; Luo, Junwei; Liu, Ke; Yin, Xiaolin; Liu, Jiarui; Lu, Wei |
| J. Visual Commun. Image Represent. | 76 |
| 2021 |
| 10.1016/j.jvcir.2021.103057 | 1047-3203 |
| Copy Move Forgery Detection based on double matching | Copy Move is a technique widespreadly used in digital image tampering, meaning Copy Move Forgery Detection (CMFD) is still a significant research. In this paper, a novel CMFD method is proposed, including double matching process and region localizing process. In double matching process, the first matching is conducted on Delaunay triangles consisting of Local Intensity Order Pattern (LIOP) keypoints, to find the approximate location of suspicious regions. In order to find sufficient keypoint pairs, the existing set of matching triangles is expanded by adding their neighbors iteratively, covering the whole tampered regions, and the second matching with a looser threshold is conducted on the vertices. In the region localizing process, considering the case of multiple copies, Density-Based Spatial Clustering of Applications with Noise (DBSCAN) is used to classify the keypoint pairs described in a new model. Experimental results indicate that the proposed method, with good robustness, outperforms some state-of-the-art methods. | | Article | Wang, Fengjie; Fan, Liyi; Shen, Yupeng; Chen, Hua; Liu, Jiarui; Wang, Zhiyu; Yu, Faxin |
| IEICE Electron. Express | 16 | 19 | 2019 | 1 - 6 | 10.1587/elex.16.20190518 | 1349-2543 |
| An effective DC offset calibration method combined with analog and digital circuits for direct conversion receivers | This paper presents a DC offset calibration (DCOC) method combined with analog and digital circuits for direct conversion receivers. To work effectively, the LNA is shut off for better isolation and replaced by an equivalent resistance to keep the same transfer function of DC offset between calibration and operation. This method adopts DACs to compensate DC offset, then averages and eliminates the residual DC offset in the digital domain. Measurements show that this DCOC method achieves 0.44 mV DC offset and improves IM2 by 10 dB. The DCOC circuits occupy 0.23 mm2 in 40 nm CMOS and consume 124 µA at 1.3 V supply. | | Conference Paper | Yang; Liu; Pang; Chi |
|
| 1774 | 1 | 2021 |
| 10.1088/1742-6596/1774/1/012067 | 1742-6596 |
| Effect of different pretreatment methods on pore structure of activated carbon | The effects of pretreatment on the pore structure of activated carbon were studied by the methods of water washing, acid washing, alkali washing and a combination of acid washing and alkali washing. It can be known from experiments that water washing has a cleaning effect on activated carbon, while acid washing helps to open the micropores of activated carbon and improve its porosity. Sodium hydroxide solution has an etching effect on activated carbon, which can increase the porosity and average particle size of activated carbon. All the pretreatment methods in this article can improve the adsorption capacity of activated carbon for nitrogen, and the pretreatment by dilute hydrochloric acid is tested to be the most effective. | | Article | Luo, Shangjun; Liu, Jiarui; Xu, Wenbo; Lu, Wei; Fang, Yanmei; Zeng, Jinhua; Shi, Shaopei |
| Signal Process. Image Commun. | 94 |
| 2021 |
| 10.1016/j.image.2021.116223 | 0923-5965 |
| Upscaling factor estimation on pre-JPEG compressed images based on difference histogram of spectral peaks | Image is one of the most widely used information carrier exchanged in the Internet, which raises a problem of privacy leakage. Private images are vulnerable to be intercepted and altered by an attacker, violating the owner's privacy. When an image is tampered maliciously, it is often necessary to perform geometric transformations such as scaling to hide the traces of tampering, introducing resampling traces. In the last two decades, spectral analysis is the most commonly used method for resampling detection. However, since JPEG compression severely interferes the statistical characteristics of resampled images and introduces blocking artifacts, the robustness is really poor for most classical spectrum-based methods in the presence of JPEG compression. In this paper, we propose a method to estimate the upscaling factors of upscaled images in the presence of JPEG compression. A comprehensive analysis in spectrum of scaled images is given. We find that both the location and their difference of spectral peaks in the spectrum of the upscaled pre-JPEG images are related to the upscaling factor. Hence, we adopt the difference histogram of spectral peaks to screen candidate upscaling factors and obtain the final estimation by additional verification step according to the location of the spectral peaks. The experimental results demonstrate the effectiveness of the proposed method. | | Article | Tang, Wei; Qiu, Jian-Guo; Deng, Xin; Liu, Shan-Shan; Cheng, Luo; Liu, Jia-Rui; Du, Cheng-You |
| PLoS ONE | 16 | 3 March | 2021 |
| 10.1371/journal.pone.0248534 | 1932-6203 |
| Minimally invasive versus open radical resection surgery for hilar cholangiocarcinoma: Comparable outcomes associated with advantages of minimal invasiveness | Background Minimally invasive surgery (MIS) provides a new approach for patients with hilar cholangiocarcinoma (HCCA). However, whether it can achieve similar outcomes to traditional open surgery (OS) remains controversial. Methods To assess the safety and feasibility of MIS for HCCA, a systematic review and meta-analysis was performed to compare the outcomes of MIS with OS. Seventeen outcomes were assessed. Results Nine studies involving 382 patients were included. MIS was comparable in blood transfusion rate, R0 resection rate, lymph nodes received, overall morbidity, severe morbidity (Clavien–Dindo classification > = 3), bile leakage rate, wound infection rate, intra-abdominal infection rate, days until oral feeding, 1-year overall survival, 2-year overall survival and postoperative mortality with OS. Although operation time was longer (mean difference (MD) = 93.51, 95% confidence interval (CI) = 64.10 to 122.91, P < 0.00001) and hospital cost (MD = 0.68, 95% CI = 0.03 to 1.33, P = 0.04) was higher in MIS, MIS was associated with advantages of minimal invasiveness, that was less blood loss (MD = -81.85, 95% CI = -92.09 to -71.62, P < 0.00001), less postoperative pain (MD = -1.21, 95% CI = -1.63 to -0.79, P < 0.00001), and shorter hospital stay (MD = -4.22, 95% CI = -5.65 to -2.80, P < 0.00001). Conclusions The safety and feasibility of MIS for HCCA is acceptable in selected patients. MIS is a remarkable alternative to OS for providing comparable outcomes associated with a benefit of minimal invasiveness and its application should be considered more. | | Article | Kong, Deli; Luo, Si; Peng, Ruichen; Liu, Jiarui; Wen, Qian |
| Shipin Kexue/Food Sc. | 42 | 4 | 2021 | 263 - 270 | 10.7506/spkx1002-6630-20200212-108 | 1002-6630 |
| Application of a Novel Fluorescent Biosensor Based on Unlabeled Gold Nanoclusters in Rapid Detection of Ochratoxin A | In this study, gold nanoclusters templated with unlabeled nucleic acid aptamers were rapidly synthesized for use in combination with gold nanoparticles modified with single-stranded DNA that is partially complementary to the DNA strands of the aptamer in a novel fluorescent composite nano-biosensor for rapid detection of ochratoxin A. The stronger binding force between the target and aptamer brought about fluorescence resonance energy transfer in the Apt-AuNCs@cDNAAuNPs sensor whose fluorescence had been quenched and consequently recovery of the lost fluorescence intensity, thereby allowing the rapid and accurate detection of ochratoxin A (OTA). The results showed that the peak value of fluorescence intensity (FI) displayed a good linear relationship with the concentration (C) of ochratoxin A within the range from 0.01 to 2.5 ng/mL, which was fitted as FI=689.84lgC + 8 315.31, with the limit of detection (LOD) of 0.025 ng/mL at signal-tonoise ratio of 3. This new fluorescent composite biosensor has the characteristics of simple synthesis, easy operation, high sensitivity, strong selectivity, good stability and a low LOD, which is expected to provide a new idea and platform for the detection of food safety hazard factors. | | Conference Paper | Liu, Jiarui; Cui, Xian |
|
| 676 | 1 | 2021 |
| 10.1088/1755-1315/676/1/012051 | 1755-1315 |
| Experimental study on self - Reset properties of rc beams with different proportions of sma wires | In order to explore the influence of SMA concrete beams with different proportions of SMA wires (unidirectional memory and hyperelastic) on the bearing capacity, five SMA concrete beams were made in this experiment. Twelve SMA wires with a diameter of 1mm were placed in the tensile zone of beams, which were reinforced according to different proportions of SMA. The experimental results show that:Within the range of 0-10kN (25% of the ultimate load of beams), the concrete beams with 70% hyperelastic SMA and 30% unidirectional memory SMA has the best stiffness. But in general, the concrete beams with 30% hyperelastic SMA and 70% unidirec-tional memory SMA has the best stiffness;After the first load, the concrete beams strengthened by SMA wires were heated to make the unidirectional memory SMA wires in the beams recover the deformation, and the second load was carried out. The results show that the beams bearing capacity can be improved when the SMA wires recover deformation after heating. The higher the SMA of unidirectional memory, the improvement of load bearing becomes better. However, it is necessary to adjust the proportion of the unidirectional memory SMA wires and the hyperelastic SMA wires to achieve the best effect on the stiffness and resilience of the beam. | | Article | Xu, Bozhi; Liu, Jiarui; Liang, Jifan; Lu, Wei; Zhang, Yue |
| Comput. Mater. Continua | 68 | 1 | 2021 | 1375 - 1388 | 10.32604/cmc.2021.016760 | 1546-2226 |
| DeepFake Videos Detection Based on Texture Features | In recent years, with the rapid development of deep learning technologies, some neural network models have been applied to generate fake media. DeepFakes, a deep learning based forgery technology, can tamper with the face easily and generate fake videos that are difficult to be distinguished by human eyes. The spread of face manipulation videos is very easy to bring fake information. Therefore, it is important to develop effective detection methods to verify the authenticity of the videos. Due to that it is still challenging for current forgery technologies to generate all facial details and the blending operations are used in the forgery process, the texture details of the fake face are insufficient. Therefore, in this paper, a new method is proposed to detect DeepFake videos. Firstly, the texture features are constructed, which are based on the gradient domain, standard deviation, gray level co-occurrence matrix and wavelet transform of the face region. Then, the features are processed by the feature selection method to form a discriminant feature vector, which is finally employed to SVM for classification at the frame level. The experimental results on the mainstream DeepFake datasets demonstrate that the proposed method can achieve ideal performance, proving the effectiveness of the proposed method for DeepFake videos detection. | | Article | Zhan, Hongbin; Pu, Shenhan; Liu, Jiarui; Wang, Yi; Liu, Xiumin; Tao, Yaping; Fei, Xu; Tian, Jing |
| Chem. Phys. Lett. | 773 |
| 2021 |
| 10.1016/j.cplett.2021.138597 | 0009-2614 |
| New insights into the detection mechanism of β-galactosidase in living cells with fluorescent probes | The mechanism of β-galactosidase detection probes ESIPT-GAL and ESIPT-OH have been investigated. The torsional potential energy curve proves the planar characteristics of the system. Combined with frontier molecular orbital and “hole-electron” analysis, there are apparent planar intramolecular charge transfer (PICT) characteristics in ESIPT-GAL and ESIPT-OH. The barrier-free intramolecular proton transfer explained the single fluorescence. Furthermore, the mechanism of ESIPT-OH fluorescent probe is the cooperation of excited-state intramolecular proton transfer (ESIPT) and PICT. The relationship between the singlet and triplet states combined with the spin coupling constant reveals that the weak fluorescence characteristic of ESIPT-GAL is caused by the intersystem crossing. | | Article | Xu, Zhaopeng; Liu, Jiarui; Lu, Wei; Xu, Bozhi; Zhao, Xianfeng; Li, Bin; Huang, Jiwu |
| J. Visual Commun. Image Represent. | 77 |
| 2021 |
| 10.1016/j.jvcir.2021.103119 | 1047-3203 |
| Detecting facial manipulated videos based on set convolutional neural networks | With the boom of artificial intelligence, facial manipulation technology is becoming more simple and more numerous. At the same time, the technology also has a large and profound negative impact on face forensics, such as Deepfakes. In this paper, in order to aggregate multiframe features to detect facial manipulation videos, we solve facial manipulated video detection from set perspective and propose a novel framework based on set, which is called set convolutional neural network (SCNN). Three instances of the proposed framework SCNN are implemented and evaluated on the Deepfake TIMIT dataset, FaceForensics++ dataset and DFDC Preview datset. The results show that the method outperforms previous methods and can achieve state-of-the-art performance on both datasets. As a perspective, the proposed method is a fusion promotion of single-frame digital video forensics network. | | Article | Liu, Jiarui; Han, Yang; Hu, Shunfeng; Cai, Yiqing; Yang, Juan; Ren, Shuai; Zhao, Yi; Lu, Tiange; Zhou, Xiangxiang; Wang, Xin |
| Front. Cell Dev. Biol. | 9 |
| 2021 |
| 10.3389/fcell.2021.667800 | 2296-634X |
| Circulating Exosomal MiR-107 Restrains Tumorigenesis in Diffuse Large B-Cell Lymphoma by Targeting 14-3-3η | Exosomes, nanometer-sized membranous vesicles in body fluids, have emerged as promising non-invasive biomarkers for cancer diagnosis. However, the function of exosomes in diffuse large B-cell lymphoma (DLBCL) remains elusive. This study aimed to investigate the role of exosomal miR-107 in lymphomagenesis and explore its clinical significance. In this study, decreased exosomal miR-107, miR-375-3p, and upregulated exosomal miR-485-3p were detected in the plasma of DLBCL patients and showed potential diagnostic value. Downregulated miR-107 expression was associated with advanced Ann Arbor stage, high IPI score, LDH, and β2-MG level in DLBCL patients. Overexpression of miR-107 by miR-107 Agomir significantly abrogated cell proliferation, induced apoptosis, and inhibited cell invasion in vitro, and repressed tumor growth in vivo. Moreover, the downregulation of miR-107 went in the opposite direction. The target genes of miR-107 were mainly enriched in the PI3K-Akt, Hippo, and AMPK signaling pathways. Notably, upregulated 14-3-3η (YWHAH) was suppressed by miR-107 in DLBCL, suggesting that miR-107 may restrain tumorigenesis by targeting 14-3-3η. In summary, this study unveils the function of miR-107 in lymphomagenesis, highlighting its potential as a diagnostic and prognostic indicator and as a new therapeutic target in the management of DLBCL. | | Article | Ren, Shuai; Cai, Yiqing; Hu, Shunfeng; Liu, Jiarui; Zhao, Yi; Ding, Mengfei; Chen, Xiaomin; Zhan, Linquan; Zhou, Xiangxiang; Wang, Xin |
| Biochem. Pharmacol. | 188 |
| 2021 |
| 10.1016/j.bcp.2021.114576 | 1873-2968 |
| Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis | Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) with high clinical heterogeneity and poor prognosis. Immune escape mediated by CD47 overexpression contributes to the limited efficacy of rituximab, an anti-CD20 antibody, which indicates a target to improve the efficacy of DLBCL treatment. Here, we validated berberine, a natural compound, as a suppressor of CD47 and revealed the involved mechanism and biological function in DLBCL. Berberine downregulated the expression of CD47 in DLBCL at the transcriptional level by suppressing c-myc expression. Berberine-induced CD47 inhibition enhanced the phagocytosis of macrophages, thereby eliminating DLBCL cells in vitro and in vivo. Interestingly, berberine enhanced the efficiency of anti-CD47 antibody and rituximab-mediated phagocytosis. Moreover, a novel prognostic model based on the combination of CD47 and CD68, a biomarker of macrophages, was established in DLBCL. Our results highlighted for the first time that berberine could restore macrophage function in the tumor microenvironment, enhance rituximab-mediated phagocytosis and promote anti-CD47 antibody function via suppressing CD47 expression, which revealed a new anti-tumor mechanism of berberine and provided novel insights into the rituximab-based immunochemotherapy and CD47-targeted immunotherapy in DLBCL. | | Article | Zhao, Jie; Wang, Jiasheng; Phillips, Stephen C.; Liang, Jinqiang; Su, Pibo; Lin, Qi; Chen, Can; Liu, Jiarui |
| Mar. Chem. | 233 |
| 2021 |
| 10.1016/j.marchem.2021.103988 | 0304-4203 |
| Non-evaporitic gypsum formed in marine sediments due to sulfate-methane transition zone fluctuations and mass transport deposits in the northern South China Sea | Gypsum (CaSO4·2H2O) of non-evaporitic origins has been observed in marine sedimentary environments over the past decade. Our understanding of related diagenetic processes has improved by analyzing the sulfur and oxygen isotopic compositions of gypsum, but, a comprehensive study of the isotopic composition of authigenic gypsum precipitated in methane-rich marine environments has not been performed to elucidate their implications for the sulfur cycle (e.g., sulfide oxidation). Furthermore, there are no studies of authigenic gypsum associated with submarine mass transport deposits, which are common sedimentary features on continental slopes. In this study, we analyzed the sulfur and oxygen isotopic compositions of gypsum and the sulfur isotopic composition of pyrite in drill cores collected from methane hydrate-bearing sites GMGS2–08, GMGS2–16, and GMGS4-W02B in the northern South China Sea to determine the formation mechanisms of authigenic gypsum. The stable sulfur isotopic analyses of gypsum and co-existing pyrite revealed that sulfate produced by pyrite oxidation contributed to gypsum precipitation. The low oxygen isotopic composition values of gypsum (−2.6 to 4.5‰ Vienna Standard Mean Ocean Water) suggest that pyrite is oxidized by metal oxides under anaerobic conditions, incorporating water oxygen, whose isotopic composition was modified by gas hydrate formation, into the produced sulfate. As pyrite oxidation also releases protons (H+) into the porewater, calcium concentrations may be elevated by the dissolution of carbonate minerals. At sites GMGS2–08 and GMGS2–16, authigenic gypsum was precipitated within paleo sulfate-methane transition zones, indicating that gypsum formation is probably associated with the downward migration of the sulfate-methane transition zone, which causes anaerobic pyrite oxidation at its original site of formation. However, at site GMGS4-W02B, most of the gypsum was distributed in a mass transport deposit characterized by a high abundance of reworked foraminiferas between the two paleo sulfate-methane transition zones. Given that seawater sulfate contributes more (>85%) than pyrite oxidation to the gypsum sulfate at site GMGS4-W02B, it is believed that authigenic gypsum formation is associated with mass transport deposits, which can rapidly trap overlying seawater sulfate within the pore space of the newly deposited sediments, combined with the sulfate and calcium from pyrite oxidation, leading to a local gypsum supersaturation. | | Article | Chen, Jiahao; Li, Haoming; Wang, Tengjia; Wang, Zhiyu; Chen, Hua; Liu, Jiarui; Yu, Faxin |
| IEICE Electron. Express | 18 | 10 | 2021 |
| 10.1587/ELEX.18.20210136 | 1349-2543 |
| A 92 fsrms jitter frequency synthesizer based on a multicore class-C voltage-controlled oscillator with digital automatic amplitude control | This letter presents a frequency synthesizer based on a multicore Class-C voltage-controlled oscillator (VCO) with a digital automatic amplitude control (AAC) loop. A novel digital tail current estimation is adopted to mitigate the risks of unexpected VCO oscillation failure, due to current shortage during frequency calibration. Meanwhile, a digital amplitude recalibration is proposed to provide continuous amplitude control, avoiding noise distortion resulted from amplitude drift after a conventional disposable amplitude calibration. The digital AAC loop achieves a specific VCO amplitude with good stability and introduces no extra noise. Fabricated in a 28 nm CMOS process, the presented frequency synthesizer occupies an active area of 1.43 mm2. By measuring a 3 GHz carrier, the open loop VCO phase noise is −132 dBc/Hz at 1 MHz offset and the close loop root mean square jitter is 81 fs. | | Article | Chen, Jiahao; Li, Haoming; Wang, Tengjia; Wang, Zhiyu; Liu, Jiarui; Yu, Faxin |
| Harbin Gongye Daxue Xuebao. | 53 | 6 | 2021 | 86 - 93 | 10.11918/201909034 | 0367-6234 |
| A low-spur reference frequency doubler with hybrid duty cycle calibration | To reduce the phase noise of fractional-N phase locked loops (PLLs) and suppress the output spurs of PLLs caused by doubling the frequency of reference clock with traditional exclusive-OR gates (XOR), a low-spur reference frequency doubler (RFD) with a hybrid duty cycle calibration loop (DCCL) was proposed. The RFD doubles the frequency of input clock and outputs the reference clock to the PLL, effectively suppressing the phase noise of the PLL by reducing the divide ratio. To reduce the frequency jitter of the reference clock and the output spurs of the PLL caused by the duty cycle deviation of the input clock, the RFD first roughly calibrates the duty cycle with a digital-controlled edge adjustor and then improves the precision with an analog DCCL. The two methods work collaboratively based on the proposed controlling algorithm, achieving a wider calibration range and a higher precision simultaneously. Simulation results show that the proposed RFD could reduce the duty cycle error of a 100 MHz input clock from 13.8% to 0.007%, and decrease the output frequency error to 380×10-6. The circuit was fabricated in a 40 nm CMOS process. Test results show that it could suppress the in-band phase noise by 6.67 dB and quantization noise by 5.61 dB, and after the duty cycle calibration, the spurs at 1/2 reference frequency offset in the output signal spectrum of the PLL were reduced by 9.52 dB. The in-band noise and quantization noise of PLLs could be reduced by doubling the frequency of the reference clock of PLLs. The spurs in the output signal spectrum of PLLs could be suppressed efficiently by calibrating the input duty cycle of the RFD. | | Article | Zhu, Jie; Wang, Jingxiang; Wang, Xin; Gao, Mingjing; Guo, Bingbing; Gao, Miaomiao; Liu, Jiarui; Yu, Yanqiu; Wang, Liang; Kong, Weikaixin; An, Yongpan; Liu, Zurui; Sun, Xinpei; Huang, Zhuo; Zhou, Hong; Zhang, Ning; Zheng, Ruimao; Xie, Zhengwei |
| Nat. Biotechnol. | 39 | 11 | 2021 | 1444 - 1452 | 10.1038/s41587-021-00946-z | 1546-1696 |
| Prediction of drug efficacy from transcriptional profiles with deep learning | Drug discovery focused on target proteins has been a successful strategy, but many diseases and biological processes lack obvious targets to enable such approaches. Here, to overcome this challenge, we describe a deep learning–based efficacy prediction system (DLEPS) that identifies drug candidates using a change in the gene expression profile in the diseased state as input. DLEPS was trained using chemically induced changes in transcriptional profiles from the L1000 project. We found that the changes in transcriptional profiles for previously unexamined molecules were predicted with a Pearson correlation coefficient of 0.74. We examined three disorders and experimentally tested the top drug candidates in mouse disease models. Validation showed that perillen, chikusetsusaponin IV and trametinib confer disease-relevant impacts against obesity, hyperuricemia and nonalcoholic steatohepatitis, respectively. DLEPS can generate insights into pathogenic mechanisms, and we demonstrate that the MEK–ERK signaling pathway is a target for developing agents against nonalcoholic steatohepatitis. Our findings suggest that DLEPS is an effective tool for drug repurposing and discovery. | | Article | Wang, Li; Chen, Jun; Su, Haojie; Ma, Xufa; Wu, Zhixu; Shen, Hong; Yu, Jia; Liu, Jiarui; Wu, Yao; Ding, Guangyi; Xie, Ping |
| Ecosystems | 25 | 2 | 2022 | 308 - 319 | 10.1007/s10021-021-00656-2 | 1435-0629 |
| Is Zooplankton Body Size an Indicator of Water Quality in (Sub)tropical Reservoirs in China? | Large zooplankton can efficiently graze on algae and thereby improve water quality. However, zooplankton body size is considered to decrease with decreasing latitude because of the high fish predation and warm temperatures at lower latitudes. To explore how fish stocking has destabilized the trophic cascade and influenced water quality along a latitudinal gradient of reservoirs, we compared zooplankton body size and trophic cascades to water quality indicators in the subtropical Lake Qiandaohu and in tropical Guangdong reservoirs. The results showed that the body length and total biomass of the dominant zooplankton in Lake Qiandaohu were much larger than those of zooplankton in the Guangdong reservoirs. Moreover, fish predation was the key factor influencing the changes in zooplankton body size and total biomass in Lake Qiandaohu. In the Guangdong reservoirs, water temperature and total phosphorus were the pivotal drivers of zooplankton body size and biomass, respectively. In addition, structural equation models showed that the decreasing zooplankton body size and biomass under fish pressure weakened the grazing pressure on phytoplankton and indirectly contributed to the low water clarity in Lake Qiandaohu. However, fish had little influence on the inefficient algal grazing of zooplankton in the Guangdong reservoirs. Overall, zooplankton can function as an indicator of water quality in fish-controlled subtropical reservoirs but not in nutrient-controlled tropical reservoirs. | | Article | Chen, Mingliang; Wu, Keke; Shen, Yupeng; Wang, Zhiyu; Chen, Hua; Liu, Jiarui; Yu, Faxin |
| IEICE Electron. Express | 18 | 11 | 2021 | 1 - 5 | 10.1587/ELEX.18.20210171 | 1349-2543 |
| A 14bit 500MS/s 85.62dBc SFDR 66.29dB SNDR SHA-less pipelined ADC with a stable and high-linearity input buffer and aperture-error calibration in 40nm CMOS | This paper presents a 14bit 500MS/s SHA-less pipelined analog-to-digital converter (ADC) implemented in 40nm CMOS. A high-linearity pseudo-differential push-pull input buffer with an anti-oscillation technique and a nonlinear parasitism eliminate technique is proposed to stably drive the pipelined stages while keeping low distortion. Moreover, a digital controlled aperture-error calibration is also employed with offset of comparators compensated in advance. Measurement results show that the ADC achieves a signal-to-noise-and-distortion-ratio (SNDR) of 66.29dB and a spurious-free-dynamic-range (SFDR) of 85.62dBc at 80.1MHz input. | | Article | Zhao, Yi;Yang, Juan;Liu, Jiarui;Cai, Yiqing;Han, Yang;Hu, Shunfeng;Ren, Shuai;Zhou, Xiangxiang;Wang, Xin |
| Cell Death Dis. | 12 | 7 | 2021 |
| 10.1038/s41419-021-03919-x | 2041-4889 |
| Inhibition of Polo-like kinase 4 induces mitotic defects and DNA damage in diffuse large B-cell lymphoma | Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of chemotherapy. Nevertheless, the role of PLK4 in diffuse large B-cell lymphoma (DLBCL) is still undefined. In this study, we discover that PLK4 is a potential target for the treatment of DLBCL, and demonstrate the efficacy of a PLK4 inhibitor when used in combination with doxorubicin. Pharmaceutical inhibition of PLK4 with CFI-400945 inhibited DLBCL cell proliferation and induced apoptotic cell death. The anti-tumor effects were accompanied by mitotic defects, including polyploidy and cytokinesis failure. Activation of p53 and Hippo/YAP tumor suppressor signaling pathway was identified as the potential mechanisms driving CFI-400945 activity. Moreover, CFI-400945 treatment resulted in activation of DNA damage response. Combining CFI-400945 with doxorubicin markedly delayed tumor progression in DLBCL xenografts. Finally, PLK4 was increased in primary DLBCL tissues and cell lines. High levels of PLK4 expression were associated with poor survival in the patients receiving CHOP-based treatment, implicating PLK4 as a predictive biomarker of DLBCL chemosensitivity. These results provide the therapeutic potential of CFI-400945 both as monotherapy or in combination with doxorubicin for the treatment of DLBCL. | | Article | Rao, Qingyang; Su, Haojie; Ruan, Linwei; Deng, Xuwei; Wang, Lantian; Rao, Xiao; Liu, Jiarui; Xia, Wulai; Xu, Pengke; Shen, Hong; Chen, Jun; Xie, Ping |
| Water Res. | 202 |
| 2021 |
| 10.1016/j.watres.2021.117392 | 1879-2448 |
| Stoichiometric and physiological mechanisms that link hub traits of submerged macrophytes with ecosystem structure and functioning | Eutrophication strongly influences plant stoichiometric characteristics and physiological status by altering nutrient and light availability in the water column. However, the mechanisms linking plant functional traits with ecosystem structure and functioning to clarify the decline of submerged macrophytes have not been fully elucidated to date. Therefore, based on a field investigation of 26 macrophytic shallow lakes on the Yangtze Plain, we first constructed a plant trait network at the whole-plant level to determine the hub traits of submerged macrophytes that play central regulatory roles in plant phenotype. Our results suggested that organ (leaf, stem, and root) phosphorus (P), starch, and total nonstructural carbohydrate (TNC) contents were hub traits. Organ starch and TNC were consistent with those in the experiment-based network obtained from a three-month manipulation experiment. Next, the mechanisms underlying the relationships between the hub traits and vital aspects of ecological performance were carefully investigated using field investigation data. Specifically, stoichiometric homeostasis of P (HP), starch, and TNC were positively associated with dominance and biomass at the species level, and community biomass at the community level. Additionally, structural equation modeling clarified not only a hypothesized pathway from eutrophication to water clarity and community TNC, but also combined effects of community TNC and HP on community biomass. That is, ecosystems dominated by more homeostatic communities tended to have more carbon (C)-rich compounds in relatively oligotrophic conditions, which promoted the primary production of macrophytes. Eutrophication was determined to affect community structure by inhibiting the predominance of more homeostatic species and the production of carbohydrates. Finally, reduced community biomass and increased nutrient contents and nutrient:C ratios in plants induced by eutrophication implied a decrease in the C sink in biomass and may potentially lead to an enhancement of litter decomposition rates and nutrient cycling rates. By adjusting plant responses to eutrophication, stoichiometric and physiological mechanisms linking plant traits with ecosystem structure have important implications for understanding ecosystem processes, and these results may contribute to practical management to achieve the restoration of submerged macrophytes and ecosystem services. | | Article | Lu, Tiange; Shi, Lei; Shi, Guanggang; Cai, Yiqing; Hu, Shunfeng; Liu, Jiarui; Ren, Shuai; Zhou, Xiangxiang; Wang, Xin |
| Cancer Cell Int. | 21 | 1 | 2021 |
| 10.1186/s12935-021-02042-3 | 1475-2867 |
| Derivation and validation of a lipid-covered prognostic model for mature T-cell lymphomas | Background: Mature T-cell lymphomas (MTCLs), a group of diseases with high aggressiveness and vulnerable prognosis, lack for the accurate prognostic stratification systems at present. Novel prognostic markers and models are urgently demanded. Aberrant lipid metabolism is closely related to the tumor progression but its prognostic significance in MTCLs remains unexplored. This study aims to investigate the relationship between dysregulated lipid metabolism and survival prognosis of MTCLs and establish a novel and well-performed prognostic scoring system for MTCL patients. Methods: A total of 173 treatment-naive patients were enrolled in this study. Univariate and multivariate Cox regression analysis were performed to assess the prognostic significance of serum lipid profiles and screen out independent prognostic factors, which constituted a novel prognostic model for MTCLs. The performance of the novel model was assessed in the training and validation cohort, respectively, by examining its calibration, discrimination and clinical utility. Results: Among the 173 included patients, 115 patients (01/2006–12/2016) constituted the training cohort and 58 patients (01/2017–06/2020) formed the validation cohort. Univariate analysis revealed declined total cholesterol (TC, P = 0.000), high-density lipoprotein cholesterol (HDL-C, P = 0.000) and increased triglycerides (TG, P = 0.000) correlated to inferior survival outcomes. Multivariate analysis revealed extranodal involved sites ≥ 2 (hazard ratio [HR]: 2.439; P = 0.036), β2-MG ≥ 3 mg/L (HR: 4.165; P = 0.003) and TC < 3.58 mmol/L (HR: 3.338; P = 0.000) were independent predictors. Subsequently, a novel prognostic model, EnBC score, was constructed with these three factors. Harrell’s C-index of the model in the training and validation cohort was 0.840 (95% CI 0.810–0.870) and 0.882 (95% CI 0.822–0.942), respectively, with well-fitted calibration curves. The model divided patients into four risk groups with distinct OS [median OS: not available (NA) vs. NA vs. 14.0 vs. 4.0 months, P < 0.0001] and PFS (median PFS: 84.0 vs. 19.0 vs. 8.0 vs. 1.5 months, P < 0.0001). Time-dependent receiver operating characteristic curve and decision curve analysis further revealed that EnBC score provided higher diagnostic capacity and clinical benefit, compared with International Prognostic Index (IPI). Conclusion: Firstly, abnormal serum lipid metabolism was demonstrated significantly related to the survival of MTCL patients. Furthermore, a lipid-covered prognostic scoring system was established and performed well in stratifying patients with MTCLs. | | Article | Liu, Jiarui; Antler, Gilad; Pellerin, André; Izon, Gareth; Dohrmann, Ingrid; Findlay, Alyssa J.; Røy, Hans; Ono, Shuhei; Turchyn, Alexandra V.; Kasten, Sabine; Jørgensen, Bo Barker |
| Geology | 49 | 7 | 2021 | 816 - 821 | 10.1130/G48415.1 | 1943-2682 |
| Isotopically “heavy” pyrite in marine sediments due to high sedimentation rates and non-steady-state deposition | Sedimentary pyrite formation links the global biogeochemical cycles of carbon, sulfur, and iron, which, in turn, modulate the redox state of the planet’s surficial environment over geological time scales. Accordingly, the sulfur isotopic composition (δ34S) of pyrite has been widely employed as a geochemical tool to probe the evolution of ocean chemistry. Characteristics of the depositional environment and post-depositional processes, however, can modify the δ34S signal that is captured in sedimentary pyrite and ultimately preserved in the geological record. Exploring sulfur and iron diagenesis within the Bornholm Basin, Baltic Sea, we find that higher sedimentation rates limit the near-surface sulfidization of reactive iron, facilitating its burial and hence the subsurface availability of reactive iron for continued and progressively more 34S-enriched sediment-hosted pyrite formation (δ34S ≈ −5‰). Using a diagenetic model, we show that the amount of pyrite formed at the sediment-water interface has increased over the past few centuries in response to expansion of water-column hypoxia, which also impacts the sulfur isotopic signature of pyrite at depth. This contribution highlights the critical role of reactive iron in pyrite formation and questions to what degree pyrite δ34S values truly reflect past global ocean chemistry and biogeochemical processes. This work strengthens our ability to extract local paleoenvironmental information from pyrite δ34S signatures. | | Article | Su, Xinghua; Jiao, Zhihua; Fu, Mengying; An, Gai; Wu, Yajuan; Tian, Qiang; Xu, Pan; Wu, Weiwei; Chang, Xuwen; Liu, Jiarui |
| Int. J. Appl. Ceram. Technol. | 18 | 6 | 2021 | 1999 - 2009 | 10.1111/ijac.13820 | 1744-7402 |
| Ultrafast synthesis and densification of ZrO2 doped KNN ceramics by reactive flash sintering | Fabrication of dense KNN-based lead-free piezoelectric ceramics at low temperatures in short time through a cost-effective way remains a challenge. Herein, this challenge could be addressed by using reactive flash sintering. It is demonstrated that the phase transformation of KNbO3-NaNbO3 into (K,Na)NbO3 and densification occur simultaneously during the flash event. Most importantly, ZrO2 doping can greatly decrease the onset flash temperature, which is ascribed to the increased conductivity of sample. In addition, the current limit has a significant effect on the phase transformation and densification. The flash-sintered KNN ceramics exhibit the good ferroelectric and piezoelectric properties. Furthermore, the ZrO2 doped and undoped KNN ceramics show a comparable coercive field Ec, which may be related to the residual point defects after the flash. Besides the Joule heating, the avalanche generation of point defects is suggested to be responsible for the ultrafast solid-state reaction and densification rates. | | Conference Paper | Dai, Zi-Ling; He, Meng-Xuan; Lv, Dan-Ran; Liu, Jia-Rui; Xu, Ling-Xuan; Wan, Peng-Cheng; Mo, Xun-Qiang |
|
| 791 | 1 | 2021 |
| 10.1088/1755-1315/791/1/012176 | 1755-1315 |
| Study on the Relationship between Vegetation Index and Bird Diversity in Beidagang Wetland | Birds are an important part of wetland ecosystem. With the development of urbanization, bird vegetation is destroyed seriously, threatening bird diversity. In view of this, this paper studied the dynamic changes of NDVI (Normalized Difference Vegetation Index) and three bird diversity indexes (Shannon-Wiener index, Simpson index, Pielou index), and explored the relationship between the two, based on the wetland bird survey data and Landsat 8 remote sensing images from 2015 to 2019 in Beidagang Wetland. The results showed that: Although the growth condition of wetland plants changed from poor to better due to the ecological water rehydration measures adopted in the later period, the three indexes leveled off except in 2018. Spearman correlation analysis showed that Shannon-Wiener index was highly negatively correlated with NDVI, and slightly negatively correlated with Simpson index and Pielou index, indicating that NDVI in Beidagang Wetland had much less impact on bird diversity than other habitat factors, and could not play a leading role. | | Article | Wang, Xiang-Yu; Liu, Jia-Rui; Liu, Yong-Xin; Donkó, Zoltan; Zhang, Quan-Zhi; Zhao, Kai; Schulze, Julian; Wang, You-Nian |
| Plasma Sources Sci. Technol. | 30 | 7 | 2021 |
| 10.1088/1361-6595/ac0b56 | 0963-0252 |
| Comprehensive understanding of the ignition process of a pulsed capacitively coupled radio frequency discharge: The effect of power-off duration | The effect of the pulse-off duration on the time evolution of the plasma and electrical parameters during the ignition phase in a pulsed capacitively coupled radio frequency argon discharge operated at 450 mTorr and 12.5 MHz is investigated synergistically by multifold experimental diagnostics, particle-in-cell/Monte Carlo collision simulations and an analytical model. In the experiment, the electron density is measured time-resolved by a hairpin probe, the spatio-temporal distribution of the electron impact excitation dynamics is studied by phase resolved optical emission spectroscopy, and the amplitudes and the relative phase, φ vi, of the discharge voltage and current are determined based on the waveforms measured by a voltage and a current probe. The experimental results show that the plasma and electrical parameters during the ignition process depend strongly on the duration of the afterglow period, T off, primarily because of the dependence of the remaining charge density on this parameter. Computed values of φ vi show a similar time-dependence compared to the experiment, if the simulations are initialized with specific initial charged particle densities, n ini. This allows us to further understand the time evolution of φ vi for different values of T off based on the simulation results together with an analytical model. In particular, the optical emission intensity is found to change with time in the same fashion as the power deposition into the system at T off 100 μs, suggesting that the power is primarily absorbed by the electrons, which dissipate their energy via inelastic collisions. The system goes through different mode transitions of electron power absorption during the ignition phase depending on T off. Specifically, for short T off (high n ini), the α mode dominates during the entire ignition process, as the electric field is largely shielded by the abundant charge located in the interelectrode space. For intermediate values of T off (moderate n ini), another excitation pattern caused by an enhanced drift electric field at the center of the gap is observed, since a large fraction of the externally applied potential can penetrate into the central region in the absence of high charged particle densities. For longer T off (very low n ini), the ignition of the pulsed plasma behaves like a gas breakdown. | | Article | Podolsky; Liu; Dinh; Doh; Guerrieri; Fragomeni |
| Case Stud. Constr. Mater. | 15 |
| 2021 |
| 10.1016/j.cscm.2021.e00637 | 2214-5095 |
| State of the art on the application of waste materials in geopolymer concrete | This review paper presents and analyses the mechanical and durability properties of geopolymer concrete (GPC) which contain various waste materials. Significant findings have concluded that the absence of guidelines for the mix design of GPC has resulted in a wide variance of design parameters and therefore strength and durability properties. The purpose of this review is to compile recent research to highlight the inadequacy of the current literature and identify areas in which the current mix design can be improved. The development of mix design guidelines that focus on optimal Si/Al ratio, NaOH concentration and sodium silicate to sodium hydroxide (SS/SH) ratio are required, as these factors are significantly affected by the addition of waste materials with varying chemical compositions and morphology. | | Article | Han, Yiming; Wang, Fengjie; Liu, Jiarui; Wang, Zhiyu; Yu, Faxin |
| Electronics (Switzerland) | 10 | 16 | 2021 |
| 10.3390/electronics10161966 | 2079-9292 |
| High-linearity direct conversion receiver with the transconductance equalization technique and dcoc method | To improve the linearity of direct conversion receivers (DCRs), two high-linearity methods for high second-order intercept points (IP2s) and high third-order intercept points (IP3s) are proposed. To improve IP3s, a transconductance equalization technique for a complementary input operational amplifier (OPAMP) is proposed in an active-RC low-pass filter (LPF), while a digital-analog hybrid DC offset calibration (DCOC) method is proposed to improve IP2s. For one thing, the proposed transconductance equalization technique employs a pair of resistors to guarantee high voltage gain for an OPAMP with two-stage Miller topology under a high-input voltage swing to improve linearity with little deterioration of the noise performance. For another, during the DCOC method, the low-noise amplifier is turned off and replaced by an equivalent resistance of the output impedance of the low-noise amplifier to ensure the accuracy and effectiveness of the DCOC method. Fabricated in 40-nm CMOS technology, the receiver with proposed methods can realize a noise fig-ure of 2.6–3.5 dB in the full frequency band, with an OIP3 of 28 dBm, an IM2 more than 70 dBc, and a remaining DC of −53.2 dBm under the total voltage gain of 60 dB. | | Article | Liu, Jiarui; Pellerin, André; Antler, Gilad; Izon, Gareth; Findlay, Alyssa J.; Røy, Hans; Ono, Shuhei; Kasten, Sabine; Turchyn, Alexandra V.; Jørgensen, Bo Barker |
| Geochim. Cosmochim. Acta | 313 |
| 2021 | 359 - 377 | 10.1016/j.gca.2021.08.018 | 0016-7037 |
| Early diagenesis of sulfur in Bornholm Basin sediments: The role of upward diffusion of isotopically “heavy” sulfide | Sediment-hosted marine sulfur cycling has played a significant role in regulating Earth's surface chemistry over our planet's history. Microbially-mediated reactions involving sulfur are often accompanied by sulfur isotope fractionation that, in turn, is captured by sulfate and sulfide minerals, providing the opportunity to track changes in the microbial utilization of sulfur and thus the marine sulfur cycle. Studying sulfur diagenesis within the Bornholm Basin, Baltic Sea, we explore the interplay between carbon, sulfur and iron, focusing on the fate of sulfur and the dynamics of the sulfur and oxygen isotopic response as a function of the varying thickness of the organic carbon-rich Holocene Mud Layer (HML) across the basin. Using a one-dimensional reaction-transport model, porewater sulfate and sulfide profiles were used to calculate net sulfate reduction rates (SRR) and net sulfide production rates, respectively. These calculations suggest a positive relationship between the thickness of the HML and net rates of sulfate reduction and sulfide production. Given that ascending sulfide is enriched in 34S relative to that produced in-situ, a heightened sulfide flux promotes spatially variable precipitation of 34S-enriched pyrite (δ34S ≈ −10‰) close to the sediment–water interface. Modeling results indicate that this isotopically “heavy” sulfide is formed as a consequence of mixing between ascending sulfide (up to +6.3‰) and that produced in-situ (ca. −40‰). Further, we show that the sulfur and oxygen isotopic composition of porewater sulfate is controlled by the net SRR: when the net SRR is high (i.e., in sulfide-replete settings) the downcore increase in δ18OSO4 is dampened relative to increase in δ34SSO4, whereas when net SRR is low (i.e., in iron-rich parts of the basin) downcore δ18OSO4 values increase while δ34SSO4 values remain invariant. We conclude that sedimentation rates and open system diffusion strongly influence the distribution of sulfur species and their sulfur isotopic composition, as well as the oxygen isotopic composition of sulfate, through the interaction between iron, sulfur and methane. This work highlights the importance of considering diffusion to better understand open system diagenesis and the δ34S signatures of sulfate and sulfide in both modern settings and ancient rocks. | | Article | Liu, Jiarui; Liu, Ye; Yu, Jianlin; Yan, Gang |
| Appl. Therm. Eng. | 200 |
| 2022 |
| 10.1016/j.applthermaleng.2021.117636 | 1359-4311 |
| Thermodynamic analysis of a novel ejector-enhanced auto-cascade refrigeration cycle | This paper proposes a novel ejector-enhanced auto-cascade refrigeration cycle (NEARC). In the novel cycle, the ejector not only replaces an expansion valve to recover partial expansion work, but also greatly reduces the throttling loss of the other expansion valve connected to the evaporator. The energy and exergy analysis methods are used to evaluate and compare the performance of NEARC using R290/R170 with conventional auto-cascade refrigeration cycle (CARC) and previously proposed ejector-enhanced auto-cascade refrigeration cycle (EARC). The simulation results show that under all given working conditions, the COP and exergy efficiency of NEARC are superior to those of CARC, but not always superior to those of EARC. With the change of initial mass fraction of R290, the COP and exergy efficiency of the three cycles all have maximum values. The maximum COP and exergy efficiency of NEARC are 42.85% and 42.71% higher than those of CARC, and 18.10% and 17.99% higher than those of EARC, respectively. When initial mass fraction of R290 is about 0.5, CARC and EARC have the best performance, and NEARC performs best when initial mass fraction of R290 is about 0.7. The comparison results demonstrate that the novel cycle has great energy-saving potential. | | Article | Jiang, Jing-Wei; Xiong, Zi-Ying; Rui, Wei; Chen, Yi-Hong; Liu, Jia-Rui; Huang, Wei-Xi |
| J. Marine Sci. Technol. | 27 | 1 | 2022 | 604 - 618 | 10.1007/s00773-021-00855-5 | 0948-4280 |
| An improved spectral method and experimental tests for the low-frequency broadband noise of marine propellers | Called by Green Ship of the Future to reduce the propeller noise pollution in the subsea environment and avoid the possibility of causing propeller–shaft–ship resonance, the low-frequency broadband noise (LFBN) of marine propellers was studied theoretically and experimentally. The spectral method is improved by considering the blade section thickness and anisotropy in the turbulence spectrum, both of which are found to be effective in improving the prediction accuracy when compared with the experimental results. A series of propellers with the same blade geometry but different blade number were tested in the large cavitation channel at the China Ship Scientific Research Centre. The peak values in all conditions were close to the first-order blade-passing frequency. The effects of blade number and the advance coefficient were investigated by testing the propellers operating under different conditions. The effects were also studied using both the spectral method and experiment, and the results were consistent. Furthermore, the quantitative dependence of the LFBN on the influencing parameters was investigated using the sensitivity analysis. The rotational speed and turbulence intensity were found to be the two main factors, with greater than 10% effects. In addition, the effects of thickness and anisotropy scaling factor were evaluated using the spectral method. The results of this study provide guidance for controlling the LFBN in propeller design and optimisation. | | Article | Liu, Jiarui; Pellerin, André; Wang, Jiasheng; Rickard, David; Antler, Gilad; Zhao, Jie; Wang, Zhou; Jørgensen, Bo Barker; Ono, Shuhei |
| Geochim. Cosmochim. Acta | 316 |
| 2022 | 309 - 330 | 10.1016/j.gca.2021.09.026 | 0016-7037 |
| Multiple sulfur isotopes discriminate organoclastic and methane-based sulfate reduction by sub-seafloor pyrite formation | The marine sulfate inventory represents the largest standing pool of electron acceptors, which, via microbial sulfate reduction, is responsible for roughly half of the organic matter mineralization globally in marine sediments. In addition to the oxidation of buried organic matter, sulfate reduction can be coupled to the oxidation of methane migrating upward. Multiple sulfur isotope ratios were measured for porewater sulfate, sulfide, elemental sulfur and pyrite from core samples collected from continental shelf (19–96 m water depth) in the Baltic Sea and slope (1098 m water depth) in the Andaman Sea, in order to test if their isotope systematics can be used to trace the two different sulfate reduction processes. For shallow shelf sediments (<43 cm below seafloor), both δ34S and Δ33S values of porewater sulfate increased with increasing depth as a result of organoclastic sulfate reduction (OSR). However, the Δ33S values of both porewater sulfate and sulfide decreased as the δ34S values increased downcore at 43–73 cm depth where sulfate reduction was coupled to anaerobic oxidation of methane (AOM). Pyrite in shelf sediments yielded positive Δ33S values, reflecting Δ33S of porewater sulfide produced by OSR. In contrast, pyrite in slope sediments yielded negative Δ33S values as low as −0.15‰, as a result of mixing of sulfides derived from OSR and AOM. This is consistent with the slowly migrating sulfate–methane transition (SMT) in slope sediments inferred from sulfur and iron speciation, carbon isotope ratios of carbonates, and magnetic susceptibility data. A stable SMT, focusing AOM at roughly the same depth over the past few millennia, further provides favorable conditions for prolonged pyrite formation with the development of cubic crystals, while the sulfur isotope difference between bulk pyrite and macroscopic pyrite reflects the significance of OSR throughout the sediment column. We conclude that minor sulfur isotopes provide a unique proxy that can be applied to differentiate OSR and AOM and the origin of pyrite in diverse sediments and sedimentary rocks. This contribution highlights strong local diagenetic controls on pyrite formation and its multiple sulfur isotopic composition in various marine settings. | | Article | Su, Haojie; Pan, Jiamin; Feng, Yuhao; Yu, Jia; Liu, Jiarui; Wang, Li; Li, Yun; Chen, Jun; Wu, Zhixu; Ma, Suhui; Fang, Jingyun; Xie, Ping |
| Ecol. Indic. | 132 |
| 2021 |
| 10.1016/j.ecolind.2021.108327 | 1470-160X |
| Stocking alien carp leads to regime shifts in native fish populations: Evidence from long-term observation and ecological modeling of a Chinese reservoir | Alien species invasions are considered to be one of the multiple key drivers that trigger ecological regime shifts in ecosystem structure and function. Predicting population collapse and understanding the self-reinforced feedback mechanisms that erode the resilience of native species are two major challenges in invasion ecology. However, to date, empirical evidence of species invasion-induced regime shifts remains scarce, and the minimum required data to generate early warning signals (EWSs) before critical transitions remains unclear, despite its importance for ecosystem management. By combining 80-year (i.e., 1936–2016) fishery data from Lake Qiandao and a theoretical competition model, we provide evidence that relative to nutrient enrichment and climate change, stocking alien fish species of silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthys nobtilis) is the most important driver leading to the collapse of local fish populations. Detectable EWSs indicated by the variance, autocorrelation and composite resilience indicators require at least ten years of data before an abrupt decline, demonstrating that a long-term ecological monitoring program is necessary for providing insight into resilience dynamics. A structural equation model (SEM) suggests that the combined effects of eutrophication, high water levels and carp stocking-induced water clarity decline may play an important role in the reduced fitness of local fish populations, which subsequently increase the carrying capacity of alien fish populations. Our results demonstrate that stocking alien carps result in competitive exclusion of local fish populations, especially in the current context of water eutrophication and global climate changes. Furthermore, quantifying the minimum required time series length with detectable EWS across various ecosystems should be further studied given that this information is critical for flexible management policies to take actions to avert the harmful transitions. | | Article | Wang, Fengjie; Wang, Zhiyu; Liu, Jiarui; Yu, Faxin |
| IEEE Trans. Circuits Syst. Express Briefs | 69 | 3 | 2022 | 879 - 883 | 10.1109/TCSII.2021.3123251 | 1558-3791 |
| A 14-Bit 3-GS/s DAC Achieving SFDR >63dB Up to 1.4GHz with Random Differential-Quad Switching Technique | This brief analyzes the data-dependent switching distortion and the image tone in the current steering digital-to-analog converter (DAC). A switching scheme called random differential-quad switching (RDQS) is presented. This RDQS technique adopts two pairs of differential switches and randomizes the selection of the two pairs. Thus the data-dependent switching distortion and the image tone caused by the mismatch between the two pairs of differential switches are disturbed. With the RDQS technique and a specially designed switching signal generator, a 14bit 3GS/s current-steering DAC is implemented in 40nm CMOS technique. Measurements show that this DAC achieves spurious free dynamic range over 63dB and suppresses the image tone by 15dB. This DAC occupies 0.9mm2 and consumes 190 mW at 1V/2.5V supply. | | Article | Hu, Shunfeng;Ren, Shuai;Cai, Yiqing;Liu, Jiarui;Han, Yang;Zhao, Yi;Yang, Juan;Zhou, Xiangxiang;Wang, Xin |
| Cell Death Differ. | 29 | 3 | 2022 | 642 - 656 | 10.1038/s41418-021-00880-2 | 1476-5403 |
| Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt–β-catenin–STAT3 signaling | Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalin superfamily and plays dual roles in prostaglandins metabolism and lipid transport. PTGDS has been involved in various cellular processes including the tumorigenesis of solid tumors, yet its role in carcinogenesis is contradictory and the significance of PTGDS in hematological malignancies is ill-defined. Here, we aimed to explore the expression and function of PTGDS in diffuse large B-cell lymphoma (DLBCL), especially the potential role of PTGDS inhibitor, AT56, in lymphoma therapy. Remarkable high expression of PTGDS was found in DLBCL, which was significantly correlated with poor prognosis. PTGDS overexpression and rhPTGDS were found to promote cell proliferation. Besides, in vitro and in vivo studies indicated that PTGDS knockdown and AT56 treatment exerted an anti-tumor effect by regulating cell viability, proliferation, apoptosis, cell cycle, and invasion, and enhanced the drug sensitivity to adriamycin and bendamustine through promoting DNA damage. Moreover, the co-immunoprecipitation-based mass spectrum identified the interaction between PTGDS and MYH9, which was found to promote DLBCL progression. PTGDS inhibition led to reduced expression of MYH9, and then declined activation of the Wnt-β-catenin-STAT3 pathway through influencing the ubiquitination and degradation of GSK3-β in DLBCL. The rescue experiment demonstrated that PTGDS exerted an oncogenic role through regulating MYH9 and then the Wnt-β-catenin-STAT3 pathway. Based on point mutation of glycosylation sites, we confirmed the N-glycosylation of PTGDS in Asn51 and Asn78 and found that abnormal glycosylation of PTGDS resulted in its nuclear translocation, prolonged half-life, and enhanced cell proliferation. Collectively, our findings identified for the first time that glycoprotein PTGDS promoted tumorigenesis of DLBCL through MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling, and highlighted the potential role of AT56 as a novel therapeutic strategy for DLBCL treatment. | | Article | Liu, Jiarui; Liu, Ye; Yu, Jianlin |
| Int. J. Refrig. | 131 |
| 2021 | 109 - 118 | 10.1016/j.ijrefrig.2021.06.010 | 0140-7007 |
| Performance analysis of a modified dual-ejector and dual-evaporator transcritical CO2 refrigeration cycle for supermarket application | This paper proposes a modified dual-ejector and dual-evaporator transcritical CO2 refrigeration cycle for supermarket application. Based on the conventional dual-evaporator transcritical CO2 refrigeration cycle, the modified cycle introduces two ejectors and a flash tank. The first liquid-vapor ejector sucks partial throttling flash vapor flowing to the low-temperature evaporator into the high-temperature evaporator; the second vapor-vapor ejector takes the vapor from the high-temperature evaporator as the primary flow to entrain the vapor from the low-temperature evaporator, and then the compressor suction pressure is lifted. Furthermore, the introduction of the first ejector increases the primary flow of the second ejector, and then improves the ability of the second ejector to lift the suction pressure of the compressor. The performance comparison between the two cycles is conducted by adopting energy and exergy analysis methods, and the efficiencies of the two ejectors are also analyzed. The comparison results demonstrate that the use of dual-ejector reduces the compressor pressure ratio by up to 19.1% under a typical working condition, and the improvements of the COP and exergy efficiency could reach up to 15.9–27.1% and 15.5–27.5% under all given working conditions. In addition, the modified cycle has an optimal gas cooler pressure of around 8.15 MPa, which is lower than the 8.3 MPa of the conventional cycle. The performance comparison results state clearly the energy-saving potential of the modified cycle and its application prospect in supermarket refrigeration. | | Article | Han, Yang; Hu, Xinting; Yun, Xiaoya; Liu, Jiarui; Yang, Juan; Tian, Zheng; Zhang, Xin; Zhang, Ya; Wang, Xin |
| Cell Death Dis. | 12 | 11 | 2021 |
| 10.1038/s41419-021-04368-2 | 2041-4889 |
| Nucleolar and spindle associated protein 1 enhances chemoresistance through DNA damage repair pathway in chronic lymphocytic leukemia by binding with RAD51 | Nucleolar and spindle-associated protein 1 (NUSAP1) is an essential regulator of mitotic progression, spindle assembly, and chromosome attachment. Although NUSAP1 acts as an oncogene involved in the progression of several cancers, the exact role of chronic lymphocytic leukemia (CLL) remains elusive. Herein, we first discovered obvious overexpression of NUSAP1 in CLL associated with poor prognosis. Next, the NUSAP1 level was modulated by transfecting CLL cells with lentivirus. Silencing NUSAP1 inhibited the cell proliferation, promoted cell apoptosis and G0/G1 phase arrest. Mechanistically, high expression of NUSAP1 strengthened DNA damage repairing with RAD51 engagement. Our results also indicated that NUSAP1 knockdown suppressed the growth CLL cells in vivo. We further confirmed that NUSAP1 reduction enhanced the sensitivity of CLL cells to fludarabine or ibrutinib. Overall, our research investigates the mechanism by which NUSAP1 enhances chemoresistance via DNA damage repair (DDR) signaling by stabilizing RAD51 in CLL cells. Hence, NUSAP1 may be expected to be a perspective target for the treatment of CLL with chemotherapy resistance. | | Conference Paper | Yao, Guangzheng; Chen, Yanyan; Cui, Kaijun; Xu, Donghui; Liu, Jiarui |
|
| 775 |
| 2022 | 759 - 771 | 10.1007/978-981-16-5429-9_57 | 1876-1119 |
| A Method of Household Car Ownership Prediction Using Ordered Probit Model | Predicting the demand for cars accurately is of great significance to urban planning and parking facilities planning. This paper uses the data from the Beijing 2010 Resident Travel Survey and takes the family income level, family demographic characteristics, the geographical environment of the family and the personal attributes of the head of the household as parameters. Random forest method is used to rank the importance of explanatory variables and carry out variable reorganization. Use the ordered probability model (Ordered Probit) to establish the relationship between explanatory variables and the number of vehicles owned by the household. The model found that the three parameters of the number of family driver’s licenses, the level of family income, and the number of people have the greatest impact on the family’s decision to own a car, and the income group mean transformation has a better fitting effect. | | Article | Liu, Mengwei; Zhang, Yujia; Wang, Jiachuang; Qin, Nan; Yang, Heng; Sun, Ke; Hao, Jie; Shu, Lin; Liu, Jiarui; Chen, Qiang; Zhang, Pingping; Tao, Tiger H. |
| Nat. Commun. | 13 | 1 | 2022 |
| 10.1038/s41467-021-27672-z | 2041-1723 |
| A star-nose-like tactile-olfactory bionic sensing array for robust object recognition in non-visual environments | Object recognition is among the basic survival skills of human beings and other animals. To date, artificial intelligence (AI) assisted high-performance object recognition is primarily visual-based, empowered by the rapid development of sensing and computational capabilities. Here, we report a tactile-olfactory sensing array, which was inspired by the natural sense-fusion system of star-nose mole, and can permit real-time acquisition of the local topography, stiffness, and odor of a variety of objects without visual input. The tactile-olfactory information is processed by a bioinspired olfactory-tactile associated machine-learning algorithm, essentially mimicking the biological fusion procedures in the neural system of the star-nose mole. Aiming to achieve human identification during rescue missions in challenging environments such as dark or buried scenarios, our tactile-olfactory intelligent sensing system could classify 11 typical objects with an accuracy of 96.9% in a simulated rescue scenario at a fire department test site. The tactile-olfactory bionic sensing system required no visual input and showed superior tolerance to environmental interference, highlighting its great potential for robust object recognition in difficult environments where other methods fall short. | | Article | Kaur, Prameet; Chua, Ellora Hui Zhen; Lim, Wen Kin; Liu, Jiarui; Harmston, Nathan; Tolwinski, Nicholas S. |
| Cells | 11 | 2 | 2022 |
| 10.3390/cells11020281 | 2073-4409 |
| Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem Cell Loss | Patients with Alzheimer’s disease suffer from a decrease in brain mass and a prevalence of amyloid-β plaques. These plaques are thought to play a role in disease progression, but their exact role is not entirely established. We developed an optogenetic model to induce amyloid-β intracellular oligomerization to model distinct disease etiologies. Here, we examine the effect of Wnt signaling on amyloid in an optogenetic, Drosophila gut stem cell model. We observe that Wnt activation rescues the detrimental effects of amyloid expression and oligomerization. We analyze the gene expression changes downstream of Wnt that contribute to this rescue and find changes in aging related genes, protein misfolding, metabolism, and inflammation. We propose that Wnt expression reduces inflammation through repression of Toll activating factors. We confirm that chronic Toll activation reduces lifespan, but a decrease in the upstream activator Persephone extends it. We propose that the protective effect observed for lithium treatment functions, at least in part, through Wnt activation and the inhibition of inflammation. | | Article | Liu, Jiarui; Oita, Azusa; Hayashi, Kentaro; Matsubae, Kazuyo |
| Sustainability | 14 | 2 | 2022 |
| 10.3390/su14021042 | 2071-1050 |
| Sustainability of Vertical Farming in Comparison with Conventional Farming: A Case Study in Miyagi Prefecture, Japan, on Nitrogen and Phosphorus Footprint | The reduced requirement for nutrients in vertical farming (VF) implies that the potential for lower environmental impact is greater in VF than in conventional farming. In this study, the environmental impacts of VF were evaluated based on a case study of VF for vegetables in Miyagi Prefecture in Japan, where VF has been utilized in post‐disaster relief operations in the wake of the 2011 Great East Japan Earthquake. The nitrogen (N) and phosphorus (P) footprints of these VFs were determined and analyzed to quantify the potential reduction in N and P emissions. First, the N and P footprints in conventional farming were calculated. Then, those footprints were compared with three different scenarios with different ratios for food imports, which equate to different levels of food self‐sufficiency. The results show a decrease in the N and P footprints with increased prefectural self‐sufficiency due to the introduction of VF. In addition to reducing the risks to food supply by reducing the dependence on imports and the environmental impacts of agriculture, further analysis reveals that VF is suitable for use in many scenarios around the world to reliably provide food to local communities. Its low vulnerability to natural disasters makes VF well suited to places most at risk from climate change anomalies. | | Article | Guo, Bingbing; Liu, Jiarui; Wang, Bingwei; Zhang, Chenyu; Su, Zhijie; Zhao, Miao; Qin, Lihua; Zhang, Weiguang; Zheng, Ruimao |
| Diabetes | 71 | 2 | 2022 | 249 - 263 | 10.2337/db21-0470 | 1939-327X |
| Withaferin A Promotes White Adipose Browning and Prevents Obesity Through Sympathetic Nerve–Activated Prdm16-FATP1 Axis | The increasing prevalence of obesity has resulted in demands for the development of new effective strategies for obesity treatment. Withaferin A (WA) shows a great potential for prevention of obesity by sensitizing leptin signaling in the hypothalamus. However, the mechanism underlying the weight- and adiposity-reducing effects of WA remains to be elucidated. In this study, we report that WA treatment induced white adipose tissue (WAT) browning, elevated energy expenditure, decreased respiratory exchange ratio, and prevented high-fat diet–induced obesity. The sympathetic chemical denervation dampened the WAT browning and also impeded the reduction of adiposity in WA-treated mice. WA markedly upregulated the levels of Prdm16 and FATP1 (Slc27a1) in the inguinal WAT (iWAT), and this was blocked by sympathetic denervation. Prdm16 or FATP1 knockdown in iWAT abrogated the WAT browning–inducing effects of WA and restored the weight gain and adiposity in WA-treated mice. Together, these findings suggest that WA induces WAT browning through the sympathetic nerve–adipose axis, and the adipocytic Prdm16-FATP1 pathway mediates the promotive effects of WA on white adipose browning. | | Article | Zhong, Chuan; Wang, Fen; Zhou, Haining; Liu, Jiarui; Hu, Jiewei; Chen, Yongjun |
| Medicine | 101 | 4 | 2022 | E28719 - E28719 | 10.1097/MD.0000000000028719 | 0025-7974 |
| Bacteremia caused by accidental injection of Bacillus licheniformis microbiota modulator through the central venous catheter: A case report | Rationale:Bacillus licheniformis (B licheniformis) is a commonly used microbiota modulator. However, infections are rarely observed in immunocompetent hosts.Patient concerns:A 67-year-old woman who underwent esophagectomy experienced accidental injection of B licheniformis and presented with chills followed by hyperpyrexia.Diagnosis:The initial diagnosis was B licheniformis bacteremia.Intervention:Based on our experience, the patient first received levofloxacin and ornidazole. The application of levofloxacin was retained based on the antibiogram results. After discharge, the antibiotics were changed to vancomycin and levofloxacin, based on sensitivity tests, until two consecutive blood cultures were negative.Outcomes:The patient recovered without any severe complications.Lessons:This is a rare report of the successful treatment of B licheniformis bacteremia caused by improper drug administration, which will provide a reference for the treatment of B licheniformis bacteremia. | | Article | Zhang, Min;Xie, Xinru;Zhang, Dong;Chen, Run;Xu, Yifei;Wang, Jiatong;Liu, Jiarui;Xu, Xiaoguang |
| Microwave Opt. Technol. Lett. | 65 | 5 | 2023 | 1117 - 1121 | 10.1002/mop.33195 | 0895-2477 |
| Nondestructive identification of wood species by terahertz spectrum | Terahertz time-domain spectroscopy (THz-TDS) has become an emerging nondestructive detection technique due to the unique properties of THz waves; it offers safety, penetrability, and fingerprint identification, especially for commonly used non-polar materials. Here, we measure the differences in THz spectra of four wood blocks (manglietia, amur linden, black walnut, and ebony) in the frequency range of 0.1–0.9 THz. In addition, we demonstrate the principal components analysis (PCA) applied in THz absorption spectra; the principal components extracted from original data by PCA can replace the original absorption coefficient data and can clearly distinguish the wood types. Results show that THz-TDS combined with PCA can be used as an effective nondestructive identification method in the field of public security, food detection, and customs anti-smuggling initiatives. | | Conference Paper | Liu, Lin; Liu, JiaRui |
| Proc. SPIE Int. Soc. Opt. Eng. | 12153 |
| 2021 |
| 10.1117/12.2626637 | 0277-786X |
| Research on image design of Chinese characters in virtual reality | Digital media technology contributes to the realization of the innovation of the graphic design of Chinese characters. From the two aspects of the artistic expression characteristics of virtual reality and the image design of virtual interactive Chinese characters, this paper discusses the forms and methods of image design of Chinese characters in virtual reality, and discusses the multi-dimensional, animated and flowing image design of Chinese characters, which includes light, color, time and movement, sound and virtual interactive elements. In this work, the virtual world constructed by digital media technology is summarized, which provides a virtual Chinese character image scene for Chinese character design. In addition, Chinese character strokes are broken up and grafted into a new virtual space effect, which enables designers and viewers to resonate through game interaction. | | Article | Zhang, Hengwei;Zhang, Ke;Liu, Jiarui;Wang, Yi;Yu, Fang |
| Photochem. Photobiol. Sci. | 21 | 6 | 2022 | 1055 - 1065 | 10.1007/s43630-022-00193-4 | 1474-9092 |
| The sensing mechanism of fluorescent probe for PhSH and the process of ESIPT | The detection mechanism of fluorescent probe FQ-DNP (DNP: 2,4-dinitropheno) for PhSH and the detailed ESIPT process of its product 2-(6-(diethylamino) quinolin-2-yl)-3–Hydroxy-4H-chromen-4-one (FQ-OH) have been revealed by density functional theory (DFT) and time-dependent density functional theory (TD-DFT). For FQ-OH, the decreased bond length of H6–N7 and RDG analysis illustrate that the strength of hydrogen bond H6–N7 has been enlarged after photoexcitation, creating a good condition for ESIPT. To illustrate the ESIPT process in detail, the potential energy curves are performed and the transition state reaction energy is calculated. In the S0 state, the FQ-OH could happen proton transfer (PT) to form keto, but the keto form is more unstable than enol form. After photoexcitation, in the S1 state, FQ-OH could happen PT to produce stable keto form. Excited dynamic simulation shows that PT happens at 71.5 fs. The calculated absorption and emission spectra are in agreement with the experimental data, and the calculated Stokes shift is 160 nm. Frontier molecular orbitals (FMOs) and hole–electron analysis show that twisted intramolecular charge transfer (TICT) is responsible for the fluorescent quenching of FQ-DNP. Graphical abstract: [Figure not available: see fulltext.]. | | Review | Cui, Tianyi; Liu, Jiarui; Lyu, Bin; Gao, Xiumei; Zhao, Xin |
| Chin. Gen. Pract. | 25 | 8 | 2022 | 1021 - 1026 | 10.12114/j.issn.1007-9572.2021.01.045 | 1007-9572 |
| Novel Developments in the Relationship of Gut Microbiota and Immune Regulation with Childhood Asthma | Bronchial asthma, commonly known as asthma, is a frequently seen chronic respiratory disease that seriously threatens human health. More than 300 million people have had asthma worldwide, and most of them are children. Epidemiological investigations have shown that the prevalence of asthma among Chinese children aged 0-14 is 2.32%, and it is increasing year by year. Children are more prone to gut flora imbalance due to underdeveloped immune system, and physiologically successional changing of gut flora, which leads to the destruction of the intestinal mucosal barrier and local immune imbalance, eventually causing the development of asthma. We reviewed the latest advances in the immune regulatory mechanism of childhood asthma, and its association with gut microbiota, as well as interventions targeting gut microbiota, providing new ideas for the treatment of childhood asthma. | | Article | Liu, Jiarui; Doh, Jeung-Hwan; Dinh, Hong Lich; Ong, Dominic E.L.; Zi, Goangseup; You, Ilhwan |
| Constr. Build. Mater. | 329 |
| 2022 |
| 10.1016/j.conbuildmat.2022.127134 | 0950-0618 |
| Effect of Si/Al molar ratio on the strength behavior of geopolymer derived from various industrial waste: A current state of the art review | Geopolymer, also termed as alkali-activated material (AAM), is a promising concrete technology having the advantages of low carbon emission and resource reclamation. Intensive studies have verified the feasibility of using waste as an aluminosilicate precursor (AP) to synthesize AAM. However, the inconsistent characteristics of raw materials are an obstacle against its industry scale application. To address this issue, Si/Al molar ratio can serve as a non-dimensional index to standardize raw material and offer a potential solution to quality control of AAM feedstock supply chain. Even though the crucial role that molar ratios will play in the quality control of AAM, studies on the correlation between Si/Al molar ratio and AAM properties are limited. To fill this gap, this paper provided an in-depth review from the perspective of the Si/Al molar ratio and summarized their correlation with properties of various types AAMs, validating the feasibility of using the molar ratio to formulate AAM and to maintain stable performances. Based on these, a three-step strategy that can more effectively convert an ever-broader range of waste material with high variability into normalized AP was proposed, which may serve as a guide regarding waste valorization and AAM quality control. | | Article | Liu, Xiumin;Wang, Yi;Liu, Jiarui;Tian, Jing;Fei, Xu |
| J. Cluster Sci. | 34 | 2 | 2023 | 813 - 822 | 10.1007/s10876-022-02258-x | 1572-8862 |
| A High Performance 2-Hydroxynaphthalene Acylhydrazone Fluorescent Chemosensor for Detection of Al Ions Through ESIPT and PET Signalling Mechanism | Acylhydrazone based chemosensors, with encouraging optical responses, have been widely developed for anticancer and antiviral activities. Excited state intramolecular proton transfer and photoinduced electron transfer (PET) play an indispensable role in the study of excited state dynamics of fluorescent sensors. In this paper, 3-hydroxy-N′-((2-hydroxynaphthalen-1-yl)methylene)-2-naphthohydrazide (NANH) chemosensor was studied using density functional theory (DFT) and time-dependent DFT. Our theoretical results show that the hydroxyl group of NANH forms an intra-molecular hydrogen bond with the adjacent imine nitrogen. And in the process of light excitation, the PET process is triggered. In addition, the acylhydrazone derivatives have a strong donor position, and when they are coordinated with Al ions, the fluorescence is enhanced by blocking the PET process. In this work, the geometric structure were optimized, the charge transfer process was studied by hole-electron analysis. The frontier molecular orbitals show that the NANH-Al-b is better stabilized than that of NANH1. | | Article | Liu, Jiarui; Liu, Ye; Yan, Gang; Yu, Jianlin |
| Int. J. Refrig. | 137 |
| 2022 | 117 - 128 | 10.1016/j.ijrefrig.2022.02.012 | 0140-7007 |
| Thermodynamic analysis on a modified auto-cascade refrigeration cycle with a self-recuperator | This paper proposes a modified auto-cascade refrigeration cycle (MARC) with a self-recuperator. The introduced self-recuperator and associated expansion valve effectively increases the refrigerant enriched with more low-boiling component in the evaporator. This case could improve the cycle performance by further choosing appropriate design-dependent cycle parameters. The energy and exergy analysis methods are used to compare and evaluate the performance of MARC with conventional auto-cascade refrigeration cycle (CARC). The simulation results show that under all given working conditions, the COP and exergy efficiency of MARC are superior to those of CARC. Among R290/R170 and R600a/R1150, R600a/R1150 is much better refrigerant mixture. Under a typical working condition, the COP of MARC using R600a/R1150 is 68.17% higher than that using R290/R170. The performance improvement of MARC is more obvious when R600a/R1150 is used. Under the typical working condition, the COP of MARC is increased by 6.24% and 24.17% using R290/R170 and R600a/R1150, respectively. When initial mass fraction of R1150 is about 0.6, the two cycles have maximum COP and exergy efficiency, and the maximum COP of MARC is 24.26% higher than that of CARC. In addition, the increase in the two-phase flow vapor quality at the condenser outlet can improve the COP, but reduce the refrigeration capacity. The COP of MARC increases by 37.56% when the quality increases from 0.4 to 0.6. It is also found for MARC that COP and refrigeration capacity are positively correlated with intermediate pressure. | | Article | Wang, Wei; Gao, Juan; Liu, Jiarui; Qi, Jinxi; Zhang, Qifan |
| Contrast Media Mol. Imaging | 2022 |
| 2022 |
| 10.1155/2022/2180374 | 1555-4317 |
| Clinical Efficacy of Dexamethasone in the Treatment of Patients with Tuberculous Meningitis: A Meta-Analysis | Objective. This study aimed to systematically evaluate the clinical efficacy of dexamethasone in patients with tuberculous meningitis (TBM) through meta-analysis. Method. PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and the Wanfang Databases were searched, and all relevant Chinese and English literature from 2000 to 2021 were retrieved from each database. We collected randomized controlled trials of conventional antituberculosis drugs combined with dexamethasone treatment (treatment group) and conventional antituberculosis drug treatment or combined with placebo treatment (control group) in TBM patients. Meta-analysis was performed with Stata16.0 software. Results. A total of 1645 articles were retrieved, and 11 articles were finally included in the study. Meta-analysis results showed that the treatment group had a significantly higher response rate and lower incidence of adverse reactions compared with the control group. Additionally, compared with the control group, the postoperative cerebrospinal fluid cell count, protein content, and glucose in the treatment group were significantly lower, while the chloride level increased. Conclusion. Conventional antituberculosis drugs combined with dexamethasone therapy can improve cerebrospinal fluid cell count, protein content, glucose, and chloride levels in patients with TBM. This treatment can improve the treatment effective rate and reduce the incidence of adverse reactions, which is considered an effective treatment for TBM. Our results provide strong evidence for enhancing existing treatment regimens and developing novel combination therapy to improve TBM treatment efficacy. | | Article | Chen, Tingting;Strauss, Harald;Fang, Yunxin;Lin, Zhiyong;Sun, Xiaoming;Liu, Jiarui;Lu, Yang;Yang, Xin;Lin, Haixin;Wu, Zhongwei;Lin, Xiao |
| Front. Earth Sci. | 10 |
| 2022 |
| 10.3389/feart.2022.862333 | 2296-6463 |
| Sulfur and Oxygen Isotope Records of Sulfate-Driven Anaerobic Oxidation of Methane in Diffusion-Dominated Marine Sediments | Organoclastic sulfate reduction (OSR) and sulfate-driven anaerobic oxidation of methane (SD-AOM) are the two major microbial pathways for sulfate consumption in marine sulfur cycle. The relative changes of sulfur and oxygen isotope ratios in pore water sulfate are affected by the mode of microbial sulfate reduction and have been applied as an indicator for assessing methane excess environments. However, so far, this isotope proxy fails to distinguish sulfate reduction processes fueled by the oxidation of organic matter or by diffusing methane. To better understand the mechanism of sulfur and oxygen isotope partitioning during OSR and SD-AOM, coupled sulfur and oxygen isotopic compositions of pore water sulfate (δSSO4 and δOSO4) were investigated from four methane diffusing sites (CL56, CL57, CL59, and CL60) of the South China Sea, supplemented by carbon isotopic composition of dissolved inorganic carbon (DIC) and sulfur isotopic composition of pyrite in bulk sediments. Pore water sulfate and DIC concentrations, as well as calculated net sulfate reduction rates suggest that the sulfate reduction at site CL57 was mainly dominated by OSR, whereas sites CL56, CL59, and CL60 were likely impacted by both OSR and SD-AOM. Furthermore, the trend of cross-plotting δOSO4 versus δSSO4 values from site CL57 was distinguishable from sites CL56, CL59, and CL60, although all study sites show similar patterns to those derived from methane limited environments. This further indicates the trajectory of sulfur and oxygen isotope partitioning was affected by the mode of sulfate reduction (i.e., OSR vs. SD-AOM). At site CL57, the low net sulfate reduction rate would lead to enhanced oxidation of intermediate sulfur species during OSR, thus leading to a higher slope in the δOSO4 vs. δSSO4 cross-plot (1.26). In contrast, the higher net sulfate reduction rates at sites CL56, CL59, and CL60 due to the impact from SD-AOM would lead to lower slopes in the δOSO4 vs. δSSO4 cross-plots (0.78 ± 0.11). This study provides new insights into the sulfur and oxygen isotope systematics during microbial sulfate reduction processes in methane diffusing environments. | | Article | Yu, Faxin;Chen, Jiahao;Li, Haoming;Wang, Tengjia;Yang, Yao;Xiong, Wenfang;Wang, Zhiyu;Liu, Jiarui |
| IEEE Trans. Circuits Syst. Express Briefs | 69 | 9 | 2022 | 3754 - 3758 | 10.1109/TCSII.2022.3174226 | 1558-3791 |
| A Low Phase Noise VCO With Placement Reordered Cores and High-Q Bond Wire Array Inductors | This brief presents a low phase noise class-C voltage-controlled oscillator with bond wire inductors. To improve the Q-factor of inductors, the voltage-controlled oscillator employs bond wires as the inductors of the resonators. A transient-analysis-compatible equivalent circuit is proposed to precisely estimate the influence of mutual inductance, parasitic components and silicon substrate. Possible phenomena of oscillation mode ambiguity and oscillation failure are analyzed to be relative with the magnetic coupling between bond wires. An equation is derived to set up the relation among oscillation mode, bond wire coupling and frequency ratio of adjacent oscillators. And a costless placement reorder method is proposed to prevent the oscillator cores from oscillating failure and mode ambiguity. The voltage-controlled oscillator is implemented in a 65-nm CMOS process. Ten groups of gold double bond wires with a 20 mu text{m} diameter, 70 mu text{m} height and 800 mu text{m} horizontal length are adopted as the inductors. The total tuning range of the oscillator is from 2.22 GHz to 4.46 GHz. When oscillating at 4.46 GHz and the output frequency divide ratio is 2, the output signal provides phase noise performance of -137.3 dBc/Hz at 1 MHz offset from 2.23 GHz. The maximum power consumption is 38 mW and each oscillator core occupies a chip area of only 0.112 mm2. | | Article | Gao, Fei;Wang, Feifei;Ding, Yuyang;Liu, Yuntao;Ni, Ning;Chen, Yizhen;Wang, Zilin;Liu, Jiarui |
| Radiat. Phys. Chem. | 198 |
| 2022 |
| 10.1016/j.radphyschem.2022.110221 | 1879-0895 |
| Establishment of pulsed X-ray reference radiation field and measurement of related parameters | The international research on radiation protection dosimetry mainly focuses on continuous radiation. However, pulsed radiation has been widely used in the fields of new detector development, radiographic inspection, X-ray diagnosis, nuclear accident emergency and scientific research, the measurement of pulsed dose (rate) is very difficult. In order to solve the technical problem of pulse response test of active radiation dosimeter, the generation principle of pulsed X-ray and gamma ray radiation field is discussed, and the reference radiation field of pulsed X-ray is established based on three kinds of X-ray machines. Combined with the transfer ionization chamber and pulse width measurement system, the research of pulsed radiation dose (rate) measurement technology is carried out. The experimental results show that the pulse width of the established pulsed X-ray reference radiation field can be adjusted between 50 ns and 10 s, and the instantaneous dose rate range is 2.5 mSv/h-6.7 × 105 Sv/h, which can be widely used to study the pulsed X-ray response characteristics of active radiation dosimeter. This work can be widely used to study the pulsed X-ray response characteristics of active radiation dosimeter, which is of great significance to solve the calibration problem of pulsed radiation dose monitoring instrument. | | Article | Zhang, Hengwei;Li, Zixian;Liu, Jiarui;Wang, Yi |
| J. Mol. Liq. | 361 |
| 2022 |
| 10.1016/j.molliq.2022.119555 | 0167-7322 |
| Effect of intermolecular hydrogen bonds on the proton transfer and fluorescence characteristics of 1′-hydroxy-2′-acetonaphthone | 1′-hydroxy-2′-acetonaphthone (HAN) is a useful fluorescence probe based on excited state intramolecular proton transfer (ESIPT). A number of experiments had explored the fluorescence properties of HAN in different microenvironments and applied HAN to bioimaging. However, the mechanism of fluorescence properties of HAN in different microenvironments was not been fully reported. Thus, our research aims to investigate the proton transfer (PT) and fluorescence characteristics of HAN in different microenvironments, focusing on revealing the hydrogen bond dynamics in high-polar aqueous solution (HAN-H2O) and low-polar hydrophobic pocket of bovine serum albumin by the density functional theory (DFT) and time-dependent density functional theory (TD-DFT). Explicit water molecules were placed around HAN to simulate the hydrogen bond interactions between HAN and the water molecules in an aqueous solution. The intermolecular hydrogen bonds slightly affect the geometric structures of HAN, but would inhibit the ESIPT process while increasing the charge transfer distance, leading to red shift of fluorescence. Upon photoexcitation, the intramolecular hydrogen bond had been strengthened, providing the driving force of PT, which resulted in HAN and HAN-H2O undergoing ultrafast ESIPT process. Meanwhile, after photoexcitation, the intermolecular hydrogen bonds were significantly enhanced, decreasing the energy of HAN-H2O in the excited state and promoted the radiationless deactivation of HAN-H2O. Therefore, HAN has weak fluorescence in the aqueous solution. | | Article | Krause, Sebastian J.E.;Liu, Jiarui;Young, Edward D.;Treude, Tina |
| Earth Plan. Sci. Lett. | 593 |
| 2022 |
| 10.1016/j.epsl.2022.117681 | 0012-821X |
| Δ13CH3D and Δ12CH2D2 signatures of methane aerobically oxidized by Methylosinus trichosporium with implications for deciphering the provenance of methane gases | Aerobic oxidation of methane (MOx) is an important biologically mediated process that consumes methane in a wide range of environments. Here we report results of culture experiments with the aerobic methane-oxidizing bacterium Methylosinus trichosporium (OB3b) that are used to characterize the mass-18 isotopologue (Δ13CH3D and Δ12CH2D2) signatures of MOx in residual methane gases. MOx activity was confirmed by simultaneous decrease of methane and oxygen in the bulk gas headspace. Bulk carbon (13C/12C) and hydrogen (D/H) isotope ratios of the methane gas increased while both Δ13CH3D and Δ12CH2D2 decreased as the oxidation proceeded. The corresponding fractionation factors (α) calculated from our experimental results are 0.98485 ± 0.00006 for 13C/12C, 0.7265 ± 0.0010 for D/H, 0.7141 ± 0.0011 for 13CH3D/12CH4, and 0.4757 ± 0.0023 for 12CH2D2/12CH4. Deviations of the mass-18 fractionation factors from the Rule of the Geometric Mean (RGM) expressed as γ values are 0.9981 ± 0.0017 for 13CH3D/12CH4 and 0.9013 ± 0.0045 for 12CH2D2/12CH4. Our α and γ values suggest that while MOx fractionates 13CH3D within error of the RGM, the Δ13CH3D and Δ12CH2D2 trajectories are very sensitive to even small deviations in 13CH3D/12CH4 from the RGM. Fractionation of 12CH2D2 deviates considerably from RGM, and this causes dramatic and robust effects on the trajectories of residual methane in Δ13CH3D vs. Δ12CH2D2 space. Our models suggest that Δ13CH3D and Δ12CH2D2 could potentially mimic microbial methanogenesis signatures in an environment that exhibits a strong Rayleigh Distillation process with little to no replenishment of methane during oxidation. However, in closed or open systems where oxidation is attended by simultaneous methane production, we find that modest increases in Δ13CH3D and dramatic increases in Δ12CH2D2 are to be expected, thus resulting in isotopologue signatures distinct from microbial methanogenesis. The overall trend in these conditions suggest that methane altered by MOx is distinguishable from other methane sources in Δ13CH3D and Δ12CH2D2 space. | | Article | Zhang, Quan-Zhi;Liu, Jia-Rui;Liu, Yong-Xin;Lu, Wen-Qi;Sun, Jing-Yu;Wang, You-Nian |
| Plasma Sources Sci. Technol. | 31 | 7 | 2022 |
| 10.1088/1361-6595/ac7903 | 0963-0252 |
| Enhanced heating in plasma bulk due to electron cyclotron resonance in weakly magnetized capacitively coupled plasmas | An enhanced electron heating mechanism based on a resonance between the cyclotron motion of electrons and radio frequency (rf) electric field in the plasma bulk is reported in weakly magnetized capacitively coupled argon plasmas at low pressure. When the electron cyclotron frequency coincides with the applied power source frequency, the bulk electrons can continuously acquire energy from the background electric field within certain rf periods during the cyclotron motion, inducing overall distinct increase of excitation rate and electron temperature in the plasma bulk. This enhanced electron heating effect has been examined by a combination of kinetic particle simulations, experimental measurements, and an analytical model, and the dynamics of electrons are revealed at resonant conditions. | | Article | Liu, Yu;Chen, Mingliang;Wang, Chenge;Liu, Jiarui;Wang, Zhiyu;Chen, Hua;Yu, Faxin |
| IEICE Electron. Express | 19 | 15 | 2022 |
| 10.1587/elex.19.20220084 | 1349-2543 |
| A parasitic elimination bootstrapped switch and a fast settling residual amplifier for high-speed and high-resolution pipelined ADC | This letter proposes a parasitic elimination bootstrapped switch and a fast settling residual amplifier to be used in multiplying digital-toanalog converter (MDAC) in order to improve the performance of pipelined ADC at high frequency. The parasitic elimination bootstrapped switch improves the sampling spurious free dynamic range (SFDR) by more than 6 dB by shielding the nonlinear parasitic capacitance of the MOS transistor substrate. In addition, at high frequency, the negative zero point introduced by the later stage switch-capacitor circuit (which is easy to be ignored) will seriously deteriorates the settling time of residual amplifier in the former stage. A new zero-pole elimination technique is proposed, which greatly reduces the settling time of residual amplifier by nearly 11% and further improve the performance ofMDAC. Simulated in 28 nmCMOStechnology, as the input signal is 1.38 GHz, the former stage of the pipelined ADC implements high-speed high-resolution to obtain a SFDR of 75.77 dB and a signal-to-noise-plus-distortion ratio (SNDR) of 68.05 dB at a sampling frequency of 2.2 GS/s. | | Article | Duan, Shucheng;Liu, Jia Rui;Wang, Xin;Sun, Xue Mei;Gong, Han Sheng;Jin, Cheng Wu;Eom, Seok Hyun |
| Molecules | 27 | 15 | 2022 |
| 10.3390/molecules27154782 | 1420-3049 |
| Thermal Control Using Far-Infrared Irradiation for Producing Deglycosylated Bioactive Compounds from Korean Ginseng Leaves | Although ginseng leaf is a good source of health-beneficial phytochemicals, such as polyphenols and ginsenosides, few studies have focused on the variation in compounds and bioactivities during leaf thermal processing. The efficiency of far-infrared irradiation (FIR) between 160 C and 200 C on the deglycosylation of bioactive compounds in ginseng leaves was analyzed. FIR treatment significantly increased the total polyphenol content (TPC) and kaempferol production from panasenoside conversion. The highest content or conversion ratio was observed at 180 C (FIR-180). Major ginsenoside contents gradually decreased as the FIR temperature increased, while minor ginsenoside contents significantly increased. FIR exhibited high efficiency to produce dehydrated minor ginsenosides, of which F4, Rg6, Rh4, Rk3, Rk1, and Rg5 increased to their highest levels at FIR-190, by 278-, 149-, 176-, 275-, 64-, and 81-fold, respectively. Moreover, significantly increased antioxidant activities were also observed in FIR-treated leaves, particularly FIR-180, mainly due to the breakage of phenolic polymers to release antioxidants. These results suggest that FIR treatment is a rapid and efficient processing method for producing various health-beneficial bioactive compounds from ginseng leaves. After 30 min of treatment without leaf burning, FIR-190 was the optimum temperature for producing minor ginsenosides, whereas FIR-180 was the optimum temperature for producing polyphenols and kaempferol. In addition, the results suggested that the antioxidant benefits of ginseng leaves are mainly due to polyphenols rather than ginsenosides. | | Article | Wang, Xinyue;Wu, Xianyu;Liu, Jiarui |
| Sustainability | 14 | 15 | 2022 |
| 10.3390/su14158998 | 2071-1050 |
| Optimization Models of Actuated Control Considering Vehicle Queuing for Sustainable Operation | How to sustainably conduct intersection operations is a key issue of the current research. For an actuated control intersection, queued vehicles, control parameters, and phase schemes all affect the operation effect. This paper discusses queued vehicles at actuated intersections and their influence on signal timing. First, this paper establishes an improved traffic wave model and proposes a vehicle queuing model on this basis. Second, by analyzing the queuing and dispersion process of queued vehicles, a minimal green time calculation model is proposed. Then, this paper establishes a maximal green time calculation model aiming at minimizing average vehicle delay and maximizing traffic capacity under different phase schemes, and considers the influence of queued vehicles. Lastly, the models are verified separately; results show that the average error of the minimal green time model was 4.18%, and the average optimization rate of the maximal green time model was 9.27%. It is proved that the models achieved great accuracy and optimization effects, which could potentially improve intersection sustainability. | | Article | Wu, Jiayun;Zhang, Mingxiao;Liu, Jiarui;Huang, Yongji;Xu, Liangnian;Deng, Zuhu;Zhao, Xinwang |
| Int. J. Mol. Sci. | 23 | 16 | 2022 |
| 10.3390/ijms23169435 | 1661-6596 |
| Efficient Anchoring of Erianthus arundinaceus Chromatin Introgressed into Sugarcane by Specific Molecular Markers | Erianthus arundinaceus is a valuable gene reservoir for sugarcane improvement. However, insufficient molecular markers for high-accuracy identification and tracking of the introgression status of E. arundinaceus chromatin impede sugarcane breeding. Fortunately, suppression subtractive hybridization (SSH) technology provides an excellent opportunity for the development of high-throughput E. arundinaceus-specific molecular markers at a reasonable cost. In this study, we constructed a SSH library of E. arundinaceus. In total, 288 clones of E. arundinaceus-specific repetitive sequences were screened out and their distribution patterns on chromosomes were characterized by fluorescence in situ hybridization (FISH). A subtelomeric repetitive sequence Ea086 and a diffusive repetitive sequence Ea009, plus 45S rDNA-bearing E. arundinaceus chromosome repetitive sequence EaITS were developed as E. arundinaceus-specific molecular markers, namely, Ea086-128, Ea009-257, and EaITS-278, covering all the E. arundinaceus chromosomes for high-accuracy identification of putative progeny. Both Ea086-128 and Ea009-257 were successfully applied to identify the authenticity of F1, BC1, BC2, BC3, and BC4 progeny between sugarcane and E. arundinaceus. In addition, EaITS-278 was a 45S rDNA-bearing E. arundinaceus chromosome-specific molecular marker for rapid tracking of the inherited status of this chromosome in a sugarcane background. Three BC3 progeny had apparently lost the 45S rDNA-bearing E. arundinaceus chromosome. We reported herein a highly effective and reliable SSH-based technology for discovery of high-throughput E. arundinaceus-specific sequences bearing high potential as molecular markers. Given its reliability and savings in time and efforts, the method is also suitable for development of species-specific molecular markers for other important wild relatives to accelerate introgression of wild relatives into sugarcane. | | Review | Jin, Bao;Zhang, Yang;Zhang, Zongyu;Yang, Guorong;Pan, Yujia;Xie, Liangzhen;Liu, Jiarui;Shen, Wenjuan |
| Evid.-Based Complement. Altern. Med. | 2022 |
| 2022 |
| 10.1155/2022/8698755 | 1741-4288 |
| The Efficacy and Safety of Dingkun Pill in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Objective. Dingkun Pill (DKP) is a proprietary Chinese medicine that has been utilized for patients with gynecological diseases, and its clinical application has been widely accepted in China. However, the effects of DKP on reproduction and metabolism in women with polycystic ovary syndrome (PCOS) have never been systematically evaluated. Our objective was to evaluate the efficacy and safety of DKP in treating reproductive and metabolic abnormalities with PCOS. Methods. We searched in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and Chinese Biomedical Literature Database up until January 2022 to identify randomized controlled trials (RCTs). The methodological quality of the included RCTs was estimated using the Cochrane collaboration risk-of-bias instrument, and the meta-analysis was performed using RevMan. Results. A total of 22 RCTs (including 1994 participants) were identified. DKP, combined with ovulation-inducing drugs (OID) or combined oral contraceptives (COC) was superior to OID or COC alone in improving the pregnancy rate (relative risk (RR) 1.84, 95% CI 1.62 to 2.11 and RR 1.38, 95% CI 1.16 to 1.64, respectively), ovulation rate (RR 1.38, 95% CI 1.03 to 1.84 and RR 1.23, 95% CI 1.11 to 1.37, respectively), endometrial thickness (weighted mean difference (WMD) 2.50, 95% CI 1.91 to 3.09 and WMD 0.62, 95% CI 0.08 to 1.16, respectively), luteinizing hormone (WMD -1.93, 95% CI -2.80 to-.07 and WMD -1.79, 95% CI -2.66 to-0.92, respectively), and testosterone (standardized mean difference (SMD) -2.12, 95% CI -3.01 to-1.24 and SMD -1.21, 95% CI -1.64 to-0.78, respectively). DKP combined with COC led to a greater improvement in homeostasis model assessment-β (WMD 20.42, 95% CI 16.85 to 23.98) when compared with COC alone. There was a significant difference between DKP and COC in terms of decreasing total cholesterol (WMD -0.37, 95% CI -0.72 to-0.02), triacylglycerol (WMD -0.85, 95% CI -1.50 to-0.20), and free fatty acid (WMD -130.00, 95% CI -217.56 to-42.22). However, DKP did not affect the follicle stimulating hormone, fasting blood glucose, fasting insulin, body mass index, waist-to-hip ratio, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol. Adverse reactions were more common in COC alone compared to DKP and COC in combination (RR 0.22, 95% CI 0.07 to 0.63). Conclusion. DKP shows promise in modifying reproductive and metabolic parameters in patients with PCOS and may be used as a primary choice in conventional or complementary therapies for PCOS. The quality of the evidence analyzed was suboptimal, and therefore, our results should be interpreted cautiously. More prospective large-scale and well-designed RCTs, as well as longer intervention durations are required in the future to draw more reliable conclusions. | | Review | Jin, Bao;Zhang, Yang;Zhang, Zongyu;Yang, Guorong;Pan, Yujia;Xie, Liangzhen;Liu, Jiarui;Shen, Wenjuan |
| Evid.-Based Complement. Altern. Med. | 2022 |
| 2022 |
| 10.1155/2022/8698755 | 1741-4288 |
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| | Article | Ding, Rui;Zhang, Haicheng;Liu, Chunrong;Xu, Daolin;Shi, Qijia;Liu, Jiarui;Zou, Weisheng;Wu, Yousheng |
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| 9 | 6 | 2024 | 517 - 527 | 10.1016/j.joes.2022.08.003 | 2468-0133 |
| Connector configuration effect on the dynamic characteristics of multi-modular floating structure | In this study, a wave flume experiment is implemented in order to investigate the effect of connector topology on the dynamic characteristics of a modular floating structure. Three configurations of flexible connectors were designed for the experiment tests of a three-modular floating platform under various wave conditions. The results illustrate the module responses, relative displacements of connecting points between adjacent modules, and connector loads for floating structures with different types of connectors in the parameters region of non-dimensional module length. The comparison study demonstrates that the connector type III, which can provide appropriate constraint stiffness in all three degrees of freedom, generally delivers better dynamic stability to the floating platform. The longitudinal loads for the three types of connectors remain at the same level. Additionally, the mechanism of different types of connectors on the dynamic features of system is analyzed. This work can provide a few experimental guidelines for the connector design of floating structure in engineering practice. | | Article | Sun, Ze;Bian, Mengchun;Ding, Jun;Liu, Jiarui;Zhang, Haicheng;Xu, Daolin |
| J. Mar. Sci. Eng. | 10 | 10 | 2022 |
| 10.3390/jmse10101459 | 2077-1312 |
| Study on the Wind and Wave Environmental Conditions of the Xisha Islands in the South China Sea | Wind and waves are the main factors of environmental loading on ships and offshore structures. Thus, detailed understanding of wind and wave conditions can improve the design and maintenance of these structures. This paper developed a validated long-term wind and wave hindcast database covering the recent 32 years from 1988 to 2019. The spatial distribution of wind and wave characteristics for the whole Xisha Islands’ domain were analyzed. Frequency and directional distributions of wind speeds and significant wave heights were investigated at several locations around typical islands. Extreme value models were used to estimate the wind speed for 100-year return levels, whereas environmental contour approaches were utilized to establish the extreme sea-state parameters for 50- and 100-year return periods. It was found that the Weibull distribution was better fitted to the significant wave heights of the Xuande Atoll’s sites in the open sea, while the exponential Weibull distribution provided a better fit at the Yongle Atoll’s sites where waves are sheltered. | | Review | Wang, Zijian;Liu, Jiarui;Xie, Jingri;Yuan, Xingxing;Wang, Bingyu;Shen, Wenjuan;Zhang, Yang |
| Front. Oncol. | 12 |
| 2022 |
| 10.3389/fonc.2022.947332 | 2234-943X |
| Regulation of autophagy by non-coding RNAs in gastric cancer | Autophagy is a conserved cellular self-digesting process that degrades obsoleting proteins and cellular components and plays a crucial role in the tumorigenesis, metastasis, and drug resistance of various tumors such as gastric cancer (GC). As a hotspot in molecular biology, non-coding RNAs (ncRNAs) are involved in the regulation of multiple biological processes, such as autophagy. Increasing evidence indicate that various ncRNAs exert double roles in the initiation and progression of GC, either serve as oncogenes or tumor suppressors. Recent studies have shown that some ncRNAs could modulate autophagy activity in GC cells, which would affect the malignant transformation and drug resistance. Whether the function of ncRNAs in GC is dependent on autophagy is undefined. Therefore, identifying the underlying moleculr targets of ncRNAs in autophagy pathways and the role of ncRNA-regulated autophagy in GC could develop new treatment interventions for this disease. This review summarizes the autophagy process and its role in GC, and the regulatory mechanisms of ncRNAs, as well as focuses on the dual role of ncRNAs-mediated autophagy in GC, for the development of potential therapeutic strategies in GC patients. | | Review | Wang, Zijian;Liu, Jiarui;Xie, Jingri;Yuan, Xingxing;Wang, Bingyu;Shen, Wenjuan;Zhang, Yang |
| Front. Oncol. | 12 |
| 2022 |
| 10.3389/fonc.2022.947332 | 2234-943X |
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| | Review | Wang, Zijian;Liu, Jiarui;Xie, Jingri;Yuan, Xingxing;Wang, Bingyu;Shen, Wenjuan;Zhang, Yang |
| Front. Oncol. | 12 |
| 2022 |
| 10.3389/fonc.2022.947332 | 2234-943X |
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| | Review | Wang, Zijian;Liu, Jiarui;Xie, Jingri;Yuan, Xingxing;Wang, Bingyu;Shen, Wenjuan;Zhang, Yang |
| Front. Oncol. | 12 |
| 2022 |
| 10.3389/fonc.2022.947332 | 2234-943X |
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| | Article | Wang, Haoran;Yu, Hao;Liu, Jiarui;Kondo, Sosuke;Okubo, Nariaki;Kasada, Ryuta |
| Corros. Sci. | 209 |
| 2022 |
| 10.1016/j.corsci.2022.110818 | 0010-938X |
| Characterization and corrosion behavior of Al-added high Mn ODS austenitic steels in oxygen-saturated lead–bismuth eutectic | Novel Al-added high-Mn oxide dispersion-strengthened (ODS) austenitic steels dispersed with YAlO3 type oxide particles were developed. The corrosion behavior of ODS steels was investigated in oxygen-saturated lead–bismuth eutectic (LBE) at 450 C for 430 h. Compared with arc-melted non-ODS steels, ODS steels possessed superior corrosion resistance, which is attributed to a continuous Al-rich oxide layer that can be formed in the ODS steels. The detailed corrosion behavior of ODS steels is discussed in comparison to non-ODS steels. | | Article | Hu, Hongyu;Liu, Jiarui;Chen, Guoying;Zhao, Yuting;Men, Yuzhuo;Wang, Pin |
| IET Intel. Transport Syst. | 17 | 5 | 2023 | 867 - 877 | 10.1049/itr2.12311 | 1751-9578 |
| Driver identification through vehicular CAN bus data: An ensemble deep learning approach | Driver identification using in-vehicle data is receiving considerable attention in the field of intelligent transportation owing to the advances in deep learning (DL). In order to improve accuracy and robustness of identification, this paper proposes an ensemble deep learning framework that integrates a modified one-dimensional convolutional neural network (M 1-D CNN) and bidirectional long short-term memory (BLSTM) to improve the performance and robustness of driver identification using information extracted from vehicular CAN-bus signals. The M 1-D CNN architecture is developed by adopting inception blocks, residual connection, and global average pooling to obtain optimal deep-feature representations of local time series. The BLSTM is used to learn the bidirectional long-term temporal dependencies. Results of extensive experiments using real driving data show that the proposed ensemble DL model can improve the accuracy and robustness of driver identification. Furthermore, four data augmentation methods, namely up-sampling, adding noise, data reversal, and random drifting, are used to expand the original training data to improve the performance of the ensemble method. Especially, few-shot learning is performed using the four data augmentation methods, and it shows excellent potential for driver identification with limited data. | | Article | Huang, Edwin W.;Ding, Shuhan;Liu, Jiarui;Wang, Yao |
| Phys. Rev. Res. | 4 | 4 | 2022 |
| 10.1103/PhysRevResearch.4.L042015 | 2643-1564 |
| Determinantal quantum Monte Carlo solver for cluster perturbation theory | Cluster perturbation theory (CPT) is a technique for computing the spectral function of fermionic models with local interactions. By combining the solution of the model on a finite cluster with perturbation theory on intracluster hoppings, CPT provides access to single-particle properties with arbitrary momentum resolution while incurring low computational cost. Here, we introduce determinantal quantum Monte Carlo (DQMC) as a solver for CPT. Compared to the standard solver, exact diagonalization (ED), the DQMC solver reduces finite size effects through utilizing larger clusters, allows study of temperature dependence, and enables large-scale simulations of a greater set of models. We discuss the implementation of the DQMC solver for CPT and benchmark the CPT + DQMC method for the attractive and repulsive Hubbard models, showcasing its advantages over standard DQMC and CPT + ED simulations. | | Article | He, Tianzhen;Chen, Yibo;Yang, De;Islam, Md Sahidul;Chou, Chon-Kit;Liu, Jiarui;Faustman, Denise L.;Oppenheim, Joost J.;Chen, Xin |
| Cell. Oncol. | 46 | 1 | 2023 | 167 - 177 | 10.1007/s13402-022-00742-0 | 2211-3436 |
| TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells | Background: TNFR2 expression is a characteristic of highly potent immunosuppressive tumor infiltrating CD4+Foxp3+ regulatory T cells (Tregs). There is compelling evidence that TNF through TNFR2 preferentially stimulates the activation and expansion of Tregs. We and others, therefore, proposed that targeting TNFR2 may provide a novel strategy in cancer immunotherapy. Several studies have shown the effect of TNFR2 antagonistic antibodies in different tumor models. However, the exact action of the TNFR2 antibody on Tregs remained understood. Method: TY101, an anti-murine TNFR2 antibody, was used to examine the effect of TNFR2 blockade on Treg proliferation and viability in vitro. The role of TNFR2 on Treg viability was further validated by TNFR2 knockout mice and in the TY101 antagonistic antibody-treated mouse tumor model. Results: In this study, we found that an anti-mouse TNFR2 antibody TY101 could inhibit TNF-induced proliferative expansion of Tregs, indicative of an antagonistic property. To examine the effect of TY101 antagonistic antibody on Treg viability, we treated unfractionated lymph node (L.N.) cells with Dexamethasone (Dex) which was known to induce T cell death. The result showed that TY101 antagonistic antibody treatment further promoted Treg death in the presence of Dex. This led us to find that TNFR2 expression was crucial for the survival of Tregs. In the mouse EG7 lymphoma model, treatment with TY101 antagonistic antibody potently inhibited tumor growth, resulting in complete regression of the tumor in 60% of mice. The treatment with TY101 antagonistic antibody elicited potent antitumor immune responses in this model, accompanied by enhanced death of Tregs. Conclusion: This study, therefore, provides clear experimental evidence that TNFR2 antagonistic antibody, TY101, can promote the death of Tregs, and this effect may be attributable to the antitumor effect of TNFR2 antagonistic antibody. | | Review | Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L.;Liu, Zhuang;Hadi, Muhammad N.S. |
| Constr. Build. Mater. | 362 |
| 2023 |
| 10.1016/j.conbuildmat.2022.129784 | 0950-0618 |
| Methods to evaluate and quantify the geopolymerization reactivity of waste-derived aluminosilicate precursor in alkali-activated material: A state-of-the-art review | The utilization of industrial waste as an aluminosilicate precursor (AP) for alkali-activated material (AAM) production can provide an outlet for the growing waste stream and relief to landfill. However, to achieve the transformation of extremely varied waste into normalized APs with stable performance on an industrial scale, a universal testing method and criteria for quantifying the geopolymerization reactivity (GR) of APs are crucial. To facilitate the establishment of a more consistent method for determining the GR of APs, this paper reviewed and compared four mainstream methods for GR quantification: quantitative X-ray diffraction (QXRD)–based methods, energy-dispersive X-ray spectroscopy (EDS)–based methods, selective dissolution, and leaching tests. QXRD-based and EDS-based methods, as conventional and robust methods for material characterization, have gained excellent agreement with each other on the determination of inherent amorphous phases of APs, which have been proven indicative of GR to some extent. However, the inability of QXRD-based and EDS-based methods to evaluate GR under real reaction environments should also be highlighted, as not all the amorphous phases are chemically involved in the reaction. Selective dissolution and leaching tests have also been developed to address this issue, and these have proved more indicative. However, the parameters of these two methods—such as reagent type, contact time, and temperature—should be optimized further and unified to improve their accuracy and viability. | | Review | Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L.;Liu, Zhuang;Hadi, Muhammad N.S. |
| Constr. Build. Mater. | 362 |
| 2023 |
| 10.1016/j.conbuildmat.2022.129784 | 0950-0618 |
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| | Review | Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L.;Liu, Zhuang;Hadi, Muhammad N.S. |
| Constr. Build. Mater. | 362 |
| 2023 |
| 10.1016/j.conbuildmat.2022.129784 | 0950-0618 |
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| | Review | Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L.;Liu, Zhuang;Hadi, Muhammad N.S. |
| Constr. Build. Mater. | 362 |
| 2023 |
| 10.1016/j.conbuildmat.2022.129784 | 0950-0618 |
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| | Article | Liu, Jiarui;Yang, Guotian;Yang, Xiyun |
| Taiyangneng Xuebao. | 43 | 11 | 2022 | 215 - 223 | 10.19912/j.0254-0096.tynxb.2021-0506 | 0254-0096 |
| Research on wind turbine fault warning method based on deep convolution auto-encoder | Early fault warning through wind turbine condition monitoring can prevent further development of faults and reduce wind farm operation and maintenance costs. To fully explore the time sequence information of parameters of wind turbine supervisory control and data acquisition (SCADA) and the nonlinear relationship between them, A wind turbine condition monitoring and fault warning method based on deep convolutional auto-encoder (DCAE) which combines the auto-encoder (AE) and convolutional neural network (CNN) is proposed. Firstly, based on the historical SCADA offline data, the DCAE for wind turbine condition monitoring is established. Then the reconstruction error is analyzed to determine the alarm threshold. Finally, the EMWA control chart is used to monitor the status of a wind turbine in real-time. Taking the failure of a 2 MW doubly-fed wind turbine blade as an example, the proposed DCAE method is verified. The results show that the DCAE method proposed in this paper is effective in early warning of the wind turbine failure, and is superior to the existing deep learning-based wind turbine condition monitoring methods. The proposed method significantly improve reconstruction accuracy, reduce model parameters and training time. | | Article | Liu, Jiarui;Yang, Guotian;Li, Xinli;Hao, Shumin;Guan, Yingming;Li, Yaqi |
| Meas. Sci. Technol. | 34 | 3 | 2023 |
| 10.1088/1361-6501/aca496 | 1361-6501 |
| A deep generative model based on CNN-CVAE for wind turbine condition monitoring | Auto-encoder (AE)-based condition monitoring (CM) methods for fault detection of wind turbines have received considerable attention due to their powerful feature extraction ability. However, traditional AE-based monitoring methods can only learn point-to-point features by minimizing reconstruction errors, which leads to a low sensitivity to anomaly data and weak robustness to noise data. To this end, we introduce a novel deep generative method based on the convolutional neural network (CNN)-conditional variational auto-encoder (CVAE). The key idea of CNN-CVAE is to unify the representation learning capacity of the CVAE and CNN. Specifically, CVAE can learn a probability distribution model by being trained on an anomaly-free supervisory control and data acquisition systems (SCADA) dataset; CNN and deconvolution operations are adopted for better time-series feature extraction and reconstruction performance. A statistical process control chart is applied to determine the alarm threshold. The effectiveness of the CNN-CVAE-based method is validated by datasets collected by SCADA installed in a commercial wind farm in China for impending blade breakage and gearbox failure. Abundant experiments with state-of-the-art deep learning-based CM methods are conducted, which indicate that our proposed method outperforms other methods in robustness, fault detection data sensitivity, fault warning time, and model parameters. | | Article | Liu, Xiumin;Liu, Jiarui;Jiang, Junjie;Wang, Yi |
| Comput. Theor. Chem. | 1220 |
| 2023 |
| 10.1016/j.comptc.2022.113978 | 2210-271X |
| A ratiometric fluorescent probe 4-(benzothiazol-2-yl)-2-hydroxy benzaldehyde for detecting malononitrile: Theoretical investigation on the ICT and ESIPT mechanism | The first benzothiazole-ratio probe, 4-(benzothiazol-2-yl)-2-hydroxy benzaldehyde (HBTA), dynamically tracks the concentration of malononitrile by showing its sensitivity to the two phases (organic and aqueous) of malonitrile. In order to explore the sensing mechanisms of probe HBTA, the density functional theory (DFT) and time-dependent DFT were used. We first demonstrated that the single fluorescence observed in the experiment was due to HBTA-Enol rather than HBTA-Keto, and observed the local excited state and charge transfer state during the excitation process of HBTA. Additionally, the sensing mechanism of HBTA in two different solvents (organic and aqueous) was studied, and we found that malononitrile could be detected by HBTA efficiently and sensitively in the physiological environment. Meanwhile, the geometric parameters and reduction density gradient were calculated. Furthermore, we used frontier molecular orbitals (FMOs) and hole-electrons to analyze the charge distribution, providing strong evidence for the possibility of excited-state intramolecular proton transfer (ESIPT) and intramolecular charge-transfer (ICT) processes occurring. | | Article | Ding, Rui;Zhang, Haicheng;Xu, Daolin;Liu, Chunrong;Shi, Qijia;Liu, Jiarui;Zou, Weisheng;Wu, Yousheng |
| Nonlinear Dyn. | 111 | 7 | 2023 | 6239 - 6259 | 10.1007/s11071-022-08163-2 | 0924-090X |
| Experimental and numerical study on motion instability of modular floating structures | The parametric resonance, found in a single floating body, discloses that the kinetic energy could be transferred from heave mode to roll mode and causes motion instability if there is an integer multiple relationship between the two mode natural frequencies. For multi-module floating structures, the event of parametric resonance has not been investigated, but important for the stability and safety design of the floating platforms. In this paper, an experimental test is carried out using five box-type floating modules in a wave flume and observes the existence of the parametric resonance between the heave mode and roll mode. A mathematical model, validated by the experiment data, is built up for the theoretical analysis of the influential factors of the parametric resonance. The effects on the motion instability of wave condition, connector stiffness and number of modules are analyzed. It reveals that an appropriate stiffness setting of the connectors could eliminate the parametric resonance of multi-module floating structures. This theoretical finding is confirmed in a further experiment test on a five-module floating structure in the wave flume. | | Article | Wang, Bingwei;Zhao, Miao;Su, Zhijie;Jin, Baohua;Yang, Xiaoning;Zhang, Chenyu;Guo, Bingbing;Li, Jiebo;Hong, Weili;Liu, Jiarui;Zhao, Yun;Hou, Yujia;Lai, Futing;Zhang, Wei;Qin, Lihua;Zhang, Weiguang;Luo, Jianyuan;Zheng, Ruimao |
| Adv. Sci. | 10 | 5 | 2023 |
| 10.1002/advs.202205173 | 2198-3844 |
| RIIβ-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning | The RIIβ subunit of cAMP-dependent protein kinase A (PKA) is expressed in the brain and adipose tissue. RIIβ-knockout mice show leanness and increased UCP1 in brown adipose tissue. The authors have previously reported that RIIβ reexpression in hypothalamic GABAergic neurons rescues the leanness. However, whether white adipose tissue (WAT) browning contributes to the leanness and whether RIIβ-PKA in these neurons governs WAT browning are unknown. Here, this work reports that RIIβ-KO mice exhibit a robust WAT browning. RIIβ reexpression in dorsal median hypothalamic GABAergic neurons (DMH GABAergic neurons) abrogates WAT browning. Single-cell sequencing, transcriptome sequencing, and electrophysiological studies show increased GABAergic activity in DMH GABAergic neurons of RIIβ-KO mice. Activation of DMH GABAergic neurons or inhibition of PKA in these neurons elicits WAT browning and thus lowers body weight. These findings reveal that RIIβ-PKA in DMH GABAergic neurons regulates WAT browning. Targeting RIIβ-PKA in DMH GABAergic neurons may offer a clinically useful way to promote WAT browning for treating obesity and other metabolic disorders. | | Article | Sun, Ze;Zhou, Ye;Ding, Jun;Liu, Jiarui;Xu, Daolin;Zhang, Haicheng |
| J. Environ. Eng. | 149 | 3 | 2023 |
| 10.1061/JOEEDU.EEENG-7144 | 0733-9372 |
| Assessment of WAVEWATCH-III in Wind Wave Modeling of the Xisha Islands | The Xisha islands is a unique area where offshore structures can be utilized as exploration bases in the remote sea. Forecasting of sea state parameters is critical for the design and operation of offshore structures. The goal of this work is to establish an effective operational model to simulate wind waves in the Xisha Islands based on the third-generation wave model WAVEWATCH-III. During the process, two significant difficulties are highlighted and addressed: grid modeling optimization and physical source terms assessment. Typhoon-induced waves using different grid modeling techniques and physical parameterizations were modeled and evaluated using buoy measurements near islands and reefs. It was found that the unstructured triangular grid had a better performance than the other grid options in complex terrain environments like the Xisha Islands. The ST2 source-term package can provide efficient and accurate results in significant wave heights than the other source-term packages in the South China Sea. | | Article | Hu, Xinting;Han, Yang;Liu, Jiarui;Wang, Hua;Tian, Zheng;Zhang, Xin;Zhang, Ya;Wang, Xin |
| Exp. Hematol. Oncol. | 12 | 1 | 2023 |
| 10.1186/s40164-022-00364-0 | 2162-3619 |
| CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia | Background: Cytidine triphosphate synthase 2 (CTPS2) is an essential metabolic enzyme that catalyzes the biosynthesis of CTP. CTP synthases contribute to lymphocytes proliferation and tumorigenesis, but the role of CTPS2 in chronic lymphocytic leukemia (CLL) remains undefined. Methods: In silico analysis was performed to quantified the expression and clinical analysis of CTPS2 and BRCA1. The expression was then validated on the internal sets. Loss-and gain-of-function assays were conducted to investigate the physiological phenotypes in CLL. RNA-seq was employed to probe the molecular mechanism of CTPS2. Results: Herein, significant elevated expression of CTPS2 was observed in CLL patients compared to normal CD19 + B cells, which was verified in three independent cohorts. Furthermore, overexpression of CTPS2 was closely associated with undesired prognostic indicators, including unmutated IGHV status and chromosome 11q23 deletion. Additionally, elevated CTPS2 expression predicted adverse overall survival and treatment-free survival with independent prognostic significance. Downregulation of CTPS2 in CLL cells exhibited attenuated cell proliferation, arrested G2/M cell cycle and increased apoptosis. The addition of CTP or glutamine could reverse the above effects. Since RNA-seq showed the enrichment in DNA damage and response signaling, we subsequently found that silence of CTPS2 remarkably elevated DNA damage and decreased DNA repair. It was demonstrated that CTPS2 mediated DNA damage response via interacting with Breast Cancer 1 (BRCA1) protein in CLL through CoIP assays and rescued experiments. Conclusions: Collectively, our study generated the novel findings that CTPS2 promoted CLL progression via DNA damage response and repair pathway. Targeting nucleotide metabolism potentially became an attractive strategy for treatment against CLL. | | Article | Liu, Jiarui;Yang, Guotian;Wang, Xiaowei |
| Xitong Fangzhen Xuebao | 34 | 11 | 2022 | 2348 - 2358 | 10.16182/j.issn1004731x.joss.21-0261 | 1004-731X |
| A Wind Turbine Fault Diagnosis Method Based on Siamese Deep Neural Network | In order to effectively extract the fault features of time series data in supervisory control and data acquisition (SCADA), considering the advantages of one-dimensional convolutional neural network (1-D CNN) for extracting local time series features and the advantages of long-term memory (LSTM) which can extract long-term dependent features, a method for fault diagnosis of wind turbines based on 1-D CNN-LSTM is proposed. To solve the problem of the scarcity of fault samples of wind turbines based on the siamese network architecture, a wind fault diagnosis method based on siamese 1-D CNN-LSTM is proposed. The proposed siamese 1-D CNN-LSTM method relies on a small amount of sample data to effectively extract the fault features of the wind turbine. The results show that 1-D CNN-LSTM is better than other existing deep learning methods. When the training samples are insufficient, the proposed siamese 1-D CNN-LSTM can significantly improve the fault diagnosis results. | | Article | Ping, Xie;Jun, Chen;Jiarui, Liu |
| Hupo Kexue/J. Lake Sc. | 35 | 1 | 2023 | 1 - 11 | 10.18307/2023.0199 | 1003-5427 |
| A regime shift from cyanobacterial steady state to non-cyanobacterial one by using nontraditional biomanipulation-A whole lake testing experiment in Lake Donghu, Wuhan | Biological controls of phytoplankton are divided into traditional biomanipulation using zooplankton and nontraditional biomanipulation using filter-feeding fishes, and the former theory developed by western scholars are suitable for controlling small algae, while the latter one developed by Chinese scholars are effective for controlling colony-forming cyanobacteria (especially Microcystis). Lake Donghu is a eutrophic lake, located in Wuhan City, China, with a surface area of ca. 32 km2. Before 2021, cyanobacterial blooms had been absent from the main part of the lake (Guozhenghu area, 12.8 km2 ) for more than 30 years. However, in the summer of 2021, Microcystis blooms suddenly occurred in the lake, with a maximum coverage of approximately 87%. After examining the long-term monitoring data of the Donghu Experimental Station of Lake Ecosystems, we found that current nutrient (nitrogen and phosphorus) levels are still high enough for the outburst of cyanobacterial blooms in this lake. As it is impossible to efficiently decrease the nutrients within a short period of time (e.g. a couple of years), non-traditional biomanipulation (using the native filter-feeding silver and bighead carps with an appropriate abundance) was applied to counteract the occurrence of cyanobacterial blooms, and as a result, no blooms were present in 2022 in spite of an extremely hot and dry summer, i.e., the Lake Donghu ecosystems was shifted quickly from a bloom steady state to a non-bloom one, demonstrating a new regime shift, and achieving a success that the traditional biomanipulation had never had before. Conclusively, the non-traditional biomanipulation theory was tested and validated using a whole lake experiment, providing an environmentally friendly, extremely low-cost and rather effective way to control colony-forming cyanobacterial blooms in eutrophic lakes. | | Conference Paper | Cui, Zhehao;Huang, Siqi;Liu, Jiarui;Zhu, Junde |
|
| 308 |
| 2021 |
| 10.1051/e3sconf/202130802002 | 2555-0403 |
| Impact and Potential Solutions toward Ocean Acidification | Ocean acidification is a new problem for humans that rose recently. It has been drawing attention from people. It is getting more serious and important with the continuous carbon emission to the atmosphere. The threatens from ocean acidification are affecting multiple characters, especially organisms like marine animals and marine plants. Researches show the change in the pH will affect the lifespan and the reproduction process of marine organisms. Besides the impact on organisms, ocean acidification is also likely to impact the global climate. For places located around the tropical area, ocean acidification will bring more frequent storms and hurricanes. Focused on the problem, we want to seek solutions. However, currently, there are no direct ways to address the problem of ocean acidification. Some hypotheses have been made, such as managing the seaweed and the precipitation method, but these approaches are immature and currently inapplicable. The most practical method to slow down ocean acidification is to make agreements and regulations to directly control carbon emission. Future agreements should increase the collaboration internationally and apply the most suitable measures locally. This research aims to provide background knowledge for future studies about the ocean. | | Article | Yue, Xia;Liu, Jiarui;Chen, Kairui;Zhang, Yuanqing;Hu, Zikai |
| Front. Neurorobotics | 16 |
| 2023 |
| 10.3389/fnbot.2022.1103462 | 1662-5218 |
| Prescribed performance adaptive event-triggered consensus control for multiagent systems with input saturation | In this paper, a prescribed performance adaptive event-triggered consensus control method is developed for a class of multiagent systems with the consideration of input dead zone and saturation. In practical engineering applications, systems are inevitably suffered from input saturation. In addition, input dead zone is widely existing. As the larger signal is limited and the smaller signal is difficult to effectively operate, system efficacious input encounters unknown magnitude limitations, which seriously impact system control performance and even lead to system instability. Furthermore, when constrained multiagent systems are required to converge quickly, the followers would achieve it with drastic and quick variation of states, which may violate the constraints and even cause security problems. To address those problems, an adaptive event-triggered consensus control is proposed. By constructing the transform function and the barrier Lyapunov function, while state constrained is guaranteed, multiagent systems quickly converge with prescribed performance. Finally, some examples are adopted to confirm the effectiveness of the proposed control method. | | Article | He, Juan;Liu, Jiarui;Cheng, Meiqi;Sun, Jingyu;Chen, Wei;Pan, Weidong |
| Chiang Mai J. Sci. | 50 | 1 | 2023 |
| 10.12982/CMJS.2023.001 | 0125-2526 |
| Response to Magnetic Field-Induced Stress on the Demographics and anti-ROS Activity of Aphid Macrosiphum rosae L. (Hemiptera:Aphididae) | Magnetic field plays an essential role for many species, including the migratory pest aphid. Our previous study investigated the long-term exposure of static magnetic fields on the growth development and productivity of the aphid Macrosiphum rosae, however, it is necessary to expand the knowledge of short-term exposure on the insects for a wider spectrum of magnetic field radiation. To achieve this, aphid nymphs were exposed to four magnetic field of induction at 0.065T, 0.1T, 0.176T and 0.28T for 4min under laboratory conditions. The results showed that the short-term magnetic radiation significantly prelonged the four instar development while shortened the first, second and third instar period. 0.28 T radiations caused significantly difference in the parameters of TPOP, adult longevity and total longevity (3.2d, 7.07d, and 8.82d, compared with the control of 4.94d, 8.06d, and 10.23d, respectively). Population parameter of r was 0.057d with 0.28 T compared with the control of 0.150 d. The SOD, CAT and POD activity increased more than 30% in static magnetic fields compared with the controls. Our study presents a feasible evidence showing the growth development change as a representative disturbing symptom for short-term exposure to magnetic fields, and the static magnetic field applied being capable of modifying the fitness components and antioxidant defense in aphids. | | Article | Luo, Lijuan;Liu, Jiarui;Shen, Hanyi;Lai, Yuping |
| Neurocomputing | 530 |
| 2023 | 139 - 149 | 10.1016/j.neucom.2023.01.086 | 1872-8286 |
| Vote or not? How language mimicry affect peer recognition in an online social Q&A community | As Q&A Communities become not only a source of information, but an interaction platform where people gain social recognition, the research into factors impacting viewers’ peer recognition of online contribution helps identify an effective model for such interaction. This study focuses on finding the connection between language mimicry and the peer recognition of online contributions. We collected a total of 13,109 contributions from Fluther, an online Q&A community. Language features including linguistic similarity, text resemblance and peer recognition of online contributions were analysed, with the contributors’ followers and past responses serving as moderators. Linear regression was adopted to provide empirical evidence. This study demonstrates that language mimicry between the contributor and the information seeker has significant positive effect on the peer recognition of online contributions by the viewers. Moreover, the number of contributors’ past expertise mitigates the positive influence of linguistic similarity and text resemblance while their popularity strengthens the influence. It is a novel direction as prior language mimicry studies mainly focused on dyadic communication, whereas this research study aims to examine the influence of language mimicry on peer recognition of online contribution. The study extends the literature on language mimicry and provides practical implications. | | Article | Hu, Hongyu;Liu, Jiarui;Chen, Guoying;Zhao, Yuting;Gao, Zhenhai;Zheng, Rencheng |
| IEEE Trans. Intell. Transp. Syst. | 24 | 5 | 2023 | 5159 - 5171 | 10.1109/TITS.2023.3240185 | 1558-0016 |
| Driver Identification Using Deep Generative Model With Limited Data | The scarcity of driving data constrains the accuracy of deep learning (DL)-based driver identification methods in practical application scenarios. To address this issue, this study proposes a novel unsupervised deep generative model called the convolution condition variant autoencoder (CCVAE) for driving data augmentation. In CCVAE, aided by driver identification information, the condition variant autoencoder can learn the real driving data distribution of each driver through an unsupervised learning paradigm; and aiming for better feature representation ability, convolutional neural network and deconvolution are leveraged, respectively. Therefore, a large number of synthetic samples can be generated by the generative part of the CCVAE. We demonstrate the effectiveness of the CCVAE through extensive experimental analysis using a real dataset collected from a vehicular CAN bus; the improvement of the DL-based driver identification results is demonstrated using synthetic samples. For instance, when only using 2% of the original data, approximately 20% improvement is achieved in terms of four evaluation indicators for two commonly used DL-based driver identification methods, namely, 1-D CNN and LSTM. Furthermore, several comparable experiments with state-of-the-art deep generative methods reveal the superior performance of the proposed CCVAE with respect to identification results, synthetic data quality, and model computation time. Therefore, the proposed model accomplishes a breakthrough in driver identification with limited data and shows great potential in data-driven applications of intelligent vehicles. | | Article | Wang, Jianhui;Yan, Yancheng;Liu, Jiarui;Philip Chen;Liu, Zhi;Zhang, Chunliang |
| ISA Trans. | 137 |
| 2023 | 59 - 73 | 10.1016/j.isatra.2023.01.032 | 0019-0578 |
| NN event-triggered finite-time consensus control for uncertain nonlinear Multi-Agent Systems with dead-zone input and actuator failures | This paper develops a Neural Network (NN) event-triggered finite-time consensus control method for uncertain nonlinear Multi-Agent Systems (MASs) with dead-zone input and actuator failures. In practical applications, actuator failures would inevitably arise in MASs. And the time, pattern, and value of the failures are unknown. Besides, the actuators of MASs also suffer from dead-zone nonlinearity. No matter actuator failures or dead-zone input would dramatically affect the performance and stability of MASs. To address these issues, finite-time adaptive controllers capable of simultaneously compensating for actuator failures and dead-zone input are constructed by adopting the backstepping technology. Meanwhile, the NN control scheme is adopted to handle the unknown nonlinear dynamics of each agent. Furthermore, an event-triggered control mechanism is established that no longer requires continuous communication on the control network. Under the proposed control method, all followers achieve finite-time synchronization, irrespective of the presence of limited bandwidth, unknown failures, and dead-zone input. These results are demonstrated by simulations. | | Review | Wang, Yang;Liu, Jiarui;Zhang, Zhaoli;Meng, Xiangren;Yang, Tingxuan;Shi, Wangbin;He, Ronghai;Ma, Haile |
| Foods | 12 | 5 | 2023 |
| 10.3390/foods12050971 | 2304-8158 |
| Insights into Ultrasonication Treatment on the Characteristics of Cereal Proteins: Functionality, Conformational and Physicochemical Characteristics | Background: It would be impossible to imagine a country where cereals and their byproducts were not at the peak of foodstuff systems as a source of food, fertilizer, or for fiber and fuel production. Moreover, the production of cereal proteins (CPs) has recently attracted the scientific community’s interest due to the increasing demands for physical wellbeing and animal health. However, the nutritional and technological enhancements of CPs are needed to ameliorate their functional and structural properties. Ultrasonic technology is an emerging nonthermal method to change the functionality and conformational characteristics of CPs. Scope and approach: This article briefly discusses the effects of ultrasonication on the characteristics of CPs. The effects of ultrasonication on the solubility, emulsibility, foamability, surface-hydrophobicity, particle-size, conformational-structure, microstructural, enzymatic-hydrolysis, and digestive properties are summarized. Conclusions: The results demonstrate that ultrasonication could be used to enhance the characteristics of CPs. Proper ultrasonic treatment could improve functionalities such as solubility, emulsibility, and foamability, and is a good method for altering protein structures (including surface hydrophobicity, sulfhydryl and disulfide bonds, particle size, secondary and tertiary structures, and microstructure). In addition, ultrasonic treatment could effectively promote the enzymolytic efficiency of CPs. Furthermore, the in vitro digestibility was enhanced after suitable sonication treatment. Therefore, ultrasonication technology is a useful method to modify cereal protein functionality and structure for the food industry. | | Review | Wang, Yang;Liu, Jiarui;Zhang, Zhaoli;Meng, Xiangren;Yang, Tingxuan;Shi, Wangbin;He, Ronghai;Ma, Haile |
| Foods | 12 | 5 | 2023 |
| 10.3390/foods12050971 | 2304-8158 |
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| | Article | Ding, Rui;Zhang, Haicheng;Xu, Daolin;Liu, Jiarui;Liu, Leilei;Wu, Yousheng |
| J. Environ. Eng. | 149 | 5 | 2023 |
| 10.1061/JOEEDU.EEENG-7151 | 0733-9372 |
| Characteristics of Floating Arrays from Aligned to Staggered Patterns | In nature, staggered structures, such as knitted baskets and brick patterns in the structure of buildings, always exhibit the feature of structural reinforcement. Can floating arrays become more dynamically stationary if floating modules of an array are interconnected in a staggered pattern rather than in an aligned pattern? This work examined the dynamic characteristics of staggered floating arrays. A floating array with 12 identical semisubmersible modules in a 3×4 configuration was used to study the effects of staggered structure on the dynamic characteristics of floating systems. A network modeling method considering the geometric effect of connectors was used to establish the analysis model. The numerical analysis was conducted in three main aspects. First, the impact of the staggered deployment of modules on the stiffness feature of the floating structure was investigated. Subsequently, the variation of the stability of floating array with increasing staggered displacement was studied, and the corresponding dynamic mechanism is discussed in detail. Furthermore, the characteristic transition of the floating array evolving from aligned pattern to brick-pattern with different staggered displacements is studied. The numerical results demonstrate that the staggered deployment of modules could increase the floating system's stiffness along the longitudinal direction and improve the stability of heave and pitch motions near the head wave. This work could provide guidelines for the configuration design of floating islands for optimal ocean space utilization. | | Article | Liu, Jiarui;Harris, Rachel L.;Ash, Jeanine L.;Ferry, James G.;Krause, Sebastian J.E.;Labidi, Jabrane;Prakash, Divya;Sherwood Lollar, Barbara;Treude, Tina;Warr, Oliver;Young, Edward D. |
| Geochim. Cosmochim. Acta | 348 |
| 2023 | 165 - 186 | 10.1016/j.gca.2023.02.022 | 0016-7037 |
| Reversibility controls on extreme methane clumped isotope signatures from anaerobic oxidation of methane | Microbial anaerobic oxidation of methane (AOM) substantially mitigates atmospheric methane emissions on Earth and is a process to consider for astrobiological targets where methane has been detected. The measurement of doubly substituted, or “clumped”, methane isotopes has proven useful in tracing processes of methane formation and oxidation. Both near-equilibrium and extreme disequilibrium methane clumped isotope signatures can be attributed to AOM, but, to date, understanding the mechanistic and environmental controls on those signatures has been lacking. We report measurements of methane clumped isotope compositions of residual methane in AOM-active microbial incubations using sediment slurries from Svalbard and Santa Barbara Channel methane seeps. Incubation experiments of Svalbard sediment slurries resulted in residual methane with very high Δ13CH3D and Δ12CH2D2 values up to 19.5‰ and 65.1‰, respectively. We found similarly high Δ13CH3D and Δ12CH2D2 values in fluid samples from the Chamorro Seamount, a serpentinite mud volcano in the Mariana forearc, suggesting that minimal reversibility of AOM intracellular reactions leads to kinetic fractionation of clumped isotopologues. When conditions were consistent with a low thermodynamic drive for AOM, however, methane isotopologues approached intra-species quasi-equilibrium. This was clearly observed in isotope exchange experiments with methyl-coenzyme M reductase (Mcr) and in microbial incubations of the Santa Barbara Channel sediment slurries. Using an isotopologue fractionation model, we highlight the critical role of reversibility in controlling the trajectory of gases in Δ13CH3D vs. Δ12CH2D2 space during AOM. The near-equilibrium methane isotopologue signatures are generalized as a result of the Mcr-catalyzed intracellular isotope exchange operating under near-threshold free energy conditions, as shown in the deep-biosphere incubations. Our results show that the reversibility of the Mcr-catalyzed reaction is central to understanding the meaning of methane isotopologue ratios affected by microbial production and oxidation. | | Article | Zhong, Xinqin;Zhao, Yucui;Huang, Lu;Liu, Jiarui;Wang, Kaiyue;Gao, Xiumei;Zhao, Xin;Wang, Xiaoying |
| Front. Microbiol. | 14 |
| 2023 |
| 10.3389/fmicb.2023.1140498 | 1664-302X |
| Remodeling of the gut microbiome by Lactobacillus johnsonii alleviates the development of acute myocardial infarction | Introduction: The gut microbial community, which can be disturbed or repaired by changes in the internal environment, contributes to the development of acute myocardial infarction (AMI). Gut probiotics play a role in microbiome remodeling and nutritional intervention post-AMI. A newly isolated Lactobacillus johnsonii strain EU03 has shown potential as a probiotic. Here, we investigated the cardioprotective function and mechanism of L. johnsonii through gut microbiome remodeling in AMI rats. Methods: A rat model of left anterior descending coronary artery ligation (LAD)-mediated AMI was assessed with echocardiography, histology, and serum cardiac biomarkers to evaluate the beneficial effects of L. johnsonii. The immunofluorescence analysis was utilized to visualize the intestinal barrier changes. Antibiotic administration model was used for assessing the gut commensals’ function in the improvement of cardiac function post-AMI. The underlying beneficial mechanism through L. johnsonii enrichment was further investigated by metagenomics and metabolomics analysis. Results: A 28-day treatment with L. johnsonii protected cardiac function, delayed cardiac pathology, suppressed myocardial injury cytokines, and improved gut barrier integrity. The microbiome composition was reprogrammed by enhancing the abundance of L. johnsonii. Microbiome dysbiosis by antibiotics abrogated the improvement of cardiac function post-AMI by L. johnsonii. L. johnsonii enrichment caused remodeling of gut microbiome by increasing the abundance of Muribaculaceae, Lactobacillus, and decreasing Romboutsia, Clostridia UCG-014, which were correlated with cardiac traits and serum metabolic biomarkers 16,16-dimethyl-PGA2, and Lithocholate 3-O-glucuronide. Conclusion: These findings reveal that gut microbiome remodeling by L. johnsonii ameliorates the cardiac function post-AMI and might advance microbiome-targeted nutritional intervention. | | Conference Paper | Li, Jiangrong;Qiao, Tiantian;Ma, Jianwei;Liu, Jiarui;Zhu, Jiming;Xie, Qiang |
| Lect. Notes Electr. Eng. | 845 LNEE |
| 2023 | 1455 - 1464,1455 - 1464 | 10.1007/978-981-19-6613-2_143 | 1876-1119 |
| Extended Dissipative Control for Discrete-Time T-S Fuzzy Singular Delay Systems | In this paper, the problem of extended dissipative control is studied for discrete-time fuzzy singular delay systems. By using some new techniques on matrix convexification, the forward difference of summation terms can be bounded. Then, a novel extended dissipativity based admissibility criterion of singular systems is obtained. And the derived condition is expressed in terms of sam-of-squares (SOS). A numerical example result can show the correctness of the proposed approach. | | Article | Chang, Xin;Liu, Xiting;Liu, Jiarui;Zhang, Mingyu;Gu, Yu;Wang, Nan;Wang, Houjie;Zhuang, Guangchao;Yu, Junjie;Chen, Jing |
| Palaeogeogr. Palaeoclimatol. Palaeoecol. | 618 |
| 2023 |
| 10.1016/j.palaeo.2023.111513 | 0031-0182 |
| Late Quaternary marine transgressions inferred from the pyrite sulfur content and isotopes within core sediments from the southeast coast of China | Paleoenvironmental reconstructions of coastal areas during geological history are critical for understanding past responses to marine transgression. Identifying transgressive layers in sedimentary strata is therefore of great importance. To this end, we examined the content and isotopic composition of pyrite sulfur, in combination with classical organic geochemical indicators (e.g., C/N ratio and the δC of organic carbon), to trace the marine transgressions along the southeast coast of China since Marine Isotope Stage (MIS) 5. Our results suggest that the mass ratio of total organic carbon and pyrite sulfur (C/S ratio) is sensitive to seawater intrusion. Three transgressive layers were identified by low C/S ratios in core NDGK2, which correspond to sea level rise during MIS5, MIS3, and MIS1. Sediments deposited during MIS1 are represented by low C/S ratios with an average of 2.31, while those deposited during MIS5 and MIS3 have slightly higher C/S ratios, indicating a less extensive influence of seawater. Pyrite production in sediments deposited during MIS5 and MIS3 may have been limited by sulfate supply, as reflected by more positive values of δSpyr, whereas pyrites deposited during MIS1 were likely formed without sulfate limitation, as reflected by more negative values of δSpyr. The isotopic signals of pyrite sulfur thus further confirm the inference based on the C/S ratio. The magnitude of the transgression increased from MIS5 to MIS1, which is in agreement with the findings from classical organic geochemical indicators examined in this study, as well as geochemical and micropaleontological salinity indicators from previous studies. Our findings provide a promising method for identifying marine transgressions and their magnitude from the depositional record, especially when sedimentary strata lack diagnostic micropaleontological and sedimentological characteristics. | | Article | Jiang, Kaixi;Lin, Chunming;Zhang, Xia;Zhao, Yanyan;Lang, Xianguo;Su, Ming;Wang, Ce;Lei, Yaping;Liu, Jiarui |
| Earth Plan. Sci. Lett. | 610 |
| 2023 |
| 10.1016/j.epsl.2023.118118 | 0012-821X |
| Storm-driven variations in depositional environments modify pyrite sulfur isotope records | The sulfur isotopic composition of marine pyrite (δSpyr) is one of the major geochemical tools to reconstruct global changes in Earth's surface environment. Storm-driven variations in depositional environments, however, can play key roles in modifying the δSpyr signal. Here we present δSpyr values in a complete Holocene muddy storm deposit on the East China coastal plain, which is identified by comprehensive analyses of sediment components, organic matter composition, bulk organic carbon isotopic ratios, carbon and oxygen isotopic ratios of carbonates and trace element concentrations. We find that positive (+5.8‰ to +15.8‰) and negative (−9.0‰ to −19.7‰) δSpyr values were preserved in two successive intervals of the muddy storm deposit (ca. 62 cm long), corresponding to the high-energy storm peak phase (HESPP) and the waning-energy late storm phase (WELSP), respectively. We propose that the S enrichment in pyrite from the HESPP is most likely due to a combination of storm reworking of sediments and high sedimentation rates, which involves various physical and chemical processes leading to the accumulation of S-enriched pyrite, such as oxidation of near-surface sulfides, reduced exchange of sulfate between sediment pore fluids and the overlying water column, and/or input of excess reactive iron minerals. In contrast, lower sedimentation rates and limited sedimentary remobilization during the WELSP allow the isotopic signal of early-formed S-enriched pyrite to be preserved. The striking shift in δSpyr values, therefore, reflects a dramatic change in the local depositional environment between the HESPP and WELSP, suggesting that non-steady-state deposition induced by storm activity facilitates the formation of isotopically “heavy” pyrite. This sharp shift can be further generalized as a characteristic feature of δSpyr values in storm deposits. Our work highlights the critical impact of weather- and climate-event-driven depositional variations on δSpyr values, adding to the growing evidence emphasizing the local environmental and diagenetic controls on these records. | | Article | Chen, Feng;Wang, Yeke;He, Jun;Smith, Carl;Xue, Ge;Zhao, Yan;Peng, Yanghui;Zhang, Jia;Liu, Jiarui;Chen, Jun;Xie, Ping |
| BMC Genomics | 24 | 1 | 2023 |
| 10.1186/s12864-023-09244-1 | 1471-2164 |
| Alternative signal pathways underly fertilization and egg activation in a fish with contrasting modes of spawning | Background: The processes of fertilization and egg activation are vital for early embryogenesis. However, while the mechanisms associated with key events during these processes differ among species and modes of spawning, the signal pathways underlying these processes are opaque for many fishes, including economically important species. Results: We investigated phenotypic traits, ultrastructure and protein expression levels in the eggs of the topmouth culter (Culter alburnus), a protected and economically important freshwater fish that exhibits two spawning modes, producing semi-buoyant eggs and adhesive eggs. Unfertilized eggs of C. alburnus were examined, as well as eggs at fertilization and 30 min post fertilization. Our results showed that in semi-buoyant eggs, energy metabolism was activated at fertilization, followed by elevated protein expression of cytoskeleton and extracellular matrix (ECM)-receptor interactions that resulted in rapid egg swelling; a recognized adaptation for lotic habitats. In contrast, in adhesive eggs fertilization initiated the process of sperm-egg fusion and blocking of polyspermy, followed by enhanced protein expression of lipid metabolism and the formation of egg envelope adhesion and hardening, which are adaptive in lentic habitats. Conclusion: Our findings indicate that alternative signal pathways differ between modes of spawning and timing during the key processes of fertilization and egg activation, providing new insights into the molecular mechanisms involved in adaptive early embryonic development in teleost fishes. | | Article | Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L.;Dinh, Hong Lich;Podolsky, Zak;Zi, Goangseup |
| J. Build. Eng. | 71 |
| 2023 |
| 10.1016/j.jobe.2023.106559 | 2352-7102 |
| Investigation on red mud and fly ash-based geopolymer: Quantification of reactive aluminosilicate and derivation of effective Si/Al molar ratio | The utilization of red mud (RM) as an aluminosilicate precursor (AP) for geopolymer production is attracting increasing research interest. This use of RM offers a desirable outlet for the increasing RM inventory and provides a sustainable solution for the immobilization of heavy metals and the valorization of waste as eco-friendly building materials. However, the effect of RM and its caustic residue on geopolymerization remains uncertain because of the extremely varied characteristics of RM. This study investigates the potential of using RM supplied from a local alumina refinery as an AP. First, RM was used to partially replace fly ash (FA) and the strength activity index (SAI) of the RM was evaluated. Second, to gain a deeper insight into the effect of caustic residue on geopolymerization, performances of traditional FA-based geopolymer and red-mud–fly-ash (RMFA)–based geopolymer under different NaOH concentrations were investigated and compared. Third, based on alkali leaching tests, the effective molar ratios considering the reactive content of RM and FA were developed, compared with conventional nominal molar ratio, and verified intensively using scanning electron microscopy–energy-dispersive spectroscopy (SEM-EDS). | | Article | Liu, Jiarui;Yang, Guotian;Li, Xinli;Wang, Qianming;He, Yuchen;Yang, Xiyun |
| ISA Trans. | 139 |
| 2023 | 586 - 605 | 10.1016/j.isatra.2023.03.045 | 0019-0578 |
| Wind turbine anomaly detection based on SCADA: A deep autoencoder enhanced by fault instances | An increasing number of deep autoencoder-based algorithms for intelligent condition monitoring and anomaly detection have been reported in recent years to improve wind turbine reliability. However, most existing studies have only focused on the precise modeling of normal data in an unsupervised manner; few studies have utilized the information of fault instances in the learning process, which results in suboptimal detection performance and low robustness. To this end, we first developed a deep autoencoder enhanced by fault instances, that is, a triplet-convolutional deep autoencoder (triplet-Conv DAE), jointly integrating a convolutional autoencoder and deep metric learning. Aided by fault instances, triplet-Conv DAE can not only capture normal operation data patterns but also acquire discriminative deep embedding features. Moreover, to overcome the difficulty of scarce fault instances, we adopted an improved generative adversarial network-based data augmentation method to generate high-quality synthetic fault instances. Finally, we validated the performance of the proposed anomaly detection method using a multitude of performance measures. The experimental results show that our method is superior to three other state-of-the-art methods. In addition, the proposed augmentation method can efficiently improve the performance of the triplet-Conv DAE when fault instances are insufficient. | | Article | Lv, Bin;Guo, Jinhe;Du, Yaodong;Chen, Yang;Zhao, Xin;Yu, Bin;Liu, Jiarui;Cui, Tianyi;Mao, Haoping;Wang, Xiaoying;Gao, Xiumei |
| Br. J. Pharmacol. | 180 | 16 | 2023 | 2156 - 2171 | 10.1111/bph.16069 | 1476-5381 |
| Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A to ameliorate lipopolysaccharide-induced acute lung injury | Background and Purpose: Respiratory diseases have become a global health problem and may lead to acute lung injury (ALI) in severe cases. ALI progression is associated with complex pathological changes; however, there are currently no effective therapeutic drugs. Excessive activation and recruitment of immunocytes in the lungs and the release of large amounts of cytokines are considered the primary causes of ALI, but the cellular mechanisms involved remain unknown. Therefore, new therapeutic strategies need to be developed to control the inflammatory response and prevent the further aggravation of ALI. Experimental Approach: Lipopolysaccharide was administered to mice via tail vein injection to establish an ALI model. Key genes regulating lung injury in mice were screened by RNA sequencing (RNA-seq), and their regulatory effects on inflammation and lung injury were assessed in in vivo and in vitro experiments. Key Results: The key regulatory gene KAT2A up-regulated the expression of inflammatory cytokines and induced lung epithelial injury. Chlorogenic acid, a small natural molecule and KAT2A inhibitor, inhibited the inflammatory response and significantly improved the decreased respiratory function caused by lipopolysaccharide administration in mice by inhibiting the expression of KAT2A. Conclusion and Implications: Targeted inhibition of KAT2A suppressed the release of inflammatory cytokines and improved respiratory function in this murine model of ALI. Chlorogenic acid, a specific KAT2A-targeting inhibitor, was effective in treating ALI. In conclusion, our results provide a reference for the clinical treatment of ALI and contribute to the development of novel therapeutic drugs for lung injury. | | Article | Liu, Jia-Rui;Liu, Yong-Xin;Wang, You-Nian |
| Plasma Sources Sci. Technol. | 32 | 4 | 2023 |
| 10.1088/1361-6595/acc685 | 0963-0252 |
| A comprehensive study on the electron cyclotron resonance effect in a weakly magnetized capacitively coupled RF plasma: experiment, simulation and modeling | The electron cyclotron resonance (ECR) effect in a weakly magnetized capacitively coupled radio frequency (RF) plasma was previously observed with optical emission spectroscopy (OES) in experiments and analyzed by particle-in-cell/Monte Carlo collision (PIC/MCC) simulations (Zhang et al 2022 Plasma Sources Sci. Technol. 31 07LT01). When the electron cyclotron frequency equals the RF driving frequency, the electron can gyrate in phase with the RF electric field inside the plasma bulk, being continuously accelerated like microwave ECR, leading to prominent increases in the electron temperature and the excitation or ionization rate in the bulk region. Here, we study further the basic features of the RF ECR and the effects of the driving frequency and the gas pressure on the RF ECR effect by OES and via PIC/MCC simulations. Additionally, a single electron model is employed to aid in understanding the ECR effect. It is found that the maximum of the measured plasma emission intensity caused by ECR is suppressed by either decreasing the driving frequency from 60 MHz to 13.56 MHz or increasing the gas pressure from 0.5 Pa to 5 Pa, which shows a qualitative agreement with the change of the excitation rate obtained in the simulations. Besides, the simulation results show that by decreasing the driving frequency the electron energy probability function (EEPF) changes from a convex to a concave shape, accompanied by a decreased electron temperature in the bulk region. By increasing the gas pressure, the EEPF and the electron temperature show a reduced dependence on the magnitude of the magnetic field. These results suggest that the ECR effect is more pronounced at a higher frequency and a lower gas pressure, primarily due to a stronger bulk electric field, together wih a shorter gyration radius and lower frequency of electron-neutral collisions. | | Article | Cai, Yiqing;Chen, Xiaomin;Lu, Tiange;Yu, Zhuoya;Hu, Shunfeng;Liu, Jiarui;Zhou, Xiangxiang;Wang, Xin |
| BMC Cancer | 23 | 1 | 2023 |
| 10.1186/s12885-023-10830-5 | 1471-2407 |
| Single-cell transcriptome analysis profiles the expression features of TMEM173 in BM cells of high-risk B-cell acute lymphoblastic leukemia | Background: As an essential regulator of type I interferon (IFN) response, TMEM173 participates in immune regulation and cell death induction. In recent studies, activation of TMEM173 has been regarded as a promising strategy for cancer immunotherapy. However, transcriptomic features of TMEM173 in B-cell acute lymphoblastic leukemia (B-ALL) remain elusive. Methods: Quantitative real-time PCR (qRT-PCR) and western blotting (WB) were applied to determine the mRNA and protein levels of TMEM173 in peripheral blood mononuclear cells (PBMCs). TMEM173 mutation status was assessed by Sanger sequencing. Single-cell RNA sequencing (scRNA-seq) analysis was performed to explore the expression of TMEM173 in different types of bone marrow (BM) cells. Results: The mRNA and protein levels of TMEM173 were increased in PBMCs from B-ALL patients. Besides, frameshift mutation was presented in TMEM173 sequences of 2 B-ALL patients. ScRNA-seq analysis identified the specific transcriptome profiles of TMEM173 in the BM of high-risk B-ALL patients. Specifically, expression levels of TMEM173 in granulocytes, progenitor cells, mast cells, and plasmacytoid dendritic cells (pDCs) were higher than that in B cells, T cells, natural killer (NK) cells, and dendritic cells (DCs). Subset analysis further revealed that TMEM173 and pyroptosis effector gasdermin D (GSDMD) restrained in precursor-B (pre-B) cells with proliferative features, which expressed nuclear factor kappa-B (NF-κB), CD19, and Bruton’s tyrosine kinase (BTK) during the progression of B-ALL. In addition, TMEM173 was associated with the functional activation of NK cells and DCs in B-ALL. Conclusions: Our findings provide insights into the transcriptomic features of TMEM173 in the BM of high-risk B-ALL patients. Targeted activation of TMEM173 in specific cells might provide new therapeutic strategies for B-ALL patients. | | Article | Liu, Shuhao;Su, Chang;Zhang, Junhua;Takeda, Shiro;Liu, Jiarui;Yang, Ruochen |
| Land | 12 | 4 | 2023 |
| 10.3390/land12040767 | 2073-445X |
| Cross-Cultural Comparison of Urban Green Space through Crowdsourced Big Data: A Natural Language Processing and Image Recognition Approach | Understanding the relationship between environmental features and perceptions of urban green spaces (UGS) is crucial for UGS design and management. However, quantifying park perceptions on a large spatial and temporal scale is challenging, and it remains unclear which environmental features lead to different perceptions in cross-cultural comparisons. This study addressed this issue by collecting 11,782 valid social media comments and photos covering 36 UGSs from 2020 to 2022 using a Python 3.6-based crawler. Natural language processing and image recognition methods from Google were then utilized to quantify UGS perceptions. This study obtained 32 high-frequency feature words through sentiment analysis and quantified 17 environmental feature factors that emerged using object and scene recognition techniques for photos. The results show that users generally perceive Japanese UGSs as more positive than Chinese UGSs. Chinese UGS users prioritize plant green design and UGS user density, whereas Japanese UGS focuses on integrating specific cultural elements. Therefore, when designing and managing urban greenspace systems, local environmental and cultural characteristics must be considered to meet the needs of residents and visitors. This study offers a replicable and systematic approach for researchers investigating the utilization of UGS on a global scale. | | Article | Wang, Lantian;Rao, Qingyang;Su, Haojie;Ruan, Linwei;Deng, Xuwei;Liu, Jiarui;Chen, Jun;Xie, Ping |
| Sci. Total Environ. | 850 |
| 2022 |
| 10.1016/j.scitotenv.2022.158092 | 1879-1026 |
| Linking the network topology of plant traits with community structure, functioning, and adaptive strategies of submerged macrophytes | Plant trait network analysis can calculate the topology of trait correlations and clarify the complex relationships among traits, providing new insights into ecological topics, including trait dimensions and phenotypic integration. However, few studies have focused on the relationships between network topology and community structure, functioning, and adaptive strategies, especially in natural submerged macrophyte communities. In this study, we collected 15 macrophyte community-level traits from 12 shallow lakes in the Yangtze River Basin in the process of eutrophication and analyzed the changes in trait network structure (i.e., total phosphorus, TP) by using a moving window method. Our results showed that water TP significantly changed the topology of trait networks. Specifically, under low or high nutrient levels, the network structure was more dispersed, with lower connectance and higher modularity than that found at moderate nutrient levels. We also found that network connectance was positively correlated with community biomass and homeostasis, while network modularity was negatively correlated with community biomass and homeostasis. In addition, modules and hub traits also changed with the intensity of eutrophication, which can reflect the trait integration and adaptation strategies of plants in a stressful environment. At low or high nutrient levels, more modules were differentiated, and those modules with higher strength were related to community nutrition. Our results clarified the dynamics of community structure and functioning from a new perspective of plant trait networks, which is key to predicting the response of ecosystems to environmental changes. | | Article | Zhou, Zhen;Zhuang, Guang-Chao;Mao, Shi-Hai;Liu, Jiarui;Li, Xiao-Jun;Liu, Qiao;Song, Guo-Dong;Zhang, Hong-Hai;Chen, Zhaohui;Montgomery, Andrew;Joye, Samantha;Yang, Gui-Peng |
| Geophys. Res. Lett. | 50 | 8 | 2023 |
| 10.1029/2022GL101605 | 1944-8007 |
| Methanol Concentrations and Biological Methanol Consumption in the Northwest Pacific Ocean | Methanol metabolism can play an important role in marine carbon cycling. We made contemporaneous measurements of methanol concentration and consumption rates in the northwest Pacific Ocean to constrain the pathways and dynamics of methanol cycling. Methanol was detected in relatively low concentrations (<12–391 nM), likely due to rapid biological turnover. Rates of methanol oxidation to CO2 (0.9–130.5 nmol L day) were much higher than those of assimilation into biomass (0.09–6.8 nmol L day), suggesting that >89.7% of methanol was utilized as an energy source. Surface water acted as a net methanol sink at most sites, with an average flux of 9 μmol L day. Atmospheric deposition accounted for 22.7% of microbial methanol consumption in the mixed layer, illustrating that the atmosphere is less important than internal processes for driving methanol cycling in these pelagic waters. | | Article | Chen, Xinyu;Feng, Jin;Zhang, Yuan;Liu, Jiarui;Zhang, Lijia;Zeng, Pu;Wen, Langbo;Wang, Xin;Zhang, Yi |
| Front. Genet. | 14 |
| 2023 |
| 10.3389/fgene.2023.1150976 | 1664-8021 |
| MYBL2 alternative splicing-related genetic variants reduce the risk of triple-negative breast cancer in the Chinese population | Background: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer, and studies have found an association between the Myb proto-oncogene like 2 (MYBL2) gene and TNBC development; however, the specific mechanisms underlying development remain unknown. Recent studies have reported the association of alternative splicing (AS) with cancer, providing new approaches to elucidate the carcinogenesis mechanism. This study aimed to identify MYBL2 AS-related genetic variants that influence the risk of developing TNBC, providing new ideas for probing the mechanism of TNBC and novel biomarkers for TNBC prevention. Methods: We conducted a case-control study of 217 patients with TNBC and 401 cancer-free controls. The CancerSplicingQTL database and HSF software were used to screen for MYBL2 AS-related genetic variants. The association of sample genotypes with the risk of TNBC development and with clinicopathological features was analysed via unconditional logistic regression. Combining multiple platforms, the candidate sites were subjected to biological function analysis. Results: Two AS-associated SNPs, rs285170 and rs405660, were identified using bioinformatics analysis. Logistic regression analysis showed that both rs285170 (OR = 0.541; 95% CI = 0.343–0.852; p = 0.008) and rs405660 (OR = 0.642; 95% CI = 0.469–0.879; p = 0.006) exhibited protective effects against TNBC under the additive model. Stratification analysis showed that these two SNPs had more significant protective effects in the Chinese population aged ≧50 years. Additionally, we found that rs405660 was associated with the risk of lymph node metastasis (OR = 0.396, 95% CI = 0.209–0.750, p = 0.005) in TNBC. Functional analysis revealed that both rs285170 and rs405660 are associated with splicing of exon 3 and that the exon 3-deleted spliceosome does not increase breast cancer risk. Conclusion: We found for the first time that MYBL2 AS-related genetic variants are associated with reduced TNBC susceptibility in the Chinese population, especially in women aged ≧50 years. | | Article | Peng, Xiaoye;Yu, Faxin;Wang, Zhiyu;Liu, Jiarui;Wang, Chenge;Wang, Jing |
| IEEE Access | 11 |
| 2023 | 48739 - 48748 | 10.1109/ACCESS.2023.3276715 | 2169-3536 |
| A Frequency-Domain I/Q Imbalance Calibration Algorithm for Wideband Direct Conversion Receivers Using Low-Cost Compensator | The amplitude and phase imbalances of the in-phase (I) and quadrature (Q) branches inherent in the direct conversion receiver structure cause the generation of image frequency interference signals. In this paper, a frequency-domain I/Q imbalance calibration algorithm is proposed for wideband direct conversion receivers. The I/Q imbalance model is rebuilt by applying the infinitesimal method and FFT algorithm. The mathematical expressions for the exact computation of the I/Q imbalance parameters are derived based on the frequency-domain statistical properties of the baseband signal. The two phase parameters, frequency-dependent I/Q imbalance (FD-IQI) and frequency-independent I/Q imbalance (FI-IQI), are separated according to the parity properties of the imbalance parameter. To avoid the interference from the transmitter, the receiver impairment estimation is performed using a frequency offset (FO) DC training signal, and a low-cost real-valued compensation (RVC) filter is introduced to correct the impairments of the received signal. The performances of the proposed calibration model are evaluated through simulations and experiments. The simulation results show that the image rejection ratio (IRR) is improved to 80-120 dBc and can also exceed 40 dBc at high noise levels. The experimental results based on the CX9261A evaluation board show that the average IRR of the multi-tone signal is increased by 24.99 dB, and the IRR of the wideband signal is increased by 19.08 dB. | | Conference Paper | Xu, Wenhao;Tian, Xiangke;Ma, Baocong;Gao, Tian;Wen, Dinghu;Ma, Xuchuang;Liu, Jiarui |
| ITNEC - IEEE Inf. Technol., Netw., Electron. Autom. Control Conf. |
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| 2023 | 588 - 591 | 10.1109/ITNEC56291.2023.10082683 |
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| Research to Three-box Stair Sweeping Robot Based on Guideway Lifting Mechanism | The traditional floor sweeping robot will be replaced by an intelligent, autonomous floor cleaning robot. Aiming at the fact that the traditional robot cannot clean the three-dimensional position, an intelligent cleaning robot is designed for stair cleaning, which integrates vacuuming and mopping. Using three sections of lifting structure to climb the stairs, the Mecanum wheel can realize the lateral movement of the three-side cleaning robot on the stairs, the bottom is equipped with infrared sensor, to ensure that it can not fall down the narrow stairs. The robot can better save the manpower and material resources of cleaning stairs, so that the sweeping robot is more widely used. | | Article | Liu, Jiarui;Liu, Ye;Yu, Jianlin;Yan, Gang |
| Appl. Therm. Eng. | 230 |
| 2023 |
| 10.1016/j.applthermaleng.2023.120835 | 1359-4311 |
| Thermodynamic analysis of a novel vapor-injection Joule-Thomson refrigeration cycle with a binary hydrocarbon mixture for −86 C freezer | This paper proposes a novel vapor-injection Joule-Thomson refrigeration cycle with mixed-refrigerant. The introduction of the compressor with vapor-injection can reduce the pressure ratio of each compression stage, thus reducing the compressor power and discharge temperature. The thermodynamic analysis results show that the performance of the novel cycle is better than that of the basic Joule-Thomson cycle. In addition, this paper studies the binary hydrocarbons applied in −86 C freezers, and find a binary hydrocarbon R601a/R1150 with Superior performance. The mass fractions of R1150 in R601a/R1150 corresponding to the maximum COP of the novel cycle and basic cycle are 0.45 and 0.44, respectively. Moreover, the maximum COP of the novel cycle is 19.25% higher than that of the basic cycle. The comparison results demonstrate that the novel cycle has a great energy-saving potential. In addition, at different condenser outlet temperatures of 16 C, 25 C and 32 C, both cycles have the optimal condensation pressure of 300 kPa, 500 kPa and 650 kPa with respect to COP. For the novel cycle, the compressor injection ratio has little effect on COP. The increase of intermediate pressure can improve cycle performance, but too high intermediate pressure is not conducive to the normal operation of the system. Furthermore, the exergy analysis result shows that the location of the largest exergy destruction rate is in the compressors for both cycles, followed by the recuperators, condensers, evaporators, and capillary tubes. | | Article | Ding, Jing;Meng, Zhuocheng;Zhang, Yan;Cui, Xiaohua;Liu, Jiarui;He, Jiao;Zhang, Yang;Li, Yajuan;Yang, Liu |
| Chin. Gen. Pract. | 26 | 23 | 2023 | 2923 - 2929 | 10.12114/j.issn.1007-9572.2023.0016 | 1007-9572 |
| Retrospective Analysis of 2 992 Times of Therapeutic Drug Monitoring of Valproic Acid from 2019 to 2021 | Background Valproic acid，as a mood stabilizer，has been extensively used for the treatment of bipolar disorder and other psychiatric conditions. Although therapeutic drug monitoring（TDM）of valproic acid has been carried out at home and abroad for many years，controversies persist regarding the influence of age，sex and other factors on its plasma concentration. Objective To analyze the TDM results of valproic acid，providing a reference for rationalized individualized treatment of bipolar disorders or other psychiatric conditions. Methods Through the laboratory information system of Ruimei Medical Laboratory，information on TDM of valproic acid in outpatients and inpatients（including the patient's age，sex，TDM raw data，monitoring samples，and monitoring frequency）was obtained from Xi'an Mental Health Center from 2019 to 2021. The plasma concentration of valproic acid was classified into three categories（<50 mg/L，50-100 mg/L and >100 mg/L）according to the therapeutic window range recommended in the Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology（hereinafter referred to as AGNP Consensus），and the percent of each category was calculated. And subsequent data analysis was performed using MedCalc 5.2. Results A total of 2 431 patients were monitored 2 992 times for understanding valproic acid treatment status，of which 1 637 were for men，and 1 355 for women. The frequencies of TDM of valproic acid increased by 54.93% in 2020 and 44.00% in 2021 compared to those reported in 2019. The proportion of patients who received only once was about 74.41%. Compared with inpatients，outpatients had higher prevalence of receiving one TDM of valproic acid（χ=95.15，P<0.001），and lower prevalence of receiving two，or at least three TDM of valproic acid（χ=49.41，34.24，P<0.001）. The plasma valproic acid concentration in inpatients was higher than that in outpatients（Z=-11.60，P<0.001）. Meanwhile，higher plasma valproic acid concentration was observed in female patients than in male patients（Z= -4.39，P<0.001）. However，there was no significant difference between the age groups（Z=0.75，P>0.05）. For each study year 2019-2021，the proportion of plasma concentration of valproic acid within the therapeutic window was 57.72%，which was significantly higher than that of the proportion of below and above the therapeutic window（χ=155.38，1 216.68，P<0.001）. The proportion of the plasma valproic acid concentration（<50 mg/L，50-100 mg/L，or >100 mg/L） had statistically significant differences between different age and gender groups，and over the years（P<0.05）. The plasma valproic acid concentration ranged between 40-80 mg/L for males，females，or total participants，which was slightly lower than the therapeutic range（50-100 mg/L）recommended by the AGNP Consensus. Conclusion The individual treatment program in patients should be determined clinically according to age and sex to increase the proportion of plasma valproic acid concentration in the therapeutic window. Additionally，TDM of valproic acid should be emphasized in inpatients and outpatients to ensure safe and effective medication administration in clinical practice. | | Article | Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L.;Wang, Sen;Yang, Yuxin;Dinh, Hong Lich;Zi, Goangseup |
| Constr. Build. Mater. | 393 |
| 2023 |
| 10.1016/j.conbuildmat.2023.132107 | 0950-0618 |
| Correlation between dissolubilities of Si, Al, and Fe from aluminosilicate precursor and strength of fly ash-based geopolymer | Fly ash (FA) is the most used aluminosilicate precursor to synthesize geopolymer. However, as a coal-combustion by-product, the inherent characteristics of FA can be significantly altered by multiple factors such as coal sources, combustion temperatures, particle size, and impurity level. Thus, unstable performances of FA-based geopolymer due to extremely varied reactivity of FA have been widely reported in the literature and are limiting the further valorization of FA. To offset the inconsistent characteristics of FA, this study provides a universal index to quantify and evaluate its reactivity to be used as aluminosilicate precursor feedstock. Alkali leaching tests were conducted on seven types of FA sourced from six different coal power plants in the Southeast Queensland region to determine the dissolubilities and dissolution efficiencies of reactive Si and Al within 2 h. The dissolubility and dissolution efficiency demonstrated decent correlations with the mechanical properties of the resultant FA-based geopolymer, especially 7-day strength. Moreover, bulk and reactive Si/Al molar ratios were derived to distinguish each type of FA further and verified by scanning electron microscopy / energy-dispersive X-ray spectroscopy. Lastly, a reactivity index considering the dissolution efficiency of Si, Al, and Fe and reactive Si/Al molar ratios was developed and correlated to the mechanical properties of FA-based geopolymer. Dissolubility at a leaching time of 30 min best reflected the reactivity of FA, having the highest correlation coefficient of 0.82. | | Article | Dinh, Hong Lich;Doh, Jeung-Hwan;Liu, Jiarui;Lu, Limin;Song, Hwacheol;Park, Dongcheon |
| J. Build. Eng. | 76 |
| 2023 |
| 10.1016/j.jobe.2023.107094 | 2352-7102 |
| Comprehensive assessment of geopolymer concrete mechanical and environmental performance with glass cullet fine aggregates | Despite its established reputation and extensive testing as an alternative to conventional cement, geopolymer continues to heavily rely on natural aggregates. The disposal of waste glass presents a significant global challenge as it constitutes a substantial portion of solid waste. This study investigates the application of geopolymer mortar, wherein waste glass cullet serves as the principal component for fine aggregate. Two distinct curing methods, namely ambient and elevated temperatures, were employed to evaluate the mechanical properties of the material in accordance with standards. An optimal aggregate-to-binder ratio of 1:2.5 was determined to achieve suitable workability for in-situ casting applications. Following a 28-day curing period, the geopolymer mortar underwent testing for compressive and tensile strength, bringing acceptable results at 46 MPa and 2.8 MPa, respectively. Additionally, the study examined the relationship between compression and tension characteristics of geopolymer mortar and, through regression analysis, established correlations that accurately predicted data from other published works. Furthermore, the carbon footprint of geopolymer was compared to that of ordinary Portland cement (OPC) concrete, with geopolymer demonstrating the potential to significantly reduce the environmental impact of cement manufacturing, saving 27.76% of the carbon footprint per m in comparison to OPC. This study emphasizes the strong mechanical qualities of geopolymer products, which give them a great probability of being employed in industry and creating a new market for waste materials through the usage of by-products. | | Article | Gao, Fei;Wang, Feifei;Liu, Yuntao;Ding, Yuyang;Chen, Yizhen;Ni, Ning;Wang, Ziling;Liu, Jiarui;Wang, Ziye;Zhao, Xu |
| Yuanzineng Kexue Jishu. | 57 | 2 | 2023 | 389 - 397 | 10.7538/yzk.2022.youxian.0176 | 1000-6931 |
| Establishment and Study of Pulsed X-ray Reference Radiation Field | Research on radiation protection dosimetry mainly focuses on continuous radiation in the world, but pulsed ionizing radiation has been widely used in the fields of industrial detection, X-ray diagnosis, security inspection and scientific research. The active electronic dosimeter has been widely used in the fields of environmental monitoring, regional monitoring, personal dose monitoring and emergency monitoring. The active electronic dosimeters are calibrated in continuous radiation field, and they cannot measure short pulse and high dose rate pulsed ionizing radiation accurately. The active radiation dosimeter can be divided into G-M counter type, scintillator detector type, semiconductor detector type and ionization chamber type according to different radiation detection principles. The measurement of pulsed X-ray dose is very difficult due to its short duration and high instantaneous dose rate. Taking nanosecond radiation pulse as an example, its single pulse dose usually reaches more than 1 μSv, and the instantaneous dose rate can reach more than 105 Sv/h. For G-M counter and semiconductor detector, there are problems of measurement stacking and detection dead time, so it is difficult to achieve such a high dose-rate response, and there is an over-response problem in the instrument, which will inevitably affect the accuracy of monitoring results. The measurement of pulsed radiation dose (rate) is difficult. However, pulsed ionizing radiation has been widely used in many fields, such as the development of new detector, industrial flaw detection, X-ray diagnosis, nuclear emergency response and scientific research, etc. In this paper, the reference ionizing radiation field of pulsed X-ray was established based on steady-state X-ray machine, pulsed X-ray machine and portable X-ray machine. In order to measure the dose of pulsed reference field, the theoretical calculation, Monte Carlo simulation and experiment method were used to develop a secondary standard ionization chamber for millisecond pulsed X-rays. From the experimental data, it can be seen that the mainstream active dosimeters currently sold have low pulse dose response and even give false readings, which are not suitable for short pulse and high dose rate measurement and early warning, will cause safety trouble to personal. The dosimetric characteristics, such as pulse time, pulse dose and instantaneous dose rate were studied based on pulsed X-ray secondary standard ionization chamber and pulsed time measurement system. The lower limit and upper limit of instantaneous dose rate of the established pulsed X-ray reference radiation field are 2.5×10 Sv/h and 6.7×10 Sv/h respectively. Pulse time is adjustable between 50 ns and 10 s. The dose rate range of pulsed X-ray reference radiation field established in this study covers environmental level, radiation protection level, diagnosis level, treatment level, emergency level and nuclear critical accident level, which can be used to calibrate the pulsed radiation dose monitoring instrument. It is helpful to further study the pulsed radiation response characteristics of active radiation dosimeter and personal radiation dosimeter. | | Article | Song, Yaguang;Wang, Yilun;Liu, Jiarui;Chen, Hua;Yu, Faxin |
| IEICE Electron. Express | 20 | 9 | 2023 |
| 10.1587/elex.20.20230086 | 1349-2543 |
| A 0.1-1.9 GHz 65nm CMOS variable-gain mixer-first receiver with DSA and noise-shaping TIA | In this letter, we proposed a highly linear mixer-first receiver with a discrete-step attenuator (DSA) and a noise-shaping TIA. A resistorreuse technique is devoted to improving linearity and attenuation flatness of the DSA with frequency independance, and a negative impedance chopping method is proposed to reduce the in-band noise of the TIA. Measurement results show that the receiver achieves > 13 dBm IIP3 and in-band noise floor has been depressed by 4 dB, with only consuming 2.82mW under 1.3V supply. | | Article | Xu, Yantian;Wang, Zhiyu;Liu, Jiarui;Chen, Hua;Yu, Faxin |
| IEICE Electron. Express | 20 | 9 | 2023 |
| 10.1587/elex.20.20230035 | 1349-2543 |
| Multi-chip phase synchronization circuit of fractional-N PLL | A digital integrated circuit to realize multi-chip phase synchronization of fractional-N PLL with local oscillator divider is designed. An offset of fractional frequency ratio is added in phase difference calculation, which effectively avoids the large calculation error under some special fractional frequency ratios. Different from traditional one-time synchronization, a synchronization method with tracking mode is proposed, which can further reduce the phase error. The test result of the chip finished in 65 nm COMS shows that the method of tracking mode and adding the fractional frequency ratio's offset are effective to reduce the error of phase synchronization to about 0.2. | | Article | Cao, Xu;Du, Zhong-Rui;Liu, Xin;Wang, Xiong;Li, Chong;Zhou, Sai-Nan;Liu, Jia-Rui;Xu, Ping-Yi;Ye, Jun-Li;Zhao, Qing;Zhao, Fang;Wong, Ka-Hing;Dong, Xiao-Li |
| Biomed. Pharmacother. | 165 |
| 2023 |
| 10.1016/j.biopha.2023.115100 | 0753-3322 |
| Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms | The use of oral agents that can modify the gut microbiota (GM) could be a novel preventative or therapeutic option for Parkinson's disease (PD). Maslinic acid (MA), a pentacyclic triterpene acid with GM-dependent biological activities when it is taken orally, has not yet been reported to be effective against PD. The present study found both low and high dose MA treatment significantly prevented dopaminergic neuronal loss in a classical chronic PD mouse model by ameliorating motor functions and improving tyrosine hydroxylase expressions in the substantia nigra pars compacta (SNpc) and increasing dopamine and its metabolite homovanillic acid levels in the striatum. However, the effects of MA in PD mice were not dose-responsive, since similar beneficial effects for low and high doses of MA were observed. Further mechanism studies indicated that low dose MA administration favored probiotic bacterial growth in PD mice, which helped to increase striatal serotonin, 5-hydroxyindole acetic acid, and γ-aminobutyric acid levels. High dose MA treatment did not influence GM composition in PD mice but significantly inhibited neuroinflammation as indicated by reduced levels of tumor necrosis factor alpha and interleukin 1β in the SNpc; moreover, these effects were mainly mediated by microbially-derived acetic acid in the colon. In conclusion, oral MA at different doses protected against PD via distinct mechanisms related to GM. Nevertheless, our study lacked in-depth investigations of the underlying mechanisms involved; future studies will be designed to further delineate the signaling pathways involved in the interactive actions between different doses of MA and GM. | | Article | Wang, Jianhui;Liu, Jiarui;Li, Yonghua;Chen, C. L. Philip;Liu, Zhi;Li, Fangyi |
| IEEE Trans. Autom. Sci. Eng. | 21 | 3 | 2024 | 4016 - 4027 | 10.1109/TASE.2023.3291716 | 1558-3783 |
| Prescribed Time Fuzzy Adaptive Consensus Control for Multiagent Systems with Dead-Zone Input and Sensor Faults | A prescribed time fuzzy adaptive consensus control method is constructed for multiagent systems with sensor faults and dead-zone input. Sensor faults inevitably occur in actual engineering systems and may distort the state information. Besides, the control effect would be further dramatically affected when systems exist dead-zone input. Thus, a fuzzy adaptive compensation strategy is established by the bounded adaptive optimized method to eliminate the impact of the above constraints. Furthermore, a given performance consensus control method is investigated with the aid of nonlinear transformation. Meanwhile, combined with the prescribed time technology, it further achieves that the systems settling time can be preselected while the performance of the systems is given. Finally, some simulation experiments are adopted to demonstrate the feasibility and effectiveness of the investigated control method. Note to Practitioners-This work studies the consensus problem for multiagent systems, which is important in engineering collaborative applications. Due to measurement noise and electronic damage, sensor faults inevitably happen in industrial applications. Besides, dead-zone input often occurs in actual systems as physical properties of electronic components. Based on the bounded adaptive optimized method, a fuzzy adaptive compensation strategy is constructed to deal with those issues. To further improve the control performance in the collaborative process, prescribed time technology and given performance strategy are applied to construct the control method. The investigated approach can be useful in multiagent systems to achieve more steady consensus operation, which is more in line with the application requirements. | | Article | Ding, Jing;Yang, Liu;Zhang, Yan;Meng, Zhuocheng;Ren, Jianli;Zhang, Suo;Liu, Jiarui;Cui, Xiaohua |
| Ther. Drug Monit. | 45 | 4 | 2023 | 425 - 427 | 10.1097/FTD.0000000000001093 | 1536-3694 |
| Usefulness of Therapeutic Drug Monitoring and Pharmacogenetics for a Patient Treated with Olanzapine, Buspirone, and Fluvoxamine: A Case Study | Background:A patient, with a mental disorder caused by an intracranial infection, treated with olanzapine, fluvoxamine, and buspirone. The plasma exposure of olanzapine was too high at standard doses, with evidence indicating that it was caused by drug-drug interactions.Methods:Using pharmacogenomics and therapeutic drug monitoring to guide drug dose adjustment for a patient in clinical practice.Results:The patient underwent pharmacogenetic testing in addition to therapeutic drug monitoring as part of a pharmacist-led comprehensive evaluation of medication therapy management in a clinical setting, resulting in improved clinical efficacy that allowed discharge from a psychiatric hospital.Conclusions:This case study demonstrates that therapeutic drug monitoring combined with pharmacogenetic-guided dose adjustment can aid in the management of patients receiving complex pharmacological treatments. | | Article | Liu, Bo;Kuang, Min-Quan;Luo, Yang;Li, Yongkai;Hu, Cheng;Liu, Jiarui;Xiao, Qian;Zheng, Xiquan;Huai, Linwei;Peng, Shuting;Wei, Zhiyuan;Shen, Jianchang;Wang, Bingqian;Miao, Yu;Sun, Xiupeng;Ou, Zhipeng;Cui, Shengtao;Sun, Zhe;Hashimoto, Makoto;Lu, Donghui;Jozwiak, Chris;Bostwick, Aaron;Rotenberg, Eli;Moreschini, Luca;Lanzara, Alessandra;Wang, Yao;Peng, Yingying;Yao, Yugui;Wang, Zhiwei;He, Junfeng |
| Phys. Rev. Lett. | 131 | 2 | 2023 |
| 10.1103/PhysRevLett.131.026701 | 0031-9007 |
| Tunable Van Hove Singularity without Structural Instability in Kagome Metal CsTi3Bi5 | In kagome metal CsV3Sb5, multiple intertwined orders are accompanied by both electronic and structural instabilities. These exotic orders have attracted much recent attention, but their origins remain elusive. The newly discovered CsTi3Bi5 is a Ti-based kagome metal to parallel CsV3Sb5. Here, we report angle-resolved photoemission experiments and first-principles calculations on pristine and Cs-doped CsTi3Bi5 samples. Our results reveal that the van Hove singularity (vHS) in CsTi3Bi5 can be tuned in a large energy range without structural instability, different from that in CsV3Sb5. As such, CsTi3Bi5 provides a complementary platform to disentangle and investigate the electronic instability with a tunable vHS in kagome metals. | | Article | Sun, Anzhu;Ding, Jun;Liu, Jiarui;Zhou, Heng;Zhang, Jiale;Zhang, Peng;Dong, Junwei;Sun, Ze |
| Appl. Sci. | 13 | 13 | 2023 |
| 10.3390/app13137695 | 2076-3417 |
| Improved Detector Based on Yolov5 for Typical Targets on the Sea Surfaces | Detection of targets on sea surfaces is an important area of application that can bring great benefits to the management and control systems in marine environments. However, there are few open-source datasets accessible for the purpose of object detection on seas and rivers. In this paper, a study is conducted on the improved detection algorithms based on the YOLOv5 model. The dataset for the tests contains ten categories of typical objects that are commonly seen in the contexts of seas, including ships, devices, and structures. Multiple augmentation methods are employed in the pre-processing of the input data, which are verified to be effective in enhancing the generalization ability of the algorithm. Moreover, a new form of the loss function is proposed that highlights the effects of the high-quality boxes during training. The results demonstrate that the adapted loss function contributes to a boost in the model performance. According to the ablation studies, the synthesized methods raise the inference accuracy by making up for several shortcomings of the baseline model for the detection tasks of single or multiple targets from varying backgrounds. | | Article | Liu, Jiarui;Yuan, Feipeng;Luo, Shan;Wang, Ying;Wu, Xingyao;Xie, Hongding;Tang, Yong;Li, Yulong;Zou, Qiongyu;Xi, Qiang;Wen, Qian;Yi, Sili |
| Polyhedron | 243 |
| 2023 |
| 10.1016/j.poly.2023.116544 | 0277-5387 |
| Oligo (ethylene glycol)-functionalized fluorescent sensor for the determination of Hg in aqueous solution | For mercury (II) ion (Hg) fluorescent sensors, excellent water solubility is a critical property to ensure Hg detection sensitivity in biological and ecological environments. Although many organic fluorescent Hg sensors have been reported, only a few applied in purely aqueous media. Herein, we synthesized a simple oligo (ethylene glycol)-functionalized organic fluorescent sensor (NP-DT-OEG) for the determination of Hg in aqueous media based on a specific Hg-triggered dithioacetal deprotection reaction mechanism. NP-DT-OEG exhibits excellent water solubility and fast response of Hg with remarkable selectivity in a purely aqueous media, the fluorescence intensity increased linearly with Hg concentration within the range from 0 to 20 μM and the detection limit was determined to be 6.2 nM. In practical application, NP-DT-OEG was able to determine Hg in crayfish meat and serum samples. Moreover, bioimaging studies indicated that NP-DT-OEG exhibited low cytotoxicity as well as excellent cell membrane permeability, and has been successfully used for monitoring Hg in living cells. | | Article | Ding, Jing;Yang, Liu;Cui, Xiaohua;Li, Luyao;Liu, Jiarui;Sun, Hongrui;Wang, Ting;Zhang, Yan |
| Asian J. Psychiatry | 87 |
| 2023 |
| 10.1016/j.ajp.2023.103699 | 1876-2026 |
| A 5-year retrospective study of amisulpride steady-state plasma concentration in patients with schizophrenia in real-life settings based on therapeutic drug monitoring data | Objective: Here, we present a retrospective analysis of the last 5 years’ data collected in real-life settings as direct evidence to evaluate the optimal therapeutic window of amisulpride (AMI) for psychiatric patients. Methods: Retrospective analysis of the therapeutic drug monitoring (TDM) results of AMI in outpatients and inpatients were obtained from the Xi'an Mental Health Center from 2017 to 2021. Results: The interquartile (P25–P75) AMI concentrations ranged 212.20–574.25 ng/mL. The results showed that the proportion of outpatients who received TDM once was significantly higher than that of inpatients who received TDM once (P < 0.001), whereas the reverse was true for those who experienced TDM more than twice (P < 0.001). Higher estimated plasma concentrations were identified in inpatients, female patients, and patients over 59 years of age. Nearly 57.21% of the samples had high concentrations (>320 ng/mL). Conclusions: The optimal therapeutic reference range for AMI may require reconstruction to guide the use of AMI for the treatment of schizophrenia. | | Article | Qu, You;Hu, Hongyu;Liu, Jiarui;Zhang, Zhengguang;Li, Yechen;Ge, Xiaojun |
| IEEE Trans. Instrum. Meas. | 72 |
| 2023 |
| 10.1109/TIM.2023.3301060 | 1557-9662 |
| Driver State Monitoring Technology for Conditionally Automated Vehicles: Review and Future Prospects | Conditionally automated vehicles can be operated on most regular roads without driver's supervision. They show excellent potential for market adoption and are now being targeted by numerous auto manufacturers for mass production. The system of such a vehicle enables it to autonomously perform dynamic driving tasks (DDTs) within the operational design domain, but, once this system fails or malfunctions, the vehicle will be unable to reliably complete a DDT. In such cases, the system will send a takeover request, following which the driver needs to immediately take control of the vehicle. The driver's physical and mental states, as well as the nondriving-related tasks that they are engaged in, affect the time required for them to perform the takeover and the quality of the takeover. To manage driving risks and guarantee the safety of drivers during automated driving, an automated driving system should be able to monitor a driver's state and behavior, assess their level of alertness, and perform the appropriate actions as required. In recent years, techniques for monitoring a driver's state have been widely researched, and several practical methods have been proposed. In this review, we review representative methods, aiming to introduce the concept of driver state monitoring to a broader audience. First, we identified a few typical driver states that are important in driver state monitoring from the perspective of application demands for driver state monitoring in conditionally automated driving. Then, we categorized and reviewed existing studies on driver state monitoring according to the types of sensing data employed by previously proposed methods. In addition, we collected datasets corresponding to different data types for driver state monitoring. Finally, by analyzing existing issues in driver state monitoring in relation to conditionally automated driving, we provided several suggestions for future research directions in this area and discussed potential challenges and possible solutions. | | Article | Liu, Jiarui;Fu, Yuchen |
| Energy | 284 |
| 2023 |
| 10.1016/j.energy.2023.128730 | 0360-5442 |
| Renewable energy forecasting: A self-supervised learning-based transformer variant | Reliable and accurate renewable energy forecasting (REF) has substantial impact on society by helping with daily planning and mitigating the instability of power system. Providing a state-of-the-art (SOTA) solution for REF can power it to take on more sophisticated tasks and solve frontier problems to play a greater role in modern society. Aiming this goal, this work proposes a novel Transformer-based model, named Graph Patch Informer (GPI), for REF. Compared with existing REF models and mainstream Transformer, our model has three main characteristics: (1) Segment-wise self-attention is designed, which benefits Transformer by preserving the temporal information hidden in the continuous signals, (2) Graph Attention Networks with adaptive adjacent matrix is proposed to capture the inter-temporal dependencies automatically, (3) A new training strategy, that is, self-supervised pre-training followed by fine-tuning, is introduced to enhance the representation learning. To validate the performance of GPI, five experiments are conducted on four datasets covering solar radiation (SR), photovoltaic power (PVP), wind speed (WS) and wind power (WP). Experiments show that GPI goes beyond SOTA Autoformer by 23.67%–40.75% on MSE. It demonstrates that GPI can provide an effective solution for REF and have SOTA performance on SR, PVP, WS, WP forecasting tasks. Experiments also show that GPI can mitigate the adverse influences caused by missing values to a certain degree. | | Article | Fu, Wenlong;Fu, Yuchen;Li, Bailing;Zhang, Hairong;Zhang, Xuanrui;Liu, Jiarui |
| Appl. Energy | 348 |
| 2023 |
| 10.1016/j.apenergy.2023.121587 | 0306-2619 |
| A compound framework incorporating improved outlier detection and correction, VMD, weight-based stacked generalization with enhanced DESMA for multi-step short-term wind speed forecasting | Precise wind speed forecasting contributes to wind power consumption and power grid schedule as well as promotes the implementation of global carbon neutrality policy. However, in existing research, the negative impact of outliers on forecasting models is ignored and the inherent shortcomings of the single predictors have not been taken seriously. Moreover, the intrinsic parameters of predictors are set by manual and empirical methods in some research, leading to difficulties in achieving optimal forecasting performance. To solve the shortcomings of existing research, a multi-step short-term wind speed forecasting framework is proposed by incorporating boxplot-medcouple (MC), variational mode decomposition (VMD), phase space reconstruction (PSR), weight-based stacked generalization with enhanced differential evolution slime mold algorithm (DESMA). Firstly, boxplot-MC is employed to achieve outlier detection and correction for preprocessing original wind speed data by analyzing values and trends. Then, the modified data is further adaptively decomposed into multiple subsequences by VMD, after which each subsequence is constructed into feature matrices through PSR. Subsequently, weight-based multi-model fusion strategy in layer-1 of stacked generalization is proposed to integrate the predicting values acquired by three primary learners, of which the weight coefficients are calculated with the error between actual values and predicting values. After that, kernel extreme learning machine (KELM) in layer-2 of stacked generalization is applied to predict the fusion result to obtain forecasting value corresponding to each subsequence. Meanwhile, an enhanced DESMA based on slime mold algorithm (SMA) and differential evolution (DE) is proposed to calibrate the parameters of KELM. Eventually, the final wind speed forecasting results are attained by summing the prediction values of all subsequences. Furthermore, comparative experiments from different aspects are undertaken on real datasets to ascertain the availability of the proposed framework. The experimental results are clarified as follows: (1) outlier detection and correction employing boxplot-MC is dedicated to analyzing values and trends effectively, with which the negative impact of outliers can be weakened while retaining valid data significantly; (2) VMD can prominently reduce the non-smoothness and volatility of wind speed data; (3) weight-based stacked generalization is conducive to exploiting the advantages of individual primary learners, contributing to compensating for instability; (4) DESMA enhances prediction accuracy by optimizing the parameters of KELM. Additionally, the code has been made available at https://github.com/fyc233/a-multi-step-short-term-wind-speed-forecasting-framework.git. | | Conference Paper | Li, Zhi Chao;Zhang, Chun Guang;Liu, Jia Rui;Chu, Shuai;Gong, Ying Jiao;Geng, Wei |
| J. Phys. Conf. Ser. | 2561 | 1 | 2023 |
| 10.1088/1742-6596/2561/1/012010 | 1742-6596 |
| A Novel Pulse Excitation Circuit Model and Analysis of Its Magnetic Induction Advantages | In this paper, we discuss the excitation module in the magnetic induction system. First, we start from the traditional sinusoidal input resonant excitation circuit and give the frequency domain equation of its excitation current. Then, we propose a new module based on pulse excitation and give the corresponding excitation equation in the frequency domain. After that, we deduce the mathematical model of excitation gain of new and old modules using application and technology and finally obtain intuitive mathematical analysis graphics for engineering promotion. | | Article | Liu, Jia-rui;Chen, Bo-xue;Jiang, Mei-ting;Cui, Tian-yi;Lv, Bin;Fu, Zhi-fei;Li, Xue;Du, Yao-dong;Guo, Jin-he;Zhong, Xin-qin;Zou, Ya-dan;Zhao, Xin;Yang, Wen-zhi;Gao, Xiu-mei |
| Food Sci. Nutr. | 11 | 11 | 2023 | 6974 - 6986 | 10.1002/fsn3.3622 | 2048-7177 |
| Polygonatum odoratum polysaccharide attenuates lipopolysaccharide-induced lung injury in mice by regulating gut microbiota | Polygonatum odoratum is appreciated for its edible and medicinal benefits especially for lung protection. However, the contained active components have been understudied, and further research is required to fully exploit its potential application. We aimed to probe into the beneficial effects of Polygonatum odoratum polysaccharide (POP) in lipopolysaccharide-induced lung inflammatory injury mice. POP treatment could ameliorate the survival rate, pulmonary function, lung pathological lesions, and immune inflammatory response. POP treatment could repair intestinal barrier, and modulate the composition of gut microbiota, especially reducing the abundance of Klebsiella, which were closely associated with the therapeutic effects of POP. Investigation of the underlying anti-inflammatory mechanism showed that POP suppressed the generation of pro-inflammatory molecules in lung by inhibiting iNOS M1 macrophages. Collectively, POP is a promising multi-target microecological regulator to prevent and treat the immuno-inflammation and lung injury by modulating gut microbiota. | | Article | Zhang, Zhaoli;Yang, Tingxuan;Wang, Yang;Liu, Jiarui;Shi, Wangbin;Hu, Haochen;Meng, Yang;Meng, Xiangren;He, Ronghai |
| Foods | 12 | 15 | 2023 |
| 10.3390/foods12152926 | 2304-8158 |
| Influence of Multi-Frequency Ultrasound Treatment on Conformational Characteristics of Beef Myofibrillar Proteins with Different Degrees of Doneness | This study evaluated the effect of multi-frequency sonication (20 kHz, 25 kHz, 28 kHz, 40 kHz, 50 kHz) on structural characteristics of beef myofibrillar proteins (MPs) with different degrees of doneness (Rare 52~55 C, Medium Rare 55~60 C, Medium 60~65 C, Medium Well 65~69 C, Well Down 70~80 C, and Overcooked 90 C). The results showed that surface hydrophobicity and sulfhydryl content increased with the increase in degree of doneness. At the same degree of doneness, the sulfhydryl group contents reached the maximum at a frequency of 28 kHz. In addition, the absolute value of ζ-potential was significantly decreased after ultrasonic treatment (p < 0.05). SDS gel electrophoresis showed that the bands of beef MPs were not significantly affected by various ultrasonic frequencies, but the bands became thinner when the degree of doneness reached overcooked. Fourier transform infrared spectrum showed that with the increase of ultrasonic frequency, α-helix content decreased, and random coil content significantly increased (p < 0.05). The results of atomic force microscopy indicated that the surface structure of beef MPs was damaged, and the roughness decreased by sonication, while the roughness significantly increased when the degree of doneness changed from medium to overripe (p < 0.05). In conclusion, multi-ultrasound combined with degree of doneness treatment alters the structural characteristics of beef MPs. | | Article | Liu, Jiarui;Zhang, Lijia;Tang, Mingwen;Chen, Xinyu;Yang, Caiyun;Li, Yong;Feng, Jin;Deng, Yan;Wang, Xin;Zhang, Yi |
| Eur. J. Cancer Prev. | 32 | 5 | 2023 | 450 - 459 | 10.1097/CEJ.0000000000000800 | 0959-8278 |
| Functional variant rs10175368 which affects the expression of CYP1B1 plays a protective role against breast cancer in a Chinese Han population | Objective Cytochrome P450 1B1 (CYP1B1) genetic variants are relevant in the pathogenesis of breast cancer. Exploring the relationships between CYP1B1 functional variants and breast cancer could improve our understanding of breast cancer molecular pathophysiology. Methods This is a two-stage hospital-based case-control study of a Chinese Han population. Genotyping was performed to identify candidate gene variants. 3DSNP, ANNOVAR, and RegulomeDB were used to determine functional single nucleotide polymorphisms (SNPs). The relationship between candidate variants and breast cancer risk was evaluated through unconditional logistic regression analysis. The PancanQTL platform was used to perform cis and trans expression quantitative trait loci (eQTL) analysis of positive SNPs. The GSCA platform was then used to compare the gene expression levels of potential target genes between breast cancer tissue and normal tissue adjacent to the cancer. Results rs10175368-T acted as a protective factor against breast cancer based on an additive model [odds ratio (OR) = 0.722, 95% confidence interval (CI) = 0.613-0.850; P < 0.001], and was identified as a protective factor in the postmenopausal population (OR = 0.601; 95% CI, 0.474-0.764; P < 0.001). eQTL analysis and analysis of differential expression in carcinoma and paracancerous tissues revealed that the expression level of CYP1B1-AS1 was associated with rs10175368 and that CYP1B1-AS1 had significantly higher expression levels in breast cancer tissues than in paracancerous tissues. Conclusion We show, for the first time in a Chinese Han population, that the functional variant rs10175368 plays a protective role against breast cancer, especially in the postmenopausal population. | | Article | Liu, Jiarui;Chen, Jiawei;Sun, Zhengyi;Zhang, Haicheng;Yuan, Qingsong |
| Metals | 13 | 8 | 2023 |
| 10.3390/met13081377 | 2075-4701 |
| A Study on Fatigue Crack Closure Associated with the Growth of Long Crack in a New Titanium Alloy | In this article, the fatigue crack closure in a new titanium alloy is carried out under constant amplitude cyclic loading with the combination of the simulation method and experiments. A numerical simulation of the crack closure effect on a new titanium alloy under different load ratios was carried out to analyze the effect of grid size on the crack closure level and to obtain the fatigue crack opening load level under different load ratios. The experimental study of the fatigue crack growth rate of the new titanium alloy under different load ratios has demonstrated that the fatigue crack growth rate is affected by the stress ratio. With the increase in load ratio, the crack expansion rate of new titanium also increases. Combined with the simulation, the experiments show that the crack closure effect induced by the plastic region at the crack tip is the main reason for the load ratio effect on the fatigue crack expansion rate of the new titanium alloy. | | Article | Cai, Yiqing;Chen, Xiaomin;Lu, Tiange;Fang, Xiaosheng;Ding, Mengfei;Yu, Zhuoya;Hu, Shunfeng;Liu, Jiarui;Zhou, Xiangxiang;Wang, Xin |
| Int. J. Biol. Sci. | 19 | 14 | 2023 | 4627 - 4643 | 10.7150/ijbs.85236 | 1449-2288 |
| Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma | Genomic instability is a significant driver of cancer. As the sensor of cytosolic DNA, the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a critical role in regulating anti-tumor immunity and cell death. However, the role and regulatory mechanisms of STING in diffuse large B-cell lymphoma (DLBCL) are still undefined. In this study, we reported that sterile alpha motif and HD domain-containing protein 1 (SAMHD1) deficiency induced STING expression and inhibited tumor growth in DLBCL. High level of SAMHD1 was associated with poor prognosis in DLBCL patients. Down-regulation of SAMHD1 inhibited DLBCL cell proliferation both in vitro and in vivo. Moreover, we found that SAMHD1 deficiency induced DNA damage and promoted the expression of DNA damage adaptor STING. STING overexpression promoted the formation of Caspase 8/RIPK3/ASC, further leading to MLKL phosphorylation, Caspase 3 cleavage, and GSDME cleavage. Up-regulation of necroptotic, apoptotic, and pyroptotic effectors indicated STING-mediated PANoptosis. Finally, we demonstrated that the STING agonist, DMXAA, enhanced the efficacy of a PD-L1 inhibitor in DLBCL. Our findings highlight the important role of STING-mediated PANoptosis in restricting DLBCL progression and provide a potential strategy for enhancing the efficacy of immune checkpoint inhibitor agents in DLBCL. | | Article | Sun, Minghao;Wei, Siming;Liu, Jiarui;Wang, Luyao;Zhang, Yu;Hu, Limin;Piao, Jingxi;Liang, Zhao;Jiang, Hongwei;Xin, Dawei;Zhao, Ying;Chen, Qingshan;Foyer, Christine H.;Liu, Chunyan;Qi, Zhaoming |
| Theor. Appl. Genet. | 136 | 10 | 2023 |
| 10.1007/s00122-023-04461-4 | 1432-2242 |
| The impact of GmTSA and GmALS on soybean salt tolerance: uncovering the molecular landscape of amino acid and secondary metabolism pathways | Key message: GmTSA and GmALS were screened out for salt stress in soybean and explore the poteintial amino acid secondary metabolism pathways. Abstract: Soybean (Glycine max L.) is an oil and protein crop of global importance, and salinity has significant effects on soybean growth. Here, a population of soybean chromosome segment substitution lines was screened to identify highly salt-tolerant lines. In total, 24 quantitative trait loci (QTLs) on seven chromosomes were associated with salt tolerance, and CSSL_R71 was selected for further analysis. Although numerous genes were differentially expressed in CSSL_R71 in response to salt statically no differently, transcript levels of classical salt-response genes, including those of the salt overly sensitive pathway. Rather, salt tolerance in CSSL_R71 was associated with changes in amino acid and lipid metabolism. In particular, changes in p-coumaric acid, shikimic acid, and pyrrole-2-carboxylic acid levels accompanied salt tolerance in CSSL_R71. Eleven differentially expressed genes (DEGs) related to amino acid and secondary metabolism were identified as candidate genes on the substituted chromosome fragment. Six of these showed differences in coding sequence between the parental genotypes. Crucially, overexpression of GmTSA (Glyma.03G158400, tryptophan synthase) significantly enhanced salt tolerance in soybean hairy roots, whereas overexpression of GmALS (Glyma.13G241000, acetolactate synthase) decreased salt tolerance. Two KASP markers were developed for GmALS and used to genotype salt-tolerant and salt-sensitive lines in the CSSL population. Non-synonymous mutations were directly associated with salt tolerance. Taken together, these data provide evidence that changes in amino acid and secondary metabolism have the potential to confer salt tolerance in soybean. | | Article | Wang, Jianhui;Hu, Zikai;Liu, Jiarui;Zhang, Yuanqing;Gu, Yixiang;Huang, Weicong;Tang, Ruizhi;Wang, Fang |
| Actuators | 12 | 9 | 2023 |
| 10.3390/act12090364 | 2076-0825 |
| Adaptive Self-Triggered Control for Multi-Agent Systems with Actuator Failures and Time-Varying State Constraints | This work focuses on the consensus problem for multi-agent systems (MASs) with actuator failures and time-varying state constraints, and presents a fixed-time self-triggered consensus control protocol. The use of time-varying asymmetrical barrier Lyapunov functions (BLF) avoids the violation of time-varying state constraints in MASs, ensuring stability and safety. Meanwhile, the system’s performance is further enhanced by leveraging the proposed adaptive neural networks (NNs) control method to mitigate the effects of actuator failures and nonlinear disturbances. Moreover, a self-triggered mechanism based on a fixed-time strategy is proposed to reach rapid convergence and conserve bandwidth resources in MASs. The mechanism achieves consensus within a predefined fixed time, irrespective of the system’s initial states, while conserving communication resources. Finally, the proposed method’s effectiveness is confirmed through two simulation examples, encompassing diverse actuator failure scenarios. | | Article | Chen, Run;Wang, Jiatong;Peng, Zhongze;Liu, Jiarui;Zhang, Min |
| Opt. Mater. | 145 |
| 2023 |
| 10.1016/j.optmat.2023.114380 | 0925-3467 |
| Flexible all-optical terahertz switch based on electromagnetically induced transparent-like metamaterial | The electromagnetically induced transparent-like metamaterials have received much attention because of their excellent slow-light properties and strong nonlinear effects. They have many promising applications in novel terahertz functional devices, high-sensitivity sensors, and optical storages. In this paper, a flexible terahertz switching device based on the electromagnetically induced transparent-like effect was proposed. The device exhibited a significant slow light phenomenon without pumped laser. Meanwhile, it is demonstrated that the device has a large modulation depth and excellent tunable slow light performance with low-power pumped laser. Its amplitude modulation depth can reach 60.4% and the group delay modulation can reach 32.5 ps. And the minimum group velocity of the device in slow terahertz light can reach 0.69 × 10 m/s. Moreover, the flexible substrate of the proposed device is not easily damaged. It makes the device suited for more complex environments well. Therefore, the device will have great potential for future research on high-performance terahertz switching devices. | | Article | Zhou, Luhua;Fang, Junyi;Xiong, Zimo;Wu, Weifeng;Liu, Jiarui;Lu, Qiao;Ling, Hongqing;Kong, Danyu |
| Bull. Bot. Res. | 43 | 5 | 2023 | 657 - 666 | 10.7525/j.issn.1673-5102.2023.05.003 | 1673-5102 |
| Evaluation on Waterlogging Tolerance of Different Tomato Germplasm | To screen out the tomato(Solanum)germplasm with waterlogging tolerance, 50 tomato germplasm were selected as the research object, and the survival rate and physiological indexes were compared after semi-submerged and submerged treatments respectively. The results showed that 12 waterlogging tolerant tomato germplasm with 100% survival rate after seven days submergence treatment were selected, and 12 waterlogging-tolerant germplasm were observed and distributed in S. lycopersicum, S. lycopersicum var. cerasiforme and S. pimpinellifolium respectively. Further analysis on waterlogging-tolerant tomato TK017 and waterlogging-sensitive tomato TK039 revealed that tomato TK017 could control the content of reactive oxygen species more effectively under submergence condition, and improved the waterlogging tolerance of tomato. | | Article | Li, Qizhi;Huang, Hsiao-Yu;Ren, Tianshuang;Weschke, Eugen;Ju, Lele;Zou, Changwei;Zhang, Shilong;Qiu, Qingzheng;Liu, Jiarui;Ding, Shuhan;Singh, Amol;Prokhnenko, Oleksandr;Huang, Di-Jing;Esterlis, Ilya;Wang, Yao;Xie, Yanwu;Peng, Yingying |
| Phys. Rev. Lett. | 131 | 11 | 2023 |
| 10.1103/PhysRevLett.131.116002 | 0031-9007 |
| Prevailing Charge Order in Overdoped La2-xSrxCuO4 beyond the Superconducting Dome | The extremely overdoped cuprates are generally considered to be Fermi liquid metals without exotic orders, whereas the underdoped cuprates harbor intertwined states. Contrary to this conventional wisdom, using Cu L3-edge and O K-edge resonant x-ray scattering, we reveal a charge order (CO) correlation in overdoped La2-xSrxCuO4 (0.35≤x≤0.6) beyond the superconducting dome. This CO has a periodicity of ∼6 lattice units with correlation lengths of ∼20 lattice units. It shows similar in-plane momentum and polarization dependence and dispersive excitations as the CO of underdoped cuprates, but its maximum intensity differs along the c direction and persists up to 300 K. This CO correlation cannot be explained by the Fermi surface instability and its origin remains to be understood. Our results suggest that CO is prevailing in the overdoped metallic regime and requires a reassessment of the picture of overdoped cuprates as weakly correlated Fermi liquids. | | Article | Liu, Jiarui;Fu, Yuchen |
| Energy | 284 |
| 2023 |
| 10.1016/j.energy.2023.129242 | 0360-5442 |
| Decomposition spectral graph convolutional network based on multi-channel adaptive adjacency matrix for renewable energy prediction | The intermittence and randomicity of renewable energy can seriously disrupt its productivity and reliability, particularly in unforeseen circumstances. Yet, most existing renewable energy prediction (REP) methods fail to model the inter-temporal correlations among input variables and suffer from impractical decomposition process, resulting in less good prediction accuracy. Aiming to improve these issues and power REP technique to better serve modern society, this work proposes a novel decomposition spectral graph convolutional network, named DASGCN, as a general solution for REP. Compared with existing REP models, DASGCN has two main characteristics: (1) It incorporates a carefully designed decomposition block which can decompose input multivariate time series efficiently, (2) A multi-channel adaptive adjacent matrix is proposed to model the complex correlation among entangled input variables automatically and generate the interpretable graph structure without prior domain knowledge. The comprehensive experiments on four real-world datasets demonstrate that the proposed DASGCN can significantly outperform benchmark models and achieve high performance on wind speed, wind power, solar radiation and photovoltaic power prediction tasks. | | Article | Qiu, Zining;Yang, Xiaodan;Ni, Bowen;Liu, Jiarui;Sun, Hongming;Chen, Jing;Li, Cheng-Peng;Du, Miao |
| Mater. Chem. Front. | 7 | 21 | 2023 | 5439 - 5446 | 10.1039/d3qm00682d | 2052-1537 |
| A superhydrophilic self-supported nickel/terbium oxide electrode for the alkaline hydrogen evolution reaction at high current density | The development of highly efficient and robust non-noble-metal electrocatalysts for the alkaline hydrogen evolution reaction at high current density is the key for industrialization of anion exchange membrane water electrolysis. This work develops a new-style superhydrophilic self-supported Ni/Tb2O3 electrocatalyst, which shows excellent catalytic performance for the alkaline HER, with a low overpotential of 71.4 mV at −10 mA cm, a low Tafel slope of 43.9 mV dec, and robust stability at a high current density of 500 mA cm. The incorporated Tb2O3 with high oxophilicity promotes the water dissociation, thereby facilitating the Volmer step of the alkaline HER. The electronic redistribution in the Ni/Tb2O3 heterostructure optimizes the hydrogen adsorption energy of Ni, thus synergistically accelerating the HER kinetics. Moreover, the thermodynamically stable Tb2O3 mitigates the oxidation corrosion of Ni, thus improving its catalytic stability. In addition, the superhydrophilic self-supported electrode structure of Ni/Tb2O3 expedites the electron conduction and accelerates the gas bubble release timely for the production of H2, further enhancing the catalytic activity and stability at high current density. | | Article | Zhang, Yi;Liu, Jiarui;Liang, Jun;Lang, Jie;Zhang, Lijia;Tang, Mingwen;Chen, Xinyu;Xie, Yan;Zhang, Jianlin;Su, Liyu;Wang, Xin |
| BMC Med. Educ. | 23 | 1 | 2023 |
| 10.1186/s12909-023-04746-8 | 1472-6920 |
| Online education isn’t the best choice: evidence-based medical education in the post-epidemic era—a cross-sectional study | Background: The COVID-19 pandemic led many educational institutions to shift to online courses, making blended education a significant trend in teaching. We examined the effectiveness of blended learning in an evidence-based medicine course. Methods: We compared the examination scores of a blended learning group, an online only group, and a traditional offline group and conducted a questionnaire survey on students’ preferences for different learning modes and the reasons for their preferences. A total of 2100 undergraduate students in clinical medicine were included in this cross-sectional study. Examination results were collected, and questionnaires were administered to the study participants. We compared the mean scores and exam pass rates of the three teaching groups using ANOVA and ctest for multiple comparisons. Results: The blended group’s exam scores and pass rate were significantly higher than those of the offline and online groups. Furthermore, 71.6% preferred the blended teaching mode. In the survey on " learning effectiveness”, the majority of the students believed that blended education could better enhance the initiative of learning, the interest of the course, the pertinence of the learning content, the comprehension of evidence-based medical thinking, and the basic skills of evidence-based practice. Subsequently, in a questionnaire administered to a blended group of students, their foremost reason for liking online instruction was ‘flexible in time and space’ (99%), followed by ‘can be viewed repeatedly, facilitating a better understanding of knowledge points’ (98%). Their foremost reason for liking offline teaching was ‘helps to create a good learning atmosphere’ (97%), followed by ‘teachers can control students’ learning status in real time’ (89%). Conclusions: This study explored the effectiveness of learning in evidence-based medicine courses by comparing the learning outcomes and personal perceptions of three different teaching modes. This is the first cross-sectional study in which three different teaching models are compared and discussed in an evidence-based medicine course. We also elaborate on the specific instructional protocols for each model. This study shows that using a blended education approach in evidence-based medicine courses can improve students’ learning motivation, autonomy, and satisfaction. It also enhances instructional efficiency, thereby improving students’ understanding of the course content. | | Conference Paper | Li, Zhichao;Zhang, Chunguang;Liu, Jiarui;Chu, Shuai;Gong, Yingjiao;Geng, Wei |
| Proc. - IEEE World Conf. Appl. Intell. Comput., AIC |
|
| 2023 | 923 - 927 | 10.1109/AIC57670.2023.10263887 |
|
| Study on Pulse Low-Frequency Excitation Model and its Winding Technology | In this paper, we propose and discuss a new excitation model for low-frequency electromagnetic induction. First, the hardware principle and frequency domain mathematical expression of the model are given, and then the gain equation with the traditional RLC resonance model is obtained. In order to accurately obtain the inductance of the excitation winding under different structures, the factors affecting self-induction and mutual inductance of the solenoid multi-layer winding are analyzed in detail. Finally, through reasonable assumptions and the characteristics of inductance processing, the gain equation is necessary to be deformed and simplified, and is directly displayed in the three-dimensional surface graph. | | Article | Liu, Jiarui;Li, Xinli;Li, Chaojie;Yang, Guotian;Li, Yaqi;Qiu, Jing;Dong, Zhao Yang |
| IEEE Trans. Instrum. Meas. | 72 |
| 2023 |
| 10.1109/TIM.2023.3324347 | 1557-9662 |
| When Deep Normal Behavior Models Meet Fault Samples: A Generalized Wind Turbine Anomaly Detection Scheme | Anomaly detection (AD) is of great importance to wind turbine (WT) prognostic health management systems. With the rising application of deep learning (DL), both deep regression- and deep reconstruction-based normal behavior modeling (NBM) methods have shown great promise for WT AD. However, massive missing and false alarms still could be witnessed in existing methods due to the lack of effective mining of interdependent relationships between normal and anomalies. Hence, this article proposes a generalized Siamese NBM scheme that can be applied to most existing backbones. By considering fault samples, a parameter-shared backbone and two auxiliary regularization terms are designed to explore characteristics between anomaly and normal. To alleviate the dependence on manual annotation for fault instances, a density-based clustering algorithm is adopted for the predefined outliers chosen. Furthermore, to enhance the trustworthiness of the proposed scheme, we implement a label correction based on temporal neighbor consistency. The experimental results show that the proposed Siamese NBM scheme improves state-of-the-art studies greatly. The outliers filtered by clustering can work as manually labeled samples without large fluctuation, also providing discriminative information. The label correction method can not only improve the reliability of the proposed Siamese NBM scheme but also the comparative deep methods, especially for those weak anomaly detectors. | | Article | Huang, Guojing;Wang, Zhiyu;Liu, Jiarui;Chen, Hua;Yu, Faxin |
| IEICE Electron. Express | 20 | 19 | 2023 |
| 10.1587/elex.20.20230358 | 1349-2543 |
| An enhanced peak limited digital predistortion based on indirect learning architecture | The peak power of the digital predistortion (DPD) will be uncontrollably expand when the power amplifier (PA) is driven in the oversaturated state. To solve this problem, this letter proposes a peak limited digital predistortion method. By filtering the data used for predistortion coefficient extraction, the peak power of the predistorted signal can be effectively controlled. The memory effect of PA is considered during the data filtering. Less data samples are needed for coefficient extraction, which reduces the computational cost. Simulation verifies the effectiveness of the proposed method, and experimental results show that the adjacent channel leakage ratio (ACLR) can have 12.4 dB improvement when the tested PA is operated in an oversaturated state. | | Article | Chen, Yu-Ru;Liu, Jia-Rui;Zheng, Wen-Ting;Yue, Zhi-Ying;Shen, Hong;Cheng, Xin-Liang;Wu, Zhi-Xu;Xie, Ping |
| Acta. Hydrobiol. Sinica. | 47 | 12 | 2023 | 1877 - 1888 | 10.7541/2023.2023.0089 | 1000-3207 |
| THE DRIVING FORCES FOR DOMINANT GENUS SUCCESSION OF PHYTOPLANKTON AND PROLIFERATION OF FILAMENTOUS CYANOBACTERIA: A CASE STUDY OF QIANDAOHU RESERVOIR | As the primary producers of aquatic ecosystems, phytoplankton communities play important roles in shaping ecosystem stability and function. In recent years, the excessive proliferation and algal bloom of filamentous cyanobac-teria in many oligo-mesotrophic reservoirs have been reported more and more frequently. In order to explore the driving forces of dominant genus succession of phytoplankton and the mechanism of excessive proliferation of filamentous cyanobacteria in large reservoirs, the Qiandaohu Reservoir was chosen as the case study. The relationships between the variation of phytoplankton community structure and environmental factors during the period from 2017 to 2021 were studied. A total of 92 genera which belong to 8 phyla were identified in Qiandaohu Reservoir, which were mainly com-posed of Bacillariophyta, Chlorophyta and Cyanophyta. The results found that both the density and biomass of phyto-plankton in Qiandaohu Reservoir showed a yearly increasing trend, especially with regards to cyanobacterial density which increased significantly. In 2021, the annual average density and biomass of phytoplankton reached 1.54× 10 cells/L and 2.23 mg/L, respectively, which increased by 161.02% and 52.74% compared with 2017. During the period from 2017 to 2021, the dominant genus of cyanobacteria shifted from being dominated by Microcystis and Do-lichospermum to various filamentous cyanobacteria including Pseudanabaena, Leptolyngbya, Raphidiopsis, and Do-lichospermum. The phytoplankton functional group (FG) analysis also showed similar result, with the main dominant functional group being various filamentous cyanobacteria H1, S1 and SN instead of M and heterocystous filamentous cya-nobacteria H1. During the monitoring period, the mean annual values of TN and TN/TP ratio in Qiandaohu Reservoir decreased significantly, while TP showed an increasing trend. The Mantel Test and SEM analysis indicated that the surface runoff input from rainfall contributed significantly to the increase in TP, and the increase in total biomass of phyto-plankton was significantly correlated with TP, WT, DO, pH, SD and Temp. The total density of phytoplankton was mainly by TN, WT, pH, SD, Pre and Temp. Moreover, the changes in density and biomass of cyanobacteria were both driven by TN, WT, pH, SD and Pre. The redundancy analysis (RDA) showed that the changes of dominant genera and dominant functional groups were jointly driven by TN, TP and WT. The responses of filamentous cyanobacteria to nutrition differed among genera. The dominant genera Pseudanabaena, Raphidiopsis and Leptolyngbya which belong to FGs S1 and SN were all negatively related to TN but Dolichospermum which belong to FGs H1 were positively correlated with TN and TP. The decrease of TN concentration might be one of the main reasons for the increase of the number of dominant filamentous cyanobacteria species in Qiandaohu Reservoir. The results of this study suggest that algal community composition in oligo-mesotrophic reservoirs are more susceptible to change caused by extreme climates (rainstorm, elevated temperature, etc.), nutrient inputs and water disturbances. Intense rainfall could increase water mix-ing and nutrient pulse supply, which might trigger excessive proliferation of filamentous cyanobacteria in reservoirs. The response of filamentous cyanobacteria to environmental factors are complex, which need to be further studied in different genera. Our study can provide important implications for the prediction, prevention and control of cyanobac-terial blooms in oligo-mesotrophic reservoirs. | | Article | Liu, Jia-Rui;Zhang, Jia-Le;Zhang, Hai-Cheng;Xu, Dao-Lin;Wen, Jing;Liu, Lei-Lei;Wang, Xin-Yu |
| Chuan Bo Li Xue. | 27 | 11 | 2023 | 1671 - 1684 | 10.3969/j.issn.1007-7294.2023.11.009 | 1007-7294 |
| Optimization study on stiffness configuration of flexible connectors for rectangular array-type floating platform | A modularized very large floating platform forms a multi-oscillator system with flexible-rigid-flu⁃ id coupling. The flexible connectors are one of the most important parts of a multi-module floating platform, appropriate configuration of connectors’stiffness is helpful to improve the safety and stability of the system. The dynamic model of a rectangular array-type floating platform was established based on linear wave theory and related dynamics theories. The linear weighted sum method and genetic algorithm (GA) were used for op⁃ timizing stiffness configuration of flexible connectors of the rectangular array-type floating platform under three typical layouts. A series of optimal stiffness configuration results were obtained by changing the weights of the optimization indexs and the relative displacement constraints, the general laws of connectors’stiffness configuration for the rectangular array-type floating platform and the loads’coupling effect between two-di⁃ rectional-layout connectors were studied, which provide guidance for the design of connectors’stiffness con⁃ figuration of rectangular array-type floating platforms under different arrangements. | | Article | Xu, Jiabing;Liu, Jiarui;Yao, Tianen;Li, Yang |
| Big Data | 11 | 5 | 2023 | 355 - 368 | 10.1089/big.2021.0365 | 2167-647X |
| Prediction and Big Data Impact Analysis of Telecom Churn by Backpropagation Neural Network Algorithm from the Perspective of Business Model | This study aims to transform the existing telecom operators from traditional Internet operators to digital-driven services, and improve the overall competitiveness of telecom enterprises. Data mining is applied to telecom user classification to process the existing telecom user data through data integration, cleaning, standardization, and transformation. Although the existing algorithms ensure the accuracy of the algorithm on the telecom user analysis platform under big data, they do not solve the limitations of single machine computing and cannot effectively improve the training efficiency of the model. To solve this problem, this article establishes a telecom customer churn prediction model with the help of backpropagation neural network (BPNN) algorithm, and deploys the MapReduce programming framework on Hadoop platform. Using the data of a telecom company, this article analyzes the loss of telecom customers in the big data environment. The research shows that the accuracy of telecom customer churn prediction model in BPNN is 82.12%. After deploying large data sets, the learning and training time of the model is greatly shortened. When the number of nodes is 8, the acceleration ratio of the model remains at 60 seconds. Under big data, the telecom user analysis platform not only ensures the accuracy of the algorithm, but also solves the limitations of single machine computing and effectively improves the training efficiency of the model. Compared with that of the existing research, the accuracy of the model is improved by 25.36%, and the running time is shortened by about twice. This business model based on BPNN algorithm has obvious advantages in processing more data sets, and has great reference value for the digital-driven business model transformation of the telecommunications industry. | | Article | Cui, Lipeng;Liu, Jiarui |
| IEEE Access | 11 |
| 2023 | 123830 - 123845 | 10.1109/ACCESS.2023.3329573 | 2169-3536 |
| Virtual Human: A Comprehensive Survey on Academic and Applications | As a creative method for virtual human individuals based on multiple fusion technologies such as artificial intelligence, computer graphics, and speech synthesis, virtual human technology has developed rapidly since its birth, and continuous discussions and studies have been conducted in both academia and industry. Starting from the film and television industries, the cross-disciplinary application of virtual human has been continuously recognized and applied in fields such as media, games, and finance. Although virtual human has achieved sufficient development and innovation, it faces many challenges such as emotion recognition, privacy, and security, as well as the uncanny valley effect. This article starts with the development history of virtual human and analyzes the current academic research status and application scenarios in combination with the characteristics, technical architecture, and application of virtual human technology. At the same time, this article sorts out seven mainstream application scenarios of virtual human and analyzes their main advantages and possible future challenges. This article provides a valuable reference for subsequent related research by exploring development trends, application fields, and future research trends in virtual human. | | Article | Yin, Kangli;Qiao, Tianci;Zhang, Yongkang;Liu, Jiarui;Wang, Yuzhen;Qi, Fei;Deng, Junlin;Zhao, Cheng;Xu, Yongcheng;Cao, Yemin |
| BMJ Open Diabetes Res. Care | 11 | 6 | 2023 |
| 10.1136/bmjdrc-2023-003523 | 2052-4897 |
| Unraveling shared risk factors for diabetic foot ulcer: A comprehensive Mendelian randomization analysis | Introduction Diabetic foot ulcer (DFU) stands as a severe diabetic lower extremity complication, characterized by high amputation rates, mortality, and economic burden. We propose using Mendelian randomization studies to explore shared and distinct risk factors for diabetic lower extremity complications. Research design and methods We selected uncorrelated genetic variants associated with 85 phenotypes in five categories at the genome-wide significance level as instrumental variables. Genetic associations with DFU, diabetic polyneuropathy (DPN), and diabetic peripheral artery disease (DPAD) were obtained from the FinnGen and UK Biobank studies. Results Body mass index (BMI) emerged as the only significant risk factor for DPAD, DPN, and DFU, independent of type 2 diabetes, fasting glucose, fasting insulin, and HbA1c. Educational attainment stood out as the sole significant protective factor against DPAD, DPN, and DFU. Glycemic traits below the type 2 diabetes diagnosis threshold showed associations with DPAD and DPN. While smoking history exhibited suggestive associations with DFU, indicators of poor nutrition, particularly total protein, mean corpuscular hemoglobin, and mean corpuscular volume, may also signal potential DFU occurrence. Conclusions Enhanced glycemic control and foot care are essential for the diabetic population with high BMI, limited education, smoking history, and indicators of poor nutrition. By focusing on these specific risk factors, healthcare interventions can be better tailored to prevent and manage DFU effectively. | | Article | Zhang, Yongkang;Zong, Yuan;Liu, Jiarui;Yin, Kangli;Wang, Yuzhen;Bian, Yuefeng;Huang, Yichen;Liu, Wei;Cao, Yemin |
| Cerebrovasc. Dis. Extra | 13 | 1 | 2023 | 83 - 89 | 10.1159/000534466 | 1664-5456 |
| Clopidogrel-Related High Residual Platelet Reactivity Associated with Estimated Glomerular Filtration Rate in Patients with Acute Ischemic Stroke | Introduction: There are few studies on the relationship between the occurrence of clopidogrel-related high residual platelet reactivity (HRPR) and estimated glomerular filtration rate (eGFR) at admission in patients with ischemic stroke. The aim of this study was to investigate the possible relationship between the two. Methods: Patients who were hospitalized and diagnosed with acute ischemic stroke were recruited from July 1, 2017, to June 30, 2018, at Shanghai TCM-Integrated Hospital. Renal function was measured within 24 h of enrollment and eGFR was calculated. Patients were tested for platelet reactivity using the VerifyNow system after 7 days of antiplatelet therapy with clopidogrel 75 mg/d alone, and patients with P2Y12 reaction unit values ≥230 were diagnosed with HRPR. The association between HRPR and eGFR was analyzed. Results: A total of 274 patients were enrolled in the study, of whom 91 (33.21%) had HRPR. Multivariate logistic regression analysis suggested that an increased risk of HRPR was independently associated with female sex and reduced eGFR (female sex: OR = 2.24, 95% CI: 1.26-3.99, p = 0.006; mild chronic kidney disease [CKD]: OR = 2.95, 95% CI: 1.47-5.93, p = 0.002; moderate CKD: OR = 3.07, 95% CI: 1.08-8.75, p = 0.04). Conclusion: Decreased eGFR is an independent risk factor for the occurrence of HRPR in patients with ischemic stroke. | | Article | Liu, Yingyue;Chu, Yurou;Liu, Jiarui;Ge, Xueling;Ding, Mei;Li, Peipei;Liu, Fang;Zhou, Xiangxiang;Wang, Xin |
| Ann. Med. | 55 | 2 | 2023 |
| 10.1080/07853890.2023.2282652 | 1365-2060 |
| Incidence and mortality of second primary malignancies after lymphoma: a population-based analysis | Background: Second primary malignancies (SPMs) account for an increasing proportion of human malignancies. We estimated the incidence, risk factors and outcomes in lymphoma survivors with SPMs. Methods: Patients diagnosed with SPMs after primary lymphoma from 2010 to 2021 were included in this study. The incidence, mortality and clinical characteristics of SPMs in our center and Surveillance, Epidemiology, and End Results database were delineated and analyzed. Standardized incidence ratio quantified second cancer risk. Results: A total of 2912 patients of lymphoma were included, 63 cases of SPM met the inclusion criteria, with the prevalence of SPMs after lymphoma was 2.16%. The male-to-female ratio of 2.32:1. The majority of these patients were older (≥60 years old, 61.90%) and previously treated with chemotherapy (68.25%). The common types among SPMs were digestive system tumors (42.86%), respiratory system tumors (20.63%) and urinary system tumors (12.70%). Additionally, cancer risks were significantly elevated after specific lymphoma though calculating the expected incidence. In terms of mortality, the diagnosis of SPMs was significantly associated with an increased risk of death over time. Moreover, although the outcome was favorable in some SPM subtypes (thyroid and breast cancer), other SPMs such as stomach and lung tumors had a dismal prognosis. Conclusion: With the improvement of medical standards, the survival of lymphoma patients has been prolonged. However, the incidence of SPM is increasing, particularly among men and older lymphoma survivors. Therefore, more attention should be invested in the SPM to further improve the prognosis of these patients. | | Article | Krause, Sebastian J. E.;Liu, Jiarui;Yousavich, David J.;Robinson, DeMarcus;Hoyt, David W.;Qin, Qianhui;Wenzhöfer, Frank;Janssen, Felix;Valentine, David L.;Treude, Tina |
| Biogeosciences | 20 | 20 | 2023 | 4377 - 4390 | 10.5194/bg-20-4377-2023 | 1726-4189 |
| Evidence of cryptic methane cycling and non-methanogenic methylamine consumption in the sulfate-reducing zone of sediment in the Santa Barbara Basin, California | The recently discovered cryptic methane cycle in the sulfate-reducing zone of marine and wetland sediment couples methylotrophic methanogenesis to anaerobic oxidation of methane (AOM). Here we present evidence of cryptic methane cycling activity within the upper regions of the sulfate-reducing zone, along a depth transect within the Santa Barbara Basin, off the coast of California, USA. The top 0-20 cm of sediment from each station was subjected to geochemical analyses and radiotracer incubations using 35S-SO4C-mono-methylamine, and C-CH4 to find evidence of cryptic methane cycling. Methane concentrations were consistently low (3 to 16 μM) across the depth transect, despite AOM rates increasing with decreasing water depth (from max 0.05 nmol cm d at the deepest station to max 1.8 nmol cm d at the shallowest station). Porewater sulfate concentrations remained high (23 to 29 mM), despite the detection of sulfate reduction activity from 35S-SO4 incubations with rates up to 134 nmol cm d. Metabolomic analysis showed that substrates for methanogenesis (i.e., acetate, methanol and methylamines) were mostly below the detection limit in the porewater, but some samples from the 1-2 cm depth section showed non-quantifiable evidence of these substrates, indicating their rapid turnover. Estimated methanogenesis from mono-methylamine ranged from 0.2 to 0.5 nmol cm d. Discrepancies between the rate constants (k) of methanogenesis (from C-mono-methylamine) and AOM (from either C-mono-methylamine-derived C-CH4 or from directly injected C-CH4) suggest the activity of a separate, concurrent metabolic process directly metabolizing mono-methylamine to inorganic carbon. We conclude that the results presented in this work show strong evidence of cryptic methane cycling occurring within the top 20 cm of sediment in the Santa Barbara Basin. The rapid cycling of carbon between methanogenesis and methanotropy likely prevents major build-up of methane in the sulfate-reducing zone. Furthermore, our data suggest that methylamine is utilized by both methanogenic archaea capable of methylotrophic methanogenesis and non-methanogenic microbial groups. We hypothesize that sulfate reduction is responsible for the additional methylamine turnover, but further investigation is needed to elucidate this metabolic activity. | | Article | Wang, Li;Liu, Jiarui;Bao, Zhen;Ma, Xufa;Shen, Hong;Chen, Jun;Xie, Ping |
| Sci. Total Environ. | 912 |
| 2024 |
| 10.1016/j.scitotenv.2023.168981 | 1879-1026 |
| Predictable shifts in diversity and ecosystem function in phytoplankton and zooplankton communities along thermocline stratification intensity continua | Thermocline stratification is a global threat to water quality in drinking water reservoirs, though its underlying mechanisms are not clear. The impacts of thermocline stratification intensity on biodiversity-ecosystem relationships were assessed using phytoplankton and zooplankton indicators from four stages of stratification in Lake Qiandaohu. There were significant differences in biomass, species diversity, and resource use efficiency (RUEpp = phytoplankton biomass/total phosphorus) for phytoplankton between continuous stratification and mixing periods, but only in FDis and RaoQ diversity indices for zooplankton. Phytoplankton species diversity and RUE were higher in the formative and stable periods, while zooplankton species diversity and zooplankton biomass/phytoplankton biomass (RUEzp) were lower. When combining the data from the four periods, a negative linear pattern was found between phytoplankton Simpson's, functional dispersion (FDis), and Rao's Quadratic (RaoQ) diversity indices, and thermocline depth (TD). Only zooplankton FDis and RaoQ diversity indices were significantly positively related to TD. Phytoplankton RUE was significantly negatively related only to its Pielou's evenness (J) diversity, while zooplankton RUE was significantly negatively related to its J, FDis, and RaoQ diversity indices. The results of structural equation models (SEMs) showed that the R of RUE for phytoplankton was much higher than that for zooplankton. Thermocline stratification intensity exerted an indirect positive effect on phytoplankton RUE by affecting species diversity but had a negative effect on zooplankton RUE. These findings underscore the negative influence of thermocline stratification resulting in various biodiversity changes in freshwater ecosystems. | | Article | Liu, Jia-Rui;Chen, Bo-Xue;Huang, Jia-Qi;Li, Xue;Cui, Tian-Yi;Lv, Bin;Fu, Zhi-Fei;Zhao, Xin;Yang, Wen-Zhi;Gao, Xiu-Mei |
| J. Pharm. Biomed. Anal. | 239 |
| 2024 |
| 10.1016/j.jpba.2023.115911 | 1873-264X |
| Fingerprinting and characterization of the polysaccharides from Polygonatum odoratum and the in vitro fermented effects on Lactobacillus johnsonii | Polygonatum odoratum (Yu-Zhu) can be utilized to treat the digestive and respiratory illness. Previous studies have revealed that the underlying therapeutic mechanism of P. odoratum polysaccharides (POPs) is associated with remodeling the gut microbiota. However, POPs in terms of the chemical composition and fermentation activities have been understudied. Here we developed the three-level fingerprinting approaches to characterize the structures of POPs and probed into the beneficial effects on promoting the growth and fermentation of Lactobacillus johnsonii. POPs were prepared by water decoction followed by alcohol sedimentation, while trifluoroacetic acid under different conditions to prepare the hydrolyzed oligosaccharides and monosaccharides. POPs exhibited three main molecular distribution of 601–620 kDa, 4.12–6.09 kDa, and 3.57–6.02 kDa. Hydrolyzed oligosaccharides with degree of polymerization (DP) 2–13 got primarily characterized by analyzing the rich fragmentation information obtained by hydrophilic interaction chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (HILIC/IM-QTOF-MS). Amongst them, the DP5 oligosaccharide was characterized as 1,6,6-kestopentaose. The molecular ratio of Fru: Ara: Glc: Gal: Xyl was 87.72: 0.30: 11.56: 0.19: 0.23. In vitro fermentation demonstrated that 4.5 mg/mL of POPs could significantly promote the growth of L. johnsonii. Co-cultivated with 4.5 mg/mL of POPs, L. johnsonii exhibited stronger antimicrobial activity against Klebsiella pneumoniae. The concentrations of short-chain fatty acids in the POPs-lactobacilli fermented products, including acetic acid, isobutyric acid, and isovaleric acid, were increased. Conclusively, POPs represent the promising prebiotic candidate to facilitate lactobacilli, which is associated with exerting the health benefits. | | Conference Paper | Yang, Yubing;Zhang, Chunguang;Yu, Xiaochen;Liu, Jiarui |
| Int. Conf. Power Sci. Eng., ICPSE |
|
| 2023 | 79 - 85 | 10.1109/ICPSE59506.2023.10329294 |
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| Structural Optimization Design of Electromagnetic Boiler Heater Based on Multi-physical Field | In order to obtain the structure of electromagnetic boiler heater with maximum heat exchange efficiency, five parameters of heater: heating rod diameter, heating rod uniform distribution diameter, heating rod uniform distribution angle, non-metallic shell inner wall diameter and non-metallic shell wall thickness were selected as design parameters. Based on the multi-physical field coupling calculation, the response surface model and genetic algorithm were used to optimize the design parameters of the heater, and the structural parameters with the highest heat transfer efficiency were obtained. The heat transfer efficiency of the optimized heater reached 97.8 %, which was 5.8 % higher than that of the prototype heater structure. | | Article | Zhang, Ke;You, Xiuzhi;Liu, Xiaodong;Liu, Jiarui;Zhu, Wanhua |
| Electronics (Switzerland) | 12 | 24 | 2023 |
| 10.3390/electronics12244900 | 2079-9292 |
| Inversion of Target Magnetic Moments Based on Scalar Magnetic Anomaly Signals | As a key physical property of underwater ferromagnetic targets, magnetic moment can reflect important information such as the mass and heading of the target. However, most of the current magnetic moment estimation methods rely on vector magnetic field sensors or sensor arrays to measure the magnetic field, which limits its application in remote target magnetic moment calculation on mobile platforms to some extent. To solve this problem, a real-time magnetic moment inversion method based on the high-precision scalar magnetic measurement data of a high-speed moving platform is proposed in this paper. The method allows the estimation of the magnetic moment of underwater ferromagnetic targets by the scalar magnetic measurement data of an optical pump magnetic field sensor mounted on a high-speed moving platform. The experimental results show that this method has high precision in estimating magnetic moment; the average error of the magnetic moment amplitude was only 5.85%, while the average errors of the magnetic moment inclination and magnetic moment deflection were 1.58 and 2.79, respectively. These results provide a new and effective way to estimate the magnetic moment of underwater ferromagnetic targets and are expected to have important practical applications. | | Article | Zhang, Lingyan;Wang, Yun;Liu, Jiarui |
| Technol. Lang. | 4 | 3 | 2023 | 40 - 48 | 10.48417/technolang.2023.03.04 | 2712-9934 |
| Artistic Creation in Virtual Space | The purpose of this paper is to discuss the changes brought by artificial intelligence to future art creation and to explore how art creation in virtual space will unfold. The language, concepts, and ideas of art creation in the contemporary age are rapidly transforming. The further development of digital technology makes it possible to create in a virtual space, and we no longer need to rely on the presence of analogical tools to create excellent works. Virtual reality and augmented reality technologies have been able to bring the integration of human and virtual environments to a new level, and the language of art is being redefined. By sorting out the relationship between art creation language and symbols and the future transformation of art creation language brought about by new media, this paper focuses on the changes in four aspects of future art creation: the transformation of art creation’s space, language, tools, and mode. Finally, this paper uses the practice of children's art education projects as an example to illustrate the form of art language expression in virtual space, and to provide a reference for the future art creation methods in virtual space. | | Article | Wang, Li;Liu, Jiarui;Bao, Zhen;Ma, Xufa;Shen, Hong;Xie, Ping;Chen, Jun |
| Sci. Total Environ. | 913 |
| 2024 |
| 10.1016/j.scitotenv.2023.169712 | 1879-1026 |
| Thermocline stratification favors phytoplankton spatial overlap and species diversity in a subtropical deep reservoir | Spatial segregation of species along opposing resource gradients is a major research topic in ecology as it enables the coexistence and maintenance of high diversity. Thermocline stratification causes heterogeneous resource distribution, however, the effect of thermocline stratification on phytoplankton dynamic in-depth profiles is still unclear. To understand the underlying mechanism behind the effects of thermocline stratification on phytoplankton species diversity in stratified lakes, the monthly changes in thermocline parameters, deep chlorophyll maxima (DCM) parameters, spatial overlap (SO) among major phytoplankton taxonomic groups, and phytoplankton species diversity were evaluated in Lake Qiandaohu in the Zhejiang Province of China from April 2017 to December 2018. Thermocline depth (TD) was significantly negatively related to thermocline strength (TS). The monthly air temperature was the main driver behind the thermocline and the seasonal thermal-stratification cycle was divided into two stratification stages. Significant linear relationships were observed between the DCM parameters (depth, concentration, and thickness) and TD during the strong stratification period. TD was significantly positively related to phytoplankton species diversity and the SO between Cryptophyta and Chlorophyta as well as between Cryptophyta and Bacillariophyta during weak stratification periods. Significant positive correlations were observed between SO and Shannon diversity during both periods. Structural equation modeling (SEM) showed that air temperature significantly decreased TD and increased species diversity by increasing SO during the strong stratification period. Strong stratification under warming favored the formation of shallower and thinner DCMs, leading to phytoplankton coexistence and maintenance of high species diversity through a preclusion of dominance. This study characterized the temporal dynamics of phytoplankton dynamic in-depth profiles in response to strong stratification from warming. | | Article | Dinh, Hong Lich;Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L. |
| Constr. Build. Mater. | 411 |
| 2024 |
| 10.1016/j.conbuildmat.2023.134741 | 0950-0618 |
| Influence of Si/Al molar ratio and ca content on the performance of fly ash-based geopolymer incorporating waste glass and GGBFS | This study delved into the utilization of waste glass powder (WGP) and ground granulated blast-furnace slag (GGBFS) as a binder and waste glass cullet (WGC) fine aggregate in fly ash (FA) based geopolymer concrete. The inherent characteristics of WGP, WGC, FA and GGBFS can be significantly altered by multiple factors such as sources, combustion temperatures, particle size, and impurity level. To offset the inconsistent characteristics of listed waste materials, this study provides a universal index to quantify and evaluate its reactivity to be used as aluminosilicate precursor and aggregate feedstock Ten distinct groups were examined: in five groups WG replaced fly ash at varying percentages (0, 10, 20, 30, 40%), and in five groups WG was used as a sand substitute with different fly ash and slag ratios (20, 40, 60, 80%). Alkali leaching tests were conducted on WGP, WGC, FA and GGBFS to determine the dissolubility and dissolution rate of reactive silica (Si) and calcium (Ca) within 3 h. The dissolubility and dissolution efficiency demonstrated decent correlations with the mechanical and durability properties of the resultant FA-based geopolymer. Leaching tests demonstrate that Ca from WGP, WGC, FA and GGBFS readily leaches out and reacts in both ambient and oven curing, while Si only exhibits activity primarily in high-temperature environments. Overall, the reactivity of Ca from GGBFS and WG improved by up to 50% and 30% in compressive strength and water absorption, respectively. Moreover, based on alkali leaching test, the most effective molar ratios (Si/Al=3.5–4) demonstrated the highest compressive strength (60–70 MPa), and verified intensively using scanning electron microscopy–energy-dispersive spectroscopy (SEM-EDS). Lastly, this study revealed that WGC as fine aggregate with the size of 20 µm also leached out a significant amount of Ca to the geopolymerization process. | | Review | Li, Yinlong;Liu, Guoqiang;Liu, Jiarui;Chen, Qi;Yan, Gang |
| J. Refrig. | 45 | 1 | 2024 | 1 - 17 | 10.3969/j.issn.0253-4339.2024.01.001 | 0253-4339 |
| Review of Research Progress on Auto-cascade Refrigeration Systems and Component Separation, Migration, and Regulation | Auto-cascade refrigeration technology has broad application prospects in refrigeration and cryogenic refrigeration owing to its wide operating temperature range, simplicity, and reliability. The construction of new refrigeration cycles and the diversification of mixtures have been extensively studied. The active regulation of mixture mass fraction in auto-cascade refrigeration systems to improve performance has been a technical bottleneck and research challenge. This study first reviews the state-of-the-art of auto-cascade refrigeration systems and describes the history of refrigeration cycles. Research on the component separation and migration characteristics of zeotropic mixtures, which affect system efficiency, is also summarized. Research on component separation is discussed in terms of refrigeration cycle improvement and the separation performance of the key component-the gas-liquid separator. The causes of component migration, the current status of research on component migration characteristics, and theoretical models of phase accumulation are summarized. Based on this, existing research methods for the regulation of zeotropic mixture components in auto-cascade refrigeration systems are presented. This study summarizes the current status and research directions of component optimization and control as a reference for further performance improvement of auto-cascade refrigeration systems. | | Review | Li, Yinlong;Liu, Guoqiang;Liu, Jiarui;Chen, Qi;Yan, Gang |
| J. Refrig. | 45 | 1 | 2024 | 1 - 17 | 10.3969/j.issn.0253-4339.2024.01.001 | 0253-4339 |
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| | Article | Yang, Qingxia;Chen, Shuman;Jiang, Wenyu;Mi, Lan;Liu, Jiarui;Hu, Yu;Ji, Xinglai;Wang, Jun;Zhu, Feng |
| Anal. Chem. | 96 | 4 | 2024 | 1410 - 1418 | 10.1021/acs.analchem.3c03212 | 1520-6882 |
| MultiClassMetabo: A Superior Classification Model Constructed Using Metabolic Markers in Multiclass Metabolomics | Multiclass metabolomics has become a popular technique for revealing the mechanisms underlying certain physiological processes, different tumor types, or different therapeutic responses. In multiclass metabolomics, it is highly important to uncover the underlying biological information on biosamples by identifying the metabolic markers with the most associations and classifying the different sample classes. The classification problem of multiclass metabolomics is more difficult than that of the binary problem. To date, various methods exist for constructing classification models and identifying metabolic markers consisting of well-established techniques and newly emerging machine learning algorithms. However, how to construct a superior classification model using these methods remains unclear for a given multiclass metabolomic data set. Herein, MultiClassMetabo has been developed for constructing a superior classification model using metabolic markers identified in multiclass metabolomics. MultiClassMetabo can enable online services, including (a) identifying metabolic markers by marker identification methods, (b) constructing classification models by classification methods, and (c) performing a comprehensive assessment from multiple perspectives to construct a superior classification model for multiclass metabolomics. In summary, MultiClassMetabo is distinguished for its capability to construct a superior classification model using the most appropriate method through a comprehensive assessment, which makes it an important complement to other available tools in multiclass metabolomics. MultiClassMetabo can be accessed at http://idrblab.cn/multiclassmetabo/. | | Article | Liu, Jiarui;Lin, Xinyi;Wang, Xiaojie;Feng, Liqing;Zhu, Shixin;Tian, Runmeng;Fang, Jingping;Tao, Aifen;Fang, Pingping;Qi, Jianmin;Zhang, Liwu;Huang, Yongji;Xu, Jiantang |
| BMC Plant Biol. | 24 | 1 | 2024 |
| 10.1186/s12870-024-04739-9 | 1471-2229 |
| Genomic and cytogenetic analyses reveal satellite repeat signature in allotetraploid okra (Abelmoschus esculentus) | Background: Satellite repeats are one of the most rapidly evolving components in eukaryotic genomes and play vital roles in genome regulation, genome evolution, and speciation. As a consequence, the composition, abundance and chromosome distribution of satellite repeats often exhibit variability across various species, genome, and even individual chromosomes. However, we know little about the satellite repeat evolution in allopolyploid genomes. Results: In this study, we investigated the satellite repeat signature in five okra (Abelmoschus esculentus) accessions using genomic and cytogenetic methods. In each of the five accessions, we identified eight satellite repeats, which exhibited a significant level of intraspecific conservation. Through fluorescence in situ hybridization (FISH) experiments, we observed that the satellite repeats generated multiple signals and exhibited variations in copy number across chromosomes. Intriguingly, we found that five satellite repeats were interspersed with centromeric retrotransposons, signifying their involvement in centromeric satellite repeat identity. We confirmed subgenome-biased amplification patterns of these satellite repeats through existing genome assemblies or dual-color FISH, indicating their distinct dynamic evolution in the allotetraploid okra subgenome. Moreover, we observed the presence of multiple chromosomes harboring the 35 S rDNA loci, alongside another chromosomal pair carrying the 5 S rDNA loci in okra using FISH assay. Remarkably, the intensity of 35 S rDNA hybridization signals varied among chromosomes, with the signals predominantly localized within regions of relatively weak DAPI staining, associated with GC-rich heterochromatin regions. Finally, we observed a similar localization pattern between 35 S rDNA and three satellite repeats with high GC content and confirmed their origin in the intergenic spacer region of the 35 S rDNA. Conclusions: Our findings uncover a unique satellite repeat signature in the allotetraploid okra, contributing to our understanding of the composition, abundance, and chromosomal distribution of satellite repeats in allopolyploid genomes, further enriching our understanding of their evolutionary dynamics in complex allopolyploid genomes. | | Article | Yue, Zhiying;Chen, Yuru;Wu, Zhixu;Cheng, Xinliang;Bao, Zhen;Deng, Xuwei;Shen, Hong;Liu, Jiarui;Xie, Ping;Chen, Jun |
| J. Hazard. Mater. | 466 |
| 2024 |
| 10.1016/j.jhazmat.2024.133539 | 1873-3336 |
| Thermal stratification controls taste and odour compounds by regulating the phytoplankton community in a large subtropical water source reservoir (Xin'anjiang Reservoir) | 2-Methylisoborneol (2-MIB) and geosmin are compounds released by algae that significantly degrade reservoir water quality, posing a threat to both the safety of drinking water and the quality of aquatic products sourced from these environments. However, few studies have explored how enhanced thermal stratification affects the occurrence and regulation of odorants in large drinking water reservoirs. Through systematic monitoring and investigation of Xin'anjiang Reservoir, we found that enhanced thermal stratification promotes filamentous cyanobacteria, particularly Leptolyngbya sp., as the primary contributor to 2-MIB production within the 1–10 m layer of the water column. The highest 2-MIB concentration, 92.5 ng/L, was recorded in the riverine region, which was 2.54 and 14.52 times higher than that in the transitional and central parts of the reservoir, respectively. Temperature indirectly impacted algal growth and odorant production by modulating TN/TP ratios. Geosmin concentration responded rapidly to relatively low TN/TP ratios (< 25). Our findings suggest that phosphorus control in estuaries should be enhanced during thermal stratification period. In summary, our study provides valuable insights to inform pragmatic water intake strategies and the distribution and release of odorants caused by thermal stratification. This is particularly relevant in the context of future global warming and extremely high temperatures during the warm season. | | Article | Liu, Jiarui;Treude, Tina;Abbasov, Orhan R.;Baloglanov, Elnur E.;Aliyev, Adil A.;Harris, Carolynn M.;Leavitt, William D.;Young, Edward D. |
| Geology | 52 | 1 | 2024 | 22 - 26 | 10.1130/G51667.1 | 1943-2682 |
| Clumped isotope evidence for microbial alteration of thermogenic methane in terrestrial mud volcanoes | Methane in oil reservoirs originates mostly from thermogenic sources, yet secondary microbial methane production from petroleum biodegradation is known to be pervasive. The conventional approach for identifying this secondary microbial methane commonly relies on geochemical characteristics of other gas molecules such as the carbon isotopic composition of carbon dioxide and propane. This information is sometimes obscured by isotopic variations in source material and may not be available in certain geological reservoirs. To better constrain the presence of secondary microbial methane, we studied the clumped isotopologue compositions of methane in terrestrial Azerbaijanian mud volcanoes, which support the occurrence of secondary microbial gas. Here, a deficit in Δ12CH2D2 of thermogenic methane occurs due to different δD of hydrogen sources that contribute to the formation of methane molecules (i.e., combinatorial effect). The △12CH2D2 is expected to move toward equilibrium as thermal maturity increases. More importantly, both Δ13CH3D and Δ12CH2D2 values of methane approach low-temperature thermodynamic equilibrium in most gases, suggesting that the original thermogenic methane has been altered by newly formed microbial methane in addition to isotope exchange among methane molecules catalyzed by the methyl-coenzyme M reductase enzyme. We conclude that methane clumped isotopes provide a unique proxy for identifying secondary microbial methane and understanding the exact evolution stages for natural gases. | | Review | Liu, Jiarui;Xu, Yidong;Zhang, Wensheng;Ye, Jiayuan;Wang, Rui |
| Prog. Nucl. Energy | 169 |
| 2024 |
| 10.1016/j.pnucene.2024.105106 | 0149-1970 |
| Solidification performance and mechanism of typical radioactive nuclear waste by geopolymers and geopolymer ceramics: A review | The radioactive waste generated from nuclear fuel cycles poses significant risks to the natural environment and the health of surrounding residents. Thus, the utilization of appropriate solidification materials is essential for their safe disposal. Geopolymers, as a novel type of cementitious material, exhibit effective immobilization properties for radioactive nuclear waste. Moreover, the amorphous nature of geopolymers can transform into crystalline ceramics upon heat treatment, demonstrating enhanced and superior capability for immobilizing radionuclides. In this paper, we employ Citespace software to conduct a visual analysis of existing literature in the domains of “Geopolymer for radioactive waste immobilization” and “Geopolymer ceramics for radioactive waste immobilization.” Exploiting the physicochemical properties of geopolymers, we analyze their immobilization performance and mechanisms for typical radioactive nuclear waste. Building on this foundation, we delve into the ceramicization process of geopolymers, summarizing three enhanced methods for efficiently immobilizing Cs using geopolymer ceramics. Finally, the challenges and prospects of utilizing geopolymer and geopolymer ceramics for immobilizing radioactive nuclear waste are discussed. This offers novel research avenues for scientists to explore the development of geopolymers as cost-effective, high-performance materials to address the issue of radioactive waste contamination. | | Review | Liu, Jiarui;Xu, Yidong;Zhang, Wensheng;Ye, Jiayuan;Wang, Rui |
| Prog. Nucl. Energy | 169 |
| 2024 |
| 10.1016/j.pnucene.2024.105106 | 0149-1970 |
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| | Review | Liu, Jiarui;Xu, Yidong;Zhang, Wensheng;Ye, Jiayuan;Wang, Rui |
| Prog. Nucl. Energy | 169 |
| 2024 |
| 10.1016/j.pnucene.2024.105106 | 0149-1970 |
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| | Review | Liu, Jiarui;Xu, Yidong;Zhang, Wensheng;Ye, Jiayuan;Wang, Rui |
| Prog. Nucl. Energy | 169 |
| 2024 |
| 10.1016/j.pnucene.2024.105106 | 0149-1970 |
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| | Article | Liu, Jiarui;Liu, Ye |
| Case Stud. Therm. Eng. | 54 |
| 2024 |
| 10.1016/j.csite.2024.104071 | 2214-157X |
| Experimental investigation of a bypass two-circuit cycle refrigerator-freezer with low GWP zeotropic refrigerants | Based on the pursuit of lower temperatures and environmentally friendly refrigerants in domestic refrigerator-freezers, this paper investigates the performance of a hydrocarbon mixture R600/R290 in a bypass two-circuit cycle applied in −40 C frost-free refrigerator-freezer. With the aim of achieving a temperature below −40 C in the freezer compartment and saving energy consumption in the entire system, experiments are conducted to explore the optimal composition and charge of R600/R290. The results indicate that when the total charge of R290/R600 is 77 g and the mass fraction is 43 %/57 %, the freezer compartment can reach −40.6 C and has a low daily energy consumption of 1.514 kW h/24h at the ambient temperature of 32 C. In addition, the effect of fan voltage, which is used to characterize the airflow rate in the freezer compartment, on the system performance at different ambient temperatures is also studied. Under the premise that the charge of R290/R600 is 77 g and the mass fraction is 48 %/52 %, when the fan voltage is 7.5 V, the system daily energy consumption is the lowest. At this time, the system daily energy consumption at 25 C and 32 C ambient temperatures is 1.161 kW h/24h and 1.553 kW h/24h, respectively. | | Conference Paper | Zheng, Yeping;Li, Tingting;Li, Wei;Lei, Faxing;Liu, Jiarui;Fan, Yibo |
| Proc. Int. Conf. ASIC |
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| 2023 |
| 10.1109/ASICON58565.2023.10396052 | 2162-755X |
| A Low-Complexity Algorithm for JPEG-LS-Based RAW Domain Compression | In this paper, a novel lossless and near-lossless RAW image compression algorithm based on JPEG-LS is proposed. To achieve high performance and low complexity, the algorithm reduce the context module, merge the run mode with the regular mode and propose an adaptive Golomb-Rice coding technique. The algorithm mainly consists of four parts : pixel structure conversion, pixel prediction, run mode module and adaptive Golomb-Rice coding module. Compared to JPEG-LS, this algorithm achieves comparable performance to JPEG-LS while reducing complexity. Additionally, it allows users to adjust parameters to achieve lossless and near-lossless compression supporting random access and non-random access. | | Article | Zhang, Yifei;Xu, Shuxin;Liu, Jiarui;Zhang, Kaiyuan;Guan, Yu;Li, Shaoxiang |
| Appl. Surf. Sci. | 655 |
| 2024 |
| 10.1016/j.apsusc.2024.159645 | 0169-4332 |
| Carbon quantum dots enhanced polyurethane-urea nanocomposites with mechanical reinforcement and room-temperature self-healing performance | Developing high-performance polymer composites with self-healing and recyclable performance is crucial for long-term durability of the devices. This paper presents a novel method by incorporating carbon quantum dots (CQDs) into the chain extension reaction of polymers to construct self-healing polyurethane-urea (PUU) with excellent integrated mechanical and multi-recyclable properties. By the introduction of the CQDs with surface containing ample amide, carboxyl, and hydroxyl groups, the cross-linking networks are formed, and simultaneously, abundant H-bonds at the interface between CQDs nanospheres and PUU matrix provide strong interfacial interactions, which endows material reinforcement and self-healing effect. The addition of a very low amount of CQDs (0.15 wt%) can significantly improves the mechanical performance, especially the tensile stress and toughness, which increased about 74.4 % (35.2 MPa to 61.4 MPa) and 115.2 % (34.8 MJ·m to 74.9 MJ·m), respectively. Besides, unlike other nanofillers, the addition of CQDs (more than 1 wt%) enables the PUU with excellent self-healing and recycling properties, and for 3 wt% addition, the room temperature self-healing efficiency can even achieve 97.0 % for 24 h without external intervention. Furthermore, the addition of the CQDs can also significantly the damping effect of the polymers. It is highly anticipated that the research will provide a facile method to construct high performance polymer materials. | | Review | Yan, Mengyu;Liu, Jiarui;Guo, Yiming;Hou, Qingtao;Song, Jiaqi;Wang, Xiaoqin;Yu, Weihua;Lü, Yang |
| Aging Clin. Exp. Res. | 36 | 1 | 2024 |
| 10.1007/s40520-023-02662-x | 1720-8319 |
| Comparative efficacy of non-invasive brain stimulation for post-stroke cognitive impairment: a network meta-analysis | Background: Non-invasive brain stimulation (NIBS) is a burgeoning approach with the potential to significantly enhance cognition and functional abilities in individuals who have undergone a stroke. However, the current evidence lacks robust comparisons and rankings of various NIBS methods concerning the specific stimulation sites and parameters used. To address this knowledge gap, this systematic review and meta-analysis seek to offer conclusive evidence on the efficacy and safety of NIBS in treating post-stroke cognitive impairment. Methods: A systematic review of randomized control trials (RCT) was performed using Bayesian network meta-analysis. We searched RCT in the following databases until June 2022: Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and EMBASE. We compared any active NIBS to control in terms of improving cognition function and activities of daily living (ADL) capacity following stroke. Results: After reviewing 1577 retrieved citations, a total of 26 RCTs were included. High-frequency (HF)-repetitive transcranial magnetic stimulation (rTMS) (mean difference 2.25 [95% credible interval 0.77, 3.66]) was identified as a recommended approach for alleviating the global severity of cognition. Dual-rTMS (27.61 [25.66, 29.57]) emerged as a favorable technique for enhancing ADL function. In terms of stimulation targets, the dorsolateral prefrontal cortex exhibited a higher ranking in relation to the global severity of cognition. Conclusions: Among various NIBS techniques, HF-rTMS stands out as the most promising intervention for enhancing cognitive function. Meanwhile, Dual-rTMS is highly recommended for improving ADL capacity. | | Review | Yan, Mengyu;Liu, Jiarui;Guo, Yiming;Hou, Qingtao;Song, Jiaqi;Wang, Xiaoqin;Yu, Weihua;Lü, Yang |
| Aging Clin. Exp. Res. | 36 | 1 | 2024 |
| 10.1007/s40520-023-02662-x | 1720-8319 |
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| | Review | Yan, Mengyu;Liu, Jiarui;Guo, Yiming;Hou, Qingtao;Song, Jiaqi;Wang, Xiaoqin;Yu, Weihua;Lü, Yang |
| Aging Clin. Exp. Res. | 36 | 1 | 2024 |
| 10.1007/s40520-023-02662-x | 1720-8319 |
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| | Article | Zhang, Yongkang;Ran, Qingzhi;Yin, Kangli;Wang, Yinkai;Liu, Jiarui;Zong, Yuan;Wang, Yuzhen;Cao, Yemin |
| Thromb. Res. | 236 |
| 2024 | 37 - 50 | 10.1016/j.thromres.2024.02.010 | 1879-2472 |
| The effects of CYP2C19 genotype polymorphism and clopidogrel resistance on ischemic event occurrence in patients with peripheral arterial disease undergoing revascularization: A prospective cohort study | Introduction: Peripheral arterial disease (PAD) affects approximately 236 million people worldwide. Therefore, this study aimed to investigate the relationship between CYP2C19 genotype polymorphisms and clopidogrel resistance (CR) following revascularization in patients with PAD. Materials and methods: In total, 345 patients who underwent PAD revascularization were monitored for five years and risk factors for ischemic events were identified. Platelet reactivity and CYP2C19 genotypes were measured, and patients were classified as normal, intermediate, or poor metabolizers based on their genotypes. The study endpoint was defined as an ischemic event, that encompassed major adverse cardiovascular or limb events, or all-cause death. Results: In this study, ischemic events following PAD revascularization were associated with patient age, prior minor amputation, the Rutherford category before revascularization, indications for revascularization, index ankle-branchial index before revascularization, CYP2C19 phenotypes, and CR. Intermediate and poor metabolism, the Rutherford category before revascularization, and CR were independent risk factors for ischemic events in patients after PAD revascularization. Similarly, intermediate and poor metabolism, the Rutherford category before revascularization, and CR were independent risk factors for ischemic events in patients with PAD after revascularization within five years. Intermediate and poor metabolizers had a higher platelet reactivity and risk of CR than normal metabolizers. However, poor metabolizers had a higher platelet reactivity and risk of CR than intermediate metabolizers. Furthermore, the hazard ratio for ischemic events increased with platelet reactivity. This effect was more prevalent in intermediate and poor metabolizers than in normal metabolizers. Conclusions: Ischemic events in patients after PAD revascularization were affected by independent risk factors. Decreased clopidogrel metabolism increased the platelet reactivity and CR in patients after PAD revascularization. Furthermore, high platelet reactivity was associated with an increased risk of ischemic events in patients with intermediate and poor metabolism. | | Review | Guo, Yiming;Song, Jiaqi;Yan, Mengyu;Chen, Yingxi;Huang, Lihong;Liu, Jiarui;He, Yurou;Lü, Yang;Yu, Weihua |
| Mol. Biol. Rep. | 51 | 1 | 2024 |
| 10.1007/s11033-024-09293-z | 1573-4978 |
| The role of NLRP6 in the development and progression of neurological diseases | The nervous system possesses the remarkable ability to undergo changes in order to store information; however, it is also susceptible to damage caused by invading pathogens or neurodegenerative processes. As a member of nucleotide-binding oligomerization domain-like receptor (NLR) family, the NLRP6 inflammasome serves as a cytoplasmic innate immune sensor responsible for detecting microbe-associated molecular patterns. Upon activation, NLRP6 can recruit the adapter protein apoptosis-associated speck-like protein (ASC) and the inflammatory factors caspase-1 or caspase-11. Consequently, inflammasomes are formed, facilitating the maturation and secretion of pro-inflammatory cytokines such as inflammatory factors-18 (IL-18) and inflammatory factors-1β (IL-1β). Precise regulation of NLRP6 is crucial for maintaining tissue homeostasis, as dysregulated inflammasome activation can contribute to the development of various diseases. Furthermore, NLRP6 may also play a role in the regulation of extraintestinal diseases. In cells of the brain, such as astrocytes and neurons, NLRP6 inflammasome are also present. Here, the assembly and subsequent activation of caspase-1 mediated by NLRP6 contribute to disease progression. This review aims to discuss the structure and function of NLRP6, explain clearly the mechanisms that induce and activate NLRP6, and explore its role within the central and peripheral nervous system. | | Review | Guo, Yiming;Song, Jiaqi;Yan, Mengyu;Chen, Yingxi;Huang, Lihong;Liu, Jiarui;He, Yurou;Lü, Yang;Yu, Weihua |
| Mol. Biol. Rep. | 51 | 1 | 2024 |
| 10.1007/s11033-024-09293-z | 1573-4978 |
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| | Review | Guo, Yiming;Song, Jiaqi;Yan, Mengyu;Chen, Yingxi;Huang, Lihong;Liu, Jiarui;He, Yurou;Lü, Yang;Yu, Weihua |
| Mol. Biol. Rep. | 51 | 1 | 2024 |
| 10.1007/s11033-024-09293-z | 1573-4978 |
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| | Review | Guo, Yiming;Song, Jiaqi;Yan, Mengyu;Chen, Yingxi;Huang, Lihong;Liu, Jiarui;He, Yurou;Lü, Yang;Yu, Weihua |
| Mol. Biol. Rep. | 51 | 1 | 2024 |
| 10.1007/s11033-024-09293-z | 1573-4978 |
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| | Article | Chen, Lihua;Zhang, Meiwei;Yu, Weihua;Yu, Juan;Cui, Qiushi;Chen, Chenxi;Liu, Junjin;Huang, Lihong;Liu, Jiarui;Yu, Wuhan;Li, Wenjie;Zhang, Wenbo;Yan, Mengyu;Wu, Jiani;Wang, Xiaoqin;Song, Jiaqi;Zhong, Fuxing;Liu, Xintong;Wang, Xianglin;Li, Chengxing;Tan, Yuantao;Sun, Jiangshan;Li, Wenyuan;Lü, Yang |
| J. Alzheimer's Dis. | 97 | 4 | 2024 | 1661 - 1672 | 10.3233/JAD-230518 | 1875-8908 |
| A Fully Automated Mini-Mental State Examination Assessment Model Using Computer Algorithms for Cognitive Screening | Background: Rapidly growing healthcare demand associated with global population aging has spurred the development of new digital tools for the assessment of cognitive performance in older adults. Objective: To develop a fully automated Mini-Mental State Examination (MMSE) assessment model and validate the model’s rating consistency. Methods: The Automated Assessment Model for MMSE (AAM-MMSE) was an about 10-min computerized cognitive screening tool containing the same questions as the traditional paper-based Chinese MMSE. The validity of the AAM-MMSE was assessed in term of the consistency between the AAM-MMSE rating and physician rating. Results: A total of 427 participants were recruited for this study. The average age of these participants was 60.6 years old (ranging from 19 to 104 years old). According to the intraclass correlation coefficient (ICC), the interrater reliability between physicians and the AAM-MMSE for the full MMSE scale AAM-MMSE was high [ICC (2,1)=0.952; with its 95%CI of (0.883,0.974)]. According to the weighted kappa coefficients results the interrater agreement level for audio-related items showed high, but for items “Reading and obey”, “Three-stage command”, and “Writing complete sentence” were slight to fair. The AAM-MMSE rating accuracy was 87%. A Bland-Altman plot showed that the bias between the two total scores was 1.48 points with the upper and lower limits of agreement equal to 6.23 points and −3.26 points. Conclusions: Our work offers a promising fully automated MMSE assessment system for cognitive screening with pretty good accuracy. | | Article | Wang, Xuan;Kim, Myungjin;Han, Ruoqi;Liu, Jiarui;Sun, Xuemei;Sun, Shuyang;Jin, Chengwu;Cho, Dongha |
| Foods | 13 | 4 | 2024 |
| 10.3390/foods13040607 | 2304-8158 |
| Increasing the Amounts of Bioactive Components in American Ginseng (Panax quinquefolium L.) Leaves Using Far-Infrared Irradiation | Both the roots and leaves of American ginseng contain ginsenosides and polyphenols. The impact of thermal processing on enhancing the biological activities of the root by altering its component composition has been widely reported. However, the effects of far-infrared irradiation (FIR), an efficient heat treatment method, on the bioactive components of the leaves remain to be elucidated. In the present study, we investigated the effects of FIR heat treatment between 160 and 200 C on the deglycosylation and dehydration rates of the bioactive components in American ginseng leaves. As the temperature was increased, the amounts of common ginsenosides decreased while those of rare ginsenosides increased. After FIR heat treatment of American ginseng leaves at an optimal 190 C, the highest total polyphenolic content and kaempferol content were detected, the antioxidant activity was significantly enhanced, and the amounts of the rare ginsenosides F4, Rg6, Rh4, Rk3, Rk1, Rg3, and Rg5 were 41, 5, 37, 64, 222, 17, and 266 times higher than those in untreated leaves, respectively. Moreover, the radical scavenging rates for 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) and the reducing power of the treated leaf extracts were 2.17, 1.86, and 1.77 times higher, respectively. Hence, FIR heat treatment at 190 C is an efficient method for producing beneficial bioactive components from American ginseng leaves. | | Article | Wang, Xinchu;Chen, Biying;Chen, Linyong;Dong, Guannan;Csernica, Timothy;Zhang, Naizhong;Liu, Jiarui;Shuai, Yanhua;Liu, Cong-Qiang;Xu, Zhanjie;Li, Si-Liang;Xu, Sheng |
| Fuel | 365 |
| 2024 |
| 10.1016/j.fuel.2024.131307 | 0016-2361 |
| Biogenic methane clumped isotope signatures: Insights from microbially enhanced coal bed methane | Biogenic (microbial) methane is an imperative natural gas resource and plays an important role in the global carbon cycle. Determining isotope systematics in microbially enhanced coal bed methane (MECBM) informs methane biogeochemical processes and environmental impacts. Here, we conduct laboratory MECBM experiments using coal samples of differing maturities (from lignite to anthracite) and report analytical results of methane production, bulk and clumped isotopes (δC, δD, ΔCH3D and ΔCH2D2). We reproduce the differential reversibility in methanogenic reactions, which exhibits a correlation with kinetic clumped isotope fractionation (ΔCH3D from +0.17 ‰ to +4.04 ‰). The exogenous combinatorial effects play a greater role in determining the negative ΔCH2D2 (<–30 ‰). In the microcosm of MECBM, coal and amendments are suggested to significantly increase methane production (from 82.4 ± 17.1 to 344.6 ± 22.8 μmol CH4/g coal), with effects controlled by substrate coal bioavailability rather than coal thermal maturity. This suggests the possibility of MECBM attempts to utilize high thermal maturity coal. We perform machine learning models and improve the accuracy of biogenic CH2D2 predictions, which help understand the mechanism of methane formation, and further provide new insights into clumped isotope effects among different biogenic methane sources. Our incubation experimental and compiled dataset (n = 275) better constrain biological participation in the methane formation process and potentially be used for methane sources tracing. | | Article | Lu, Jian-Qi;Yang, Zhao;Fan, Kang-Hsien;Wu, Jia;Liu, Jia-Rui;Yang, Xu-Yue |
| Mater. Charact. | 210 |
| 2024 |
| 10.1016/j.matchar.2024.113707 | 1044-5803 |
| Characteristics and mechanical properties of retractable pin-tool friction stir welded joints of A356-alloy LPDC hollow hubs | To produce high-performance noise- and weight-reducing A356-alloy hollow hubs, hub-rims and hubcaps were prepared separately through low-pressure die casting and joined together through retractable pin-tool friction stir welding (RPT-FSW). The effects of the pin retraction speed (6–37.5 mm/min) on the microstructural and mechanical properties were analysed. The results showed that the stirred zone (SZ) could be divided into a double stirred zone (DSZ) and single stirred zone (SSZ) within the pin retraction region. During the pin retraction stage, the DSZ underwent severe deformation and had a longer high-temperature duration, had larger recrystallised grains after the second dynamic recrystallisation, and had a finer and denser β'′ phase after dissolution and re-precipitation. In contrast, the SSZ underwent static recovery due to the low processing temperature, resulting in less-coarsened original recrystallised grains accompanied by much coarsened original β'′ precipitates. The combination of severer deformation and higher temperature resulted in coarser nanoscale Si precipitations in the DSZ than in the SSZ. Statistical data showed that β'′ precipitates dominated the variation in strength in the RPT-FSW region. As slow pin retraction and a long thermal experience coarsened the β'′ precipitates, a U-type Vickers hardness distribution instead of a W-type Vickers hardness distribution formed in the SSZ. This distribution degraded the service performance of the RPT-FSW joints. An appropriately high pin retraction speed improved the strength of the RPT-FSW joints and the fatigue life of the A356-alloy hollow hubs. | | Article | Liu, Jiarui;Li, Jin;Tan, Xiaofei;Tian, Jing;Fei, Xu;Wang, Yi |
| J. Photochem. Photobiol. A Chem. | 452 |
| 2024 |
| 10.1016/j.jphotochem.2024.115592 | 1010-6030 |
| Unraveling the mechanism for fluorescent characteristics of probe 1 and DEASH | In the previous experiment, probe 1, ((1E,1′E)-hydrazine-1,2-diylidenebis(methanylylidene))bis(5-(diethylamino)-2,1-phenylene) diacrylate, was synthesised to identify Cys. Probe 1 could process TICT by overcoming the potential barrier of 2.27 kcal/mol in the S1 state, resulting in the fluorescence quenching phenomenon. After combining with Cys, DEASH was generated. Not only did approximately 100 nm Stokes' shift occur in the S1 state, but other parameters, including primary hydrogen bond properties, infrared vibrational spectra, and interaction region indicator (IRI) further demonstrated ESIDPT process tended to occur in the S1 state. Although the potential energy surfaces in the S1 state evidenced that ESIDPT process could proceed by the stepwise pathway, the keto form wasn't stable, preferring to remain in the enol form simply in the S1 state. In general, we illustrated the corresponding fluorescence quenching mechanism and specific ESIDPT process. It is promising that this work could be crucial in offering theoretical basis for similar molecular systems. | | Article | Liu, Qiao;Du, Guanxiang;Li, Xiao-Jun;Liu, Jiarui;Meng, Ni;Li, Chun-Yang;Liu, Xiting;Zhang, Guiling;Yang, Gui-Peng;Joye, Samantha;Zhuang, Guang-Chao |
| J. Geophys. Res. Oceans | 129 | 3 | 2024 |
| 10.1029/2023JC020280 | 2169-9291 |
| Dynamics and Controls of Methane Oxidation in the Aerobic Waters of Eastern China Marginal Seas | Aerobic methane oxidation (MOx) mediated by methanotrophs is a crucial mechanism in controlling methane emissions from the surface ocean to the atmosphere. Coastal waters dominate global oceanic methane emissions, but the dynamics, controls and roles of MOx remain largely unconstrained in the marginal seas around China. Here, we conducted a variety of biogeochemical analyses to investigate the controls of methane cycling and the dynamics of methanotrophic activity in the East China Sea and Yellow Sea. Methane was supersaturated in the surface seawater and the concentrations ranged from 2.8 to 19.8 nM. The distribution of methane was regulated by the sources and sinks, which were influenced largely by hydrological and biogeochemical factors. Methane was turned over rapidly with high rates (k: 5 × 10–0.04 d), indicating the enzymatic capability of methanotrophic biomass to metabolize methane. Rates of MOx varied significantly between sites (1 × 10–0.60 nM d) and relatively high MOx rates were observed in shallow waters. MOx exhibited the Michaelis-Menten kinetics with the Vmax of 0.30 nM d and a Km of 78.3 nM. Methanotrophic activity was impacted by environmental factors such as methane availability, nutrient levels, bacterial production and temperature. Nutrient addition experiments demonstrated that phosphate elevated MOx rates, while the activity was largely inhibited by ammonium probably due to competitive inhibition of the methane monooxygenase by ammonia. Comparing the depth-integrated MOx rates with the air-sea fluxes at selected sites showed that methane consumed through microbial oxidation accounted for up to 78.1% of the total methane loss (=sum of MOx rates and air-sea flux), highlighting the role of MOx as a microbial filter for methane emissions. | | Article | Li, Tao;Wu, Yongyi;Yu, Guoliang;Li, Shengxian;Ren, Yifeng;Liu, Yadong;Liu, Jiarui;Feng, Hao;Deng, Yu;Chen, Mingxing;Zhang, Zhenyu;Min, Tai |
| Nat. Commun. | 15 | 1 | 2024 |
| 10.1038/s41467-024-46891-8 | 2041-1723 |
| Realization of sextuple polarization states and interstate switching in antiferroelectric CuInP2S6 | Realization of higher-order multistates with mutual interstate switching in ferroelectric materials is a perpetual drive for high-density storage devices and beyond-Moore technologies. Here we demonstrate experimentally that antiferroelectric van der Waals CuInP2S6 films can be controllably stabilized into double, quadruple, and sextuple polarization states, and a system harboring polarization order of six is also reversibly tunable into order of four or two. Furthermore, for a given polarization order, mutual interstate switching can be achieved via moderate electric field modulation. First-principles studies of CuInP2S6 multilayers help to reveal that the double, quadruple, and sextuple states are attributable to the existence of respective single, double, and triple ferroelectric domains with antiferroelectric interdomain coupling and Cu ion migration. These findings offer appealing platforms for developing multistate ferroelectric devices, while the underlining mechanism is transformative to other non-volatile material systems. | | Article | Liu, Jiarui;Xu, Yidong;Wang, Jialei;Zhang, Wensheng;Ye, Jiayuan;Wang, Rui |
| J. Aust. Ceram. Soc. (Singapore) | 60 | 4 | 2024 | 1131 - 1151 | 10.1007/s41779-024-01018-6 | 2510-1560 |
| The immobilizing performance and mechanism of geopolymer and its derivative materials for high-level radionuclides Cs and Sr: a review | How to properly handle the high-level radionuclides cesium(Cs) and strontium(Sr) generated during the nuclear fuel cycle has become a challenging issue. Geopolymer, a novel aluminosilicate inorganic gel material, can be in-situ converted into zeolite and ceramics, exhibiting excellent immobilization capability for radioactive nuclides. This work provides a comprehensive review of the research on the conversion and synthesis methods of geopolymer into zeolite and ceramics, and conducts a detailed analysis of the performance and mechanisms of geopolymers, geopolymer-zeolite composites, and geopolymer ceramics in the immobilization of Cs and Sr. Through a thorough analysis and summary of existing literature, this study presents the optimal conditions for the conversion of geopolymers into zeolite and proposes improved methods for geopolymer ceramic immobilization of Cs. Furthermore, a comparison and analysis are conducted of the applicability, as well as the advantages and disadvantages of these three solidification matrices in immobilizing Cs and Sr. Finally, the challenges and prospects faced by geopolymer and its derivative materials in the immobilization of high-level radionuclides Cs and Sr are discussed. | | Review | Ding, Yidan;Zhao, Tongyi;Fang, Jianing;Song, Jiexin;Dong, Haobo;Liu, Jiarui;Li, Sijin;Zhao, Min |
| Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology | 16 | 2 | 2024 |
| 10.1002/wnan.1958 | 1939-5116 |
| Recent developments in the use of nanocrystals to improve bioavailability of APIs | Nanocrystals refer to materials with at least one dimension smaller than 100 nm, composing of atoms arranged in single crystals or polycrystals. Nanocrystals have significant research value as they offer unique advantages over conventional pharmaceutical formulations, such as high bioavailability, enhanced targeting selectivity and controlled release ability and are therefore suitable for the delivery of a wide range of drugs such as insoluble drugs, antitumor drugs and genetic drugs with broad application prospects. In recent years, research on nanocrystals has been progressively refined and new products have been launched or entered the clinical phase of studies. However, issues such as safety and stability still stand that need to be addressed for further development of nanocrystal formulations, and significant gaps do exist in research in various fields in this pharmaceutical arena. This paper presents a systematic overview of the advanced development of nanocrystals, ranging from the preparation approaches of nanocrystals with which the bioavailability of poorly water-soluble drugs is improved, critical properties of nanocrystals and associated characterization techniques, the recent development of nanocrystals with different administration routes, the advantages and associated limitations of nanocrystal formulations, the mechanisms of physical instability, and the enhanced dissolution performance, to the future perspectives, with a final view to shed more light on the future development of nanocrystals as a means of optimizing the bioavailability of drug candidates. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology. | | Article | Liu, Jiarui;Bi, Shuangjie;Ye, Shandong |
| Miznar. Endokrinol. Zurnal. | 15 | 8 | 2019 | 583 - 590 | 10.22141/2224-0721.15.8.2019.191680 | 2307-1427 |
| The reno-protective effect of metformin against type 2 diabetic rats via up-regulating renal tissue pigment epithelium-derived factor expression | Background. Diabetic nephropathy has become the primary cause of end-stage renal disease worldwide. Pigment epithelium-derived factor (PEDF) is an endogenous anti-inflammatory factor in vivo, which can inhibit the expression of pathogenic factors — transforming growth factor β1 and connective tissue growth factor, and suppresses extracellular matrix protein production in diabetic kidney, suggesting an antifibrogenic activity. The aim of this study was to investigate the effect of metformin on renal tissue PEDF expression in type 2 diabetic rats and explore its possible underlying protective mechanisms in renal injury. Materials and methods. Ten clean male Sprague-Dawley rats were randomly selected as the normal control group. Type 2 diabetes model were induced by a high-fat diet and intraperitoneal injection of 30 mg/kg streptozotocin. A total of 30 type 2 diabetic rats were divided into 3 groups, which were treated with metformin 300 mg/kg/day (MET group, n = 10), glibenclamide 5 mg/kg/ day (GLY group, n = 10), or saline (DM group, n = 10) by gavage for 8 weeks. Various biochemical parameters, kidney histopathology and renal tissue PEDF expression levels were examined. Results. At the 8 week, fasting blood glucose, glycated hemoglobin, triglyceride levels, urinary albumin and PEDF excretion, serum creatinine and blood urea nitrogen in MET group and GLY group decreased significantly compared to DM group, there were no significant differences in fasting blood glucose and glycated hemoglobin between MET group and GLY group. The histological examinations revealed amelioration of diabetes-induced glomerular pathological changes following treatment with MET and GLY when compared to DM group. In addition, urinary albumin and PEDF excretion were decreased, glomerular pathological changes was lightened and protein and mRNA expression of renal tissue PEDF were increased more in MET group compared with GLY group. Conclusions. Metformin reduced urinary albumin excretion in diabetic rats, and improved podocyte morphology and structural damage. The mechanism may be partly related to its role in restoring PEDF expression and inhibiting urinary excretion of PEDF. | | Article | Hou, KeGui;Zhang, Hongli;Song, Wenpeng;Li, Shi;Liu, JiaRui;Ma, Zhaofeng |
| Front. Med. | 11 |
| 2024 |
| 10.3389/fmed.2024.1342792 | 2296-858X |
| Association between life’s essential 8 and periodontitis: a study based on NHANES 2009–2014 | Background: This research aims to investigate the relationship between Life’s Essentials 8 (LE8), the American Heart Association’s latest indicator, and periodontitis. The purpose is to provide guidance on preventative measures. Methods: Data for our investigation were obtained from the National Health and Nutrition Examination Survey (NHANES) 2009–2014, with a total of 8,784 participants eligible. LE8 scores were compiled from 8 index scores (the score for each component of diet, physical activity, nicotine exposure, sleep duration, body mass index, blood lipids, blood glucose, and blood pressure). Periodontitis was classified by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP). The study utilized multivariable logistic analyses to investigate the potential correlation. Results: After controlling for all covariates, LE8 was discovered to have a significant negative correlation with periodontitis prevalence [0.91 (0.88, 0.94)]. This trend continued to hold statistical significance even after converting LE8 into a categorical variable. Furthermore, a noteworthy adverse correlation was discovered across both genders, specifically males [0.35 (0.22, 0.55)] and females [0.39 (0.25, 0.60)], as well as for the majority of categorical classifications, namely ethnicity, age, education level, and marital status. However, only the age subgroups displayed some degree of significant difference from each other. Conclusion: Life’s essential 8 was negatively associated with periodontitis, but more prospective trails are needed to confirm our findings. | | Article | Yu, Zihan;Li, Xianju;Quan, Yanni;Chen, Jiawen;Liu, Jiarui;Zheng, Nairen;Liu, Shuwen;Wang, Yini;Liu, Wanlin;Qiu, Chen;Wang, Yi;Zheng, Ruimao;Qin, Jun |
| Cell Rep. | 43 | 5 | 2024 |
| 10.1016/j.celrep.2024.114142 | 2639-1856 |
| Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis | Despite medical advances, there remains an unmet need for better treatment of obesity. Itaconate, a product of the decarboxylation of the tricarboxylic acid cycle intermediate cis-aconitate, plays a regulatory role in both metabolism and immunity. Here, we show that itaconate, as an endogenous compound, counteracts high-fat-diet (HFD)-induced obesity through leptin-independent mechanisms in three mouse models. Specifically, itaconate reduces weight gain, reverses hyperlipidemia, and improves glucose tolerance in HFD-fed mice. Additionally, itaconate enhances energy expenditure and the thermogenic capacity of brown adipose tissue (BAT). Unbiased proteomic analysis reveals that itaconate upregulates key proteins involved in fatty acid oxidation and represses the expression of lipogenic genes. Itaconate may provoke a major metabolic reprogramming by inducing fatty acid oxidation and suppression of fatty acid synthesis in BAT. These findings highlight itaconate as a potential activator of BAT-mediated thermogenesis and a promising candidate for anti-obesity therapy. | | Article | Zhao, Yijin;Wang, Jiaqi;Yang, Wanmin;Chen, Jing;Liu, Jiarui |
| Physica. C. Supercond. | 621 |
| 2024 |
| 10.1016/j.physc.2024.1354516 | 0921-4534 |
| The levitation force and stiffness enhancement of single domain GdBCO bulk superconductor by an axial background magnetic field | How to improve the levitation force (FL) and its stiffness between a permanent magnet and a REBCO bulk superconductor is one of the most key and attractive problems to be solved for practical applications. In this paper, we provided a novel hybrid magnet added superconductor system (HMS) to enhance the levitation force and the stiffness, the HMS sample is assembled by a single domain GdBCO bulk with an attached permanent magnet (PM) serving as an axial background magnetic field. The results indicate that (1) the FL increased first and decreased then with the increase of the PM diameter (dPM), the largest FL is achieved when the dPM approaches the diameter of the GdBCO bulk, FL has been improved up to 152% with a thinner PM; (2) the FL increased with the increase of the PM thickness and saturated at a certain value, FL have been improved up to 168% with a thicker PM; (3) the stiffness of FL has been improved up to 187% and 201% with the increase of the PM diameter and thickness; (4) the FL and its stiffness enhancement dependent on the positive trapped field of the field cooled HMS samples. The results are of great significance to improve the performance and stability of maglev systems, the mechanism for enhancing the levitation force and stiffness property has been investigated in details. | | Conference Paper | Liu, Jiahui;Zhang, Chunguang;Liu, Jiarui;Chu, Shuai;An, Lei;Wu, Ye |
| Mech. Mach. Sci. | 156 |
| 2024 | 417 - 431 | 10.1007/978-981-97-1678-4_39 | 2211-0992 |
| Optimization of Structural Parameters for the Polyurethane Wheel of the Wall Climbing Robot for Storage Tank Cleaning | The wall climbing robot for storage tank cleaning uses polyurethane integrated wheels. The structural parameters of the polyurethane wheel affect the compression deformation of the wheel. If the compression deformation is too small, it will reduce the frictional force between the wheel and the steel plate, causing a risk of slipping. The article focuses on the research of the polyurethane wheel of the wall climbing robot for storage tank cleaning. Based on the three-parameter Mooney-Rivlin model, the parameters C10, C01, and C11 of the polyurethane material are determined by the compression test of the polyurethane. Based on the optimization goal, which is to maximize the compression deformation of the polyurethane wheel, optimize the parameters including thickness, radian and fillet of the polyurethane layer by Response Surface Methodology (RSM). Ultimately obtain the optimized size of the polyurethane layer that meets the requirements of actual working conditions. | | Article | Wang, Ruhao;Gao, Peng;Liu, Jiarui;Wang, Zhiyu;Wang, Chenge;Yu, Faxin |
| Electronics (Switzerland) | 13 | 9 | 2024 |
| 10.3390/electronics13091653 | 2079-9292 |
| A Hybrid Scheme for TX I/Q Imbalance Self-Calibration in a Direct-Conversion Transceiver | A generic transmitter (TX) I/Q imbalance self-calibration method, which was designed based on a hybrid analog and digital structure, is proposed in this paper. The whole calibration scheme was implemented using low-complexity digital–analog circuits based on a zero-force feedback loop. In order to eliminate the negative effect of local oscillator (LO) harmonics on the calibration, we used a variable-delay line (VDL) in the analog domain instead of the digital phase compensator. The prototype chip was fabricated within a 0.2∼5.0 GHz direct-conversion transmitter in a 65 nm CMOS process, and measurements found an image rejection ratio (IRR) of 65 dBc. | | Conference Paper | Liu, Jiarui;Liu, Jinhai;Shen, Xiangkai;Xu, Hang;Wu, Zhenning |
| Lect. Notes Electr. Eng. | 1176 LNEE |
| 2024 | 260 - 268 | 10.1007/978-981-97-1099-7_25 | 1876-1119 |
| TBIC-RRT*: A Novel Efficient Approach for Robot Motion Planning | In this paper, the Triangular Bidirectional Intelligent Connection RRT* (TBIC-RRT*) is introduced, which is able to find the initial feasible solution quickly while increasing the convergence for real-time robot motion planning. Initially, a bidirectional method is introduced in order to quickly find the initial feasible obstacle-free solutio. In addition, based on the triangular-inequality principle, the ancestor set matrix and near set matrix are provided in order to achieve rapid optimization. The proposed method is verified in several typical complex instances including dense clutter, simple maze, narrow passage, and local trap environments. The experiments results indicates that the proposed algorithm can efficiently identify the initial feasible obstacle-free solution and ensures the asymptotic optimality. | | Article | Liu, Jiarui;Li, Pan;Wang, Wenxiang;Bai, Liangjiu;Chen, Hou;Yang, Lixia;Yin, Kun;Yang, Huawei;Wei, Donglei |
| Ind. Crops Prod. | 216 |
| 2024 |
| 10.1016/j.indcrop.2024.118728 | 0926-6690 |
| Functionalized cellulose nanocrystals construct self-healing nanocomposite hydrogel-based sweat sensors for glucose detection | Based on the structural characteristics of the abundant active sites on its surface, cellulose nanocrystals (CNCs) not only have widespread applications as ideal reinforcements in composites, but also they demonstrate significant potential for applications in electrochemical sensing. Herein, the glucose oxidase (GOx) was successfully loaded onto the surface of CNCs using bovine serum albumin (BSA) as a bridge, and the CNCs@BSA-GOx/PVA self-healing nanocomposite hydrogels were prepared together with poly(vinyl alcohol) (PVA). The maximum fracture stress of the hydrogel was 0.79 MPa, and the self-healing rate was as high as 87.85 % at room temperature, showing excellent mechanical properties and self-healing efficiency. In addition, a hydrogel-based sweat sensor for the electrochemical detection of sweat glucose were constructed by using a simple strategy. This glucose sweat sensor exhibited a low detection limit (8.2 μM) and good linearity (R = 0.9948). This work provides a novel approach for the development of sweat sensors, making it possible to achieve sensitive detection of glucose in sweat. | | Article | Chen, Wei;Liu, Bing-Wen;Liu, Jia-Rui;Wang, Kun;Bao, Yan-Xu;Tang, Guo-Qiang;Li, Xiao-Bin |
| Chuan Bo Li Xue. | 28 | 5 | 2024 | 705 - 715 | 10.3969/j.issn.1007-7294.2024.05.007 | 1007-7294 |
| Suppression of cylindrical vortex induced vibration by control rods and forced rotation | To effectively suppress cylindrical vortex induced vibration (VIV), the suppression of cylindrical VIV based on the combined control rod-forced rotation structure was discussed in this paper. Numerical simulations of the cylindrical VIV at low Reynolds number were carried out for comparison and analysis of the flow characteristics, vibration response and hydrodynamic response under different numbers of control rods and rotation rates of the cylinder. The results show that compared with the bare cylinder, the control rods have a positive effect on VIV suppression. For three and five control rods, up to 98% of the cylindrical amplitude suppression can be achieved by adjusting the rotation rate (three control rods, rotation rate 0.4-0.6; five control rods, rotation rate 0-0.2). The amplitude suppression range of the cylinder is identical to the drag reduction range of the cylinder. For the four and six control rods, the effect of rotation on amplitude suppression is small. Vortex shedding on the main cylindrical surface and vortex merging will cause high amplitude fluctuations in the fluid force coefficients, resulting in a high cylindrical amplitude response. For the cylindrical surface with no vortex merging and insignificant vortex shedding, there are no significant fluctuations in the fluid force coefficients and the cylindrical amplitude is significantly reduced. | | Article | Ren, Kaige;Zhou, Yalan;Liu, Jiarui;Yu, Ziyin;Ma, Xin;Si, Ruotong;Wen, Zhang;Xu, Wen;Tang, Aohan;Shen, Jianlin;Goulding, Keith;Liu, Xuejun |
| Atmosphere | 15 | 5 | 2024 |
| 10.3390/atmos15050583 | 2073-4433 |
| A Decadal Change in Atmospheric Nitrogen Deposition at a Rural Site in Southern China | Elevated atmospheric reactive nitrogen (Nr) emissions and the subsequent nitrogen (N) deposition have negatively impacted the global environment, particularly in China. In order to assess the long-term trends in atmospheric N deposition in the south of China, Taojiang County in Hunan Province was selected as a representative rural area for study. We analyzed interannual variation in atmospheric Nr, including gaseous ammonia (NH3), nitrogen dioxide (NO2), nitrate acid (HNO3) vapor, particulate ammonium (NH4), and nitrate (NO3) in air and NH4-N and NO3-N in precipitation from 2011 to 2020. The 10-year average atmospheric wet-plus-dry N deposition was 41.9 kg N ha yr, which decreased by approximately 24% after 2012, indicating that NH3 and NOx emissions were effectively reduced by emission controls introduced in 2013. Wet deposition accounted for approximately 74% of the total N deposition and was significantly influenced by annual precipitation amount. Reduced N (NH3, pNH4, and NH4 in rainwater) was the dominant form, comprising approximately 58% of the total N deposition, while oxidized N (pNO3, NO2, HNO3, and NO3 in rainwater) accounted for 42% of the total N deposition. Atmospheric HNO3, NO2, and NH3 concentrations and deposition declined by 30–80% over the decade, while particulate NH4 and NO3 concentrations and deposition remained at relatively stable levels, which suggests that ongoing research and policy should focus on rural particulate pollution. Future strategies must concentrate on the integrated control of NH3 and NOx emissions to mitigate air pollution and protect human health, particularly in rural areas because current abatement efforts are primarily directed toward urban areas and the industrial sector, whereas non-point source NH3 pollution, influenced mainly by agricultural activities, dominates in rural regions. | | Article | Wang, Juncai;Liu, Jiarui;Ren, Zhongyuan;Sun, Tianyu;Doh, Jeung-Hwan |
| Constr. Build. Mater. | 435 |
| 2024 |
| 10.1016/j.conbuildmat.2024.136818 | 0950-0618 |
| Mechanical and micro properties of concrete slurry waste geopolymer under various curing conditions | Amid accelerating urbanization, the extensive use of concrete poses significant environmental challenges, particularly from the generation of concrete slurry waste (CSW). The high alkalinity and substantial volumes of CSW escalate recycling costs. Existing strategies, focused on reusing CSW into concrete production, fall short of addressing environmental pollution fundamentally. Geopolymer, now viewed as a sustainable alternative to ordinary Portland cement, has validated fly ash (FA) as an effective aluminosilicate precursor (AP). Herein, this study introduces a novel methodology to incorporate CSW into FA-based geopolymer. The impacts of CSW replacement ratio, alkali concentration, and curing conditions on the mechanical properties of geopolymer are examined. It has been preliminarily observed that elevated curing poses a positive impact on the strength of CSW-FA geopolymer whilst the CSW addition poses a negative one. Notably, under elevated curing, geopolymer with a 25% CSW replacement ratio consistently maintains a strength activity index above 80%. Further, the crystalline & amorphous phase and elemental concentration under various CSW replacement ratios and curing conditions were characterized. Tests indicate that Calcite is a significant reaction product from the addition of CSW, whilst elevated curing can facilitate the formation of Albite and Anorthite but inhibits the generation of Larnite and Bavenite. Furthermore, this study innovatively explores the correlation between the elemental molar ratios in bulk and crystalline composition with the strength of the resultant CSW-FA geopolymer. The Na/Ca molar ratio in the crystalline composition exhibits a strong and positive correlation. | | Article | Yang, Chenglin;Liu, Jiarui;Liu, Pengxiao;Wang, Wenxiang;Chen, Hou;Bai, Liangjiu;Yang, Huawei;Yang, Lixia;Wei, Donglei |
| Chem. Eng. J. | 493 |
| 2024 |
| 10.1016/j.cej.2024.152276 | 1385-8947 |
| Phytic acid extracted cellulose nanocrystals for designing self-healing and anti-freezing hydrogels’ flexible sensor | Phytic acid (PA), a naturally occurring organic acid, has been extensively researched in various fields such as flame retardants, electroactive materials, metal coatings and flexible sensors. This study proposes a method for extracting cellulose nanocrystals (CNCs) utilizing PA and ingeniously applies them to hydrogels, endowing the hydrogels with exceptional mechanical properties, anti-freezing capabilities and high electrical conductivity. First of all, the CNCs@PA and PA were integrated into a multi-component network consisting of hyperbranched polyethyleneimine (HPEI), polyvinyl alcohol (PVA), and zinc chloride (ZnCl2), and their complex interactions resulted in the formation of a robust three-dimensional structure. Consequently, the hydrogels formed after just a single freeze–thaw cycle exhibited exceptional mechanical properties (2.6 MPa) and a significant self-healing ability (92.3 %). Moreover, the strategic addition of PA to the hydrogels effectively immobilizes H2O, providing anti-freeze properties and enabling the hydrogels to maintain their structure and performance even at −20.0 C. Notably, following hydrolysis, PA generates a substantial number of hydrogen ions, markedly enhancing the conductivity (2.3 S/m) and a sensitivity gauge factor (GF = 2.5) of the hydrogels. This work offers a cost-effective, eco-friendly, and scalable method for the manufacturing of nanomaterials, and opens new avenues for creating anti-freeze wearable flexible sensors. | | Article | Liu, JiaRui;Li, DongFei;Zhai, NaiCui;Yuan Long;Zhou, Mi |
| Spectrochim. Acta Part A Mol. Biomol. Spectrosc. | 319 |
| 2024 |
| 10.1016/j.saa.2024.124525 | 1386-1425 |
| Raman spectroscopy study on terephthalamide crystal at high pressures | In this study, we have investigated the structural stability of terephthalamide (TPA) crystal at pressure from ambient to 15 GPa in the diamond anvil cell at room temperature by Raman spectroscopy. Assignment for the Raman vibration modes of TPA crystal at ambient conditions has been performed based on the density functional theory (DFT) calculations. Pressure-induced structural transition was monitored using in-situ Raman spectroscopy. Remarkable changes (including the appearance of new Raman peaks, disappearance of original Raman bands, discontinuous changes in the pressure dependence of some Raman wavenumbers at different pressures) in Raman spectra were observed at approximately 1.3 and 5.2 GPa, provided clear evidences for two pressure-induced phase transitions: phase I to phase II at ∼1.3 GPa, phase II to phase III at ∼5.2 GPa. | | Article | Lindsay, Melody R.;D'Angelo, Timothy;Munson-McGee, Jacob H.;Saidi-Mehrabad, Alireza;Devlin, Molly;McGonigle, Julia;Goodell, Elizabeth;Herring, Melissa;Lubelczyk, Laura C.;Mascena, Corianna;Brown, Julia M.;Gavelis, Greg;Liu, Jiarui;Yousavich;Hamilton-Brehm, Scott D.;Hedlund, Brian P.;Lang, Susan;Treude, Tina;Poulton, Nicole J.;Stepanauskas, Ramunas;Moser, Duane P.;Emerson, David;Orcutt, Beth N. |
| Proc. Natl. Acad. Sci. U. S. A. | 121 | 15 | 2024 |
| 10.1073/pnas.2309636121 | 1091-6490 |
| Species-resolved, single-cell respiration rates reveal dominance of sulfate reduction in a deep continental subsurface ecosystem | Rates of microbial processes are fundamental to understanding the significance of microbial impacts on environmental chemical cycling. However, it is often difficult to quantify rates or to link processes to specific taxa or individual cells, especially in environments where there are few cultured representatives with known physiology. Here, we describe the use of the redox-enzyme-sensitive molecular probe RedoxSensor Green to measure rates of anaerobic electron transfer physiology (i.e., sulfate reduction and methanogenesis) in individual cells and link those measurements to genomic sequencing of the same single cells. We used this method to investigate microbial activity in hot, anoxic, low-biomass (~10 cells mL) groundwater of the Death Valley Regional Flow System, California. Combining this method with electron donor amendment experiments and metatranscriptomics confirmed that the abundant spore formers including Candidatus Desulforudis audaxviator were actively reducing sulfate in this environment, most likely with acetate and hydrogen as electron donors. Using this approach, we measured environmental sulfate reduction rates at 0.14 to 26.9 fmol cell h. Scaled to volume, this equates to a bulk environmental rate of ~10 pmol sulfate L d, similar to potential rates determined with radiotracer methods. Despite methane in the system, there was no evidence for active microbial methanogenesis at the time of sampling. Overall, this method is a powerful tool for estimating species-resolved, single-cell rates of anaerobic metabolism in low-biomass environments while simultaneously linking genomes to phenomes at the single-cell level. We reveal active elemental cycling conducted by several species, with a large portion attributable to Ca. Desulforudis audaxviator. | | Article | Zhang, Min;Liu, Jiarui;Xu, Xiaoguang;Zhang, Bingyuan;Hou, Shaodong;Wang, Minghong;Song, Qi |
| IEEE Sensors J. | 24 | 15 | 2024 | 23723 - 23728 | 10.1109/JSEN.2024.3407127 | 1558-1748 |
| THz Multidimensional Spectroscopy Sensing: A Novel Approach for High-Precision Metal Slag Recognition Using Packed Gratings | The accurate differentiation of slag types is pivotal for the metal market, given its implications for safety, environmental impact, and economic recovery of precious metals. However, conventional analytical techniques, such as XRD and scanning electron microscope (SEM)-EDS, are fraught with high costs, lengthy procedures, and potential dangers. In this investigation, we unveil an innovative method that harnesses the power of multidimensional spectroscopy, the linear discriminant analysis (LDA) algorithm, and THz time-domain spectroscopy (THz-TDS), obviating these challenges. Through a unique 'mask filling' fabrication technique, we create devices laden with metallic particles. These devices, when interrogated with the aforementioned spectroscopic and analytical tools, yield a wealth of information, due to their integrated external controls. By distilling the essence of the spectral data via LDA, we craft a sophisticated multidimensional dataset that elevates the precision of slag classification from a lackluster 75.0% to an impressive 95.8%. Our strategy stands as a beacon of progress, offering a safer, swifter, and more economically viable pathway to the characterization of metal slags. | | Article | Cui, Tianyi;Liu, Jiarui;Chen, Boxue;Lv, Bin;Yang, Wenzhi;Zhao, Xin;Gao, Xiumei |
| J. Funct. Foods | 118 |
| 2024 |
| 10.1016/j.jff.2024.106276 | 1756-4646 |
| Polygonatum odoratum polysaccharide ameliorates the allergic airway inflammation through regulating the gut microbiota and inhibiting gut-lung migration of ILC2s | Polygonatum odoratum is widely recognized to conribute to various health benefits, primarily attributed to its polysaccharide (POP). Polysaccharides are not directly and readily absorbed by the gastrointestinal system, but can interact with the gut microbes. This study aims to clarify the mechanism of POP in mitigating and preventing OVA-induced allergic airway inflammation via the gut-lung axis. The results showed that POP improved the symptoms associated with allergic respiratory responses, and the efficacy of POP was impeded due to the disruption of gut microbiota caused by antibiotics. The POP altered gut microbiota effectively alleviated the type 2 inflammation, reduced the number of ILC2s in the lung and gut, and inhibited the movement of intestinal ILC2s towards the lung. Clostridia UCG-014 and Rikenellaceae RC9 were figured out as pathogenic bacteria inhibited by POP. This study provides a reference for therapeutic application of POP in managing allergic airway inflammation via the gut-lung axis. | | Conference Paper | Sun, Yize;Liu, Jiarui;Ma, Yunpu;Tresp, Volker |
| ICASSP. IEEE Int. Conf. Acoust. Speech Signal Process. Proc. |
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| 2024 | 236 - 240 | 10.1109/ICASSP48485.2024.10445875 | 1520-6149 |
| DIFFERENTIABLE QUANTUM ARCHITECTURE SEARCH FOR JOB SHOP SCHEDULING PROBLEM | The Job shop scheduling problem (JSSP) plays a pivotal role in industrial applications, such as signal processing (SP) and steel manufacturing, involving sequencing machines and jobs to maximize scheduling efficiency. Before, JSSP was solved using manually defined circuits by variational quantum algorithm (VQA). Finding a good circuit architecture is task-specific and time-consuming. Differentiable quantum architecture search (DQAS) is a gradient-based framework that can automatically design circuits. However, DQAS is only tested on quantum approximate optimization algorithm (QAOA) and error mitigation tasks. Whether DQAS applies to JSSP based on a more flexible algorithm, such as variational quantum eigensolver (VQE), is still open for optimization problems. In this work, we redefine the operation pool and extend DQAS to a framework JSSP-DQAS by evaluating circuits to generate circuits for JSSP automatically. The experiments conclude that JSSP-DQAS can automatically find noise-resilient circuit architectures that perform much better than manually designed circuits. It helps to improve the efficiency of solving JSSP. | | Article | Liu, Jiarui;Jiang, Yujie;Yuan, Dai;Zhang, Zhifen;Liu, Xin;Zhao, Wenbo;Xu, Hongzhi |
| Mol. Carcinog. | 63 | 8 | 2024 | 1429 - 1435 | 10.1002/mc.23742 | 1098-2744 |
| Atypical BCR-ABL1 transcript in mixed phenotype acute leukemia with bone marrow necrosis | Mixed phenotype acute leukemia (MPAL) is a type of acute leukemia in which encompasses mixed features of myeloid, T-lymphoid, and/or B-lymphoid differentiation. Philadelphia chromosome-positive (Ph) MPAL is a rare subgroup with a poor prognosis and accounts for ＜1% of adult acute leukemia. Until now, there is still no consensus on how to best treat Ph MPAL. Here, we report a 62-year-old male with Ph (atypical e13a2 BCR-ABL1 fusion protein) MPAL. This patient presented with recurrent and intense bone pain due to bone marrow necrosis (BMN). Besides, he did not achieve a complete remission for the first two chemotherapies, until he received flumatinib combined with hyper-CVAD (B) (a dose-intensive regimen include methotrexate and cytarabine). To our knowledge, this is the first report to describe the coexistence of BMN and atypical e13a2 BCR-ABL1 transcripts in patients with MPAL. This finding will bring new understandings in the diagnosis and treatment of Ph MPAL. | | Article | Liu, Xiting;Wang, Houjie;Liu, Jiarui;Zhuang, Guang-Chao |
| J. Earth Sci. | 35 | 4 | 2024 | 1378 - 1381 | 10.1007/s12583-024-1998-4 | 1867-111X |
| Microbial Sulfate Reduction and Its Role in Carbon Sequestration in Marine Sediments |
| | Article | Liu, Jia-Rui;Wang, Xiao-Kun;Wang, Li;Zhao, Kai;Liu, Yong-Xin;Song, Yuan-Hong;Wang, You-Nian |
| Plasma Processes Polym. | 21 | 8 | 2024 |
| 10.1002/ppap.202300219 | 1612-8869 |
| An experimental and computational investigation of discharge mode transitions in a partially magnetized radio frequency capacitively coupled oxygen discharge | A magnetized capacitively coupled oxygen plasma was studied synergistically using phase resolved optical emission spectroscopy and particle-based kinetic simulation. Discharge mode transitions from ambipolar mode into drift mode and finally into α mode induced by increasing the magnetic field were observed at different driving frequencies and different electrode gaps. The simulation results demonstrate that the discharge operating in the same mode exhibits a similar degree of electronegativity. By increasing driving frequency or electrode gap, the same discharge mode transition tends to occur at a lower magnetic field, and, meanwhile, the high electric field and electron power absorption shift from the bulk region to the sheath edge. | | Article | Zhou, Tianjun;Liu, Jiarui;Liu, Pengxiao;Wang, Wenxiang;Bai, Liangjiu;Chen, Hou;Yang, Huawei;Yang, Lixia;Wei, Donglei |
| ACS Appl. Polymer Mat. | 6 | 13 | 2024 | 7393 - 7407 | 10.1021/acsapm.4c00512 | 2637-6105 |
| Carboxymethyl Cellulose Sodium Nanocomposite Hydrogels for Flexible Sensors of Human Motion and Glucose Levels in Sweat | In recent years, there has been an increasing interest in the use of biomass-based nanocomposite hydrogels for wearable flexible sweat sensors. In this manuscript, the design of a dual-network hydrogel using sodium carboxymethyl cellulose (CMC-Na) to develop a high-performance nanocomposite hydrogel flexible sensor is considered to be an effective method for accurate monitoring of human movement and continuous noninvasive measurement of glucose levels in sweat. The gel has a measurement gauge factor (GF) of 1.34 and a toughness of 4.18 MJ/m, exhibiting excellent mechanical properties and self-healing capabilities (92.6%). As a flexible motion sensor, it can accurately identify various human movements. By incorporating glucose oxidase-thioglycolic acid-gold nanoparticles (GTAN) nanomaterials into the hydrogel, stable and excellent electrocatalytic activity for sweat glucose measurement was achieved. The sensor has a detection limit (LOD) of 0.28 μM and a wide operating range. Additionally, different testing methods show good linear relationships, indicating the sensor’s universality in measurement. By analyzing daily physical activities and levels of glucose in sweat, monitoring of individual health can be achieved, thereby expanding the potential of next-generation noninvasive multifunctional sensing systems. | | Article | Liu, Jiarui;Yang, Kun;Wang, Jiamin;Zhou, Xu;Jiang, Yaozhi;Shao, Changkun;Lu, Hui;Yao, Xiangnan;Sun, Jing;Shi, Jiancheng |
| Clim. Dyn. | 62 | 8 | 2024 | 8019 - 8034 | 10.1007/s00382-024-07320-0 | 1432-0894 |
| Impacts of a shallow convection scheme on kilometer-scale atmospheric simulations over the Tibetan Plateau | Satellite observations show that cumulus is one of the dominant cloud types in the summer over the Tibetan Plateau (TP), indicating prevalent shallow convection (ShCn). However, the impacts of ShCn parameterization on simulations of near-surface atmospheric variables and land-atmosphere interaction over the TP remain largely unknown. This study conducts simulations at 5-km grid-spacing with the Weather Research and Forecasting (WRF) model for the TP in July and August of three years. The result with/without the University of Washington (UW) ShCn scheme is evaluated against in situ observations. The evaluation shows that the ShCn scheme improves the simulations of 2-m air temperature, relative humidity, precipitation amount, and the diurnal cycle of precipitation. It also reduces light rainfall, implying its potential to lessen the general bias of “too much light rain” in climate models. Furthermore, the simulation with the scheme shows that ShCn brings moist air from the planetary boundary layer (PBL) into the free atmosphere, generally lowering and delaying the accumulation of convective available potential energy, reducing precipitation amount and soil moisture. This air exchange also reduces cloud water content and enhances surface net radiation, strengthening sensible heat flux and evaporation. This, in turn, enables the PBL to grow through both air entrainment and surface sensible heating, leading to warmer and drier low-level profiles. These impacts are most pronounced in the interior of the TP, where strong surface sensible heat and low-level convergence trigger convection, but the lack of water vapor inhibits deep convection. | | Review | Meng, Hongyan;Lv, Xiangru;Zhang, Rong;Feng, Yuping;Wang, Jing;Liu, Jiarui;Zhang, Juxia |
| J. Alzheimer's Dis. | 100 | 1 | 2024 | 29 - 40 | 10.3233/JAD-240325 | 1875-8908 |
| Occurrence and Risk Factors for Cognitive Decline Shared by Couples: A Systematic Review and Meta-Analysis | Background: To date, the magnitude of association and the quality of evidence for cognitive decline (mild cognitive impairment, Alzheimer’s disease, and dementia) in couples and risk factors for outcomes have not been reviewed and analyzed systematically. Objective: The aim of this study was to investigate the concordance of cognitive impairment in unrelated spouses and to qualitatively describe potential risk factors. Methods: Eight databases were searched from inception to October 20, 2023. Eligible studies were independently screened and assessed for quality. Statistical analysis was conducted using Stata 15.1 software. The study was preregistered with PROSPERO (CRD42023488024). Results: Eleven studies involving couples were included, with moderate to high evidence quality. Compared to controls, spouses of individuals with cognitive impairment had lower cognitive scores (Cohen’s d: 0.18-0.62) and higher risk of cognitive decline (OR = 1.42, 95% CI: 1.15–1.76). The consistency of cognitive impairment between spouses was attributed to three theories: 1) the impact of caregiving stress experienced by the spouse; 2) assortative mating, which suggests that individuals select partners with similar characteristics; and 3) the influence of shared living environments and lifestyles. Conclusions: The cognitive status of one spouse can affect the cognitive function of the other spouse. It is important to consider shared lifestyle, environmental, and psychobehavioral factors, as they may contribute to the risk of cognitive decline by couples. Identifying these factors can inform the development of targeted recommendations for interventions and preventive measures. | | Article | Huang, Guojing;Xu, Dong;Gao, Peng;Zhou, Min;Liu, Jiarui;Wang, Zhiyu |
| Electronics (Switzerland) | 13 | 13 | 2024 |
| 10.3390/electronics13132459 | 2079-9292 |
| A Wideband Timing Mismatch Calibration Design for Time-Interleaved Analog-to-Digital Converters with Fast Convergence | This paper presents a design for timing mismatch calibration in a TIADC (Time-Interleaved Analog-to-Digital Converter) with wideband inputs. By exploiting the approximately linear relationship between the autocorrelation properties of sub-ADCs and timing mismatch, we achieve rapid convergence of error estimation. A low-cost detection method is proposed based on the convergent monotonicity of the Least Mean Square (LMS) algorithm, which can automatically correct the calibration direction when the input signal goes beyond the Nyquist zone. Physical test results indicate that the spurs caused by timing mismatch can be suppressed by 26–30 dB using the proposed method. | | Article | Liu, Yuqing;Chu, Wencheng;Xu, Yaozu;Yuan, Zijian;Liu, Jiarui;Zhao, Haitao;Liu, Quan;Zhang, Wu |
| J. Solid State Electrochem. | 28 | 11 | 2024 | 4105 - 4118 | 10.1007/s10008-024-06005-2 | 1433-0768 |
| The effect of coprecipitation and heating temperature on structural evolution and electrochemical performance of iron-based prussian blue analogs | Iron-based Prussian blue analogs (PBAs) are synthesized using a modified coprecipitation approach at different temperatures to study the effect of coprecipitation reaction temperature on structural and electrochemical performance. The experimental results showed that the iron-based PBAs transferred from the cubic structure to the monoclinic phase as the temperature increased from 5 C to 60 C, with the former exhibiting rich-in-boundary morphology and the latter showing a well-defined cubic shape. The electrochemical performance of the samples is closely related to the structure: the PBAs with monoclinic structures exhibit a higher charge/discharge specific capacity than those of PBAs with cubic structures. In addition, the samples are further treated at 270 C, new phases are probed, and the charge/discharge specific capacity for the HT-PB-60 sample is significantly improved by more than 36.15%. | | Article | Liu, Jiarui;Yang, Kun;Zhao, Dingchi;Wu, Peili;Wang, Jiamin;Zhou, Xu;Lin, Yanluan;Lu, Hui;Jiang, Yaozhi;Shi, Jiancheng |
| Geophys. Res. Lett. | 51 | 14 | 2024 |
| 10.1029/2024GL109180 | 1944-8007 |
| Cloud Radiative Feedback to the Large-Scale Atmospheric Circulation Greatly Reduces Monsoon-Season Wet Bias Over the Tibetan Plateau in Climate Modeling | Over-estimation of summer precipitation over the Tibetan Plateau (TP) is a well-known and persistent problem in most climate models. This study demonstrates the impact of a Gaussian Probability Density Function cloud fraction scheme on rainfall simulations using the Weather Research and Forecasting model. It is found that this scheme in both 0.1 and 0.05 resolutions significantly reduces the wet bias through both local feedbacks and large-scale dynamic process. Specifically, increased cloud water/ice content with this scheme reduces surface shortwave radiation, and consequently surface heat fluxes and evapotranspiration. This, in turn, dampens the large-scale thermal effect of the TP and weakens the exaggerated monsoon circulation and low-level moisture convergence. It is this large-scale dynamic process that contributes the most (∼70%) to the wet bias reduction. Although this paper presents a modeling study, it highlights the cloud radiative feedback to the large-scale dynamics and precipitation over the TP. | | Article | Sun, Jing;Dang, Lili;Zhang, Bing;Xu, Kaijiang;Luo, Chao;Zhao, Fuhai;Wang, Zhiyu;Liu, Jiarui;Chen, Hua;Yu, Faxin |
| IEICE Electron. Express | 21 | 12 | 2024 |
| 10.1587/elex.21.20240209 | 1349-2543 |
| A compact 2–18 GHz ultra-wideband frequency-conversion T/R module based on a 3D heterogeneous integrated process | In this letter, a compact 2–18 GHz ultra-wideband frequency-conversion transmit/receive (T/R) module based on a three-dimensional heterogeneous integration (3DHI) process is designed and fabricated. An ultra-wideband impedance matching method is introduced to address the structural discontinuities within the 3D interconnections. Through silicon via (TSV) shielding and cavity designs are leveraged to reduce the impact of local oscillator (LO) leakage. The compact module consists of stacked four-layer silicon interposers and two-layer embedded chips is employed by a 3DHI process with wafer-to-wafer (W2W) bonding, the dimensions of which is only 10.1 mm × 10.1 mm × 1.0 mm. The measured results show that the saturated output power reaches 19 dBm at 2 GHz and 16.9 dBm at 18 GHz, and the rejection of image frequencies exceeds 70 dBc. | | Article | Gao, Yang;Liu, Jiarui;Wang, Changjun;Ma, Yan;Zhou, Ying;Dong, Ting;Wang, Tao;Sun, Yulu;Gu, Chaojiang |
| Shengwu Gongcheng Xuebao Chin. J. Biotechnol. | 40 | 7 | 2024 | 2195 - 2210 | 10.13345/j.cjb.230859 | 1872-2075 |
| Establishment of a humanized mouse model of HIV-1 infection and quantification of integrated HIV proviral DNA in vivo | In recent years, virological, pathological, and immunological studies need to be carried out for the emerging anti-human immunodeficiency virus (HIV) therapies such as gene therapy, broadly neutralizing antibodies, and the derived chimeric antigen receptor (CAR)-T immunotherapy, which necessitates suitable, simple, and inexpensive small-animal models and methods for accurate quantification of the viral genome in the HIV-1 infected. In our research, the HIV-∆ENV-Jurkat-EGFP-mCherry cell line was engineered through the infection with a dual-labelled HIV pseudovirus. A nested quantitative PCR (nested-qPCR) method with the cellular genome as the integrated standard was established for the quantification of HIV proviral copies. We administered intravenous injections of healthy human peripheral blood mononuclear cell (PBMC) into NOD/Prkdcscid/IL2rgnull (NPG) mice. To verify engraftment kinetics, we analyzed the percentages of hCD45+, hCD3+, hCD4+, and hCD8+ cells in the peripheral blood of hu-PBMC-NPG mice. To evaluate HIV-1 infection in hu-PBMC-NPG mice, we inoculated these mice with HIV NL4-3-NanoLuc by intraperitoneal (IP) injection. We then monitored the luciferase expression by the small animal imaging system and measured the viral load in the spleen by qPCR. The infiltration of human PBMCs in mice was detected 3–5 weeks after intravenous injection, and the percentage of hCD45 in humanized mouse PBMCs were more than 25% five weeks after IP inoculation. The expression of the virus-associated luciferase protein was detected by luciferase imaging 27 days post infection. Moreover, the viral total DNA, RNA, and proviral DNA copies reached 18 000 copies/10 cells, 15 000 copies/μg RNA, and 15 000 copies/10 cells, respectively, in the mouse spleen. Taken together, we reported a convenient method for building a simple humanized mouse model of HuPBMC-NPG/severe combined immunodeficiency (SCID) by intravenous injection with hu-PBMCs without advanced surgical skills and irradiation. Furthermore, we established a convenient method for the efficient determination of proviral DNA to assess HIV replication in vivo, viral reservoir sizes, and efficacy of novel anti-HIV therapies including CAR-T immunotherapy and gene therapy. | | Article | Liu, Jiarui;Yu, Jianlin;Yan, Gang |
| Appl. Therm. Eng. | 255 |
| 2024 |
| 10.1016/j.applthermaleng.2024.124015 | 1359-4311 |
| Experimental study on Joule-Thomson refrigeration system with R1150/R290/R601a for ultra-low temperature medical freezer | Since the global outbreak of the COVID-19, the requirement for ultra-low temperature medical freezers has increased rapidly. Joule-Thomson refrigeration systems, known for their simple structure and low cost, are an excellent choice for ultra-low temperature medical freezers. To further improve the performance of Joule-Thomson system for large-capacity ultra-low temperature freezer, this study conducted a series of experiments on the performance of a ternary hydrocarbon mixture R1150/R290/R601a. The impacts of refrigerant charge, capillary tube size, compressor speed, and environmental temperature on the steady-state and dynamic performance were investigated in detail. The results showed that under a fixed system configuration and charge, the freezer can achieve an ultra-low temperature of −82.2 C and a COP of 0.256 at an environmental temperature of 25 C, while maintaining a low compressor pressure ratio not exceeding 12. Furthermore, the matching relationship between capillary size and charge was emphatically studied, and it was found that the optimal refrigerant charge increased as the inside diameter of the capillary tube decreased or its length increased. The inside diameter had a more significant effect on system performance than the length. The suitable charge was 225–275 g for capillary tubes with an inside diameter of 1.4 mm, and increased to 400–450 g for an inside diameter of 0.7 mm. In addition, the experiments with various compressor speeds indicated that, before the cabinet temperature dropped to −40 C, the variation of compressor speed had little effect on the pull-down rate. However, the higher the compressor speed, the lower the cabinet temperature that can be achieved. When the speed was 3500 rpm, the system achieved its lowest daily energy consumption, which was 8.42 kW·h/24 h. | | Article | Liu, Jiarui;Chen, Yuheng;Zhang, Haicheng |
| Intl. J. Dyn. Cont. | 12 | 12 | 2024 | 4423 - 4431 | 10.1007/s40435-024-01478-5 | 2195-2698 |
| Propulsion characteristics of half-cycle-actuated bistable caudal fin | The fish can improve their propulsion performance by adjusting their body swing stiffness. Bistable mechanism, as a nonlinear stiffness device, has property of periodically release and store the potential energy, which can be used as a passive control method for stiffness. In this study, an efficient propulsion method embedded with bistable mechanism is proposed to improve the swimming performance of a caudal fin-actuated bionic fish. The nonlinear dynamic model of the caudal fin-actuated bionic fish is investigated for numerical simulation analysis. A bistable mechanism is introduced as a nonlinear moment, and the hydrodynamic force is derived using an empirical formula. Besides, an actuated strategy with active control moment and passive potential energy release is proposed to achieve periodic driving. Finally, swimming speed and propulsion efficiency are utilized to evaluate propulsion performance of the bistable caudal fin. Both swimming speed and propulsion efficiency can be enhanced using the proposed propulsion method of half-cycle-actuated bistable caudal fin. | | Conference Paper | Xu, Hang;Liu, Jinhai;Jiang, Lin;Li, Qiangxin;Liu, Jiarui |
| Proc. Chin. Control Decis. Conf., CCDC |
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| 2024 | 3993 - 3997 | 10.1109/CCDC62350.2024.10587452 |
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| Simulation analysis of magnetic focusing for buried pipeline | The detection of buried pipelines is urgent, as they are prone to leakage due to their harsh underground environment. The transient electromagnetic method is the most commonly used detection method, which has the issue of magnetic signal not focusing, and the response signal reflects the average metal content over a large range. To address the issue, the concept of magnetic focusing has been proposed. Three types of magnetic focusing coil structures were designed, and the distribution characteristics of magnetic signals were solved through two-dimensional simulation. It was found that conical coil, double coil overlapping, and double coil non overlapping all have good focusing effects. Finally, the correctness of the proposed structure is verified through 3D simulation. | | Conference Paper | Jin, Zhijing;Liu, Jiarui;Lyu, Zhiheng;Poff, Spencer;Sachan, Mrinmaya;Mihalcea, Rada;Diab, Mona;Schölkopf, Bernhard |
| Int. Conf. Learn. Represent., ICLR |
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| 2024 |
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| CAN LARGE LANGUAGE MODELS INFER CAUSATION FROM CORRELATION? | Causal inference is one of the hallmarks of human intelligence. While the field of Causal NLP has attracted much interest in the recent years, existing causal inference datasets in NLP primarily rely on discovering causality from empirical knowledge (e.g., commonsense knowledge). In this work, we propose the first benchmark dataset to test the pure causal inference skills of large language models (LLMs). Specifically, we formulate a novel task CORR2CAUSE, which takes a set of correlational statements and determines the causal relationship between the variables. We curate a large-scale dataset of more than 200K samples, on which we evaluate seventeen existing LLMs. Through our experiments, we identify a key shortcoming of LLMs in terms of their causal inference skills, and show that these models achieve almost close to random performance on the task. This shortcoming is somewhat mitigated when we try to re-purpose LLMs for this skill via finetuning, but we find that these models still fail to generalize - they can only perform causal inference in in-distribution settings when variable names and textual expressions used in the queries are similar to those in the training set, but fail in out-of-distribution settings generated by perturbing these queries. CORR2CAUSE is a challenging task for LLMs, and can be helpful in guiding future research on improving LLMs' pure reasoning skills and generalizability. | | Conference Paper | Liu, Jiarui;Li, Jiangrong;Zhu, Jiming |
| Proc. Conf. Fully Actuated System Theory Appl., FASTA |
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| 2024 | 517 - 522 | 10.1109/FASTA61401.2024.10595222 |
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| Extended Dissipative Sliding Mode Control for T-S Fuzzy Polynomial Singular System | In this paper, the problem of extended dissipative sliding mode control for discrete-time nonlinear singular systems are addressed. First, the T-S fuzzy polynomial singular systems are constructed to represent nonlinear singular systems with parameter uncertainties. A different delay-dependent sliding mode surface is built based on the dynamic event-triggered mechanism. Then, the sliding mode control law is obtained, which guarantees the reachability of the closed-loop system. The admissibility with extended dissipativity is established by SOS. Finally, a numerical example is given to demonstrate the correctness of the proposed strategy. | | Conference Paper | Zheng, Yuxin;Mo, Jiongjiong;Liu, Jiarui;Yu, Faxin |
| Int. Conf. Electron. Technol. Inf. Sci., ICETIS |
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| 2024 | 704 - 710 | 10.1109/ICETIS61828.2024.10593766 |
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| A Generic UVM Verification Framework Based on Two-Stage Comparison for Protocol-Agnostic Data Streams in Digital Designs | Unlike data packets governed by specific protocols, the data stream of input and output ports in signal processing blocks within chips lacks flags such as start and end, hindering individual data packet comparison during verification. A protocol-agnostic data stream verification framework based on the universal verification methodology (UVM) is proposed. Two-stage comparison is employed to match the outputs of the reference model and the design under test (DUT), enabling real-time comparison of the protocol-agnostic data stream. The stimulus generator operates independently outside the UVM environment, delivering stimuli to the DUT through a generic data interface. Featuring high-level abstraction and easy scalability, this framework is suited for complex scenarios with multi-module cascading. Finally, it facilitates the construction of a digital down converter (DDC) verification platform, and running on an Intel Core i7-8086K processor with 6 cores, achieved comparison of all module data streams in just 9 seconds. Moreover, this platform has also been extended to other different digital designs, all completing verification at a rapid pace. | | Letter | Wang, Bingwei;Yang, Xiaoning;Zhao, Miao;Su, Zhijie;Hu, Zhiping;Zhang, Chenyu;Guo, Bingbing;Liu, Jiarui;Qin, Lihua;Zhang, Weiguang;Zheng, Ruimao |
| Clin. Transl. Med. | 11 | 12 | 2021 |
| 10.1002/ctm2.641 | 2001-1326 |
| Celastrol prevents high-fat diet-induced obesity by promoting white adipose tissue browning |
| | Article | Wang, Jianhui;Wang, Haoyuan;Hu, Zikai;Liu, Jiarui;Chen, Kairui |
| Int. J. Robust Nonlinear Control | 34 | 16 | 2024 | 11312 - 11332 | 10.1002/rnc.7591 | 1049-8923 |
| Accurate trajectory tracking control for AUV under state constraints with a rapid stability dimensionality-augmented state observer | A rapid stability dimensionality-augmented state observer (RSDASO) based event-driven control strategy is presented for the autonomous underwater vehicle (AUV) trajectory tracking issue, addressing state constraints, model uncertainty, limited communication resources and unknown external time-varying disturbances. The first step is to develop a fast stability extended state observer to estimate the lumped disturbances and unmeasurable states of the system and ensure the estimation error converges in fixed time. Secondly, a fixed-time AUV trajectory tracking control method is proposed to ensure that the tracking error of the system converges within a fixed time, based on the mentioned observer. Simultaneously, to reduce the communication resource usage by the system, an event-triggered mechanism (ETM) is included in the control law. Lastly, simulation experiments verify the effectiveness of the process. | | Article | Liu, Jiarui;Yu, Jianlin;Yan, Gang |
| Energy | 307 |
| 2024 |
| 10.1016/j.energy.2024.132596 | 1873-6785 |
| Experimental study on performance characteristics of a −70 C ultra-low temperature medical freezer with mixed hydrocarbon refrigerant | It is well-known that the −70 C ultra-low temperature freezers have been widely concerned for vaccine and biomedical products storage due to the outbreak of COVID-19. This paper carries out the experimental investigation on performance characteristics of a −70 C ultra-low temperature medical freezer with single-stage Joule-Thomson refrigeration system by using binary hydrocarbon mixture R601a/R1150 and ternary mixture R601a/R290/R1150. The aim is to explore and verify hydrocarbon refrigerants that can achieve lower energy consumption, thereby providing a scientific basis for the optimization of ultra-low temperature medical freezers. The experimental results show that both R601a/R1150 and R601a/R290/R1150 with a charge of 250 g could achieve the refrigeration temperature below −70 C in a 568 L large volume vertical freezer. Comparing binary with ternary refrigerants, it is found that the addition of medium-boiling component R290 is beneficial to reduce the daily energy consumption. When the mass fraction of R601a/R1150 is 0.70/0.30, the lowest daily energy consumption for −70 C is 9.06 kW h·24 h. When the mass fraction of the R601a/R290/R1150 is 0.70/0.10/0.20, the daily energy consumption is 8.42 kW h·24 h, which is 7.06 % lower than that when using the R601a/R1150. This indicates that careful selection of refrigerant components and composition optimization can lead to substantial energy savings. Furthermore, it is also observed that among these three components, the low-boiling component R1150 has the most significant influence on the system pressures and operating power, followed by R601a and R290. | | Article | Song, Jiaqi;Huang, Haodong;Liu, Jiarui;Wu, Jiani;Chen, Yingxi;Wang, Lisong;Zhong, Fuxin;Wang, Xiaoqin;Lin, Zihan;Yan, Mengyu;Zhang, Wenbo;Liu, Xintong;Tang, Xinyi;Lü, Yang;Yu, Weihua |
| Cognitive Comput. | 16 | 6 | 2024 | 3364 - 3378 | 10.1007/s12559-024-10346-5 | 1866-9964 |
| Diagnostic Potential of Eye Movements in Alzheimer’s Disease via a Multiclass Machine Learning Model | Early diagnosis plays a crucial role in controlling Alzheimer’s disease (AD) progression and delaying cognitive decline. Traditional diagnostic tools present great challenges to clinical practice due to their invasiveness, high cost, and time-consuming administration. This study was designed to construct a non-invasive and cost-effective classification model based on eye movement parameters to distinguish dementia due to AD (ADD), mild cognitive impairment (MCI), and normal cognition. Eye movement data were collected from 258 subjects, comprising 111 patients with ADD, 81 patients with MCI, and 66 individuals with normal cognition. The fixation, smooth pursuit, prosaccade, and anti-saccade tasks were performed. Machine learning methods were used to screen eye movement parameters and build diagnostic models. Pearson’s correlation analysis was used to assess the correlations between the five most important eye movement indicators in the optimal model and neuropsychological scales. The gradient boosting classifier model demonstrated the best classification performance, achieving 68.2% of accuracy and 66.32% of F1-score in multiclass classification of AD. Moreover, the correlation analysis indicated that the eye movement parameters were associated with various cognitive functions, including general cognitive status, attention, visuospatial ability, episodic memory, short-term memory, and language and instrumental activities of daily life. Eye movement parameters in conjunction with machine learning methods achieve satisfactory overall accuracy, making it an effective and less time-consuming method to assist clinical diagnosis of AD. | | Article | Liu, Jiarui;Doh, Jeung-Hwan;Ong, Dominic E.L.;Kiely, Felicia Lee |
| Constr. Build. Mater. | 445 |
| 2024 |
| 10.1016/j.conbuildmat.2024.137943 | 0950-0618 |
| Effect of thermal pretreatment on the reactivity of red mud valorized as aluminosilicate precursor for geopolymer production | Thermal pretreatment has proven to be an effective method to improve the reactivity of red mud to be valorized as an aluminosilicate precursor for geopolymer production. This approach offers the dual advantage of recovering caustic residue in red mud and encapsulating heavy metal, thus, achieving the transformation of red mud into a cleaner and value-added construction material. However, the inconsistent properties of red mud, including variations in chemical composition, particle size, and amorphous content pose challenges and can lead to instability in geopolymer as well as the effectiveness of thermal pretreatment, limiting the scalability of red mud valorization. Here in this study, thermal pretreatment was employed on five types of red mud from three refineries by calcining each red mud at 800 C for 2 h and its effect on the reactivity of each red mud was evaluated by comparing the performance of the resultant geopolymer. The results demonstrated a significant enhancing effect from thermal pretreatment, particularly noticeable at NaOH concentrations of 4 M and 8 M. This again highlighted the potential of thermal pretreatment in the conversion of red mud into construction material. However, amplified disparities between each thermal pretreated-red mud were also observed. To further address the challenges associated with thermal pretreatment variability, the dissolubility of reactive content from each thermal pretreated-red mud under alkali environments was quantified through alkali leaching tests and correlated to the mechanical properties of its resultant geopolymer. A strong negative correlation was observed between the concentration of Si, Al, and Fe from thermal pretreated-red mud and the mechanical properties of its resultant geopolymer. This correlation has the potential to facilitate quality control measures for thermal pretreated-red mud and its derived geopolymer, enabling better process optimization and consistency in geopolymer production. | | Conference Paper | Wu, Zhenning;Zhao, Guangdong;Feng, Jian;Liu, Jiarui;Huang, Hanyang;Wang, Jianbin |
| Proc. IEEE Data Driven Control Learn. Syst. Conf., DDCLS |
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| 2024 | 333 - 338 | 10.1109/DDCLS61622.2024.10606584 |
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| Simulation Analysis of Defect Detection in Coated Pipelines Based on Pulse Eddy Current Testing | With the continuous development of the economy, the demand for fuels such as oil and natural gas has been steadily increasing. Pipeline transportation has become one of the main methods for transporting oil due to its low cost and high efficiency. Compared to traditional bare pipes, coated pipes add insulation and protective layers on the outer side, reducing the extent of damage to the pipeline. However, pipelines operate in harsh environments, often laid underground or on the seabed, making them prone to wall fractures. Currently, there is relatively little research on defect detection theories related to coated pipes. Based on pulse eddy current detection, this paper uses COMSOL Multiphysics simulation software to establish a defect detection model for coated pipelines. Through simulation analysis of defect detection on coated pipelines, we investigate the patterns of signal changes and the reasons behind these variations. This study provides theoretical and methodological support for subsequent research in this field. | | Article | Wang, Bingwei;Hu, Zhiping;Cui, Long;Zhao, Miao;Su, Zhijie;Jiang, Yong;Liu, Jiarui;Zhao, Yun;Hou, Yujia;Yang, Xiaoning;Zhang, Chenyu;Guo, Bingbing;Li, Daotong;Zhao, Liang;Zheng, Shengmin;Zhao, Yiguo;Yang, Weipeng;Wang, Dunfang;Yu, Siwang;Zhu, Shigong;Yan, Yi;Yuan, Geheng;Li, Kailong;Zhang, Wenqiang;Qin, Lihua;Zhang, Weiguang;Sun, Feng;Luo, Jianyuan;Zheng, Ruimao |
| Theranostics | 14 | 13 | 2024 | 5316 - 5335 | 10.7150/thno.97046 | 1838-7640 |
| βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning | Background: Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and adipose tissue. Deletion of the hypothalamic RIIβ gene centrally induces WAT browning, yet the peripheral mechanisms mediating this process remain unexplored. Methods: This study investigates the mechanisms underlying WAT browning in RIIβ-KO mice. Genetic approaches such as β3-adrenergic receptors (β3ARs) deletion and sympathetic denervation of WAT were utilized. Genome-wide transcriptomic sequencing and bioinformatic analysis were employed to identify potential mediators of WAT browning. siRNA assays were employed to knock down mTOR and lipin1 in vitro, while AAV-shRNAs were used for the same purpose in vivo. Results: We found that WAT browning substantially contributes to the lean and obesity-resistant phenotypes of RIIβ-KO mice. The WAT browning can be dampened by β3ARs deletion or WAT sympathetic denervation. We identified that adipocytic mTOR and lipin1 may act as mediators of the WAT browning. Inhibition of mTOR or lipin1 abrogates WAT browning and hinders the lean phenotype of RIIβ-KO mice. In human subcutaneous white adipocytes and mouse white adipocytes, β3AR stimulation can activate mTOR and causes lipin1 nuclear translocation; knockdown of mTOR and Lipin1 mitigates WAT browning-associated gene expression, impedes mitochondrial activity. Moreover, mTOR knockdown reduces lipin1 level and nuclear translocation, indicating that lipin1 may act downstream of mTOR. Additionally, in vivo knockdown of mTOR and Lipin1 diminished WAT browning and increased adiposity. Conclusions: The β3AR-activated mTOR-lipin1 axis mediates WAT browning, offering new insights into the molecular basis of PKA-regulated WAT browning. These findings provide potential adipose target candidates for the development of drugs to treat obesity. | | Article | Rao, Xiao;Chen, Jun;Wang, Shaopeng;Su, Haojie;Rao, Qingyang;Xia, Wulai;Liu, Jiarui;Fan, Xiaoyue;Deng, Xuwei;Shen, Hong;Xie, Ping |
| J. Anim. Ecol. | 93 | 10 | 2024 | 1593 - 1605 | 10.1111/1365-2656.14176 | 1365-2656 |
| Population asynchrony within and between trophic levels have contrasting effects on consumer community stability in a subtropical lake | Clarifying the effects of biodiversity on ecosystem stability in the context of global environmental change is crucial for maintaining ecosystem functions and services. Asynchronous changes between trophic levels over time (i.e. trophic community asynchrony) are expected to increase trophic mismatch and alter trophic interactions, which may consequently alter ecosystem stability. However, previous studies have often highlighted the stabilising mechanism of population asynchrony within a single trophic level, while rarely examining the mechanism of trophic community asynchrony between consumers and their food resources. In this study, we analysed the effects of population asynchrony within and between trophic levels on community stability under the disturbances of climate warming, fishery decline and de-eutrophication, based on an 18-year monthly monitoring dataset of 137 phytoplankton and 91 zooplankton in a subtropical lake. Our results showed that species diversity promoted community stability mainly by increasing population asynchrony both for phytoplankton and zooplankton. Trophic community asynchrony had a significant negative effect on zooplankton community stability rather than that of phytoplankton, which supports the match-mismatch hypothesis that trophic mismatch has negative effects on consumers. Furthermore, the results of the structural equation models showed that warming and top-down effects may simultaneously alter community stability through population dynamics processes within and between trophic levels, whereas nutrients act on community stability mainly through the processes within trophic levels. Moreover, we found that rising water temperature decreased trophic community asynchrony, which may challenge the prevailing idea that climate warming increases the trophic mismatch between primary producers and consumers. Overall, our study provides the first evidence that population and trophic community asynchrony have contrasting effects on consumer community stability, which offers a valuable insight for addressing global environmental change. | | Article | Wu, Fengjie;Liu, Jiarui;Yang, Jisen;Zhang, Lihan;He, Yan;Lin, Zhaolong |
| IEEE Access | 12 |
| 2024 | 132016 - 132026 | 10.1109/ACCESS.2024.3460393 | 2169-3536 |
| Learning Multiband-Temporal-Spatial EEG Representations of Emotions Using Lightweight Temporal Convolution and 3D Convolutional Neural Network | Emotion recognition based on electroencephalography (EEG) has become an important topic in affective computing. However, current research does not utilize the relationship between channel frequency bands, and the trainable parameters and FLOPs of the models of mainstream methods from the past two years are very large. To solve this problem, this paper proposes a new emotion recognition framework to learn the frequency band relationship of EEG and the temporal-spatial representation of the frequency domain. First, we extract the differential entropy features of the frequency band at a frequency resolution of 2 Hz to retain rich frequency band information. Second, we design a temporal convolution and 3D convolutional neural network (TC3DNet) that is a fusion of Temporal Convolutional Network (TCN) and 3D convolutional neural network (3DCNN) in series. TCN is used to learn frequency band relationships, and 3DCNN is further used to learn temporal-spatial representation. The average recognition accuracy of TC3DNet in the benchmark EEG emotion recognition SEED dataset and SEED-IV dataset is 98.48% and 95.30%, which is better than current state-of-the-art methods. The impact of different frequency band divisions on the proposed framework is also explored. Furthermore, this study visualizes the extracted features, thereby enhancing the interpretability of our work. | | Article | Ren, Jingyi;Liu, Jiarui;Zuo, Jinshi;Zhang, Zhenao;Huang, Dan;Liu, Xuanyi;Lu, Miaomiao;Zhang, Yadong;Su, Yang;Ma, Yuxia |
| Food Funct. | 15 | 19 | 2024 | 10007 - 10019 | 10.1039/d4fo03486d | 2042-6496 |
| Flaxseed oil attenuates PFOS-induced testicular damage by regulating RNA alternative splicing | Background: Perfluorooctane sulfonate (PFOS) is a persistent, widely present environmental pollutant, and its toxicity to male reproduction has gradually attracted attention. Flaxseed oil (FO) is a dietary oil abundant in α-linolenic acid and has been demonstrated to possess multiple health benefits. However, whether FO protects against PFOS-induced testicular injury and its mechanism remain unclear. Methods: C57/BL6 mice were gavaged with different concentrations of FO or PFOS (10 mg kg) for 28 days. Blood and testicular tissues were collected for histopathology, proteomics, and biochemical and molecular analyses. Results: Our results showed that FO supplementation significantly attenuated PFOS-induced testicular injury, as indicated by histopathological changes, decreased oxidative stress level, increased sperm count, decreased rate of sperm malformation, and improved functional markers of spermatogenesis. Proteomic analysis showed that differentially expressed proteins were notably enriched in spliceosome pathways. Machine learning algorithms were used to screen the hub gene, and PRPF3 and PUF60 proteins were found to be important for FO to exert protective benefits to testicular injury. Western blot results confirmed that FO supplementation could increase the protein expression of PRPF3 and decrease the protein expression of PUF60 in PFOS-exposed mice. Conclusions: This study revealed that FO can alleviate PFOS-induced testicular dysfunction by regulating RNA alternative splicing. The spliceosome-related proteins PRPF3 and PUF60 may be the potential targets for FO to alleviate PFOS-induced testicular injury. FO supplementation may be an effective dietary intervention to prevent adverse effects of PFOS on testes. | | Article | Cong, Guang-Yu;Li, Dong-Fei;Liu, Jia-Rui |
| Guang Pu Xue Yu Guang Pu Fen Xi. | 44 | 9 | 2024 | 2434 - 2438 | 10.3964/j.issn.1000-0593(2024)09-2434-05 | 1000-0593 |
| High-Pressure Raman Study of Pyromellitic Dianhydride | Raman spectra of pyromellitic dianhydride crystal have been measured from ambient to 24 GPa, and the Raman vibrational modes of pyromellitic dianhydride have been assigned. Based on the pressure dependence of Raman mode frequencies, it can be observed that a phase transition of pyromellitic dianhydride occurred from Phase I to Phase II at 2 GPa. In comparing the slopes of the pressure dependence of the Raman vibrational modes between Phase I and Phase II , it can be found that most of the slopes of Phase I were smaller than Phase II • The results indicate that the sensitivity of functional groups of pyromellitic dianhydride to pressure decreases with increasing pressure, and the molecular crystal of pyromellitic dianhydride has a more compact stacking structure in phase II • Besides, we also calculated the Raman intensities ratio of the overtone of С-О stretching vibration mode (located at 1 837 cm x) and the fundamental of C O stretching vibration mode (located at 1 865 cm-1) and the discontinuities of the Raman intensities ratio versus pressure was observed. This behavior confirms that the pyromellitic dianhydride crystal has undergone a phase transition at 2 GPa, as mentioned above. | | Article | Zeng, Zheni;Yin, Bangchen;Wang, Shipeng;Liu, Jiarui;Yang, Cheng;Yao, Haishen;Sun, Xingzhi;Sun, Maosong;Xie, Guotong;Liu, Zhiyuan |
| Bioinformatics | 40 | 9 | 2024 |
| 10.1093/bioinformatics/btae534 | 1367-4811 |
| ChatMol: interactive molecular discovery with natural language | Motivation: Natural language is poised to become a key medium for human-machine interactions in the era of large language models. In the field of biochemistry, tasks such as property prediction and molecule mining are critically important yet technically challenging. Bridging molecular expressions in natural language and chemical language can significantly enhance the interpretability and ease of these tasks. Moreover, it can integrate chemical knowledge from various sources, leading to a deeper understanding of molecules. Results: Recognizing these advantages, we introduce the concept of conversational molecular design, a novel task that utilizes natural language to describe and edit target molecules. To better accomplish this task, we develop ChatMol, a knowledgeable and versatile generative pretrained model. This model is enhanced by incorporating experimental property information, molecular spatial knowledge, and the associations between natural and chemical languages. Several typical solutions including large language models (e.g. ChatGPT) are evaluated, proving the challenge of conversational molecular design and the effectiveness of our knowledge enhancement approach. Case observations and analysis offer insights and directions for further exploration of natural-language interaction in molecular discovery. | | Article | Shen, Zecheng;Liu, Jiarui;Wang, Hao-Xin;Wang, Yao |
| Phys. Rev. Res. | 6 | 3 | 2024 |
| 10.1103/PhysRevResearch.6.L032068 | 2643-1564 |
| Signatures of the attractive interaction in spin spectra of one-dimensional cuprate chains | Identifying the minimal model for cuprates is crucial for explaining the high-Tc pairing mechanism. Recent photoemission experiments have suggested a significant near-neighbor attractive interaction V in cuprate chains, favoring pairing instability. To determine its strength, we systematically investigate the dynamical spin structure factors S(q,ω) using the density matrix renormalization group. Our analysis quantitatively reveals a notable softening in the two-spinon continuum, particularly evident in the intense spectrum at large momentum. This softening is primarily driven by the renormalization of the superexchange interaction, as determined by a comparison with the slave-boson theory. We also demonstrate the feasibility of detecting this spectral shift in thin-film samples using resonant inelastic x-ray scattering. Therefore, this provides a distinctive fingerprint for the attractive interaction, motivating future experiments to unveil essential ingredients in cuprates. | | Article | Liu, Jiarui;Wang, Lulu;Bai, Liangjiu;Wang, Wenxiang;Yang, Lixia;Chen, Hou;Yang, Huawei;Wei, Donglei |
| Macromol. Chem. Phys. | 225 | 21 | 2024 |
| 10.1002/macp.202400207 | 1521-3935 |
| Fabrication of Nanocomposite Hydrogels Based on Cellulose Nanocrystals and Multi-Walled Carbon Nanotubes for Human Motion Monitoring | In this study, a flexible sensor is successfully fabricated using self-healing nanocomposite hydrogels for monitoring human movement. The eco-friendly cellulose nanocrystals (CNCs) are used as nano-reinforcing materials, and the mechanical properties and self-healing efficiency of the materials are improved. The self-healing efficiency of hydrogels are realized by introducing a variety of reversible non-covalent interactions such as hydrogen bonding, borax chelation, and metal coordination. Notably, the mechanical strength and self-healing efficiency of these nanocomposite hydrogels can reach 2.8 MPa and 89.9%, respectively. Importantly, these self-healing nanocomposite hydrogels have been widely used in wearable flexible sensors to achieve high sensitivity to large-scale human movement. It is of great significance to design functional materials with good biocompatibility, sensitivity, and mechanical strength for wearable sensors. | | Article | Liu, Jiarui;Li, Shaozhi;Huang, Edwin W.;Wang, Yao |
| Phys. Rev. B | 110 | 11 | 2024 |
| 10.1103/PhysRevB.110.115133 | 2469-9969 |
| Charge density wave state in extremely overdoped cuprates driven by phonons | Recent resonant x-ray scattering (RXS) experiments revealed a novel charge order in extremely overdoped La2-xSrxCuO4 (LSCO) [Li, Phys. Rev. Lett. 131, 116002 (2023)0031-900710.1103/PhysRevLett.131.116002]. The observed charge order appears around the (π/3,0) wave vector, distinct from the well-known stripe fluctuations near 1/8 doping, and persists from cryogenic temperatures to room temperature. To investigate the origin of this charge order in the overdoped regime, we use determinant quantum Monte Carlo (DQMC) simulations to examine correlated models with various interactions. We demonstrate that this distinctive CDW originates from remnant correlations in extremely overdoped cuprates, with its specific pattern shaped by interactions beyond the Hubbard model, particularly electron-phonon couplings. The persistence of the (π/3,0) wave vector across different doping levels indicates the presence of nonlocal couplings. Our study reveals the significant role of phonons in cuprates, which assist correlated electrons in the formation of unconventional phases. | | Article | Xia, Wulai;Rao, Qingyang;Liu, Jiarui;Chen, Jun;Xie, Ping |
| J. Hazard. Mater. | 480 |
| 2024 |
| 10.1016/j.jhazmat.2024.135998 | 1873-3336 |
| Occurrence and characteristics of microplastics across the watershed of the world's third-largest river | While rivers as primary conduits for land-based plastic particles transferring to their “ultimate” destination, the ocean, have garnered increasing attention, research on microplastic pollution at the scale of whole large river basins remains limited. Here we conducted a large-scale investigation of microplastic contamination in water and sediment of the world's third-largest river, the Yangtze River. We found concentrations of microplastics in water and sediment to be 5.13 items/L and 113.9 items/kg (dry weight), respectively. Moreover, microplastic pollution levels exhibited a clear decreasing trend from upstream to downstream. The detected microplastics were predominantly transparent in color, with fibrous shapes predominating, sizes mainly concentrated below 1 mm and composed primarily of PP and PE polymers. Our analysis results indicated that compared to geographical and water quality parameters, anthropogenic factors primarily determined the spatial distribution pattern of microplastics. Moreover, the microplastic abundance in sediment upstream of the dam was significantly higher than that in the downstream sediment, while the trend of microplastic concentrations in water was opposite. Therefore, more effort is needed to monitor microplastic contamination and their ecological environmental effects of sediment before dams in future research. | | Article | Wang, Yuxuan;Li, Hao;Zhang, Zhihao;Wu, Futong;Liu, Jiarui;Zhu, Zhongze;Xiang, Hongfei |
| Lipids Health Dis. | 23 | 1 | 2024 |
| 10.1186/s12944-024-02313-8 | 1476-511X |
| The association between vitamin E intake and remnant cholesterol, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in US adults: a cross-sectional study | Background: Blood lipid profiles are associated with various nutritional elements and dietary factors. This study aimed to explore the association between total dietary vitamin E intake and remnant cholesterol (RC), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) using data from the National Health and Nutrition Examination Survey (NHANES). Methods: A cross-sectional analysis was conducted using NHANES 2007–2018 data. A total of 8,639 eligible participants (45.58% men and 54.42% women) with an average age of 46.12 ± 16.65 years were included in this study. Weighted multivariate linear regression and subgroup analyses were used to examine the association between vitamin E intake and RC, TC, HDL-C, and LDL-C. Smooth curve fitting was used to explore potential non-linear associations. Results: After adjusting for other covariates, multivariate linear regression analysis showed that higher vitamin E intake was negatively associated with plasma RC (β = -0.22, 95% CI: -0.27, -0.16), TC (β = -0.33, 95% CI: -0.51, -0.16), LDL-C (β = -0.25, 95% [confidence interval] CI: -0.40, -0.10) and positively associated with HDL-C (β = 0.13, 95% CI: 0.07, 0.20) in US adults. Subgroup analysis indicated that age may influence the association between vitamin E intake and RC. At the same time, gender may also affect the association between vitamin E intake and HDL-C. Conclusion: Higher vitamin E intake was negatively associated with plasma RC, TC, LDL-C and positively associated with HDL-C. | | Article | Li, Ruiheng;Liu, Jiarui;Shi, Binqin;Zhao, Hanyi;Li, Yan;Zheng, Xinran;Peng, Chao;Lv, Chunli |
| Plants | 13 | 19 | 2024 |
| 10.3390/plants13192720 | 2223-7747 |
| High-Performance Grape Disease Detection Method Using Multimodal Data and Parallel Activation Functions | This paper introduces a novel deep learning model for grape disease detection that integrates multimodal data and parallel heterogeneous activation functions, significantly enhancing detection accuracy and robustness. Through experiments, the model demonstrated excellent performance in grape disease detection, achieving an accuracy of 91%, a precision of 93%, a recall of 90%, a mean average precision (mAP) of 91%, and 56 frames per second (FPS), outperforming traditional deep learning models such as YOLOv3, YOLOv5, DEtection TRansformer (DETR), TinySegformer, and Tranvolution-GAN. To meet the demands of rapid on-site detection, this study also developed a lightweight model for mobile devices, successfully deployed on the iPhone 15. Techniques such as structural pruning, quantization, and depthwise separable convolution were used to significantly reduce the model’s computational complexity and resource consumption, ensuring efficient operation and real-time performance. These achievements not only advance the development of smart agricultural technologies but also provide new technical solutions and practical tools for disease detection. | | Article | Yan, Mengqi;Li, Xuechen;Liu, Jiarui;Li, Xinyue;Wu, Shining;Zhou, Mingyang;Cui, Yuezhi |
| J. Mater. Chem. B | 12 | 44 | 2024 | 11455 - 11463 | 10.1039/d4tb01767f | 2050-750X |
| A membrane-anchored fluorescent probe for the detection of pH in living cells and NAFLD | The abnormal pH in cell membranes can lead to disorder in membrane structure and permeability, and is also an important signal of cell cancer. The acidification of the cell membrane can lead to the disorder of cell lipid metabolism and lead to non-alcoholic fatty liver disease (NAFLD). However, fluorescent probes to detect the cell membrane pH have rarely been reported, let alone used to study NAFLD. For this, we developed a fluorescent probe (Mem-pH) that can firmly anchor the cell membrane based on lipophilic action and electrostatic action forces, and successfully detect membrane pH by fluorescence intensity. More importantly, the probe Mem-pH can quantify the pH of different kinds of cell membranes, further demonstrating that the pH of cancer cell membranes is lower than that of normal cell membranes. Furthermore, Mem-pH successfully differentiates and detects different degrees of NAFLD tissues, offering hope for timely diagnosis of NAFLD. | | Article | Ren, Jingyi;Zuo, Jinshi;Yin, Bowen;Huang, Dan;Wen, Rui;Pei, Huanting;Liu, Jiarui;Zhang, Yadong;Zhu, Siqi;Zhen, Shuman;Ma, Yuxia |
| J. Agric. Food Chem. | 72 | 42 | 2024 | 23465 - 23477 | 10.1021/acs.jafc.4c04438 | 1520-5118 |
| Flaxseed Oil Alleviates PFOS-Induced Liver Injury by Regulating Hepatic Cholesterol Metabolism | Perfluorooctanesulfonate (PFOS) is a widespread, persistent environmental pollutant that exerts apparent liver toxicity. Flaxseed oil (FO), a dietary oil rich in α-linolenic acid, has been demonstrated to possess a diverse array of health benefits. However, whether FO protects against PFOS-induced liver injury and its underlying mechanisms remain unclear. C57/BL6 mice were orally treated with different concentrations of FO alone or in combination with 10 mg/kg of PFOS for 28 consecutive days. Blood and liver tissues were collected for proteomic, histopathological, biochemical, immunohistochemical, and molecular examinations. Results demonstrated that FO supplementation reduced PFOS-induced liver injury, as evidenced by a decrease in histopathological changes, serum transaminase (ALT and AST) levels, levels of oxidative stress, and inflammatory cytokine (TNF-α, IL-1β, and IL-6) levels. Proteomic analyses showed that differentially expressed proteins were enriched in cholesterol metabolic pathways when comparing the PFOS group to the FO supplementation groups. The expression of cholesterol metabolism-related proteins was also subsequently measured, revealing that FO supplementation decreased the protein expressions of SREBP2, HMGCR, and LDLR while increasing the expression of CYP7A1. This study demonstrates that FO can alleviate PFOS-induced hepatotoxicity by regulating hepatic cholesterol metabolism, indicating that FO may serve as an effective dietary intervention for preventing liver injury caused by PFOS. | | Conference Paper | Liu, Jiarui;Fan, Xinggang;Li, Dawei;Qu, Ronghai;Liang, Ziyi |
| Int. Conf. Electr. Mach., ICEM |
|
| 2024 |
| 10.1109/ICEM60801.2024.10700499 | 00001 |
| Computationally Efficient Evaluation of PWM-Induced Losses in Inverter-Fed High Speed Permanent Magnet Machines∗ | With the application of high switching frequency inverters, the induced pulse width modulation (PWM) losses in the electrical machines can be significant especially when machines rotating at high speeds. This paper proposes a semi-analytical evaluation method to predict the harmonic field and the induced additional high frequency PWM losses. Based on the platform of MATLAB and FEMM, the proposed method combines the frozen differential permeability method (FDPM) and the linear time-harmonics magnetostatic finite element method(FEM) to predict harmonic field consider PWM. Based on the extracted harmonic magnetic parameters, semi-analytical evaluation expressions are presented to calculate PWM-induced losses in iron core, windings and permanent magnets separately. This method is implemented and verified on an inverter-fed surface-mounted permanent magnet(SPM) machine. The estimation of PWM losses shows high accuracy with efficient computation compared to conventional FEM. | | Conference Paper | Wang, Yu;Zhang, Chunguang;Li, Shangqing;Li, Zhichao;Gong, Yingjiao;Liu, Jiarui |
| J. Phys. Conf. Ser. | 2845 | 1 | 2024 |
| 10.1088/1742-6596/2845/1/012010 | 1742-6596 |
| Analysis of stiffness characteristics of helical compression springs used in high-precision instruments | Under working conditions of high-temperature, high-pressure, and strong corrosion, helical compression springs used in high-precision instruments need to maintain linear characteristics and impact resistance. To solve the problem of significantly reduced instrument accuracy due to the stiffness drift of current helical compression springs, compression stiffness characteristics are analyzed through compression tests and finite element simulations. The results indicate that the stiffness drift is caused by the sliding displacement of helical compression springs after being compressed and self-contacted. With the premise of minimizing overall effect on instruments, the helical compression spring structure was redesigned to eliminate the stiffness drift and meet requirements for impact resistance. | | Article | Zhang, Yongkang;Liu, Jiarui;Wang, Yuzhen;Zong, Yuan;Yin, Kangli;Cao, Fang;Liang, Xinyu;Cao, Yemin |
| Int. J. Gen. Med. | 17 |
| 2024 | 4595 - 4605 | 10.2147/IJGM.S477968 | 1178-7074 |
| Ruanjian Qingmai Granules for the Treatment of Early Symptomatic Peripheral Arterial Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Protocol | Purpose: Peripheral arterial disease (PAD) is a chronic ischemic disease caused by atherosclerosis of the lower extremities, with early clinical symptoms manifesting mainly as intermittent claudication. Current treatment of PAD is based on the control of cardiovascular risk factors. However, even vasoactive drugs are not ideal for improving ischemic symptoms in the lower limbs of PAD patients. Ruanjian Qingmai granules, derived from the classic formula of the late Professor Jiuyi Xi, a famous traditional Chinese medicine doctor in Shanghai, have good clinical efficacy in the treatment of the pattern of blood vessel stasis and obstruction of PAD and have been used by more than 600,000 PAD patients over the past three decades. This study aims to evaluate the efficacy and safety of Ruanjian Qingmai granules in patients with symptomatic PAD. Patients and methods: A prospective, center-randomized, double-blind, placebo-controlled clinical trial will be conducted at 9 grade A tertiary hospitals in Shanghai. It is anticipated that 250 patients with early symptomatic PAD will be recruited and randomized to the control and intervention groups (1:1 ratio of central randomization). Subjects will be treated with Ruanjian Qingmai granules or placebo at 6 g twice daily for 16 weeks. The primary efficacy indicators are the pain-free walking distance and maximum walking distance. The secondary efficacy indicators are the ankle-brachial index, walking impairment questionnaire, quality of life score, and Chinese medicine syndrome score. Conclusion: Positive results from this study will demonstrate the efficacy and safety of Ruanjian Qingmai granules in improving ischemic symptoms in patients with symptomatic PAD. Clinical Registration: This study has been registered with the Chinese Clinical Trials Registry (ChiCTR2200056109, Date: 02/01/2022, https://www.chictr.org.cn/showproj.html?proj=150982). | | Article | Li, Peiting;Yang, Ruiting;Liu, Jiarui;Huang, Chaohua;Huang, Guoqiang;Deng, Zuhu;Zhao, Xinwang;Xu, Liangnian |
| Plant Cell Environ. | 48 | 2 | 2025 | 1621 - 1642 | 10.1111/pce.15232 | 1365-3040 |
| Coexpression Regulation of New and Ancient Genes in the Dynamic Transcriptome Landscape of Stem and Rhizome Development in “Bainianzhe”—An Ancient Chinese Sugarcane Variety Ratooned for Nearly 300 Years | The sucrose yield in sugarcane largely depends on stem morphology, including length, diameter and sugar content, making sugarcane stem a key trait in breeding. The “Bainianzhe” variety from Songxi County, Fujian Province, possesses both aerial stems and rhizomes, providing a unique model for studying stem development. We performed a spatiotemporal transcriptomic analysis of the base, middle and apical sections of both aerial stems and rhizomes. The analysis categorized transcriptomes by developmental stage—base, middle and apical—rather than environmental differences. Apical segments were enriched with genes related to cell proliferation, while base segments were linked to senescence and fibrosis. Gene regulatory networks revealed key TFs involved in stem development. Orphan genes may be involved in rhizome development through coexpression networks. Plant hormones, especially genes involved in ABA and GAs synthesis, were highly expressed in rhizomes. Thiamine-related genes were also more prevalent in rhizomes. Furthermore, the apical segments of rhizomes enriched in photosynthesis-related genes suggest adaptations to light exposure. Low average temperatures in Songxi have led to unique cold acclimation in Bainianzhe, with rhizomes showing higher expression of genes linked to unsaturated fatty acid synthesis and cold-responsive calcium signalling. This indicates that rhizomes may have enhanced cold tolerance, aiding in the plant's overwintering success. | | Article | Liu, Jiarui;Wang, Yang;Shi, Wangbin;Meng, Xiangren;Mintah, Benjamin Kumah;Dabbour, Mokhtar;Zhang, Zhaoli;He, Ronghai;Ma, Haile |
| J. Food. Sci. | 89 | 12 | 2024 | 9015 - 9032 | 10.1111/1750-3841.17494 | 1750-3841 |
| How ultrasonication treatment drives the interplay between lysinoalanine inhibition and conformational performances: A case study on alkali-extracted rice residue protein isolate | Lysinoalanine (LAL) formed during alkaline extraction of rice residue protein (RRPI), which limited its application in the food industry. In this study, the influence of ultrasonication parameters (acoustic power density, ultrasound duration, and ultrasound temperature) on the inhibition of LAL formation and conformational attributes of RRPI during alkaline extraction was elucidated. The results suggested that the acoustic power density substantially modified the chemical interaction forces between RRPI molecules. At a power density of 60 W/L, the ionic bonds (14.37%) and hydrophobic interactions (49.28%) reached the maximum, while hydrogen bonds (15.29%) and disulfide bonds (21.06%) reached the minimum. Moreover, acoustic power density at 60 W/L caused a decrease of 18.02% and 12.2% in α-helix, and β-turn, respectively, shifting toward β-sheet, random coil, with an increase of 7.31% and 36.16%. Following ultrasonication, the protein particle size distribution curve shifted in the direction of smaller particle size, forming a relatively concentrated and uniform protein distribution. Sonication power, temperature, and time decreased the absolute value of Zeta potential. Furthermore, significant destruction in microstructure was elicited by sonication, which made the structure looser and more microparticles. Pearson correlation analysis suggested that the inhibition in the levels of LAL was most influenced by the increase of sulfhydryl groups and Zeta potential, as well as the reduction of α-helix content, in which the alteration of the total sulfhydryl group content had a great impact on the Zeta potential and the free sulfhydryl group. The principal component analysis demonstrated a notable correlation between the total sulfhydryl group and both the Zeta potential and free sulfhydryl group of RRPI. | | Article | Liu, Jiarui;Chen, Siqi;Zhang, Zijing;Song, Xitong;Hou, Zhiquan;Wang, Ziyi;Liu, Tao;Yang, Liqun;Liu, Yunen;Luo, Zhonghua |
| Int. J. Biol. Macromol. | 282 |
| 2024 |
| 10.1016/j.ijbiomac.2024.137107 | 1879-0003 |
| The oxidized hyaluronic acid hydrogels containing paeoniflorin microspheres regulates the polarization of M1/M2 macrophages to promote wound healing | Controlling excessive inflammation of acute wound is an effective means to shorten the healing time. Therefore, targeted control of the inflammatory response of the wound is a promising therapeutic strategy. In this study, paeoniflorin (Pae) was encapsulated in microspheres and combined with oxidized hyaluronic acid hydrogels to prepare the hydrogel loaded with Pae microspheres (Pae-MPs@OHA) to promote the healing of acute wounds in rats. The results demonstrated that the particle size of the Pae-MPs was 6.84 ± 0.51 μm, and the positive charge was 26.87 ± 1.51 mV. The uniform spherical structure of the Pae-MPs was observed by TEM. The Pae-MPs@OHA can maintain colloidal state in the range of 0.1–3.16 Hz. FTIR suggested that Pae could be effectively wrapped in MPs, and SEM indicated that the Pae-MPs@OHA had a uniform network pore structure. The Pae-MPs@OHA can realize the sustained release of Pae for 96 h. Biocompatibility experiments showed that the Pae-MPs@OHA hydrogels were safe and available. The Pae-MPs@OHA hydrogels can accelerate wound healing in rats. HE and masson staining suggested that the Pae-MPs@OHA could reduce inflammatory cell infiltration, promote re-epithelialization and collagen formation. The Pae-MPs@OHA could decrease the number of M1 and increase the number of M2 in macrophages, thus regulating the release of inflammatory factor TNF-α and IL-1β. The results of molecular docking and western blot results also confirmed that the Pae-MPs@OHA could reduce the expression of NF-κB, pNF-κB, NLRP3, ASC and pro-caspase-1. These findings suggest that the Pae-MPs@OHA has great potential for application in the treatment of inflammatory wound. | | Article | Lu, Yongxin;Yang, Guotian;Li, Xinli;Liu, Jianguo;Yang, Tianye;Liu, Jiarui |
| Int. J. Hydrogen Energy | 94 |
| 2024 | 580 - 599 | 10.1016/j.ijhydene.2024.10.426 | 0360-3199 |
| Dynamic power allocation for the new energy hybrid hydrogen production system based on WOA-VMD: Improving fluctuation balance and optimizing control strategy | The new energy hydrogen production system is subject to intermittent fluctuations, which compromise efficiency and equipment lifespan. This study proposes a new dynamic power allocation and control strategy for hybrid hydrogen production systems. By using the Whale Algorithm Optimized Variable Modal Decomposition (WOA-VMD), the fluctuating power of new energy is quantitatively decomposed and reconstructed. Based on a multi-objective optimization function, low-frequency variation components and high-frequency fluctuation components are accurately allocated between alkaline electrolyzers (ALK) and proton exchange membrane electrolyzers (PEM). The strategy effectively improves the source-load balancing capability, reducing the low-frequency fluctuation rate by 60% and reducing the high-frequency power amplitude by 70%, significantly reducing the operational demands on ALK electrolyzers, the capacity requirements of PEM electrolyzers, and the need for energy storage configuration, while also increasing hydrogen production efficiency by 7%. Compared to existing methods, the strategy has a transparent analysis process, strong interpretability, and good data reusability, making it valuable for engineering applications. | | Article | Wang, Jiamin;Yang, Kun;Yuan, Ling;Liu, Jiarui;Peng, Zhong;Ren, Zuhuan;Zhou, Xu |
| Geophys. Res. Lett. | 51 | 21 | 2024 |
| 10.1029/2024GL111056 | 1944-8007 |
| Deducing Aerodynamic Roughness Length From Abundant Anemometer Tower Data to Inform Wind Resource Modeling | Aerodynamic roughness length ((Formula presented.)) fundamentally affects land surface momentum loss and wind resource simulation, but ground truth data of (Formula presented.) are sparse in space, causing (Formula presented.) datasets used in atmospheric models are empirically estimated from land cover types through a look-up table. In this study, we derived (Formula presented.) values from 101 anemometer towers in China. Taking them as ground truth, we show that existing gridded (Formula presented.) datasets determined from either a look-up table or a machine-learning method contain considerable uncertainty and fail to capture the variability of (Formula presented.) within each land cover type, although the latter performs better. Even for the widely used ERA5, its (Formula presented.) is overestimated in wind-rich regions of China, causing an underestimation of near-surface wind speed. This highlights the necessity to improve (Formula presented.) data in atmospheric models. Current rapidly expanding anemometer towers may substantially enrich (Formula presented.) truth data and thus provide potential to improve wind resource modeling. | | Article | Lu, Yiming;Zhang, Haicheng;Liu, Jiarui;Ding, Jun;Xu, Daolin |
| Phys. Fluids | 36 | 10 | 2024 |
| 10.1063/5.0238329 | 1089-7666 |
| Caudal peduncle-inspired two-degree-of-freedom elastic coupling fin propulsion method | Marine animals orchestrate the swimming process through the coordinated interplay of body musculature, the caudal peduncle, and the caudal fin. However, understanding the coordinated action of these components to achieve high propulsive performance remains a significant challenge. The study proposes a self-propulsive physical model with two-degree-of-freedom (DoF) elastic coupling inspired by the caudal peduncle, where the caudal peduncle exhibits spring-like behaviors influencing the tail's motion along heave/pitch directions. The complex nonlinear fluid-structure interaction issues are addressed via the nonlinear vortex sheet method. The study primarily compares the propulsive performance of the two-DoF elastic coupling caudal fin model with the pitch caudal fin model. Numerical results show that the peak efficiency of the proposed model is nearly eight times that of the pitch caudal fin model. Additionally, the study reveals that the high-propulsive mechanism lies in generating the figure of a butterfly phase diagram for the hydrodynamic forces and exploiting vortices to decrease energy consumption. These findings offer novel perspectives for the future design of high-efficiency underwater robots. | | Article | Zhan, Jinyu;Peng, Suidi;Jiang, Wei;Wang, Xiang;Liu, Jiarui |
| IEEE Trans. Comput. Aided. Des. Integr. Circuits Syst. | 43 | 11 | 2024 | 3985 - 3996 | 10.1109/TCAD.2024.3437331 | 0278-0070 |
| Detecting Spoofed Noisy Speeches via Activation-Based Residual Blocks for Embedded Systems | Spoofed noisy speeches seriously threaten the speech-based embedded systems, such as smartphones and intelligent assistants. Consequently, we present an anti-spoofing detection model with activation-based residual blocks to identify spoofed noisy speeches with the requirements of high accuracy and low time overhead. Through theoretic analysis of noise propagation on shortcut connections of traditional residual blocks, we observe that different activation functions can help reducing the influence of noise under certain situations. Then, we propose a feature-aware activation function to weaken the influence of noise and enhance the anti-spoofing features on shortcut connections, in which a fine-grained processing is designed to remove noise and strengthen significant features. We also propose a variance-increasing-based optimization algorithm to find the optimal hyperparameters of the feature-aware activation function. Benchmark-based experiments demonstrate that the proposed method can reduce the average equal error rate of anti-spoofing detection from 21.72% to 4.51% and improve the accuracy by up to 37.06% and save up to 91.26% of time overhead on Jetson AGX Xavier compared with ten state-of-the-art methods. | | Article | Zhan, Jinyu;Peng, Suidi;Jiang, Wei;Wang, Xiang;Liu, Jiarui |
| IEEE Trans. Comput. Aided. Des. Integr. Circuits Syst. | 43 | 11 | 2024 | 3985 - 3996 | 10.1109/TCAD.2024.3437331 | 0278-0070 |
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| | Article | Bai, Xupeng;Liu, Jiarui;Zhou, Shujie;Wu, Lingzhi;Feng, Xiaojie;Zhang, Pumin |
| J. Exp. Clin. Cancer Res. | 43 | 1 | 2024 |
| 10.1186/s13046-024-03225-2 | 0392-9078 |
| METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer | Background: Triple-negative breast cancer (TNBC) has pronounced stemness that is associated with relapse. N-methyladenosine (mA) plays a crucial role in shaping cellular behavior by modulating transcript expression. However, the role of mA in TNBC stemness, as well as the mechanisms governing its abundance, has yet to be elucidated. Methods: We analyzed proteomic and transcriptomic data derived from breast cancer cohorts, with an emphasis on mA regulators. To unravel the role of mA in TNBC, we employed RNA sequencing, methylated RNA immunoprecipitation sequencing, RNA immunoprecipitation, chromatin immunoprecipitation, and luciferase reporter assays with mesenchymal stem-like (MSL) TNBC models. The clinical relevance was validated using human tissue microarrays and publicly accessible databases. Results: Our findings indicate that the global level of mA modification in MSL TNBC is downregulated primarily due to the loss of methyltransferase-like 14 (METTL14). The diminished mA modification is crucial for the maintenance of TNBC stemness, as it increases the expression of yes-associated protein 1 (YAP1) by blocking YTH domain-containing family protein 2 (YTHDF2)-mediated transcript decay, thereby promoting the activation of Hippo-independent YAP1 signaling. YAP1 is essential for sustaining the stemness regulated by METTL14. Furthermore, we demonstrated that the loss of METTL14 expression results from lysine-specific demethylase 1 (LSD1)-mediated removal of histone H3 lysine 4 methylation at the promoter region, which is critical for LSD1-driven stemness in TNBC. Conclusion: These findings present an epi-transcriptional mechanism that maintains Hippo-independent YAP1 signaling and plays a role in preserving the undifferentiated state of TNBC, which indicates the potential for targeting the LSD1-METTL14 axis to address TNBC stemness. | | Article | Pan, Zihang;Yao, Qiyang;Kong, Weijing;Ma, Xiaojing;Tian, Liangliang;Zhao, Yun;Zhu, Shuntian;Chen, Sheng;Sun, Mengze;Liu, Jiao;Jiang, Simin;Ma, Jianxun;Liu, Qijia;Peng, Xiaohong;Li, Xiaoxia;Hong, Zixuan;Hong, Yi;Wang, Xue;Liu, Jiarui;Zhang, Jingjing;Zhang, Wei;Sun, Bingbing;Pahlavan, Sara;Xia, Youchen;Shen, Weimin;Liu, Yuyong;Jiang, Wenjian;Xie, Zhengwei;Kong, Wei;Wang, Xi;Wang, Kai |
| Cell Stem Cell | 32 | 2 | 2025 | 227 - 9,245 | 10.1016/j.stem.2024.10.015 | 1934-5909 |
| Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery | Venous malformations (VMs) represent prevalent vascular anomalies typically attributed to non-inherited somatic mutations within venous endothelial cells (VECs). The lack of robust disease models for VMs impedes drug discovery. Here, we devise a robust protocol for the generation of human induced VECs (iVECs) through manipulation of cell-cycle dynamics via the retinoic signaling pathway. We introduce an L914F mutation into the TIE2 gene locus of induced pluripotent stem cells (iPSCs) and show that the mutated iVECs form dilated blood vessels after transplantation into mice, thereby recapitulating the phenotypic characteristics observed in VMs. Moreover, utilizing a deep neural network and a high-throughput digital RNA with perturbation of genes sequencing (DRUG-seq) approach, we perform drug screening and demonstrate that bosutinib effectively rescues the disease phenotype in vitro and in vivo. In summary, by leveraging genome editing and stem cell technology, we generate VM models that enable the development of additional therapeutics. | | Article | Zhao, Xiaotong;Deng, Maosen;Guo, Shuang;Liu, Jiarui;Liu, Na;Li, Zhe |
| Adv. Mater. Technol. | 10 | 7 | 2025 |
| 10.1002/admt.202401003 | 2365-709X |
| A Hybrid Miniaturized Modular Probe for Minimally Invasive Neural Intervention | Brain's unique anatomical structure and physiological environment make it difficult to deliver therapeutic agents such as drug or light to a focal volume in brain for disease treatment. Physically targeting a fine structure in brain with a micro-neural probe is an effective solution. Here, we present a hybrid miniaturized neural probe designed with micro-fluidic channel(s) for drug delivery, micro-electrode(s) for neural sensing and an optical fiber for optical-related treatment. These functional components are integrated in a micro-cannula (diameter <300 µm) with modular design and fabrication properties which can be conveniently adjusted for diverse applications. In vitro and in vivo tests confirm that this probe can precisely deliver drug to a focal volume in brain bypassing the blood brain barrier, and on-site neural sensing can be achieved with the integrated neural electrode. Leveraging near infrared light’s scattering properties in brain, we demonstrate in vivo with rat glioblastoma model that this hybrid neural probe can be a platform for photothermal treatment of brain tumor. With these merits, the hybrid miniaturized neural probe will be an effective tool with great translational potentials for minimally invasive neural intervention such as drug delivery or combination treatment of brain diseases. | | Review | Shen, Nana;Zhang, Zhihao;Wu, Futong;Zhu, Zhongze;Liu, Jiarui;Qi, Xiaoying;Li, Qiang;Wang, Xiaoxiong;Ma, Qingming;Xiang, Hongfei |
| Adv. Compos. Hybrid. Mater. | 8 | 1 | 2025 |
| 10.1007/s42114-024-01115-x | 2522-0136 |
| Advances in self-powered biomaterials for bone defect repair | Bone defects caused by aging populations and accidental injuries have a significant impact on human life, making bone repair and regeneration a research hotspot. The piezoelectric effect in biomaterials has shown great potential in bone defect treatment by converting mechanical stress into electrical signals to promote osteoblast behavior and subsequently accelerate bone regeneration. Electrical stimulation has been proven to improve the interfacial properties of biomaterials, enhancing cell adhesion and growth on the material surface, and promoting bone healing by regulating cellular behavior. With ongoing research on self-powered materials, various electroactive biomaterials have emerged. This review summarizes the mechanisms of bone repair and regeneration under electrical stimulation and the role of self-powered biomaterials in promoting bone regeneration by regulating the microenvironment. We present examples of applications combining biomaterials and electrical stimulation and discuss the challenges and future directions of these strategies for clinical translation. In conclusion, electroactive biomaterials show remarkable promise in bone defect treatment and provide a new therapeutic approach for bone regeneration. | | Review | Wang, Yuanhe;Shen, Nana;Zhu, Zhongze;Liu, Jiarui;Qi, Xiaoying;Liu, Zhong;Zhu, Youfu;Wang, Xiaoxiong;Long, Yunze;Xiang, Hongfei |
| Adv. Compos. Hybrid. Mater. | 8 | 1 | 2025 |
| 10.1007/s42114-024-01120-0 | 2522-0136 |
| Electrospun 3D nanofibrous materials and their applications in orthopaedics | Advancing modern technology has propelled biomedicine and materials science to the forefront of scientific interest. As modern science evolves, it demands greater synergy between disciplines. In the realm of orthopaedics, the complex architecture of bone necessitates implants that balance strength with porosity. This dual requirement beckons a profound grasp that spans the realms of biomedicine and materials science, urging a deep dive into both fields to craft the perfect synergy for bone implant materials. Journeying through materials and orthopaedic science, this article systematically discussed the preparation of 3D porous structures by electrospinning technology for orthopaedics. It began by detailing electrospinning techniques, their principles, processes, materials, and design strategies within materials science. Material characterization methods were then presented. In biomedicine, we offered a concise overview of standard testing methods, from cell viability to staining. Building on the foundational knowledge of both fields, it reviewed 3D electrospinning strategies and summarized recent research progress in bone tissue culture with this method. This review sought to offer a structured comprehension of the intersecting disciplines to researchers, establishing a robust basis for material innovation tailored to orthopaedic-specific demands. | | Article | Li, Hao;Liu, Jiarui;Cui, Huifei;Shen, Nana;Wu, Futong;Zhang, Zhihao;Zhu, Zhongze;Qiu, Chensheng;Xiang, Hongfei |
| Front. Bioeng. Biotechnol. | 12 |
| 2024 |
| 10.3389/fbioe.2024.1508385 | 2296-4185 |
| The effects of cage on endplate collapse after stand-alone OLIF: based on finite element analysis and in vitro mechanics experiments | Background: Lumbar degenerative diseases are an important factor in disability worldwide, and they are also common among the elderly population. Stand-Alone Oblique Lumbar Interbody Fusion (Stand-Alone OLIF) is a novel surgical approach for treating lumbar degenerative diseases. However, long-term follow-up after surgery has revealed the risk of endplate collapse associated with Stand-Alone OLIF procedures. This study aimed to investigate the effect of the cage factor on endplate collapse after Stand-Alone OLIF. Methods: Finite element (FE) models and calf lumbar functional units were established separately and used to simulate Stand-Alone OLIF surgery. On the L5 endplate of the FE model and the calf lumbar functional unit, 12 cage positions from anterior to posterior, 16 cage inclination angles from 0 to 15, and 4 cage heights were selected to simulate surgical models with different cage positions. Compression loads of 400N were applied to the upper surface of the superior vertebral body of the cage, and 10Nm torques in four directions were used to simulate four different physiological movements of the lumbar spine: flexion, extension, lateral curvature and torsion, in order to compare the range of motion of the surgical segment and the endplate stress. Results: When the cage is placed closer to the anterior and posterior edges of the endplate and when the height of the cage exceeds 12mm, the intervertebral range of motion at the surgical segment is greater and the stress on the endplate is higher during various lumbar spine activities. When the cage is inclined at an angle within 15, there are no significant differences in the corresponding endplate stress and the range of motion. Conclusion: For Stand-Alone OLIF surgery, inserting the cage in the central anterior-posterior position of the intervertebral space and selecting a cage with a height not exceeding 12 mm can reduce the stress on the endplate after surgery, which is more conducive to the stability of the lumbar spine postoperatively and reduces the risk of postoperative endplate collapse. The inclination angle of the cage placement does not significantly affect postoperative endplate stress or lumbar stability. | | Article | Li, Jinwen;Wu, Li;Liu, Jiarui;Wang, Xiaoying;Xue, Wei |
| Water | 16 | 24 | 2024 |
| 10.3390/w16243702 | 2073-4441 |
| DFMM-Precip: Deep Fusion of Multi-Modal Data for Accurate Precipitation Forecasting | Weather forecasting is a classical problem in remote sensing, in which precipitation is difficult to predict accurately because of its complex physical motion. Precipitation significantly impacts human life, work, and the ecological environment. Precise precipitation forecasting is vital for water resource management, ecological protection, and disaster mitigation through precise precipitation forecasting. This study introduces an innovative deep learning-based precipitation-forecasting method DFMM-Precip that integrates reanalysis of precipitation data and satellite data using a multi-modal fusion layer and predicts future precipitation details through a global–local joint temporal-spatial attention mechanism. By effectively combining satellite infrared data with reanalysis data, the approach enhances the accuracy of precipitation forecasting. Experimental results for 24 h precipitation forecasts show that DFMM-Precip’s multi-modal fusion layer successfully integrates multi-modal data related to precipitation, leading to improved forecast accuracy. In particular, the global–local joint temporal-spatial attention mechanism provides precise, detailed forecasting of spatial and temporal precipitation patterns, outperforming other state-of-the-art models. The MSE of the forecasting results is 10 times lower than that of the advanced RNN model and 2.4 times lower than that of the advanced CNN model with single-modal data input. The probability of successful rainfall prediction is improved by more than 10%. | | Review | Wang, Yuying;Fang, Xiaosheng;Liu, Jiarui;Lv, Xiao;Lu, Kang;Lu, Yingxue;Jiang, Yujie |
| Biomarker Res. | 12 | 1 | 2024 |
| 10.1186/s40364-024-00712-8 | 2050-7771 |
| PCSK9 in T-cell function and the immune response | Proprotein convertase subtilisin/kexin type 9 (PCSK9) was first reported in 2003 and confirmed to be strongly associated with familial hypercholesterolemia. Small-molecule inhibitors targeting PCSK9 provide an effective and safe method for managing hypercholesterolemia and reducing the cardiovascular risk. In recent years, increasing evidence has indicated other important roles for PCSK9 in inflammation, tumors, and even immune regulation. PCSK9 might be an attractive regulator of T-cell activation and expansion. It might mediate inflammation and regulate other types of immune cells. In this review, we summarize the current advances in the field of PCSK9 and provide a narrative of the biological processes associated with PCSK9. The relationships between PCSK9 and different T cells were investigated in depth. Finally, the signaling pathways associated with PCSK9 and the immune response are also summarized in this review. | | Article | Zhou, Peng;Wang, Zhanran;Liu, Jiarui;Yu, Zhizhou |
| Phys. Rev. B | 111 | 3 | 2025 |
| 10.1103/PhysRevB.111.035403 | 2469-9969 |
| Current-induced magnetization switching induced by Rashba and Ising spin-orbit torques | Controlling the magnetization direction of ferromagnets by utilizing the current-induced spin-orbit torque shows promising applications in low-energy spintronic devices. The magnetization dynamics of a honeycomb lattice with both Rashba and Ising spin-orbit couplings are studied by using the microscopic Landau-Lifshitz-Gilbert equation from a quantum transport perspective. In the honeycomb system with only Rashba spin-orbit coupling, the minimum magnetic field required for magnetization reversal decreases almost linearly with the increasing Rashba spin-orbit coupling strength. When Ising spin-orbit coupling is introduced, the critical magnetic field reduces significantly as Ising spin-orbit coupling strength increases. The magnetization switching is found to be determined by the cooperation of Rashba and Ising spin-orbit torques, which mainly behave as fieldlike and dampinglike torques, respectively. The reduction in the critical magnetic field due to Ising spin-orbit coupling is robust under low disorder strength. In addition, the critical magnetic field can also be reduced by the increase of bias voltages which can be attributed to the rise of Rashba spin-orbit torque. Our simulations provide an effective way to reduce the critical magnetic field for spin-orbit torque driven magnetization switching in future spintronic applications. | | Short Survey | Zhao, Linjie;Ren, Yujie;Gong, Chengjun;Xiong, Shizheng;Wang, Wenyuan;Zheng, Wanjie;Zhang, Jiaxi;Liu, Jiarui;He, Zhiheng;Yu, Jiafeng;Liang, Tingming;Guo, Li |
| Cancer Lett. | 612 |
| 2025 |
| 10.1016/j.canlet.2025.217462 | 1872-7980 |
| RMethyMD: An integrated platform for exploring RNA methylation in pan-cancer via a multiomics analysis | A user-friendly integrated database, RMethyMD (http://www.tmliang.cn/rnamethy), was developed to provide a comprehensive analysis of methylation regulators aimed at facilitating the exploration of molecular features in tumorigenesis and clinical implications in cancer diagnosis and treatment via a multiomics approach. Subsequently, molecular landscapes and a robust constructed m6A-based prognostic model using coxBoost + RSF algorithms in lung cancer highlighted m6A as a suitable marker to guide therapeutic strategy. RMethyMD provides a comprehensive resource and multiomics analysis to explore m6A-based prognostic and clinical values, thereby contributing to aiding personalized cancer therapy. | | Article | Liu, Jiarui;Klonicki-Ference, Emily;Krause, Sebastian J. E.;Treude, Tina |
| Environ. Sci. Technol. | 59 | 1 | 2025 | 513 - 522 | 10.1021/acs.est.4c10639 | 1520-5851 |
| Iron Oxides Fuel Anaerobic Oxidation of Methane in the Presence of Sulfate in Hypersaline Coastal Wetland Sediment | Wetland methane emissions are the primary natural contributor to the global methane budget, accounting for approximately one-third of total emissions from natural and anthropogenic sources. Anaerobic oxidation of methane (AOM) serves as the major sink of methane in anoxic wetland sediments, where electron acceptors are present, thereby effectively mitigating its emissions. Nevertheless, environmental controls on electron acceptors, in particular, the ubiquitous iron oxides, involved in AOM are poorly understood. Here, we explored methane sinks within a hypersaline pool situated in a coastal wetland. The geochemical profiles reveal a tiering, where microbial sulfate reduction dominates in the organic-rich surface sediment, yielding to iron reduction in the deeper organic-poor yet sulfate-rich subsurface sediment. This shift is attributed to the drilling-induced depression and subsequent diagenetic transformation of the surface sediment. Radiotracer incubations demonstrate a strong association of AOM with sulfate in surface sediment and with iron oxides in subsurface sediment. Despite high concentrations of sulfate in coastal wetlands, Fe-dependent AOM may play a significant, yet often under-considered, role as a sink for methane emissions. | | Article | Liu, Yutao;Zhao, Yali;Gong, Xuanlin;Liu, Jiarui;Wu, Chuanping;Chen, Baohui;Zhan, Hui |
| ACS Appl. Ener. Mat. | 8 | 3 | 2025 | 1830 - 1837 | 10.1021/acsaem.4c03066 | 2574-0962 |
| Advancing Anode-Free Lithium Metal Battery via Environmentally Resilient Lithium Oxalate as a Low-Voltage Prelithiation Additive | Due to the exceptionally high energy density and compatibility with the existing battery manufacturing process, the anode-free lithium metal battery (AFLMB) exhibits significant potential for practical implementation. However, the lifespan of the AFLMB is severely limited by the highly reactive lithium metal anode. Although enhanced cycling stability has been achieved through advanced electrolyte and anode design, the poor initial Coulombic efficiency (ICE) inevitably leads to reduced capacity in AFLMB. In this study, the environmentally resilient lithium oxalate (Li2C2O4) is introduced as a cathode prelithiation additive for AFLMB to offer in situ lithium supply. Complete decomposition of Li2C2O4 within 4.5 V is realized with an optimized conductive network. Characterizations including SEM, XRD, and XPS reveal that the adoption of Li2C2O4 does not adversely impact the cathode significantly, with the electrochemical performance remaining essentially unaltered. Consequently, the capacity degradation of AFLMB is markedly suppressed, with the 20% Li2C2O4-containing LFP|sodium alginate@Ag@Cu full battery exhibiting stable operation for 130 cycles without any noticeable capacity degradation. | | Article | Liu, Yu;Shen, Yupeng;Chen, Mingliang;Xu, Hui;Chen, Xubin;Liu, Jiarui;Wang, Zhiyu;Yu, Faxin |
| IEEE Trans Very Large Scale Integr VLSI Syst | 33 | 1 | 2025 | 47 - 51 | 10.1109/TVLSI.2024.3439374 | 1557-9999 |
| A Single-Stage Gain-Boosted Cascode Amplifier With Three-Layer Cascode Feedback Amplifier for Front-End SHA in High-Linearity Pipelined ADC | In this brief, a high-gain and wide-bandwidth single-stage gain-boosted cascode amplifier (GBCA) is proposed for the front-end sample-and-hold amplifier (SHA) in 14-bit 2.5-GS/s pipelined analog-to-digital converter (ADC). This GBCA is composed of a two-layer main cascode amplifier and a three-layer cascode feedback amplifier (FA). The three-layer cascode structure introduces more than 20-dB gain enhancement compared with conventional two-layer FAs. However, adjacent poles appear near the gain bandwidth product (GBW) of the three-layer cascode FA, which may seriously deteriorate the phase margin (PM) of the FA and further prolong the settling time of closed-loop GBCA. A PM expansion technique is proposed to improve the PM of FA by adding a group of switched capacitor array. At the same time, the open-loop GBCA achieves 104-dB direct-current (dc) gain and 65.2-GHz GBW, which satisfies the harsh requirements of the ping-pong interleaved SHA with 12-dB gain on-chip. The pipelined ADC fabricated in 28-nm CMOS process consumes 554 mW at 2.5-GS/s sampling rate, while achieves a signal-to-noise-and-distortion ratio (SNDR) of 52.5 dB and a spurious free dynamic range (SFDR) of 86.4 dBc with 161-MHz input signal. | | Article | Huang, Xuewei;Liu, Jiarui;Lin, Lin;Wen, Miaowen;Gan, Wancheng;Huang, Yu |
| IEEE Internet Things J. | 12 | 11 | 2025 | 16711 - 16719 | 10.1109/JIOT.2025.3534166 | 2327-4662 |
| Capacitive Sensing in High-Speed Molecular Communication System: A Noninvasive Interface for Internet of Bio-Nano Things | Molecular communication (MC) is a prominent technique within the Internet of Bio-Nano Things (IoBNT), which aims to interconnect artificial and biological devices for pioneering healthcare applications. Despite its rapid advancements in theoretical study, the experimental development of MC is still in the infancy stage, and most existing testbeds require intruding hardware into the channel during the signal detection process, potentially harming the organism. Against this background, the noninvasive interface across the internal and external information exchange of organisms is of great necessity. Specifically, this work adopts a capacitive sensing mechanism to recover information from the sensed chemical signals. Our testbed demonstrates a notably higher transmission rate than previously reported noninvasive MC approaches, underscoring its potential to advance IoBNT research. | | Article | Guo, Haoxin;Liu, Jiarui;Li, Yan;Xu, Yifei;Xu, Keyi;Fan, Anzhuo;Hao, Jiarui;Hou, Yifei;Lv, Chunli |
| Plants | 14 | 3 | 2025 |
| 10.3390/plants14030354 | 2223-7747 |
| Efficient Tomato Disease Detection Using MaxMin-Diffusion Mechanism and Lightweight Techniques | This paper proposes a disease detection model based on the maxmin-diffusion mechanism, aimed at improving the accuracy and robustness of disease detection tasks in the agricultural field. With the development of smart agriculture, automated disease detection has become one of the key tasks driving agricultural modernization. Traditional disease detection models often suffer from significant accuracy loss and robustness issues when dealing with complex disease types and dynamically changing time-series data. To address these problems, this paper introduces the maxmin-diffusion mechanism, which dynamically adjusts attention weights to enhance the model’s focus on key disease regions while suppressing interference from irrelevant areas, significantly improving the segmentation accuracy of disease regions. Through a series of experiments, the proposed model demonstrates outstanding performance across various disease detection tasks. For bacterial spot disease detection, the model achieves a precision of 0.98, recall of 0.95, accuracy of 0.96, and mIoU of 0.96, indicating that it can efficiently and accurately identify disease regions even in complex backgrounds. Compared to traditional self-attention and CBAM mechanisms, the maxmin-diffusion mechanism shows significant advantages in fine-grained feature extraction and time-series data processing, particularly in the recognition of dynamically changing disease regions, where it exhibits higher detection accuracy and robustness. Furthermore, the model underwent lightweight optimization, enabling the proposed disease detection model to not only achieve high-precision detection but also run efficiently on resource-constrained mobile devices. This provides strong technical support for the application of smart agriculture. | | Article | Zuo, Jinshi;Ren, Jingyi;Yin, Bowen;Wang, Ziyi;Cui, Qiqi;Liu, Jiarui;Huang, Dan;Pei, Huanting;Wen, Rui;Zhang, Yadong;Ma, Yuxia |
| Nutr. Rev. | 83 | 3 | 2025 | e838 - e851 | 10.1093/nutrit/nuae089 | 1753-4887 |
| Effects of Sesamin in Animal Models of Obesity-Associated Diseases: A Systematic Review and Meta-Analysis | Context: As living standards have improved and lifestyles have undergone changes, metabolic diseases associated with obesity have become increasingly prevalent. It is well established that sesamin (Ses) (PubChem CID: 72307), the primary lignans in sesame seeds and sesame oil, possess antioxidant and anti-inflammatory effects. Objective: In this study, a systematic review and meta-analysis of the effects of Ses on animal models of obesity-related diseases was performed to assess their impact on relevant disease parameters. Importantly, this study sought to provide insights for the design of future human clinical studies utilizing Ses as a nutritional supplement or drug. Data Sources: This study conducted a comprehensive search in PubMed, Web of Science, Embase, Scopus, and the Cochrane Library, identifying English language articles published from inception to April 2023. Data Extraction: The search incorporated keywords such as "sesamin,""obesity,""non-alcoholic fatty liver disease,""type 2 diabetes mellitus,"and "metabolic syndrome."The meta-analysis included 17 articles on non-alcoholic fatty liver disease, type 2 diabetes, and metabolic syndrome. Data Analysis: Overall, the pooled results demonstrated that Ses significantly reduced levels of total serum cholesterol (P =. 010), total serum triglycerides (P =. 003), alanine transaminase (P =. 003), and blood glucose (P <. 001), and increased high-density lipoprotein cholesterol levels (P =. 012) in animal models of nonalcoholic fatty liver disease. In the type 2 diabetes model, Ses mitigated drug-induced weight loss (P <. 001), high-fat-diet-induced weight gain (P <. 001), and blood glucose levels (P =. 001). In the metabolic syndrome model, Ses was associated with a significant reduction in body weight (P <. 001), total serum cholesterol (P <. 001), total serum triglycerides (P <. 001), blood glucose (P <. 001), and alanine transaminase levels (P =. 039). Conclusion: The meta-analysis results of this study suggest that Ses supplementation yields favorable effects in animal models of obesity-related diseases, including hypolipidemic, insulin-lowering, and hypoglycemic abilities, as well as organ protection from oxidative stress and reduced inflammation. Systematic Review Registration: PROSPERO registration No. CRD42023438502. | | Article | Long, Shangbin;Huang, Weicong;Wang, Jianhui;Liu, Jiarui;Gu, Yixiang;Wang, Zian |
| IEEE Trans. Autom. Sci. Eng. | 22 |
| 2025 | 6398 - 6407 | 10.1109/TASE.2024.3445135 | 1558-3783 |
| A Fixed-Time Consensus Control With Prescribed Performance for Multi-Agent Systems Under Full-State Constraints | This paper investigates a fixed-time consensus control problem of nonlinear multi-agent systems under full-state constraints. First, by designing corresponding constraint functions for system transformation, state-dependent asymmetric time-varying constraints are realized. The feasibility conditions of the system are eliminated, and the requirements on the constraint boundary are relaxed. Meanwhile, a prescribed performance function is designed for the constraints on synchronization deviation, which helps to improve the transient and steady-state performance of the system and ensure rapid consensus convergence on a fixed-time framework. Additionally, considering the frequent communication between the controller and actuator and to decrease the controller update frequency to save system bandwidth, an adaptive threshold event-triggered mechanism is developed. A dynamic parameter is introduced into the triggered mechanism to adjust the triggered threshold, thereby overcoming the issue that static parameters might cause excessive or insufficient event-triggered and avoiding Zeno behavior. Finally, the effectiveness of the proposed strategy is verified through simulation. Note to Practitioners - In complex modern engineering systems, the consensus control of multi-agent systems has become a research hotspot. In practical industrial applications, given the requirements for safety and production efficiency, it is crucial for systems to effectively constrain states and ensure performance. This study employs the prescribed performance strategy within the fixed-time framework to construct the control method. The constraints of the system's full states are achieved by transforming a constrained system into an unconstrained one. Meanwhile, the use of event-triggered mechanisms saves communication resources. The proposed method not only ensures rapid consensus convergence under full-state constraints but also enhances the control performance of multi-agent systems, closely connected to the needs of practical applications. Future research will continue to investigate how to apply it to practical engineering applications. | | Review | Zhang, Jiaxi;Guo, Haochuan;Gong, Chengxuan;Shen, Jie;Jiang, Guijie;Liu, Jiarui;Liang, Tingming;Guo, Li |
| Biochem. Pharmacol. | 236 |
| 2025 |
| 10.1016/j.bcp.2025.116848 | 1873-2968 |
| Therapeutic targets in the Wnt signaling pathway: Treating cancer with specificity | The Wnt signaling pathway is a critical regulatory mechanism that governs cell cycle progression, apoptosis, epithelial-mesenchymal transition (EMT), angiogenesis, stemness, and the tumor immune microenvironment, while also maintaining tissue homeostasis. Dysregulated activation of this pathway is implicated in various cancers, closely linked to tumor initiation, progression, and metastasis. The Wnt/β-catenin axis plays a central role in the pathogenesis of common cancers, including colorectal cancer (CRC), breast cancer (BC), liver cancer, and lung cancer. Unlike traditional chemotherapy, targeted therapy offers a more precise approach to cancer treatment. As a key regulator of oncogenesis, the Wnt pathway represents a promising target for clinical interventions. This review provides a comprehensive analysis of the Wnt signaling pathway, exploring its roles in tumor biology and its implications in human malignancies. It further examines the molecular mechanisms and modes of action across different cancers, detailing how the Wnt pathway contributes to tumor progression through mechanisms such as metastasis promotion, immune modulation, drug resistance, and enhanced cellular proliferation. Finally, therapeutic strategies targeting Wnt pathway components are discussed, including inhibitors targeting extracellular members, as well as those within the cell membrane, cytoplasm, and nucleus. The potential of these targets in the development of novel therapeutic agents underscores the critical importance of intervening in the Wnt signaling pathway for effective cancer treatment. | | Review | Yang, Zeping;Sun, Junyu;Zhang, Yupeng;Liu, Jiarui;Oh, Erwin;Ma, Zhanguo |
| Buildings | 15 | 5 | 2025 |
| 10.3390/buildings15050663 | 2075-5309 |
| A Systematic Evaluation of the Empirical Relationships Between the Resilient Modulus and Permanent Deformation of Pavement Materials | The resilient modulus (Mr) and permanent deformation of subgrade soils are key indicators for assessing pavement performance under repeated traffic loads. Although numerous studies have confirmed their importance in pavement design and performance prediction, a systematic review of empirical relationships and scientific knowledge is lacking, resulting in insufficient integration and application of current findings. To address these issues, this study systematically reviews laboratory and field-testing methods based on over 200 published papers, summarizes common empirical equations, and focuses on the feasibility and advantages of integrating AI to predict Mr. Meanwhile, by examining the main factors that influence Mr and permanent deformation, this study synthesizes and evaluates existing research to identify potential gaps. Findings indicate that laboratory and field tests effectively capture the mechanical behavior of pavement materials, and incorporating AI technology in modulus prediction enhances accuracy and efficiency while managing complex influencing factors. However, existing empirical equations have not been fully integrated with emerging technologies for validation and optimization, and some predictive models remain limited in terms of applicability and generalizability. This review highlights the need to refine empirical relationships for the resilient modulus using stochastic methods and AI techniques, thereby facilitating a more comprehensive integration of the latest testing technologies and computational tools. This research is of great significance for advancing sustainable pavement design, optimizing maintenance strategies, and guiding future research directions. | | Article | Liu, Jinhai;Xu, Hang;Jiang, Lin;Zhang, Huaguang;Liu, Jiarui |
| IEEE Trans. Instrum. Meas. | 74 |
| 2025 |
| 10.1109/TIM.2025.3547518 | 1557-9662 |
| Double Coil Compensation Method for Reducing Distortion of High-Speed MFL Signals | The magnetic flux leakage (MFL) testing is widely used in the health evaluation of oil pipelines due to its nondestructive and efficient characteristics. However, motion-induced eddy currents (MIECs), which will cause distortion of the high-speed MFL signals, are generated in pipelines due to the relative motion with magnets. The distortion signals will reduce the accuracy of defect evaluation. In terms of the above issues, a double coil compensation method is proposed. First, the causes, distribution positions, and diffusion characteristics of MIECs are determined through the theoretical analysis to clarify the reasons for the distortion of high-speed MFL signals. Second, given the asymmetric distribution characteristics of MIECs, an asymmetric structure is proposed to capture MIECs at the defects and the magnetic poles, which cause distortion of high-speed MFL signals. Third, based on the double coil groups, an active–passive strategy is proposed to distinguish pipeline surface and back defects, which ensures the integrity of defect evaluation and enhances the reliability of pipeline repair. Finally, the compensation performance and distinguishing capacity of the proposed method are verified by simulated and experimental analysis. The results show that compensated signals approximate the static MFL signals and have satisfactory performances of defect size quantification. | | Article | Zheng, Wenpeng;Lu, Xiaoge;Ye, Zihao;Liu, Jiarui;Yi, Shihe |
| Phys. Fluids | 37 | 3 | 2025 |
| 10.1063/5.0248402 | 1089-7666 |
| Visualization and spatial evolution of streamwise vortices near the minor axis of an elliptical cone | The transition of the three-dimensional boundary layer is a fundamental problem that urgently needs to be solved in the design of aerobats, among which the instability of streamwise vortices is one of the important characteristics. An experimental study on the spatial evolution law of streamwise vortices near the minor axis of an elliptical cone is conducted under Mach 6 conditions. First, a method for measuring and image correction of streamwise vortices in the cross section based on nano-tracker-based planar laser scattering technology is established, by which fine flow field structures of the boundary layer in the cross section at different streamwise positions are obtained. At the same time, combined with the temperature-sensitive paint technology, the temperature distribution of the model surface is obtained. The spatial evolution law of streamwise vortices is comprehensively analyzed, and the following conclusions are drawn. There are steady crossflow vortices on both sides of the streamwise vortices, and the temperature variation characteristics of the low-temperature regions along the flow direction controlled by the two are consistent. The steady crossflow vortices will experience an increase in amplitude and instability as they develop in space, and there is a clear correlation between the instability of the streamwise vortices and the instability of the steady crossflow vortices. The instability of streamwise vortices initially manifests as the instability of the “shoulder” structure, and the fractal dimension of the outer contour of the flow vortices shows a clear increasing trend in the flow direction. The temperature curves, fine structure images of streamwise vortices, and fractal curves reflect a good agreement in the spatial evolution law of the streamwise vortices. | | Article | Jian, Qinyan;Gao, Tinghong;Yang, Wensheng;Wang, Xinhai;He, Lishan;Liu, Jiarui;Ruan, Yunjun |
| J. Energy Chem. | 105 |
| 2025 | 797 - 805 | 10.1016/j.jechem.2024.12.065 | 2095-4956 |
| Stabilizing the solid-solution sodium storage in Cr-substituted Na3V2(PO4)3 cathode for aqueous sodium-ion batteries with long-term stability | Aqueous sodium-ion batteries (ASIBs) offer significant advantages for energy storage on a large scale, attributed to their economical cost, secure operation, and eco-friendly nature. Among the leading cathode materials for ASIBs, Na3V2(PO4)3 (NVP) exhibits excellent structural stability and a high Na diffusion coefficient, making it a promising option. However, the high solubility of vanadium-based materials in aqueous electrolytes engenders suboptimal cycling stability for Na3V2(PO4)3, constraining its application in ASIBs. Herein, the Cr-substituted Na3V1.3Cr0.7(PO4)3@C (NV1.3Cr0.7P) cathode material was synthesized via a simple sol–gel method. It is found that Cr substitution reduces the cell parameters of NV1.3Cr0.7P, effectively reinforcing the crystal structure. Furthermore, NV1.3Cr0.7P alters the Na insertion/extraction mechanism, transforming the typical two-phase reaction between Na1V2(PO4)3 and Na3V2(PO4)3 into continuous solid-solution reactions with stable intermediates. The Cr substitution diminishes the sodium-ion diffusion energy barrier in NV1.3Cr0.7P, leading to smoother Na insertion and extraction processes. Consequently, NV1.3Cr0.7P exhibits impressive cycling stability, retaining 74.8% of its capacity after 5,000 cycles at a current density of 5 A g, along with an outstanding rate performance of 79.2% at 10 A g. This work elucidates the stable Na insertion/extraction processes in Cr-substituted NV1.3Cr0.7P, offering insights into the application of vanadium-based materials in aqueous sodium-ion batteries. | | Review | Pei, Yanhong;Liang, Haijie;Guo, Yu;Wang, Boyang;Wu, Han;Jin, Zhijian;Lin, Shanyi;Zeng, Fanwei;Wu, Yifan;Shi, Qianyu;Xu, Jiuhui;Huang, Yi;Ren, Tingting;Liu, Jiarui;Guo, Wei |
| Front. Oncol. | 15 |
| 2025 |
| 10.3389/fonc.2025.1509457 | 2234-943X |
| Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024 | Background: Liquid–liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions. However, a comprehensive bibliometric analysis on LLPS and immune signaling processes in cancer is still scarce. This study aims to perform a bibliometric assessment of research to explore the landscape of LLPS research in immune signaling pathways for cancer. Methods: Utilizing the Web of Science Core Collection database and multiple analysis software, we performed quantitative and qualitative analyses of the study situation between LLPS and immune signaling in cancer from 1992 to 2024. Results: The corresponding authors were primarily from China and the USA. The most relevant references were the “International Journal of Molecular Sciences”, “Proteomics”. The annual number of publications exhibited a fast upward tendency from 2020 to 2024. The most frequent key terms included expression, separation, activation, immunotherapy, and mechanisms. Qualitative evaluation emphasized the TCR, BCR, cGAS-STING, RIG-1, NF-κB signaling pathways associated with LLPS processes. Conclusion: This research is the first to integratively map out the knowledge structure and forward direction in the area of immune transduction linked with LLPS over the past 30 years. In summary, although this research area is still in its infancy, illustrating the coordinated structures and communications between cancer and immune signaling with LLPS within a spatial framework will offer deeper insights into the molecular mechanisms of cancer development and further enhance the effectiveness of existing immunotherapies. | | Article | Liu, Jiarui;Yan, Mengyu;Chen, Lihua;Yu, Weihua;Lü, Yang |
| Sci. Rep. | 15 | 1 | 2025 |
| 10.1038/s41598-025-89980-4 | 2045-2322 |
| Construction and evaluation of a diagnostic model for Alzheimer’s disease based on mitophagy-related genes | Alzheimer’s disease (AD) is the most common cause of dementia. Mitophagy fulfills crucial functions in neurodegenerative disorders and neuronal survival but the relationship between mitophagy and AD is unclear. Mitophagy correlation scores between AD samples and control samples were calculated using single-sample GSEA (ssGSEA) based on two datasets from gene expression omnibus (GEO) database. Mitophagy-related genes (MRGs) and differentially expressed genes (DEGs) in AD screened by WGCNA and “limma” package were intersected to take common genes. These overlapping genes were further compressed and used for diagnostic modeling by adopting the recursive feature elimination (RFE) and LASSO analysis. The reliability of the diagnostic model was verified based on the receiver operating characteristic (ROC) curve. Then, a transcription factor (TF)-mRNA regulatory network of these key genes was established. Lastly, ssGSEA was employed to examine the relationship between the identified genes and cellular pathways and immune cell infiltration. AD samples had notably lower mitophagy correlation scores than control samples. A total of 12 MRGs in the module with the greatest mitophagy connection with AD patients were identified. Functional enrichment analysis revealed that the DEGs were significantly enriched in synaptic function-related pathways. Based on GSE122063, a diagnostic prediction model was created and validated using two mitophagy-related genes (YWHAZ and NDE1), showing an area under ROC curve (AUC) greater than 0.7. This confirmed that the diagnostic model had a high predictive value. The TF-mRNA network showed that four TFs, namely, FOXC1, FOXL1, HOXA5 and GATA2, were regulated by both YWHAZ and NDE1 genes. Immune infiltration analysis revealed that NDE1 promoted the infiltration of most immune cells, while YWHAZ mainly inhibited the infiltration of most immune cells. The current findings improved our understanding of mitophagy in AD, contributing to future research and treatment development in AD. | | Article | Liu, Tongtong;Xu, Luogen;Liu, Jiarui;Wang, Yao |
| Phys. Rev. X | 15 | 1 | 2025 |
| 10.1103/PhysRevX.15.011056 | 2160-3308 |
| Entanglement Witness for Indistinguishable Electrons Using Solid-State Spectroscopy | Characterizing entanglement in quantum materials is crucial for advancing next-generation quantum technologies. Despite recent strides in witnessing entanglement in magnetic materials with distinguishable spin modes, quantifying entanglement in systems formed by indistinguishable electrons remains a formidable challenge. To solve this problem, we introduce a method to extract various four-fermion correlations by analyzing the nonlinearity in resonant inelastic x-ray scattering spectra. These correlations constitute the primary components of the cumulant two-particle reduced density matrix. We further derive bounds for its eigenvalues and demonstrate the linear scaling with fermionic entanglement depth, providing a reliable witness for entanglement. Using the material-relevant strongly correlated models as examples, we show how this entanglement witness can efficiently quantify multipartite entanglement across different phase regions, highlighting its advantage over quantum Fisher information. | | Article | Wang, Jianhui;Liu, Jiarui;Chen, C. L. Philip;Chen, Kairui |
| IEEE Trans. Veh. Technol. |
|
| 2025 |
| 10.1109/TVT.2025.3554972 | 1939-9359 |
| Distributed Observer-based Formation Control for Leader-Follower Multi-UAVs with Collision Avoidance | This work investigates the formation control problem for leader-follower multi-unmanned aerial vehicles (UAVs) with obstacle avoidance based on distributed observer. Firstly, with the aid of formation information, a collision avoidance control method is proposed based on an artificial potential function, which ensures collision avoidance for the multi-UAVs as a whole. Subsequently, a novel prescribed-time distributed observer with low data transfer is developed, which is capable of estimating the states of leader UAV without the acceleration boundary of the leader UAV. Then, next by using the prescribed performance control technique to facilitate transform error, a prescribed-time formation control method is constructed to guarantee the collision avoidance among UAVs. The developed control method enables the formated follower UAVs to track the trajectory of the leader UAV within a prescribed-time, and obstacles can be effectively circumvented without disrupting the predefined formation. The efficacy of the proposed scheme is finally demonstrated through the simulation. | | Article | Wang, Yuxuan;Zhang, Zhihao;Shen, Nana;Qi, Xiaoying;Li, Hao;Wu, Futong;Zhu, Zhongze;Liu, Jiarui;Xiang, Hongfei |
| Lipids Health Dis. | 24 | 1 | 2025 |
| 10.1186/s12944-025-02527-4 | 1476-511X |
| Association between exposure to brominated flame retardants (BFRs) and blood lipid profiles in American adults: a cross-sectional study | Background: Exposure to brominated flame retardants (BFRs) has been linked to alterations in human metabolism and disease processes. However, the relationship between BFR exposure and blood lipid levels remains unclear. This study aimed to investigate the potential association between BFR exposure and blood lipid profiles in American adults. Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2005–2016. Serum concentrations of twelve BFRs, PBB153 and eleven polybrominated diphenyl ethers (PBDEs), were quantified using isotope dilution gas chromatography/high-resolution mass spectrometry (GC/HRMS). Blood lipid levels, including total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were measured enzymatically. The Friedewald equation was used to determine low-density lipoprotein cholesterol (LDL-C): [LDL-C] = [TC] − [HDL-C] − [TG/5]. Remnant cholesterol (RC) was calculated using the formula: [RC] = [TC] − [HDL-C] − [LDL-C]. Multivariable regression analyses were applied to examine the associations between individual BFRs and TC, HDL-C, LDL-C, and RC. The overall associations of BFR mixtures with blood lipids were evaluated using quantile g-computation (QGC) analyses and weighted quantile sum (WQS) regression. In order to identify potential gender-specific differences, stratified mixture analyses were performed by gender. Results: A total of 3,154 eligible participants were included. Nine BFRs with a detection rate greater than 70% were included in the analysis. Individually, PBB153, PBDE209, PBDE153, and PBDE28 were positively associated with TC and RC after adjusted all covariates. Furthermore, PBB153, PBDE209, and PBDE153 were positively associated with LDL-C. No association was found between individual BFR and HDL-C. WQS and QGC analyses confirmed that BFR mixtures were positively associated with TC, LDL-C, and RC. Conclusion: This study demonstrates that BFR exposure is associated with increased levels of TC, LDL-C, and RC, indicating an elevated risk of dyslipidemia and cardiovascular diseases. | | Article | Li, Bingxian;Wang, Xinhai;Gao, Tinghong;Yang, Wensheng;Jian, Qinyan;Liu, Jiarui;He, Lishan;Wu, Zhenhua;Ruan, Yunjun |
| J. Phys. Chem. C | 129 | 14 | 2025 | 6628 - 6637 | 10.1021/acs.jpcc.5c00253 | 1932-7455 |
| Facile Ball-Milling Synthesis of Carbon-Coated Layered K-Birnessite for High-Rate and Long-Term Potassium-Ion Batteries | Layered manganese oxide cathode materials have been widely employed in energy storage systems because of their high energy density and low cost. However, manganese-based cathodes for potassium-ion batteries face significant challenges, including large volume changes during K intercalation/deintercalation processes, severe capacity loss, and sluggish K transport kinetics. Herein, the K0.28MnO2·0.29H2O (KMO) precursor, synthesized via a solid-state reaction, was ball-milled with Ketjen black to form the KMO@C0.2 composite. The carbon coating layer prevents direct contact between KMO and the electrolyte, effectively mitigating the Jahn-Teller effect of Mn and ensuring the structural integrity of the cathode during rapid and stable K intercalation/deintercalation processes. Density functional theory (DFT) calculations confirm that the carbon layer enhances the material’s electronic conductivity, reduces the electrochemical reaction resistance, and significantly improves the sample’s rate capability. The KMO@C0.2 cathode delivers an initial discharge capacity of 137.9 mAh g at 20 mA g, a rate capability of 77.2 mAh g at 500 mA g, and retains 81% of its capacity after 300 cycles. These findings regarding the surface protection layer structure provide valuable insights for advancing manganese-based layered cathodes with enhanced interfacial stability for potassium-ion batteries. | | Article | Liu, Jiarui;Wang, Xinhai;Gao, Tinghong;Yang, Wensheng;Jian, Qinyan;Li, Bingxian;He, Lishan;Ruan, Yunjun |
| RSC Adv. | 15 | 13 | 2025 | 9875 - 9883 | 10.1039/d5ra00172b | 2046-2069 |
| A NiCo oxide/NiCo sulfate hollow nanowire-coated separator: a versatile strategy for polysulfide trapping and catalytic conversion in high-performance lithium-sulfur batteries | Lithium-sulfur batteries (LSBs) are highly anticipated due to their remarkable theoretical specific energy and energy density. Nevertheless, the polysulfide shuttle effect severely curtails their cycle life, posing a significant obstacle to commercialization. Herein, we introduce nickel-cobalt oxide/nickel-cobalt sulfate hollow nanowires (NCO/NCSO-HNWs) as a separator modification material. The ingeniously designed hollow nanostructure of NCO/NCSO-HNWs endows it with a profusion of adsorption and catalytic active sites. This unique feature enables it to not only physically adsorb lithium polysulfides (LiPSs) but also catalytically convert them, thereby remarkably enhancing the anchoring and conversion efficiency of LiPSs. The LSBs equipped with NCO/NCSO-HNWs-modified separators exhibit an outstanding initial capacity of 1260 mA h g at 0.2C. Even after 100 cycles, a high capacity of 956 mA h g is retained, corresponding to an impressive retention rate of 75.9%. Notably, at 1C, after enduring 500 cycles, the discharge capacity still stabilizes at 695 mA h g. The utilization of such hollow nanowire-based separator modification materials represents a novel and effective strategy for elevating the performance of LSBs, holding substantial promise for surmounting the challenges associated with the shuttle effect and expediting the commercialization journey of LSBs. | | Article | Fan, Xinggang;Liu, Jiarui;Liang, Ziyi;Li, Lei;Fang, Haiyang;Li, Dawei;Kong, Wubin;Qu, Ronghai |
| IEEE Trans Ind Appl |
|
| 2025 |
| 10.1109/TIA.2025.3559045 | 1939-9367 |
| A Statistical Prediction Method of AC Copper Loss in Random Wound Windings of Electrical Machines | Due to the random behavior of conductors in machines with random windings, it is difficult to predict and calculate the Alternating Current (AC) copper loss. This paper proposes a practical statistical simulation method to predict the AC copper loss in the random windings of electrical machines. The method is based on a semi-analytical method for evaluating AC copper loss. To feature the random characteristics of windings whilst minimizing complexity, a statistical winding model is established. This model uses only three parameters to control the generation of conductor arrangements with different degrees of mixing. These three parameters are calibrated by the measured data from a repeatedly inserted coil group, rather than a series of wound stator prototypes, thus significantly reducing the cost in a research and development (R&D) process. Thereafter, the statistical model with calibrated parameters is used to predict the AC copper loss of the full machine. A 48-slot 4-pole stator is used to illustrate and validate the method. The proposed method can be used to fast and practically predict the characteristics of the AC copper loss during the early stages of machine design. | | Article | Zhu, Wenju;Xu, Shuang;Li, Dongxiang;Liu, Shuixia;Peng, Wei;Wang, Shuolong;Liu, Jiarui;Ma, Kai;Wang, Xiaoqing;Cheng, Bowen |
| Int. J. Biol. Macromol. | 310 |
| 2025 |
| 10.1016/j.ijbiomac.2025.143207 | 1879-0003 |
| Homologous flame retardant - cottonseed meal modified as a flame retardant for cotton fiber durable flame retardancy | Cotton fibers are widely used in various applications due to their biodegradability, low cost, and extensive availability. The cottonseed is associated with cotton, which has a large yield. After oil extraction, the remaining cottonseed meal has a high protein content, making it a potential flame retardant for cotton fibers. This paper proposes the concept of homologous flame retardant for cotton fiber, and presents research on Cottonseed Meal Modified Flame Retardant - Homologous Durable Flame Retardant Cotton Fiber. The experiment results showed that the flame retardants CmP prepared by phosphating cottonseed meal is an effective flame retardant for cotton fiber. Both CmP1 and CmPN demonstrated self-catalytic durable grafting on the surface of Cotton fiber. Notably, the durable flame retardant CmP1-cotton and CmPN-cotton prepared by DICY catalysis exhibit superior durability and flame retardant properties, with damage lengths of 53 mm and 86 mm, respectively, and the LOI value is more than 35 %. FT-IR, XPS, and SEM results confirmed that the flame retardant was durably grafted onto the fiber surface and the superficial layer. XPS and SEM results of flame retardant cotton and char residues of TG and CCT are displayed that the two kinds of flame retardant cotton fabrics are mainly condensed phase flame retardant mechanisms, with a synergistic gas-phase effect. | | Article | He, Lishan;Wang, Xinhai;Gao, Tinghong;Yang, Wensheng;Jian, Qinyan;Liu, Jiarui;Li, Bingxian;Wu, Zhenhua;Ruan, Yunjun |
| J. Colloid Interface Sci. | 693 |
| 2025 |
| 10.1016/j.jcis.2025.137624 | 1095-7103 |
| Three-dimensional K3V3(PO4)4@Carbon core-shell coaxial nanowire networks for High-rate sodium-ion batteries | Potassium vanadium phosphate is an emerging sodium superionic conductor (NASICON) material with great potential as a cathode for sodium-ion batteries, owing to its high operating voltage, structural stability, and low cost. However, its poor electronic conductivity, along with significant volume expansion and stress effects during Na insertion and extraction, severely limits its electrochemical performance, hindering its practical application. In this study, a three-dimensional (3D) carbon-coated K3V3(PO4)4 core–shell coaxial nanowire network (KVP@C) was synthesized using a simple electrospinning method combined with high-temperature annealing. The outer carbon layer helps mitigate the volume expansion of KVP during charge and discharge cycles. Simultaneously, the 3D carbon framework enhances the interaction between the electrode material and the electrolyte, facilitating the transport and diffusion of ions and electrons. They lead to an improved specific capacity and outstanding rate performance. The KVP@C half-cell delivers an initial capacity of 103.9 mAh g at a current density of 10 mA g, a rate capability of 66.5 mAh g at 200 mA g, and a capacity retention of 83.69 % after 500 cycles. Electrochemical kinetics analysis reveals that the 3D core–shell network with a carbon coating improves both electrical conductivity and ion diffusion rates, leading to superior rate performance. Ex-situ characterization further elucidates the sodium storage mechanism of KVP@C: the concentration gradient of Na between the electrolyte and the electrode induces spontaneous Na diffusion into the electrode during the resting state. During the initial charge, both Na and K are extracted from the KVP@C electrode, with the remaining ions acting as structural supports between the KVP layer. In the subsequent charge–discharge cycles, electrochemical reactions are dominated by the reversible insertion and extraction of Na, while K no longer participates in the reactions. Density functional theory calculations confirm the chemical interaction between the carbon layer and KVP, which alters the energy band structure of the material and enhances its electrical conductivity. These findings demonstrate that the as-synthesized 3D carbon-coated KVP core–shell coaxial nanowire network offers exceptional sodium storage properties, laying a solid foundation for the practical development of high-performance sodium-ion batteries. | | Article | Sun, Jiayang;Magen, Cédric;Haghnegahdar, Mojhgan A.;Liu, Jiarui;Fernandez, Julianne M.;Farquhar, James |
| J. Geophys. Res. Biogeosci. | 130 | 4 | 2025 |
| 10.1029/2024JG008249 | 2169-8961 |
| Constraining Wetland and Landfill Methane Emission Signatures Through Atmospheric Methane Clumped Isotopologue Measurements | Microbial methane emissions are associated with a wide range of isotopic signatures, providing information about the sources and sinks of methane. Methods of directly sampling methane from environments such as wetlands may fail to capture the temporal and spatial variations in emissions at a specific site and time. The Keeling plot method is commonly used to infer the overarching isotopic signatures of methane sources. In this study, we have expanded the application of the Keeling plot from conventional stable isotope ratios to include novel clumped isotopologue compositions of methane. This advancement aims to provide more robust constraints on regional methane emission signatures. We analyzed methane isotopologue compositions from air samples collected above wetlands and landfills across Maryland, USA, and determined the end-member compositions for background air, wetland, and landfill sources. Our findings indicate that the isotopologue compositions of methane from regional wetland emissions exhibit seasonal variations—δC and δD values become less positive as winter approaches, reflecting changes in methane oxidation and production rates. The continuous monitoring of air methane isotopologue signatures will deepen our understanding of the seasonal patterns in methane emissions and contribute to refining the global methane budget, as valuable insights can be extracted from these measurements. | | Article | Liu, Jiarui;Duan, Xianglong |
| Updates Surg. |
|
| 2025 |
| 10.1007/s13304-025-02205-1 | 2038-3312 |
| Sequential comparison of single-stage laparoscopic common bile duct exploration combined with cholecystectomy |
| | Conference Paper | Chen, Xiaocan;Yin, Qilin;Liu, Jiarui;Lu, Wei;Luo, Xiangyang;Zhou, Jiantao |
| Proc. AAAI Conf. Artif. Intell. | 39 | 1 | 2025 | 75 - 83 | 10.1609/aaai.v39i1.31982 | 2374-3468 |
| GLCF: A Global-Local Multimodal Coherence Analysis Framework for Talking Face Generation Detection | Talking face generation (TFG) allows for producing lifelike talking videos of any character using only facial images and accompanying text. Abuse of this technology could pose significant risks to society, creating the urgent need for research into corresponding detection methods. However, research in this field has been hindered by the lack of public datasets. In this paper, we construct the first large-scale multi-scenario talking face dataset (MSTF), which contains 22 audio and video forgery techniques, filling the gap of datasets in this field. The dataset covers 11 generation scenarios and more than 20 semantic scenarios, closer to the practical application scenario of TFG. Besides, we also propose a TFG detection framework, which leverages the analysis of both global and local coherence in the multimodal content of TFG videos. Therefore, a region-focused smoothness detection module (RSFDM) and a discrepancy capture-time frame aggregation module (DCTAM) are introduced to evaluate the global temporal coherence of TFG videos, aggregating multi-grained spatial information. Additionally, a visual-audio fusion module (V-AFM) is designed to evaluate audiovisual coherence within a localized temporal perspective. Comprehensive experiments demonstrate the reasonableness and challenges of our datasets, while also indicating the superiority of our proposed method compared to the state-of-the-art deepfake detection approaches. | | Article | Wu, Fengjie;Yang, Jisen;Liu, Jiarui;Lin, Zhaolong;He, Yan;Zhang, Lihan |
| Biomed. Signal Process. Control | 109 |
| 2025 |
| 10.1016/j.bspc.2025.107962 | 1746-8108 |
| RLANET: An EEG denoising network for judgemental removal of long- and short-term distribution artefacts | The acquisition of electroencephalogram (EEG) signals is susceptible to contamination by various physiological artefacts, making the subsequent analysis of the EEG signals difficult. Deep learning (DL)-based methods of EEG denoising have achieved some effectiveness in addressing this issue. However, existing structural designs do not fully account for the randomness and waveform diversity of artefacts’ temporal distribution. Most network structures are processed directly on the samples disturbed by the mixture of artefacts, which overlooks the time-varying overlap between electromyography (EMG) and EEG in long-term distribution, as well as the mutual interference between long-and short-term artefacts. To overcome these issues, we propose an EEG denoising network for the judgemental removal of long- and short-term distribution artefacts. This network, which we call RLANET, consists of a segmentation network, a short-term denoising network, and a long-term denoising network. The segmentation network ResUNet is used to enable discrimination of the temporal distribution characteristics of the artefacts. The short-term denoising network LWTCN learns temporal correlations and capture local waveform variations to remove short-term distribution artefacts from EEG signals. The long-term denoising network ADDPM is used to reconstruct EEG signals affected by long-term distribution artefacts, improving the quality of noise removal. The experimental results demonstrate that RLANET's denoising performance is significantly superior to that of current mainstream denoising methods. Specifically, in the removal of mixed artefacts, RLANET achieved improvements of 1.31% and 1.5316 in Correlation Coefficient (CC) and Signal-to-Noise Ratio (SNR), respectively, demonstrating its outstanding performance in handling mixed artefacts. | | Article | Zhao, Yun;Xiong, Changxian;Wang, Bingwei;Li, Daotong;Liu, Jiarui;Wei, Shizhang;Hou, Yujia;Zhou, Yuan;Zheng, Ruimao |
| Res. | 8 |
| 2025 |
| 10.34133/research.0657 | 2639-5274 |
| The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson’s Disease | Background: A century ago, a mystery between a virus and Parkinson’s disease (PD) was described. Owing to the limitation of human brain biopsy and the challenge of electron microscopy in observing virions in human brain tissue, it has been difficult to study the viral etiology of PD. Recent discovery of virobiota reveals that viruses coexist with humans as symbionts. Newly developed transcriptomic sequencing and novel bioinformatic approaches for mining the encrypted virome in human transcriptome make it possible to study the relationship between symbiotic viruses and PD. Nevertheless, whether viruses exist in the human substantia nigra (SN) and whether symbiotic viruses underlie PD pathogenesis remain unknown. Methods: We collected current worldwide human SN transcriptomic datasets from the United States, the United Kingdom, the Netherlands, and Switzerland. We used bioinformatic approaches including viruSITE and the Viral-Track to identify the existence of viruses in the SN of patients. The comprehensive RNA sequencing-based virome analysis pipeline was used to characterize the virobiota in the SN. The Pearson’s correlation analysis was used to examine the association between the viral RNA fragment counts (VRFCs) and PD-related human gene sequencing reads in the SN. The differentially expressed genes (DEGs) in the SN between PD patients and non-PD individuals were used to examine the molecular signatures of PD and also evaluate the impact of symbiotic viruses on the SN. Findings: We observed the existence of viruses in the human SN. A dysbiosis of virobiota was found in the SN of PD patients. A marked correlation between VRFC and PD-related human gene expression was detected in the SN of PD patients. These PD-related human genes correlated to VRFC were named as the virus-correlated PD-related genes (VPGs). We identified 3 bacteriophages (phages), including the Proteus phage VB_PmiS-Isfahan, the Escherichia phage phiX174, and the Lactobacillus phage Sha1, that might impair the gene expression of neural cells in the SN of PD patients. The Proteus phage VB_PmiS-Isfahan was a common virus in the SN of patients from the United Kingdom, the Netherlands, and Switzerland. VPGs and DEGs together highlighted that the phages might dampen dopamine biosynthesis and weaken the cGAS-STING function. Interpretation: This is the first study to discover the involvement of phages in PD pathogenesis. A lifelong low symbiotic viral load in the SN may be a contributor to PD pathogenesis. Our findings unlocked the black box between brain virobiota and PD, providing a novel insight into PD etiology from the perspective of phage–human symbiosis. | | Article | Huang, Yuhang;Zhang, Haicheng;Liu, Jiarui;Li, Pengcheng;Ding, Jun;Xu, Daolin |
| Renew. Energy | 250 |
| 2025 |
| 10.1016/j.renene.2025.123383 | 1879-0682 |
| Nonlinear ocean energy harvesting method for unmanned surface vessels | Long endurance unmanned surface vessels (USVs) play a critical role in ocean monitoring, but traditional energy supply for their monitoring sensors has great problems. Harvesting wave-induced ship vibration energy is a promising solution to meet the long-term energy demands of USVs. However, traditional linear energy harvesters (L-EHs) exhibit poor performance in capturing wave-induced low-frequency vibrations. To address this issue, a bistable mechanism is introduced, and a bistable spring-mass-based EH (B-EH) is studied as an embodiment. A wave-to-wire dynamic model of the B-EH in the USV is established, and a semi-analytic solution method based on the least square method and the harmonic balance method is proposed for the fast solution of the nonlinear electromechanical coupling equations. Furthermore, the static characteristics of the B-EH and the influence of the main parameters on the average power of the B-EH are studied. The results show that the B-EH with proper parameter design has a wider bandwidth at low frequencies compared to the L-EH, making it more suitable for the long-term energy supply of the USV during operation. The bistable mechanism holds great potential to be widely used in inertial type EHs for USVs. | | Article | Liu, Jiarui;Jiao, Zhichao;Zhou, Jun;Yuan, Yuan;Li, Qiguang;Zhou, Wei;Zhang, Shuai;Yang, Shuping |
| Front. Oncol. | 15 |
| 2025 |
| 10.3389/fonc.2025.1571512 | 2234-943X |
| Acquired ROS1 fusion and iruplinalkib response in advanced NSCLC after multiple lines of systematic therapy: a case report | This is the first report of a patient with lung cancer whose primary focus was the upper lobe of the left lung combined with multiple metastases in both lungs, initially diagnosed as a non-driver gene mutation, who subsequently developed SDC4-ROS1 fusion after multiple lines of systemic therapy. When diagnosis, a needle biopsy of the primary focus revealed no driver gene mutation and low PD-L1 expression (TPS < 1%, CPS 3). From November 2022 to December 2023, the patient received sequential chemotherapy-based systemic therapy including anti-angiogenesis treatment, concurrent chemoradiation and combined immunotherapy as determined by the clinician based on the initial evaluation. In December 2023, a needle biopsy of a metastasis in the left lower lobe of the lung showed a positive SDC4-ROS1 fusion. Subsequent treatment with the oral ALK TKI iruplinalkib was initiated based on the patient’s preference, which exhibited a promising response over the next 2 months. | | Article | Huang, Xian;Wang, Xinhai;Yang, Wensheng;Gao, Tinghong;Xie, Quan;He, Lishan;Jian, Qinyan;Liu, Jiarui;Li, Bingxian;Ruan, Yunjun |
| J. Energy Storage | 127 |
| 2025 |
| 10.1016/j.est.2025.117130 | 2352-152X |
| Nitrogen- and oxygen-doped porous carbon with high specific surface area derived from loquat seed for high-performance aqueous supercapacitors | The high-value utilization of biomass waste has been one of the major research foci in recent years. In this work, loquat seed waste was carbonized via a hydrothermal method and subsequently high-temperature activated by the synergistic effect of KOH and melamine to obtain nitrogen- and oxygen-doped loquat seed-derived activated hydrothermal carbons (LSAHC-NX). The influence of melamine added in the activation process on the pore structure and electrochemical properties of LSAHC-N was systematically studied. When the mass ratio of KOH to melamine is 2:0.5, the resulting LSAHC-N0.5 exhibits an exceptional specific surface area (2919 m g) and a rich microporous and mesoporous structure, which is beneficial for electrolyte ion accumulation and transport capabilities. LSAHC-N0.5 demonstrates high specific capacitances of 392 F g (1 A g) in 6 M KOH and 688 F g (1 A g) in 2 M KOH + 0.02 M K3Fe(CN)6 aqueous electrolytes, outperforming most reported biomass-derived carbon materials. Furthermore, the LSAHC-N0.5 symmetric supercapacitor with the mixed aqueous electrolyte achieves a high specific capacitance of 92 F g (0.25 A g) and delivers a high energy density of 24.94 Wh kg at a power density of 175 W kg. | | Review | Chen, Yingxi;Liu, Jiarui;He, Yurou;Lü, Yang;Yu, Weihua |
| Mol. Neurobiol. |
|
| 2025 |
| 10.1007/s12035-025-05071-5 | 1559-1182 |
| The Role of Fatty Acid Binding Protein 7 in Neurological Diseases | Fatty acid binding protein 7 (FABP7) is a pivotal cytoplasmic protein involved in the transport and metabolism of fatty acids, with critical functions in the nervous system. This review highlights recent advances in understanding the role and mechanisms of FABP7 in neurological diseases. It begins with an overview of FABP7’s distribution and expression in the nervous system, emphasizing its involvement in essential biological processes such as lipid metabolism, energy regulation, synaptic transmission, cell growth, and neuroinflammation. This review also explores FABP7’s associations with major neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), schizophrenia, and depression, shedding light on its dual roles in neuroprotection and neurodegeneration. These findings position FABP7 as a promising target for novel therapeutic strategies. By unraveling its precise mechanisms and contributions to both neural health and disease, future research on FABP7 has the potential to revolutionize treatments for neurological disorders, offering innovative directions for therapeutic development. | | Review | Jiachang, Feng;Liuyang, Chen;Jiarui, Liu;Yan, Wang;Weiguang, Zhao;Penghui, Wang;Xiaowei, Zhang;He, Wang |
| Food. Bioprocess Technol. | 18 | 7 | 2025 | 6066 - 6094 | 10.1007/s11947-025-03866-x | 1935-5149 |
| A Review of Responsive Active Packaging in Cereal Products: Applications and Prospects | Cereals are the cornerstone of human nutrition, providing a staple source of carbohydrates, proteins, and essential nutrients that are vital for the sustenance of global populations. However, microbial contamination and lipid oxidation of cereal products have caused great losses to human beings, and even threaten human health. The food safety and shelf life of cereal products were related to the field of food packaging. Unlike traditional packaging, which primarily serves as a protective barrier, active packaging could interact with the environment inside the package to extend the shelf life of cereal products. This paper reviewed the classification of responsive active packaging, including temperature, light, pH, humidity, oxygen, and enzyme response, and briefly analyzed some of the mechanisms. And then, the application and prospects of responsive active packaging in cereals and their products were specifically discussed, in order to provide some feasible schemes for improving the safety and quality of cereal products. | | Article | Yang, Yao;Yu, Faxin;Li, Haoming;Chen, Jiahao;Wang, Tengjia;Liu, Yu;Chen, Hua;Liu, Jiarui |
| IEICE Electron. Express | 22 | 10 | 2025 |
| 10.1587/elex.22.20250135 | 1349-2543 |
| A low-fractional-spur fractional-N PLL using a probability-distribution-shaping delta-sigma modulator | This letter presents a 5.2–6.4 GHz fractional-N phase-locked loop (PLL) with low in-band fractional spurs. The proposed probability-distribution-shaping delta-sigma modulator (PDS-DSM) reduces the in-band fractional spurs arising from loop nonlinearity by changing the probability distribution of the DSM. The enhanced PDS-DSM is realized by integrating the PDS dither with a multi-mode filter at the output stage of a conventional MASH 1-1-1 architecture. The proposed PLL was fabricated in a 65 nm CMOS process. Notably, with the incorporation of second-order and third-order filtered PDS dithers in the PDS-DSM, in-band fractional spurs at 10 kHz offset from 5.825 GHz were reduced from −49.5 dBc to −58.2 dBc and −62.8 dBc respectively. | | Review | Hong, Yi;Liu, Jiarui;Wang, Weixuan;Li, Hao;Kong, Weijing;Li, Xiaoxia;Zhang, Wei;Pahlavan, Sara;Tang, Yi-Da;Wang, Xi;Wang, Kai |
| Sci. China Life Sci. |
|
| 2025 |
| 10.1007/s11427-024-2801-x | 1869-1889 |
| Pluripotent stem cell-derived cardiomyocyte transplantation: marching from bench to bedside | Cardiovascular diseases such as myocardial infarction, heart failure, and cardiomyopathy, persist as a leading global cause of death. Current treatment options have inherent limitations, particularly in terms of cardiac regeneration due to the limited regenerative capacity of adult human hearts. The transplantation of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) has emerged as a promising and potential solution to address this challenge. This review aims to summarize the latest advancements and prospects of PSC-CM transplantation (PCT), along with the existing constraints, such as immune rejection and engraftment arrhythmias, and corresponding solutions. Encompassing a comprehensive range from fundamental research findings and preclinical experiments to ongoing clinical trials, we hope to offer insights into PCT from bench to bedside. | | Article | Li, Kun;Wang, Fen;Wang, Jie;Li, Long;Liu, Hongping;Wang, Mingxia;Liu, Jiarui |
| Chin. J. Infect. Chemother. | 22 | 1 | 2022 | 78 - 84 | 10.16718/j.1009-7708.2022.01.015 | 1009-7708 |
| Surveillance of bacterial resistance in Suining Central Hospital of Sichuan in a 3-year period from 2018 to 2020 | Objective To understand the distribution and antibiotic resistance profile of clinical isolates in Suining Central Hospital from 2018 to 2020 for better rational use of antimicrobial agents. Methods The bacteria were isolated and identified and underwent antimicrobial susceptibility testing using VITEK 2 Compact or disk diffusion method according to the national standard operating procedures of clinical laboratory (4th Edition). The results were interpreted with reference to the breakpoint recommended by the CLSI (2020 version), and analyzed using WHONET 5.6 software. Results A total of 10 942 nonduplicate strains were collected from 2018 to 2020. Gram-positive bacteria accounted for 25.7%, and gram-negative bacteria 74.3%. More than half of the pathogens (57.7 %) were isolated from respiratory specimens, followed by urine (20.6%) and blood (10.5%). The top five species were Escherichia coli (23.7%), Klebsiella spp (18.9%), Staphylococcus aureus (11.8%), Pseudomonas aeruginosa (10.4%), and Acinetobacter spp (5.2%). The prevalence of methicillin-resistant S. aureus (MRSA) was 35.1%, methicillin-resistant coagulasenegative Staphylococcus (MRCNS) 80.5%. Methicillin-resistant staphylococcal strains were more resistant to most antimicrobial agents than methicillin-susceptible strains. Enterococcus faecium strains showed higher resistance rates to most antimicrobial agents than Enterococcus faecalis. None of the staphylococcal or enterococcal strains was resistant to vancomycin or linezolid. All the Streptococcus pneumoniae strains were not isolated from cerebrospinal fluid. The prevalence of penicillin-resistant S. pneumoniae (PRSP) was 4.5%. The prevalence of ESBLs-producing E. coli and K. pneumoniae was 55.5% and 15.2%, respectively. The prevalence of carbapenem-resistant E. coli and K. pneumoniae was 0.8% and 2.1%, respectively. Acinetobacter baumannii strains were relatively more resistant to most of the antimicrobial agents tested (> 40% resistant) except trimethoprim-sulfamethoxazole (28.9%), cefoperazone-sulbactam (10.6%), and levofloxacin (37.9%). About 12.3% of Pseudomonas aeruginosa isolates were resistant to imipenem. Conclusions Clinical microbiology laboratories should strengthen the surveillance of bacterial resistance for better rational use of antibiotics so as to address the increasing antimicrobial resistance. | | Article | Kong, Yajing;Wang, Qiyuan;Li, Li;Zhang, Yang;Tian, Jie;Ma, Nan;Zhou, Yaqing;Liu, Huikun;Liu, Jiawen;Ran, Weikang;Liu, Jiarui;Zhu, Chongshu;Han, Yongming;Cao, Junji |
| npj Clim. Atmos. Sci. | 8 | 1 | 2025 |
| 10.1038/s41612-025-01015-x | 2397-3722 |
| Chemical composition and mixing state of elemental carbon-containing particles from solid fuel combustion | Elemental carbon (EC), predominantly produced by solid fuel combustion, significantly influences both climate and public health. However, the physicochemical properties of EC-containing particles immediately after emission remain inadequately understood. This study investigates the chemical composition, size distribution, and mixing state of EC-containing particles from five solid fuels: wheat, corn, rice straw, bituminous coal, and anthracite. Using a single-particle aerosol mass spectrometer (SPAMS), we identified seven distinct EC-containing particle types. Our results show that biomass burning primarily produces EC-containing particles obviously coated with organic carbon (EC-OC) and organic nitrogen (EC-CN), with sizes concentrated between 0.4 and 1.0 μm. In contrast, bituminous coal emissions are dominated by sodium-rich EC-containing particles (EC-Na), while anthracite combustion predominantly produces particles coated with sulfate or nitrate (EC-NS). Bituminous coal particles are generally smaller (< 0.4 μm), likely due to higher volatile content and rapid pyrolysis. The mixing states of EC-containing particles varied markedly. Sulfate (HSO4) was strongly associated with EC-OC and EC-Na particles, resulting in a highly mixing state. Levoglucosan (C2H3O2) showed distinct patterns between biomass and coal emissions. These findings provide critical insights into the physicochemical properties of freshly emitted EC-containing aerosols, offering valuable references for atmospheric particle analysis and emission characterization. | | Conference Paper | Khanapuri, Eshaan;Chakraborty, Anusna;Thayer, Ross;Ammapalli, Jayanth;Liu, Jiarui;Lin, Szu Wei;Yadegar, Joseph |
| IEEE/ION Position, Locat. Navig. Symp., PLANS |
|
| 2025 | 1488 - 1499 | 10.1109/PLANS61210.2025.11028314 |
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| Aerial Intruder Interception Based on Threat Classification for Enhanced Situational Awareness | Intent classification of Unmanned Aerial Vehicles (UAVs) either as a standalone vehicle or in swarm is extremely important in the current world. With the rise in autonomy of these platforms, there have been several instances where UAVs have, instead of providing benefit, been a nuisance and created chaos and confusion. Activity classification for threat assessment of UAVs is a relatively new area where different types of machine learning models are been tested. In this paper, the authors have provided a methodology to passively perform intent classification and a comparative study of different classification models namely Hidden Markov Model (HMM), Convolutional Neural Network - Long Short Term Memory (CNN-LSTM), Gramian Angular fields (GAF) with CNN and Transformers have been performed for action classification for threat identification. Additionally, the authors have developed a simulator using ROS and Gazebo to deploy these models in simulation along with a resource allocation and target interception framework to demonstrate an actionable and intelligent as well as automated Counter-UAS system. | | Article | Liu, Jiarui;Wang, Qiaoqiao;Feng, Hao;Wu, Yongyi;Li, Yan;Hou, Feiyan;Min, Tai;Li, Tao |
| Nanoscale |
|
| 2025 |
| 10.1039/d5nr01908g | 2040-3372 |
| Anomalous ionic conduction in ferroelectric semiconductor junctions comprising multistate CuInP2S6 | Van der Waals ferroelectric CuInP2S6 (CIPS) has emerged as a compelling candidate for multifunctional electronic devices, attributed to its intrinsic multiple polarization states and the coupling of these states with highly active Cu ions migration. Such a “ferroionic” feature of CIPS opens a new paradigm for the next-generation multifunctional ferroelectric devices. Here, we present a comprehensive investigation of n-Si/CIPS/MoS2 ferroelectric semiconductor junction (FSJ) devices, focusing on the interplay between ferroelectric polarization and ionic migration. By employing high-resolution piezoresponse force microscopy and conductive atomic force microscopy imaging and spectroscopy methods, we revealed the distinctive dual and quadruple polarization states of the FSJ, which give rise to distinct memristive and rectifying electronic behaviors, respectively. The dual-polarization FSJ exhibits voltage- and frequency-dependent current-voltage hysteresis, while the quadruple-polarization FSJ achieves a rectification ratio exceeding 10, which can be attributed to Cu ion migration correlated with ferroelectric polarization modulation. This work establishes an effective strategy for leveraging ferroelectric-ionic coupling to achieve multifunctional device performance, paving the way for advanced electronic systems through interfacial engineering in future non-volatile memories and neuromorphic computing applications. | | Article | Liu, Jiarui;Young, Edward D.;Pellerin, André;Ash, Jeanine L.;Barrett, Gerard T.;Feng, Xiahong;Girguis, Peter R.;Krause, Sebastian J.E.;Leavitt, William D.;Murphy, Kyla;Qin, Qianhui;Teske, Andreas;Valentine, David L.;Anthony, Katey Walter;Treude, Tina |
| Sci. Adv. | 11 | 26 | 2025 |
| 10.1126/sciadv.adu1401 | 2375-2548 |
| Clumped isotopes of methane trace bioenergetics in the environment | Methane is a major greenhouse gas and a key component of global biogeochemical cycles. Microbial methane often deviates from isotope and isotopolog equilibrium in surface environments but approaches equilibrium in deep subsurface sediments. The origin of this near-equilibrium isotopic signature in methane, whether directly produced by methanogens or achieved through anaerobic oxidation of methane (AOM), remains uncertain. Here, we show that, in the absence of AOM, microbial methane produced from deep-sea sediments exhibits isotopolog compositions approaching thermodynamic equilibrium due to energy limitation. In contrast, microbial methane from salt marsh and thermokarst lakes exhibits significant hydrogen and clumped isotopic disequilibrium due to high free-energy availability. We propose that clumped isotopologs of methane provide a proxy for characterizing the bioenergetics of environments for methane production. Together, these observations demonstrate methane clumped isotopes as a powerful tool to better understand the relation between methane metabolisms and the energy landscape in natural environments. | | Conference Paper | Jin, Zhijing;Kleiman-Weiner, Max;Piatti, Giorgio;Levine, Sydney;Liu, Jiarui;Gonzalez, Fernando;Ortu, Francesco;Strausz, András;Sachan, Mrinmaya;Mihalcea, Rada;Choi, Yejin;Schölkopf, Bernhard |
| Int. Conf. Learn. Represent., ICLR |
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| 2025 | 88657 - 88686 |
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| LANGUAGE MODEL ALIGNMENT IN MULTILINGUAL TROLLEY PROBLEMS | We evaluate the moral alignment of LLMs with human preferences in multilingual trolley problems. Building on the Moral Machine experiment, which captures over 40 million human judgments across 200+ countries, we develop a crosslingual corpus of moral dilemma vignettes in over 100 languages called MULTITP. This dataset enables the assessment of LLMs' decision-making processes in diverse linguistic contexts. Our analysis explores the alignment of 19 different LLMs with human judgments, capturing preferences across six moral dimensions: species, gender, fitness, status, age, and the number of lives involved. By correlating these preferences with the demographic distribution of language speakers and examining the consistency of LLM responses to various prompt paraphrasings, our findings provide insights into cross-lingual and ethical biases of LLMs and their intersection. We discover significant variance in alignment across languages, challenging the assumption of uniform moral reasoning in AI systems and highlighting the importance of incorporating diverse perspectives in AI ethics. The results underscore the need for further research on the integration of multilingual dimensions in responsible AI research to ensure fair and equitable AI interactions worldwide. | | Article | Ping, Yang;Xu, Hao;Zhang, Zhenzhou;Liu, Jiarui;Zhang, Han;Chen, Weiwei;Wang, Qing;Zhong, Yibin;Yu, Jingwen;Yi, Shengze;Han, Jingchao |
| Infrared Phys Technol | 150 |
| 2025 |
| 10.1016/j.infrared.2025.106003 | 1350-4495 |
| Terahertz hollow cube metamaterials integrated with laser pump for sensitive detection of nitrite in water | Assessing water quality is of utmost importance as it plays a pivotal role in environmental preservation, human health protection, and the maintenance of ecological balance. By enabling the prompt identification of contaminants in aquatic ecosystems, it lays a solid foundation for the rational management and utilization of water resources. In the face of rapid fluctuations in water quality and the need for timely pollution alerts, real − time water quality monitoring has become an urgent necessity. Regrettably, existing methodologies for real − time water quality surveillance are far from satisfactory.Consequently, terahertz technology shows great potential for real − time water quality detection and is expected to overcome the limitations of current methods.This study presents an innovative application of terahertz micro − current technology for the non − contact and high − speed detection of nitrite in water. Through an in − depth exploration of the terahertz frequency range and the interaction mechanisms of nitrite molecules within this spectrum, combined with the principles of micro − current detection, we have successfully achieved rapid, accurate, and non − contact nitrite detection in water. This novel detection technique holds considerable significance for water quality monitoring and environmental conservation. | | Article | Liu, Jiarui;Jiang, Ying;Tao, Jun;Wu, Guanghui |
| Aerosp Sci Technol | 166 |
| 2025 |
| 10.1016/j.ast.2025.110606 | 1270-9638 |
| Aerodynamic shape optimization via active learning-driven design space refinement | In Aerodynamic Shape Optimization (ASO) studies, the ranges of design variables critically influence both optimization efficiency and solution quality. Traditional approaches typically maintain fixed boundaries based on experiential knowledge, struggling to balance computational efficiency with optimization outcomes. This paper proposes an innovative design space refinement framework driven by active learning. This framework offers a flexible and efficient strategy to identify a compact design space encompassing high-performance designs. Active learning enhances sampling efficiency, while the refinement mechanism progressively directs the optimization focus toward higher-performing designs. The proposed framework is validated through a comparative analysis with Principal Components Analysis (PCA), a prevalent method for reducing the number of design variables, on supercritical airfoil optimization. The results demonstrate that dynamically refining the boundaries of design variables can significantly improve the efficiency and effectiveness of ASO. By integrating active learning with adaptive design space refinement, the proposed approach effectively focuses the optimization process on regions likely to contain superior designs. | | Article | Niu, Kaiqiang;Zhang, Xuezhu;Zhu, Peifang;Liu, Jiarui;Liu, Hui;Wang, Likai;Wang, Jigang;Zhang, Jiaying;Liu, Qiang;Ma, Shuanhong;Sillanpää, Mika |
| Sep. Purif. Technol. | 377 |
| 2025 |
| 10.1016/j.seppur.2025.134343 | 1873-3794 |
| Facile synthesis of polyethyleneimine-reinforced PHTA resin for efficient Cr(VI) removal | Toxic Cr(VI) residual in water has triggered constant worries for human health. To tackle this issue, mussel-inspired chelate resins with designable structure and abundant functional groups are emerging to purify the pollutant. Herein, the poly(hydroquinone-tetraethylenepentamine/polyethyleneimine) (PHTA-m%PEIt) cross-linked resin had been firstly tailored as a representative adsorbent with respect to rapidly remove Cr(VI), originated from “self-assembly to polymerization”. Various characterizations had been performed to identify its microstructure and structure–activity relationship, including SEM, FT-IR, XPS, TGA, etc. Effects of PEI modification, solution volume, initial concentration, pH, adsorbent dosage, contact time, etc, on the removal of Cr(VI) were investigated systematically. Adsorption kinetics, isotherm, and thermodynamics had been explored to understand the uptake mechanism. Factually, the culminating impressive performance (qm = 819.67 mg g) was ascertained in PHTA-5%PEI36 candidate, due to the stronger affinity of the protonated -NH2/-NH- groups to Cr(VI) confirmed by density functional theory (DFT) and XPS investigations. A favorable monolayer chemisorption of Cr(VI) occurred on the homogeneous surface of PHTA-5%PEI36, and the adsorption rate underwent a rate-limiting step. The toxic Cr(VI) reduced to Cr(III) accompanied the adsorption procedure. Accordingly, the creditable PHTA-5%PEI36 with the strong anti-interference ability, has potential as a as a promising option for wastewater treatment. | | Patent |
| GUANGXI UNIVERSITY |
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| CN112226395 | 一株大肠杆菌工程菌及其全细胞催化产淫羊藿苷元的方法 | 本发明公开了一株重组大肠杆菌工程菌pQE‑sprha2‑pbgl及利用其全细胞催化淫羊藿苷生产淫羊藿苷元的方法，该菌株通过多顺反子形式共表达一个α‑L‑鼠李糖苷酶SPRHA2和一个β‑葡萄糖苷酶PBGL，用全细胞催化的方法，以淫羊藿苷粗提物为底物，催化其中的淫羊藿苷水解生产淫羊藿苷元。本发明构建了一个含多顺反子的重组大肠杆菌菌株，采用全细胞催化的方法，直接实现淫羊藿苷到淫羊藿苷元的转化，淫羊藿苷的水解率在98％以上。 | | Patent |
| BEIJING UNION UNIVERSITY |
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| CN109553479 | 一种磷素肥料增效剂及其制备方法 | 本发明公开一种磷素肥料增效剂，由如下成分组成：海藻提取物(按干物质含量计)20～40份；腐殖酸钾或黄腐酸30～50份；聚天冬氨酸10～20份；填充剂20份。本发明还公开了上述磷素肥料增效剂的制备方法，是以海藻提取物为基液，加入腐殖酸钾/黄腐酸及聚天冬氨酸，再经圆盘造粒，制得。本发明提供的磷素肥料增效剂可直接在土壤中施用，也与磷肥混合后施用，使磷素当季利用率大大提高。 | | Patent |
| BEIFANG UNIVERSITY OF NATIONALITIES |
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| CN210974277 | 净水机 | 本实用新型公开一种净水机，其净水腔体内设置有过滤空腔和出水空腔；过滤空腔的下端与进水管连通；进水管固定连接在净水腔体上；进水管上配装连接有压力表；净水管与进水泵配装连接；过滤空腔的内部从下倒上依次固定连接有一级净水结构、二级净水结构、三级净水结构和四级净水结构；过滤空腔与出水空腔通过小颈管连通；出水空腔的内部固定连接有紫外线灯；出水空腔通过净水出水管与加热腔体连通并固定连接；加热腔体的内部下端位置处固定连接有加热装置；加热腔体上设置有热水出水管；加热腔体通过连接件与净水腔体固定连接；有益效果：结构合理，使用方便，实用性强，生产成本低，可靠性高，且净水原料易获取、净水器的各个构件易拆卸更换。 | | Patent |
| SHANDONG GOLD MINING LINGLONG |
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| CN205627308 | 一种用于井下充填管网的高压缓冲过滤装置 | 本实用新型专利公开了一种用于井下充填管网的高压缓冲过滤装置，井下弯管管路的入料端连接有垂直管路，垂直管路连接有进料管路；缓冲罐内设有过滤网；还包括出料端与缓冲罐的进口相连接的U型管；井下弯管管路的出料端连接有一段变径管，该变径管的粗端与井下弯管管路相连接，细端与U型管的入料端相连接；U型管的入料端和出料端均位于U型管管体下端。本实用新型制作成本低，方便安装操作；降压效果明显，有效地解决了充填管网由于压力大磨损快的问题；提高了浆液面，减少了对垂直管道的磨损。 | | Patent |
| JIARUI LIU |
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| CN201906189 | 温和灸箱 | 本实用新型涉及一种温和灸箱，包括框体，其特征在于：所述框体内设有用于放置艾灸条及防止艾灸条燃烧废料下落的网片,所述框体上开口设置有既有通气口的遮板,本实用新型可以有效的调节与控制艾灸条燃烧的速度。 | | Patent |
| YUXI KAIYUAN JINLAN BIOTECHNOLOGY |
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| CN108338406 | 一种迷迭香抗氧化剂爆珠及其在卷烟滤棒中的应用 | 本发明公开了一种迷迭香抗氧化剂爆珠及其在卷烟滤棒中的应用。自由基清除剂直接添加到卷烟及滤棒中会出现稳定性较差，导致活性降低。本发明包括壳体和芯材，芯材包括以下重量份的原料：迷迭香脂溶性抗氧化剂2—5份，迷迭香水溶性抗氧化剂1—2份，雨生红球藻1—3份，溶油2—4份。还包括1—2份的蓝藻，原料重量0.2—1%的香精油。本发明相对于将抗氧化剂直接添加到烟叶或嘴棒中，由于采用了壳体包裹胶囊的形式，保证抗氧化剂添加到卷烟滤棒中能够稳定，不会产生流失及转化。迷迭香抗氧化剂、雨生红球藻及大麻籽油成分相互相浸相融，混合后还对烟气中的焦油、烟碱形成有效的吸附作用，减少了焦油、烟碱的吸入。 | | Patent |
| LUSHAN COLLEGE OF GUANGXI UNIVERSITY OF SCIENCE AND TECHNOLOGY |
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| CN208624137 | 高处水果采摘装置 | 本实用新型公开了一种高处水果采摘装置，包括伸缩杆、以俯仰角可调的方式安装于伸缩杆顶端的旋转刀具组件、用于控制旋转刀具组件俯仰角的控制机构和设置有旋转刀具组件下方的收集组件；所述旋转刀具组件包括以俯仰角可调的方式铰接于伸缩杆顶端的刀具座板、固定于刀具座板的驱动电机和转动安装于刀具座板并与驱动电机的转子传动配合的旋切盘；能够实现高处水果轻松采摘，并且操作方便，采摘效率高。 | | Patent |
| UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGY |
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| CN204665987 | 板壳式换热器 | 本实用新型涉及一种板壳式换热器，包括板片、圆柱状筒体、板束、密封胶条、导流块、板程入口接管、板程出口接管、板程总入口接管、板程总出口接管、壳程入口接管、壳程出口接管，板片并联焊接形成板束，板片间隙用密封胶条密封，板束两端与压紧钢板焊接，板程入口接管、出口接管焊接在压紧钢板上，入口接管和出口接管分别与总入口接管和总出口接管连接，密封胶条用压紧钢板压紧并与导流块连接，导流块与圆柱状筒体焊接，圆柱状筒体与板束间隔部分焊接分流板，圆柱状筒体底部与封头焊接，封头底部焊接有壳程入口接管，圆柱状筒体顶部焊接壳程出口接管，圆柱状筒体、板束与导流块所包围的壳程通道内焊接圆弧状的分流板。本实用新型结构简单，易于制造。 | | Patent |
| ZHAO JINLING |
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| CN2370416 | 单晶片水柱水膜直探头 | 本实用新型公开了一种单晶片水柱水膜直探头,适用于20—200mm厚钢板超声波探伤,属于采用局部水浸法探伤时的单晶片直探头,探头芯由壳体,吸收块,压电晶片和电极线组成,通过封闭胶封闭成一体,探头芯与水柱外壳上端口为螺纹密封连接,下端口有透声膜及封口螺母紧固封闭,水柱外壳与耐磨盘螺纹连接,可以调整水膜,探头性能满足技术标准规定,具有操作工作效率高,灵敏度高,可以保证正检率,使用方便的特点。 | | Patent | 邓贤挺 , 刘家瑞 | THE SECOND CONSTRUCTION OF CHINA CONSTRUCTION EIGHTH ENGINEERING DIVISION |
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| CN208195989 | 一种组合式钢结构焊接接火斗 | 本实用新型公开了一种组合式钢结构焊接接火斗，包括接火底盆、防风挡板以及加固板架，接火底盆呈圆形框体结构，接火底盆的内部设置有隐藏槽，隐藏槽的内部插接有防风挡板，防风挡板的底端与隐藏槽的底面之间固定连接有张拉弹簧，防风挡板的内壁上设置有第一限位孔，第一限位孔与隐藏槽的内壁设置的第一弹簧插销配合连接，且防风挡板的端面处固定连接有第二弹簧插销，第二弹簧插销与观测槽口的内壁设置的第二限位孔配合连接；在接火底盆内部设置防风挡板，防风挡板通过上下移动隐藏在隐藏槽内，减小整个装置的体积，且防风挡板配合弹簧插销和限位孔实现高度调节，便于工人根据需要自行调节防风挡板的高度。 | | Patent | 刘庆凯 , 刘家瑞 , 赵金玲 | LIU JIA RUI |
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| CN2716839 | 高速轨自动探伤用双晶探头 | 本实用新型涉及一种用于高速轨无损检测的超声波探伤探头，特别涉及一种用于高速轨轨头、轨腰、轨底自动探伤用的双晶探头。是由：水管、上盖、外壳、耐磨块、内框架、外框架、探头芯、纵轴、横轴构成，有轨头探头芯、轨腰探头芯、轨底探头芯三种形式，分别装入外壳内，用封闭胶封闭。本实用新型其上盖、外壳、内框架、外框架采用ABS塑料注塑而成，规格统一，成本低廉。可对轨头的上孔、下孔部位，轨踏面的上孔、下孔部位及轨腰的大部和轨底部位进行多部位大探测面探伤，可靠性强。轨头、轨腰、轨底探头采用同种外壳和随动框架，通用性好、易于管理。轴孔直接注塑在外壳和内框架上，易于更换。探头线采用新型电缆，衰减小、灵敏度高。 | | Patent | 王树人 , 刘家瑞 , 颜世超 | WANG SHUREN |
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| CN203370106 | 一种可控进针深度的针灸针 | 一种可控进针深度的针灸针，本实用新型涉及医疗器械领域，尤其涉及一种可控进针深度的针灸针。一种可控进针深度的针灸针，包括针尖、针体、针柄、圆环、针体套，所述针体前端设有针尖，针体后部连接针柄，所述针体与针尖外表光滑，所述针柄上设有螺纹，所述针柄后端设有圆环，所述针尖中部设有针体套，所述针体套为漏斗形。本实用新型有益效果：通过将不同规格的针体套套在相同规格的针尖上，使得针尖的进针深度可控，从而达到治疗疾病的效果。使用安全方便，精准可控。 | | Patent | 刘鹏金 , 姜培根 , 刘家瑞 , 张雪楣 , 赵海彬 , 赵金强 , 赵光义 , 刘景东 , 杨治国 , 徐振国 , 赵海杰 | SHANDONG GOLD MINING LINGLONG |
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| CN206158790 | 一种高压风多层防水辅助下灰装置 | 本实用新型是一种高压风多层防水辅助下灰装置，包括设有自动疏水阀的一级排水风包，一级排水风包分别连接有一级排水风包进风管和一级排水风包出风管；还包括设有自动疏水阀的二级排水风包，二级排水风包分别连接有二级排水风包进风管和二级排水风包出风管，其中二级排水风包进风管与一级排水风包出风管相连接；还包括设有人工放水阀门的三级滤水包，三级滤水包的一端与二级排水风包出风管相连接，另一端连接料仓进风口。采用本装置能够保证充填站灰仓下灰的流畅，使充填料均匀与尾砂混合，达到充填质量稳定的目的，从而保证矿山充填效率。 | | Patent | 刘家瑞 , 于吉乐 , 周博 , 焦冬生 | SDAAC AUTOMOTIVE AIR CONDITIONING SYSTEMS SHANGHAI |
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| CN110277605 | 新能源汽车动力电池冷却板 | 本发明提供的一种新能源汽车动力电池冷却板，包括下板片；上板片，上板片覆盖在下板片上，在下板片与上板片之间形成进口流道及出口流道；进口水管及出口水管，进口水管及出口水管分别连接在上板片上，进口水管及出口水管分别与进口流道及出口流道连通；凸包结构，凸包结构设置在下板片面向上板片的一侧。与现有技术相比，本发明的有益效果如下：可使冷却板表面温度分布均匀，有效散掉动力电池表面积聚的热量，保证动力电池在合理的工作温度下正常运行，同时其流道结构简单，能够大幅度降低冷却介质在流动中的阻力损失，降低泵功率需求，降低新能源汽车成本。有利于广泛地在生产中应用，具有重大的生产实践意义。 | | Patent | 蒋万飞 , 白腾飞 , 孙京阁 , 王风光 , 张书金 , 刘家瑞 , 孙宜耐 , 孙世杰 , 董宁涛 , 陈青林 | SHANDONG GOLD MINING LINGLONG |
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| CN208927954 | 充填料浆远距离输送二次搅拌装置 | 本实用新型涉及一种充填料浆远距离输送二次搅拌装置，包括搅拌容器以及安装在搅拌容器上与搅拌容器相通的进料管和出料管，搅拌容器的中部为圆筒形的筒体，进料管和出料管分别沿筒体切向设置，进料管的上端用于与钻孔管路连接，下端与搅拌容器一端连接，出料管的内端与搅拌容器另一端连接，外端用于与平巷管路连接，且进料管与出料管之间的夹角为90°。本实用新型利用充填料浆自流输送时产生的动能以及钻孔高差产生的压力势能、重力势能转换成动能，改变了料浆的流动方向，使料浆在搅拌容器内形成旋转、翻滚状态，达到二次搅拌效果，有效地控制了充填料浆在管路输送过程中离析的现象，无需其它动力来源，降低了生产成本，提高了作业效率。 | | Patent | 张静雨 , 张斌 , 刘家瑞 , 胡能斌 , 马思达 , 李晓波 , 钟力 | SHANGHAI DIANJI UNIVERSITY |
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| CN207757110 | 一种管件相贯线切割机器人 | 本实用新型公开了一种管件相贯线切割机器人，包括底座、第一箱体、控制面板、第二箱体、移动箱体、管套、运动单元、切割单元和管件，其中，控制面板设于第一箱体和第二箱体的连接处上端，第一箱体的侧端设有两个与燃料箱相连的连接管口，底座上设有两个支撑架，管套固定于两个支撑架的中间通孔内，管套的右端设有轴承内圈和轴承外圈，轴承内圈表面设有外齿轮，轴承外圈表面设有内齿轮，移动箱体通过左右两侧的两对小齿轮与外齿轮和内齿轮相啮合，支撑架一侧设有管驱动电机，两对小齿轮与管驱动电机相连，管驱动电机控制移动箱体围绕管套转动，管件固定于轴承内圈上，运动单元通过控制面板与切割单元相连。 | | Patent | 刘家瑞 , 张正国 | BEIFANG UNIVERSITY OF NATIONALITIES |
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| CN214842589 | 一种节水型冷却塔 | 本实用新型公开了一种节水型冷却塔。本实用新型包括冷却塔本体以及设置在冷却塔本体下方的水箱，所述冷却塔本体上设有进风口以及出风口，所述进风口上固定连接有进风网，所述出风口上设有特化翅片，所述冷却塔本体一侧固定连接有小容量储水盒，所述小容量储水盒上设有控制器，所述小容量储水盒上设有用于清洗进风网的喷淋装置，所述小容量储水盒上固定连接有和水箱配合使用的装置补水管道，在冷却塔使用的过程中，出风口处的特化翅片使得冷却塔有一定的回收水的能力，回收的水通过位于塔外部的装置进水管道储存在塔外部的小容量储水盒中，防止冷却塔本体内的水汽通过出风口排出，降低了塔内水的损失，从而降低了冷却成本。 | | Patent | 薛金龙 , 高政 , 刘家瑞 , 薛茸缤 | YUXI KAIYUAN JINLAN BIOTECHNOLOGY |
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| CN107182677 | 一种迷迭香套种作物治理石漠化的方法 | 本发明公开了一种迷迭香套种作物治理石漠化的方法，石漠化是困扰着世界各国的一个难题。本发明将适合石漠化山地种植的迷迭香种子经温室育苗：保持苗棚相对湿度75‑85%，温度15℃～25℃，株行间为5×5厘米。露地育苗，繁殖：将底部四节叶片剪去，剪口要平滑，上下均剪成45º斜面，剪好的枝条用15%高锰酸钾浸泡2min，再用含0.1mg/L生长素+20g/L遮糖液浸泡16天后即可获得生根扦插穗条。之后移栽到石漠化的地区，通过将油橄榄和薰衣草与其套种，并对整个过程进行管理，对石漠化地区的治理取得生态效益、经济效益，和社会效益。 | | Patent | 潘艳花 , 齐天荣 , 刘家瑞 , 陈明德 | PAN YANHUA |
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| CN108017451 | 一种马铃薯药肥及其制备方法 | 一种马铃薯药肥及其制备方法，本发明涉及农业技术领域；它由如下重量份成分组成：营养剂72.63～80.70份，羊粪7.92～8.8份，胡麻籽饼5.31～5.9份，聚丙烯酸钠3.15～3.5份，杜邦克露0.9～1份，安泰生杀菌剂0.09～0.10份。能够解决马铃薯种植面积大，连作年限长，土传病害发生严重和马铃薯种植田有机质含量低、保水能力差的问题，实用性更强。 | | Patent | 赵金玲 , 刘家瑞 | ZHAO JINLING |
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| CN2370417 | 双晶片水膜直探头 | 本实用新型公开了一种钢板超声波探伤双晶片水膜直探头,适用于6—60mm中厚板的探伤手检或自动检,由探头芯,耐磨盘螺纹连接构成,以调整水膜厚度,探头芯的延迟块,隔声层,压电晶片和吸收块,按优选参数调整定位封闭,隔声层镶有铜箔,使探头性能稳定,降低介面回波,提高分辨率,既满足技术标准规定要求,又达到指标优质状态工作,保证了探伤效率和正检率。本实用新型产品易加工组装,并达到要求指标,适于批量生产。 | | Patent | 薛璐 , 庞晓辰 , 赖杰甲 , 刘江霞 , 杨眉 , 李源 , 王法 , 刘家瑞 , 刘雅敏 | TIANJIN UNIVERSITY OF COMMERCE |
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| CN102524661 | 一种含有美国大杏仁的营养茶汤及其制备方法 | 本发明公开了一种含有美国大杏仁的营养茶汤及其制备方法，旨在继承传统茶汤制作工艺、风味的基础上，不会破坏美国大杏仁中所富含的蛋白质、维生素E、膳食纤维素和钙、磷等成分，使传统茶汤的口味、营养更佳，便于在家需要时自己冲制。按重量百分比由下述组分组成：糜子粉40-50％，美国大杏仁粉10-12％，美国大杏仁碎3-6％，花生仁碎6-9％，葡萄干1-4％，红糖8-10％，白糖7-10％，桂花酱7-9％，麦芽糊精0.01-0.05％。本发明的茶汤中含有美国大杏仁，通过对美国大杏仁的合理配比和加工制作过程，最大程度的保留了美国大杏仁的风味与品质，使传统茶汤的口味、营养更佳。包装成可随身携带的独立包装，食用方便。 | | Patent | 付德君 , 黎明 , 刘家瑞 , 刘传胜 | WUHAN UNIVERSITY |
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| CN201075369 | 一种用于高灵敏氦质谱检漏仪的聚焦离子源 | 本实用新型涉及一种用于高灵敏氦质谱检漏仪的聚焦离子源，由检漏口①、发射针腔②、钨针③、纳米针尖④、引出极⑤、聚焦极⑥和电路系统⑦组成，其特征在于钨针的尖端直径只有5～10μm，在钨针尖上还有纳米针尖，钨针置于发射针腔中，纳米针尖加正偏压、引出极加负电压，形成强电场，气体在检漏口进入发射针腔后向纳米针尖流动，在纳米针尖周围离化成离子，经引出极及电场引出到聚焦极，形成较强的聚集离子束流。本实用新型聚焦离子源具有聚焦好，灵敏度高，常温低温发射等优点，适用作各种高灵敏氦质谱检漏仪的离子源。 | | Patent | 邓贤挺 , 张善壮 , 刘家瑞 , 鲁凯强 | THE SECOND CONSTRUCTION OF CHINA CONSTRUCTION EIGHTH ENGINEERING DIVISION |
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| CN209764076 | 一种地砖平整度及空鼓检测工具 | 本实用新型公开了一种地砖平整度及空鼓检测工具，属于建筑施工技术领域，包括检测支架本体、空鼓锤、找平板和水平测量仪，检测支架本体包括操作杆、水平支撑杆和对称设置在水平支撑杆两端的竖直支撑杆，竖直支撑杆的上部与水支撑杆固定，下端固定找平板，找平板的底面为水平面；操作杆竖直设置，其下部与水平支撑杆的中心固定，其顶部固定有压缩弹力装置；空鼓锤的底面与找平板的底面平齐，空鼓锤的上方连接有竖直设置的小锤连接杆，所述小锤连接杆穿过水平支撑杆的中心并在操作杆的顶部连接所述压缩弹力装置；水平测量仪水平固定于检测支架本体。本实用新型一次操作即实现对地砖的平整度和空鼓两项标准进行检测，操作简单，可有效提高检测效率。 | | Patent | 王剑 , 吴兆亮 , 刘家瑞 , 吴奇飞 , 卓静 | SDAAC AUTOMOTIVE AIR CONDITIONING SYSTEMS SHANGHAI |
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| CN217585407 | 用于性能测试的散热器 | 本实用新型提供了一种用于性能测试的散热器,包括芯体、水室以及隔板；芯体的两侧对称设置有两个水室，任一水室均与芯体紧固连接；水室靠近芯体的一侧形成有开口，水室内部形成有空腔，水室的内侧壁形成有多个插槽；隔板与插槽插接配合，且隔板两侧的空腔不连通；水室内设置有两个隔板，两个隔板之间的距离与芯体的高度一致；水室与芯体之间设置有密封垫；密封垫包括多个密封条，密封条与插槽一一对应，相邻两个密封条之间形成有通孔；隔板与密封条抵紧配合。本实用新型通过插槽与隔板的配合，有助于不同高度的散热器进行试验，通过水室结构和水室芯体间的密封结构的相互配合，有助于散热器样件的重复利用，从而有助于降低项目开发成本。 | | Patent | 刘家瑞 , 甘家平 , 王磊 , 于睿 | SDAAC AUTOMOTIVE AIR CONDITIONING SYSTEMS SHANGHAI |
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| CN217585463 | 微通道换热器用集液结构及微通道换热器 | 本实用新型提供了一种微通道换热器用集液结构及微通道换热器,包括自下而上依次设置的集液管、附加腔体以及进出口管；集液管包括集液管内侧开孔和集液管外侧开孔；集液管内部设置有冷却液通道，冷却液通道通过集液管内侧开孔与附加腔体连通；附加腔体包括附加腔体下部和附加腔体上部，附加腔体下部完全包裹集液管内侧开孔；附加腔体上部上设置有腔体上部圆孔，腔体上部圆孔自附加腔体上部向上延伸出腔体上部边沿；进出口管套设在腔体上部边沿上，进出口管通过腔体上部圆孔与附加腔体连通。本实用新型有助于增大冷却液在分流和汇流过程中的流动空间，有助于改善冷却液的流量分配问题，有助于降低分、汇流时产生的水阻，从而有助于提升换热性能。 | | Patent | 刘家瑞 , 赵琰巍 , 王磊 , 于睿 | SDAAC AUTOMOTIVE AIR CONDITIONING SYSTEMS SHANGHAI |
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| CN217589125 | 电池水冷板及电动汽车 | 本实用新型提供了一种电池水冷板及电动汽车，所述电池水冷板包括上板片1、下板片2、进口水管3以及出口水管4，电池水冷板与电池电芯7贴合；上板片1的一面贴合电池电芯7形成换热面，上板片1的另一面连接下板片2；下板片2包括一体成型的下板片本体与边沿结构，下板片本体朝远离上板片1的方向凹陷，下板片本体上设置有多个凸包5与导流凸台6，边沿结构、凸包5的上表面与导流凸台6的上表面与上板片1贴合作为流通管道，流通管道均布在电池电芯7下方；进口水管3与出口水管4连接换热面且连通腔体。本实用新型与S形流道相比，水冷板表面温度分布均匀，有效散掉动力电池表面积聚的热量，保证动力电池在合理的工作温度下正常运行。 | | Patent | 于吉乐 , 刘家瑞 , 克里斯·卡宏 , 甘家平 , 于睿 , 潘朝华 , 叶强 | SDAAC AUTOMOTIVE AIR CONDITIONING SYSTEMS SHANGHAI |
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| CN115247976 | 含内翅片的换热结构及其钎焊喷涂方法 | 本发明涉及汽车换热器领域，提供了一种含内翅片的换热结构及其钎焊喷涂方法，换热结构包括扁管和翅片：扁管具有底板、一端分别与底板的两端相连的第一弧形部、第二弧形部、一端分别与第一弧形部、第二弧形部另一端相连的第一顶板、第二顶板、与第一顶板、第二顶板的另一端分别相连的第一竖直壁面、第二竖直壁面及由此构造出的第一腔体、第二腔体，第一竖直壁面、第二竖直壁面的底端均与底板内侧面抵接；翅片中部在两个竖直壁面与底板之间；翅片两端均为弯曲结构且分别延伸到第一腔体、第二腔体的内部进而呈现出第一腔体、第二腔体均被分割为多个流道。本发明加工方式简单，成本低，内部流动阻力小，实际产品耐久试验风险低。 | | Patent | 杨少宾 , 蒋维 , 邹伟华 , 杨庭栋 , 伊颖 , 曹志全 , 刘家瑞 , 张晓波 , 李宁 , 白陆 , 李波 , 陈炜 , 于晓清 , 高海鹏 , 庞小龙 , 海发林 , 罗宏洋 , 张悦 , 康瑞 | NINGXIA ULTRAHIGH PRESSURE ELECTRIC POWER ENG |
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| CN218098758 | 一种基于无人机绝缘子憎水检测辅助装置 | 本实用新型公开了一种基于无人机绝缘子憎水检测辅助装置，主体包括辅助固定方管，辅助固定方管顶端设有限制槽，限制槽内侧底端设有磁吸底板，磁吸底板顶端接触式连接有磁力球头，磁力球头顶端设有微型摄像头，辅助固定方管底端设有导向滑轨，导向滑轨底端通过滑动连接有激光瞄准器，辅助固定方管两侧设有锁紧夹板，辅助固定方管一端设有延伸夹板，延伸夹板内侧设有防滑橡胶垫，本装置主要通过无人机进行搭载使用，配合喷洒设备对输电设备的绝缘子进行憎水性检测，通过激光瞄准定位工作区域，辅助以影像数据采集并进行实时回传，有利于工作人员准确判断憎水性等级，最大限度的减少喷洒误差。 | | Patent | 俞俊 , 程小明 , 陈颖 , 刘小龙 , 刘家瑞 , 叶永林 , 杨吉 , 范亚丽 , 王西召 , 屈毫拓 | CHINA SHIP SCIENTIFIC RESEARCH CENTER |
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| CN116374083 | 一种渔业养殖平台的坐底抗台锚泊方法 | 本发明涉及一种渔业养殖平台的坐底抗台锚泊方法，养殖平台竖向布设的立柱顶部安装有主潜水绞车，立柱下部配设有导缆孔，系泊缆底端固定于海底的锚固基础上，系泊缆顶端向上穿过导缆孔后由主潜水绞车牵引；导缆孔固定于锥塞上，锥塞侧向插装至立柱下部；还包括辅潜水绞车，锥塞经由钢缆由辅潜水绞车牵引；在养殖平台主体结构调整压载水进行浮潜状态切换后，通过辅潜水绞车调整系泊缆的长度，并结合潜水绞车收紧，从而改变系泊点受力作用点和方向，增加系泊缆垂直向下的约束力分量，提升坐底正压力，以适应坐底避台状态下的抗滑移与抗倾覆，为渔业养殖平台的常态化生存与在位运行提供了一种全新的系泊定位方法。 | | Patent | 王祥 , 李红刚 , 张军 , 张立义 , 王炜 , 贺振宇 , 刘家瑞 , 任杰 | AECC AVIATION POWER |
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| CN116422996 | 一种自动涂注膏状钎料的方法 | 本发明属于焊接领域，公开了一种自动涂注膏状钎料的方法，包括：根据预设的各涂注工艺参数，通过钎料自动涂注机分别进行各试验零件的膏状钎料的自动涂注，得到若干涂注完成的试验零件；将各涂注完成的试验零件进行真空钎焊，得到若干钎焊完成的试验零件，以及将各钎焊完成的试验零件进行钎焊质量检验，得到钎焊质量检验结果最优的试验零件作为目标零件；获取目标零件的粉末状钎料用量，并根据目标零件的粉末状钎料用量设计零件的膏状钎料涂注方案，以及根据零件的膏状钎料涂注方案，通过钎料自动涂注机进行零件的膏状钎料的自动涂注。实现了膏状钎料涂注的自动化、精细化及标准化，提高了生产效率。 | | Patent | 王志华 , 刘家瑞 , 付呈才 | UNITED AUTOMOTIVE ELECTRONIC SYSTEMS |
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| CN116516116 | 一种高压喷油嘴针阀杆热处理方法 | 一种高压喷油嘴针阀杆热处理方法，采用具有连续加热功能的热处理炉，炉内具有正压的含氮气氛，将针阀杆坯件进行径向约束后横向送入热处理炉，在热处理炉的保温段内以1080±5℃下进行4min‑8min的奥氏体化加热，在保温段与冷却段交界位置利用含氮气流对针阀杆坯件进行喷射降温同时分隔保温区与冷却区的气流，使针阀杆坯件在冷却段以140‑150℃/min的速率淬火。该方法通过对热处理参数进行有效控制，能够以低成本方式对细长针阀杆实现渗氮与淬火处理，提高针阀杆成品的硬度、疲劳寿命与耐磨性能，同时有效降低热处理造成的变形量。 | | Patent | 王祥 , 王炜 , 王晓浩 , 张军 , 贺振宇 , 刘怡磐 , 雷发杰 , 刘家瑞 | AECC AVIATION POWER |
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| CN117260052 | 一种真空钎焊中心喷嘴组件的方法 | 本发明公开了一种真空钎焊中心喷嘴组件的方法，属于焊接技术领域，本发明在整体工艺路线设计上，先实现前后两段燃油导管的氩弧焊连接，然后将上述燃油导管组件的前段采用氩弧焊工艺焊接到分流器上，再然后将前段空气导管采用氩弧焊工艺焊接到分流器上。接着，采用一次进炉真空钎焊，同时焊接前后两段空气导管以及后段空气导管与后段燃油导管，从而最大程度上避免零件结构干涉，减少进炉钎焊次数，降低不稳定因素的影响。本发明所提供的成套工艺解决了真空钎焊某型带有Z字形焊缝的中心喷嘴组件时，需要兼顾焊接质量与位置度要求的技术难题，保障了某型燃气轮机的顺利交付，丰富了相关技术储备，对同类零件的加工制造具有重要的工程参考价值。 | | Patent | 刘家瑞 | LIU JIA RUI |
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| CN220309187 | 一种多角度应力钢板 | 本实用新型公开了一种多角度应力钢板，本实用新型，包括固定连接在骨关节一侧的钢板主体，所述钢板主体的一侧设有调节机构，所述调节机构包括钢板主体一端的两侧均开设有滑槽，两个所述滑槽的内壁限位滑动连接有根据病人骨关节活动进行水平移动调节的滑块，两个所述滑块的相对面均转动连接有进行角度调节的转动杆，两个所述转动杆远离滑块一端的相对面通过销轴转动连接有连接杆，所述连接杆顶部的中心位置固定连接有连接座，所述钢板主体与骨关节另一侧对称位置设有辅助机构，所述辅助机构包括骨关节远离钢板主体一端对称位置设有相同的转动杆、连接杆、连接座，所述转动杆远离连接杆一端的相背面通过销轴转动连接有固定座。 | | Patent | 陈文龙 , 吴益国 , 秦永刚 , 刘家瑞 , 金远志 , 周和平 | ZHEJIANG KANGBAHE TECH |
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| CN117686322 | 一种用于平底锅表面涂层的划痕测试装置 | 本发明涉及划痕测试技术领域，具体的说是一种用于平底锅表面涂层的划痕测试装置，包括底板，所述底板上安装有划痕机构，所述划痕机构上安装有吸尘机构，所述底板上安装有支撑机构，所述支撑机构上安装有多个夹持机构，所述夹持机构上安装有限位机构，所述支撑机构上安装有控制机构，所述支撑机构上安装有监测机构；通过支撑机构和夹持机构的安装，有利于对不同大小的平底锅进行放置稳定，并对多个放置的平底锅转动方位，进行划痕测试工作，同时通过支撑机构驱动控制机构和限位机构，利于平底锅测试时支撑稳定，通过划痕机构转动，利于对平底锅内壁进行划痕测试工作。 | | Patent | 刘家瑞 , 杨展昊 , 孙菽蓬 | LIU JIA RUI |
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| CN220696659 | 一种流化床主机装置 | 本实用新型公开了一种流化床主机装置，包括：流化床主机滤袋、设置在流化床主机各仓室的上法兰和下法兰之间的充气密封及一设置在流化床物料仓的搅拌装置，流化床主机滤袋装置为多层复合结构，从里至外依次包括：基层、金属丝网和过滤层，基层包括基层复丝经线和基层复丝纬线；充气密封设置一与压缩空气源相连的充气密封进气口。本实用新型解决了当前流化床主机滤袋易积料，易板结、透气量降低，且采用密封圈形式的法兰连接导致安装要求精度高，容易出现从法兰密封位置溢料，以及为了降低塌锅机率，通过降低喷枪喷液速度，加大风量，延长制备时间方式，导致加速过滤袋的堵塞和粘附，增加了能源消耗、降低效率的问题。 | | Patent | 赵婷 , 陈子豪 , 句红萍 , 刘家瑞 , 李庆梅 | FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIVERSITY |
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| CN220802875 | 一种肿瘤科用药物混合装置 | 本实用新型涉及药物混合技术领域，具体为一种肿瘤科用药物混合装置，包括底座和放置筐，所述底座的顶端安装有支撑架，所述支撑架的一侧安装有电机，所述支撑架的一侧安装有转盘，所述转盘的一侧远离圆心处安装有安装柱，所述安装柱的外侧活动套设有连接杆，所述放置筐的一侧安装有支撑杆，所述连接杆的底端活动套设在支撑杆外侧，所述支撑杆的一端滑动套设在支撑滑杆外侧。本实用新型通过放置筐的上下往复运动可以带动药剂瓶同步运动，从而模拟出医护人员摇晃手臂对药物进行混合的操作，使用装置对药物进行混合的过程可以解放医护人员的双手，从而使医护人员可以腾出手去配制其他需要混合的药物，提高了药物混合配制的效率。 | | Patent | 陈子豪 , 赵婷 , 句红萍 , 刘家瑞 , 李庆梅 | FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIVERSITY |
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| CN220846103 | 一种肿瘤科用的肿瘤细胞团的分选过滤装置 | 本实用新型公开了一种肿瘤科用的肿瘤细胞团的分选过滤装置，涉及分选过滤装置技术领域，包括安装板、装置本体与伸缩弹簧，且安装板的一侧分别安装有第一滤网和第二滤网，所述安装板一侧外壁的上方均安装有气动伸缩杆，且气动伸缩杆的一侧均连接有移动板，所述移动板的顶端均安装有清洁刷，所述移动板的底端均连接有刮板。本实用新型利用驱动电机工作使转盘转动，转盘带动活动杆的一端画圆运动，然后活动杆带动敲击杆左右循环移动，通过皮带带动上下两个转盘同时转动，从而使上下两个敲击杆同时左右循环移动，通过敲击杆向右移动对安装板敲击，从而使第一滤网和第二滤网震动，加快过滤效率，解决了工作效率低的问题。 | | Patent | 白庚德 , 李想 , 乔羽习 , 刘家瑞 , 丁茂林 | SHANXI AGRICULTURAL UNIVERSITY |
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| CN220897120 | 一种农业机械的防陷移动机构 | 本实用新型涉及一种农业机械的防陷移动机构，包括横板，所述横板的两侧均转动安装有四个滚轮，横板上还对称地开设有两个横槽，且两个横槽上滑动安装有滑块，滑块的顶部固定安装有电动伸缩杆，电动伸缩杆的输出端贯穿滑块并固定安装有推板，推板位于横板的下方，横槽设置为正四棱柱，推板的竖向截面设置为“工”字形结构，横板的顶部还对称地固定安装有两个竖板，竖板上设置有三个圆孔，可在失陷时进行支撑，方便将整体抬起，可防止农业机械整体陷落；本方案中整体通过地质松软的位置时，将滑块滑至陷落的滚轮处，可启动电动伸缩杆带动推板下行，可将下陷处撑起，可防止较重的农业机械直接陷落难以抬起 | | Patent | 谭国金 , 刘家瑞 , 王文盛 , 张寒 , 赵永超 , 魏智强 , 王福恩 , 王拥军 , 李汉军 , 赵京 | JILIN UNIVERSITY |
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| CN118392653 | 一种水泥基建筑材料单轴拉伸试验测试系统 | 本发明涉及一种水泥基建筑材料单轴拉伸试验测试系统，属于建筑材料单轴拉伸试验测试技术领域。本发明的水泥基建筑材料单轴拉伸试验测试系统，包括：试件形状优化模块、用于夹持试件的配套夹具优化模块、和用于对试件进行拉伸试验测试的非接触式测试模块。本发明通过优化试件尺寸及形状，解决拉力作用线与试件轴线的对中问题，并提出配套的配套夹具优化模块，避免试件在与夹具接触处因局部应力过大而发生提前断裂，可以确保测试结果精度和可靠性。并采用非接触式测试模块，解决了引伸计、应变仪进行常规的局部应变测量难以完全捕捉临界状态后区域的应变，尤其是在裂纹逐渐扩展时的技术问题，避免了应变计、引伸计等受扰动而带来的误差。 | | Patent | 王瑞 , 林杭毅 , 王佳雷 , 刘家瑞 | NINGBO UNIVERSITY OF TECHNOLOGY |
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| CN118684481 | 一种基于微波和激光双重固结作用的尾矿砂基地聚物陶瓷烧结装置及方法 | 一种基于微波和激光双重固结作用的尾矿砂基地聚物陶瓷烧结装置及方法，该装置包括基座，所述的基座内从上至下依次设置有装料口，粉碎搅拌装置，与粉碎搅拌装置承接的反应装置，与反应装置承接的模具；所述的模具的外部设置有激光源，所述的模具的底部设置有微波装置和激光装置，所述的微波装置和激光装置用于对模具内的物料作用；所述的装料口包括第一装料口和第二装料口，所述的第一装料口与所述的粉碎搅拌装置连通，所述的第二装料口与所述的反应装置相连接；具有将微波和激光技术相互结合，有效降低放射性尾矿处理成本，并且能够获得力学性能优良、化学性质稳定且放射性元素浸出率低的优点。 | | Patent | 王瑞 , 林杭毅 , 李强 , 王佳雷 , 刘家瑞 | NINGBO UNIVERSITY OF TECHNOLOGY |
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| CN118719788 | 一种放射性核素 | 一种放射性核素 | | Patent | 葛业锋 , 贺勇 , 高玉欣 , 刘家瑞 , 石灵芝 | SHANDONG KAIFENGYUAN ENVIRONMENTAL TECH |
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| CN118750894 | 一种用于化工生产的高效节能精馏塔 | 本发明公开了一种用于化工生产的高效节能精馏塔，涉及精馏塔技术领域，包括底座机构，底座机构的顶部靠近一侧边缘处固定安装有储液机构，储液机构的输出端固定连通有蒸馏机构。本发明在使用中，该装置在使用时，通过优化其内部结构，其设计直接影响分离效果和设备效率，采用新型分离式结构，通过增加气液两相不接触和增强质量传递速率，提高分离效果，设置了多组连通管和吸附盘，蒸汽进行承接引导，避免与液体出现混淆，同时，通过引导液体进入到蒸馏罐的内壁底部，使成分相同的液体聚集在一起进行统一处理，减少处理步骤，提高能源利用效率，同时，塔盘上的液体分布更加均匀，有利于减少液滴夹带现象，提高分馏速度。 | | Patent | 陆小革 , 易仕和 , 赵玉新 , 冈敦殿 , 刘家瑞 | NATIONAL UNIVERSITY OF DEFENSE TECHNOLOGY |
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| CN118794863 | 一种气动超材料渗流定量测量装置及评估方法 | 本发明公开了一种气动超材料渗流定量测量装置及评估方法，该装置包括进气组件、出气组件与壳体，壳体内有分隔上游腔室与下游腔室的隔板，隔板上设有贯通孔，气动超材料覆盖在贯通孔上，进气组件与上游腔室连通，出气组件与下游腔室连通，壳体上设有能测得上游腔室、下游腔室内压强的第一压强传感器、第二压强传感器，出气组件上有流量计。本发明应用于渗流能力评估领域，通过测量上游腔室与下游腔室的压强计算压差，与流量计所测流量相结合，评估气动超材料的渗流性能，所需器材较少，组装使用简便，操作简单、快捷，测量精度较高，能够有效地适用于航空航天领域气动材料的渗流定量测量以及渗流性能评估。 | | Patent | 王晨 , 梁忠效 , 贺振宇 , 杨红茹 , 雷发杰 , 杨开龙 , 张珂 , 刘家瑞 | AECC AVIATION POWER |
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| CN118893268 | 一种单晶工作叶片中孔径工艺孔真空钎焊的方法 | 本发明公开了一种单晶工作叶片中孔径工艺孔真空钎焊的方法，包括：获取高温合金粉膏和钴基膏状钎料；采用设定涂注方式，沿中孔径工艺孔的边缘将所述高温合金粉膏环绕涂注在单晶工作叶片上，所述设定涂注方式为：利用配套有外径为1.0mm～1.2mm针头的注射器容纳所述高温合金粉膏，在注射压力为40PSI～60PSI的条件下涂注3s～4s；所述中孔径工艺孔的直径为1.2mm～1.5mm；待所述高温合金粉膏流动填充所述中孔径工艺孔并干燥后，将所述钴基膏状钎料涂覆在所述高温合金粉膏上；在设定焊接工艺下，在真空钎焊炉内对单晶工作叶片中孔径工艺孔进行真空钎焊。本发明的目的在于解决中孔径工艺孔焊接时钎料会出现向内腔流动或掉落至内腔的问题。 | | Patent | 李学晨 , 于诗摩 , 刘家瑞 , 王元卿 , 付梦帆 | QILU UNIVERSITY OF TECHNOLOGY SHANDONG ACADEMY OF SCIENCES |
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| CN119219551 | 一种膜锚定荧光探针及其制备方法与应用 | 本发明涉及荧光探针制备以及应用技术领域，具体涉及一种膜锚定荧光探针及其制备方法与应用。本发明提供的膜锚定荧光探针能够特异性成像活细胞的细胞膜且可以定量检测不同种类细胞膜的pH以及成功区分非酒精性脂肪肝组织和检测不同病变程度的非酒精性脂肪肝组织。膜锚定荧光探针，其结构式为： | | Patent | 刘家瑞 , 赵巍 , 黄晓东 , 张华 , 俞晓明 | UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGY |
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| CN111599857 | 二维材料器件与GaN器件异质集成结构及制备方法 | 本发明提供一种二维材料器件与GaN器件异质集成结构及制备方法，在同一蓝宝石衬底上异质集成二维材料器件与GaN器件，并通过二维材料器件控制GaN器件的开、关，提高整体异质集成结构的性能，发挥GaN器件优势；通过互连电极，实现电连接，降低寄生效应；在二维材料器件中，以二维材料层作为沟道，石墨烯层作为欧姆接触，解决二维材料器件欧姆接触不良的问题；通过T型栅极作为掩膜版并进行自对准工艺，形成第二源极及第二漏极，缩短了T型栅极与源极及漏极的距离，降低了二维材料器件的接入电阻，提高了二维材料器件的性能；本发明可充分发挥GaN器件的优势，并提高整个异质集成结构的性能。 | | Patent | 莫炯炯 , 王志宇 , 陈华 , 刘家瑞 | ZHEJIANG UNIVERSITY |
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| CN111415987 | 结合二次外延及自对准工艺的氮化镓器件结构及制备方法 | 本发明提供一种结合二次外延及自对准工艺的氮化镓器件结构及制备方法，制备方法包括：提供半导体衬底，形成包括氮化镓层的外延结构，通过掩膜层保护，外延生长源极结构及漏极结构，形成栅极侧墙，形成栅极结构。本发明通过二次外延生长形成源极结构及漏极结构，可以有效降低欧姆接触电阻，在二次外延之前，通过多步离子刻蚀、氧化及酸溶剂数字刻蚀，平衡了刻蚀速率与刻蚀带来的材料损伤，在保证材料质量的同时，考虑了工艺成本。利用自对准技术，避免光刻过程中对准工艺带来的误差，精确定义了栅极尺寸。利用隔离侧墙厚度控制栅极尺寸，省去栅脚光刻步骤，简化工艺制程。本发明可在大尺寸晶圆上实现GaN材料的异质外延，节省了单位尺寸外延成本。 | | Patent | 郁发新 , 莫炯炯 , 刘家瑞 | ZHEJIANG UNIVERSITY |
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| CN111430238 | 提高二维电子气的GaN器件结构的制备方法 | 本发明提供了一种提高二维电子气的GaN器件结构的制备方法，包括如下步骤：提供一衬底，在所述衬底的上方形成沟道层；在所述沟道层的上方形成第一势垒层；将所述沟道层分为第一区域和第二区域，去除所述第一区域上方的所述第一势垒层；在所述第一区域的上方形成第二势垒层。本发明通过去除沟道层上方的第一势垒层并代以第二势垒层，提高了沟道层的二维电子气密度；通过对沟道层进行表面处理并二次外延生长第二势垒层，减少了因刻蚀损伤及异质材料原位生长所产生的界面缺陷，提升了器件性能。 | | Patent | 莫炯炯 , 王志宇 , 陈华 , 刘家瑞 , 郁发新 | ZHEJIANG UNIVERSITY |
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| 2020 |
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| CN111584347 | GaN-Si异质外延结构及制备方法 | 本发明的GaN-Si异质外延结构及制备方法，在Si基底中形成凹槽，并在凹槽底部形成局部SOI衬底，从而通过局部SOI衬底可吸收GaN层外延过程中产生的应力，降低AlxGa1-xN过渡层的厚度，减少生长工艺时间，降低工艺成本，且提高导热性能，同时局部SOI埋氧层，可提高GaN器件的击穿电压，且可减少RF应用时的损耗及串扰；通过覆盖凹槽侧壁的绝缘侧墙，可有效隔离外延生长的GaN层，降低工艺难度；在Si基底的凹槽中，进行区域选择性外延生长GaN层，可降低工艺难度；从而本发明可在大尺寸的Si基底上异质外延均匀的、高质量的GaN层。 | | Patent | ZHENG RUIMAO , LIU JIARUI | PEKING UNIVERSITY |
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| 2023 |
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| WO2024/221690
CN116554294B | TMEM52 PROTEIN FRAGMENT, ENCODING GENE, RECOMBINANT VECTOR, RECOMBINANT MICROORGANISM, AND USE THEREOF | The present invention relates to the technical filed of biomedicine, and relates to a Tmem52 protein fragment, an encoding gene, a recombinant vector, a recombinant microorganism, and a use thereof. The Tmem52 protein fragment can reduce weight, increase basal metabolic rate, prevent and treat obesity, increase insulin sensitivity, improve blood glucose regulation ability, prevent and treat diabetes, reduce serum triglyceride level, and prevent and treat hyperlipidemia, and can also be used for treating obesity and related diseases, such as diabetes and hyperlipidemia. |
| Author-作者 | Title-题名 | Source-文献来源 | Year-年 | Roll-卷 | Period-期 | PageCount-页码 | 摘要 | | 尚艳霞, 王泽松, 张早娣, 张瑞, 李慧, 周霖, 黎明, 刘家瑞, 付德君. | 串列加速器装置的功能扩展 | 武汉大学学报(理学版) | 2014 | 60 | 03 | 264-268 | 通过在2×1.7MV串列加速器前端设计并安装静电扫描装置和靶室,扩展了其0～30keV低能注入和沉积功能.利用低能离子注入的方法分别在Ni/SiO2和铜箔衬底上得到石墨烯薄膜,并运用Raman光谱和扫描电子显微镜研究了样品的形貌、薄膜层数及缺陷等性质.实验结果表明,在铜箔衬底上得到双层石墨烯薄膜.通过调试高能端和200keV注入机联机实验,在双束靶室中得到He,Li,C,N,Fe离子束,用于双束注入和辐照损伤等研究. | | 刘传胜, 黎明, 何俊, 杨铮, 周霖, 王泽松, 郭立平, 蒋昌忠, 杨世柏, 刘家瑞, Lee J C, 付德君, 范湘军. | 加速器联机装置运行状况 | 核技术 | 2010 | 33 | 12 | 891-897 | 2008年武汉大学加速器联机系统初步建成,200 kV离子注入机至透射电镜束线进行了运行调试,开展了气体离子注入单晶Si、GaAs、Ag纳米晶和超临界反应堆材料（C276和6XN）的原位结构研究。结果表明,样品在注入至一定剂量时发生明显多晶和非晶化,单晶Si出现非晶化的临界剂量在1014 cm-2。C276材料经1×1015cm-2的Ar离子辐照后,产生尺寸3-12 nm的位错环,其密度随剂量提高而增大,至5×1015cm-2出现多晶,剂量超过3×1016 cm-2出现非晶化。在加速器-电镜联机光路上安装在线RBS靶室对离子束辐照材料进行元素成分和晶格定位测试。靠近电镜端安装50 kV低能离子源,开展核材料中氦泡形成过程的原位观测。对RBS/C装置进行数字化改造,用Labview控制系统运行,目前可进行计算机控制的背散射沟道测试。 | | 刘家瑞,刘丰收. | 光纤CATV的设计及实施 | 中国有线电视 | 1998 |
| 07 |
| 光纤ＣＡＴＶ的设计及实施□刘家瑞刘丰收（河南省沁阳广播电视局４５４５５０）光纤具有传输损耗小、中继距离远、工作频带宽、抗电磁干扰能力强、传输稳定可靠、使用寿命长等优点。近几年有线广播电视的迅猛发展，由城市已普及到广大农村，解决有线广播电视主干线远距离... | | 李岱青,官宝安,万亚,刘家瑞,徐天冰. | Ne<sup>+</sup>、Ar<sup>+</sup>注入铜靶所产生的溅射原子角分布与离子入射角的关系 | 烟台师范学院学报(自然科学版) | 1992 |
| 04 | 36-39 | 在100keV入射能量下.分别测量了Ne-、Ar+在铜靶上所产生的溅射原子角分布与离子入射角度的关系 实验结果表明在40°和70°斜入射条件下,Ar+所产生的溅射原子角分布的溅射优先方向分别位于表面法线的两侧,溅射原子角分布关于表面法线明显不对称;而Ne+所对应的溅射优先方向都位于表面法线方向,且溅射原子角分布关于表面法线是对称的、用TRIM程序计算了Ne+和Ar+在铜靶中的能损和投影射程,并依据所计算的结果用级联碰撞理论分析了实验结果,比较了Ne+和Ar+各自溅射机制上的不同. | | 杨锋,雷子明,卢小林,刘参文,潘广炎,汪端伟,刘家瑞,孙湘. | Ne<sup>+</sup>离子与He、Ar原子碰撞中真空紫外辐射 | 原子与分子物理学报 | 1992 |
| 02 | 2232-2238 | 对Ne+离子与He、Ar原子碰撞过程中所产生的真空紫外辐射进行了绝对测量,观察到入射离子的电离激发过程和靶原子的电离激发过程,并以Fano和Lichten的电子提升分子轨道模型和非绝热分子轨道相关图对此进行了定性解释。 | | 潘广炎,雷子明,杨锋,卢小林,刘参文,刘家瑞,孙湘. | Ar<sup>+</sup>离子与原子碰撞中真空紫外辐射 | 物理学报 | 1991 |
| 06 | 891-896 | 对Ar+离子与He,Ne,Xe原子碰撞中的真空紫外辐射进行绝对测量,观察到入射离子的电离激发过程和靶原子电离激发过程,并以Fano和Lichten的电子提升分子轨道模型和非绝热分子轨道相关图对此进行定性解释。 | | 刘淑荣,江伟林,刘家瑞,林荫浓. | 用飞行时间法研究Si溅射离子簇质谱的结构效应 | 物理学报 | 1991 |
| 05 | 703-708 | 通过对200kV离子注入机的改造,设计出一台飞行时间(TOF)谱仪,在提高脉冲束时间分辨方面,做了很大努力。测量了单晶、多晶及非晶硅的正、负离子簇飞行谱(质量谱)。比较这三种不同结构Si样品的谱数据,发现溅射离子簇质谱分布与靶物质结构密切相关,这为理论上研究Si离子簇的溅射形成机制提供了实验依据。 | | 李岱青,刘家瑞,徐田冰,张德龙. | 金属铜在100keVAr<sup>+</sup>轰击下的溅射特性 | 烟台师范学院学报(自然科学版) | 1991 |
| 01 | 31-33 | 金属铜在100keVAr+的垂直入射和40°以及70°入射角的倾斜入射下,溅射原子角分布有较大的变化。垂直入射时溅射原子角分布关于金属表面法线是对称的;40°和70°角倾斜入射时溅射原子角分布的对称线关于表面法线分别偏离了7°和-12°产生这一现象的微观机制在于倾斜入射时入射离子所产生的反冲原子级联是非线性的。 | | 李玉璞, 王佩璇, 马如璋, 张国光, 冯永荣, 刘家瑞, 朱沛然, 邱长青, 徐田冰. | A STUDY OF THE HELIUM IMPLANTED INTO HR-1 STAINLESS STEEL BY PROTON ELASTIC SCATTERING | Nuclear Science and Techniques | 1991 |
| 01 | 25-28 | Small discs of type HR- 1 austenitic steel (OCr17Ni14MnMo) have been irradiated with 30-170 keV He+ for doses 1015- 1×1018/cm2 at 300K. 2.5 MeV enhanced proton backscattering, TEM, SEM and CEMS are used to investigate the He trapping, bubble structures and the phase stability. It is found that a maximum He concentration of -28 at. % was obtained after implantation with 70 keV He+ at a dose just below critical. The micro- Vickers hardnesses of irradiated layers decrease with increasing dose, particularly when dense bubbles formed. The isomer shift of CEMS increases in the negative direction after irradiation. The austenite is believed to be stable against radiation induced martensitic transformation. | | 潘广炎,于德洪,雷子明,杨锋,刘家瑞,孙湘. | 单电荷离子He<sup>+</sup>与靶原子Na碰撞中电子俘获激发过程 | 科学通报 | 1991 |
| 02 | 105-108 | 一、引言 最近,Aumayr等人在2-20keV能量范围内研究了He+与Na碰撞过程,给出了单电子俘获截面和NaID1,2的发射截面。Nagata等人和DuBois也分别在实验上对单电子俘获过程进行了研究。Mo’和Riera以及Shingal等人在理论上研究了He+-Na,He2+-Na碰撞激发过程。 | | 雷子明,杨锋,卢小林,刘参文,潘广炎,刘家瑞,孙湘. | Ar<sup>+</sup>离子与He、Ne、Xe原子碰撞中真空紫外辐射 | 原子与分子物理学报 | 1990 |
| S1 | 208-209 | 最近,我们利用法国进口的LHT—30真空紫外光谱仪,对Ar+离子与He、Ne、Xe原子碰撞中的真空紫外辐射进行了绝对测量。入射离子能量范围为20—130KeV,真空紫外波长范围为20—100nm。从测得的大量真空紫外光谱表明,存在着以下两个碰撞激发过程: | | 杨锋,雷子明,卢小林,刘参文,潘广炎,刘家瑞,孙湘. | He<sup>+</sup>离子与Ne、Ar原子碰撞中靶原子的电离激发过程 | 原子与分子物理学报 | 1990 |
| S1 | 210-211 | 实验装置由三部分组成:第一部分是J59—200加速器,离子源是冷阴极的潘宁源。能量范围20-200KeV,束流强度1—200微安,电荷态是通过一个磁分析器选择的;第二部分是气体靶室,真空是由分子泵和机械泵获得的,真空度可达2×10-6乇,充入靶气体后在碰撞室中的真空度为10-3—10-4乇,对于不同同的靶气体的真 | | 潘广炎,卢小林,雷子明,杨锋,刘参文,刘家瑞,孙湘. | Ne<sup>+</sup>离子与He、Ar原子碰撞中入射离子的电离激发过程 | 原子与分子物理学报 | 1990 |
| S1 | 212-213 | 通过真空紫外光谱的测量,波长范围为20-100nm,我们发现在Ne+离子与He、Ar原子碰撞中,存在着入射离子的电离激发过程。即: 1.Ne++He→Ne2+（n,l）+He+e →Ne2++He+e+hv1,2 2.Ne++Ar→Ne2+（n,l）+Ar+e →Ne2++Ar+e+hv3,4这种过程,我们在可见光范围测量中是未曾观察到的。这里的光子hv1,hv2列表如下: | | 于德洪,潘广炎,雷子明,杨锋,刘家瑞,孙湘. | Ne<sup>+</sup>离子与Li原子碰撞过程中激发态的研究 | 物理学报 | 1990 |
| 08 | 1229-1233 | 本文通过观测Ne+离子与Li原子碰撞中的发射谱,对碰撞中的电子俘获和靶激发过程进行了研究。在可见光范围给出了所观察到的各条谱线的发射截面及相应上能级的激发截面。对电子俘获过程与能量亏损和靶原了电离势的关系进行了讨论。Ne+离子能量范围为20—150keV | | 马忠权,刘家瑞. | IPM势下的轻离子能量歧离值Γ<sub>th</sub>(Z<sub>2v</sub>) | 核技术 | 1990 |
| 07 | 396-403 | 本文用IPM离子-原子作用系统势,直接计算了轻离子（如1H,4He）在部分气体、固体中的能量歧离值Γth（Z2,v）,肯定了Γth（Z2,v）随元素的原子序数Z2和离子能量Ep的变化关系。在入射质子能量Ep=340keV和992keV时,与近期的Y.Kido实验值,Lindhard-Scharff和W.K.Chu的理论值作了对比,发现本文的计算结果与实验值在2.5—4％偏差内相符合,优于其它理论方法。 | | 潘广炎,杨锋,雷子明,刘家瑞,于德洪,孙湘. | H<sup>+</sup>,H<sub>2</sub><sup>+</sup>,H<sub>3</sub><sup>+</sup>与靶原子He,Ne,Ar碰撞中靶激发的实验研究 | 原子与分子物理学报 | 1990 |
| 02 | 1375-1392 | 在H+,H2+,H3+与靶原子He,Ne,Ar碰撞过程中,我们观察到大量靶激发的信息,入射离子实验室能量为50-150keV.实验利用TN-1710光学多道分析系统（OMA）测得HeⅠ,NeⅠ,NeⅡ,ArⅠ,ArⅡ的发射光谱线,本文给出了这些谱线的发射截面.实验结果表明:上述碰撞体系中存在着两种靶激发过程,HeⅠ三重态,NeⅠ,ArⅠ谱线的发射截面在Ha++He,Ne,Ar碰撞体系中最大,在H++He,Ne,Ar碰撞体系中最小. | | 杨锋,雷子明,于德洪,潘广炎,刘家瑞,孙湘. | Ar<sup>+</sup>,Ar<sup>2+</sup>+Li,Na碰撞过程中的靶激发 | 原子与分子物理学报 | 1990 |
| 02 | 1443-1448 | 本文对Ar+,Ar2++Li,Na碰撞过程中的靶激发过程进行了实验研究。通过光学多道分析系统对这些碰撞体系所发光谱进行了绝对测量。在能量范围q×（15—150）keV内给出了相应谱线的发射截面积Li（2p）,Na（3p）激发截面。 | | 李玉璞,王佩璇,刘家瑞,朱沛然. | 用离子束研究金属中氦的行为 | 原子与分子物理学报 | 1990 |
| 02 | 1477-1485 | 本文介绍了应用离子束技术研究氦在金属中的行为,讨论了金属中氦的捕获、扩散、及氦与氢同位素的相互作用等基本特性。 | | 江伟林, 刘家瑞, 刘淑荣, 张德龙. | STRUCTURE EFFECTS OF SILICON AND CARBON BY CLUSTER MASS SPECTRA | Nuclear Science and Techniques | 1990 |
| Z1 | 46-49 | Microclusters from different structures of silicon and carbon are studied by SIMS under UHV conditions in the mass range below M=200. The sputtered mass spectra of ions Sin+, Cn+ and Cn were obtained from the 10 keV O2+ primary beam bombardment. Comparisons of each spectrum in each group have shown the strong structure effects on the cluster patterns. A brief discussion on the results has been given. | | 朱沛然, 刘家瑞, 任孟眉, 封爱国, 李大万. | DEPTH PROFILING OF <sup>1</sup>H AND/OR <sup>4</sup>He IN SOLIDS BY ERD WITH <sup>19</sup>F IONS | Nuclear Science and Techniques | 1990 |
| Z1 | 65-69 | 1H or 4He depth profiling in 1H or 4He implanted silicon samples was performed by elastic recoil detection (ERD) with multicharged 19F ions at a small accelerator. Optimization of the experimental parameters such as incident ions energy and scattering geometry were calculated by computer simulation. Depth resolution of about 20-30nm at depth of 400nm for 1H and at depth of 300nm for 4He can be obtained, respectively. | | 任孟眉, 封爱国, 朱沛然, 刘家瑞, 李大万. | CALCULATION AND OPTIMIZATION OF EXPERIMENTAL PARAMETERS IN ELASTIC RECOIL DETECTION (ERD) | Nuclear Science and Techniques | 1990 |
| Z1 | 93-98 | Elastic recoil detection (ERD) proposed for the analysis of light elements in a heavier matrix is an appropriate method for its specialities. Optimization of experimental parameters in ERD such as scattering geometry and incident beam energy is very important when using a small accelerator with energy lower than 10 MeV. In this paper a computer program ERDAl is developed for the purpose, and is proved to be useful for practical handling of ERD experiments. | | 马忠权,刘家瑞,张树生. | 用共振核反应<sup>27</sup>Al（p,γ）<sup>28</sup>Si和SOS样品研究质子在固体Si中能损的同素异形效应 | 核技术 | 1990 |
| 05 | 264-268 | 本文首次用具有衬底的薄膜Si样品SOS和共振核反应27Al（p,γ）26Si,于能量Ep=774keV和992keV,系统地研究了质子在固体中能损的结构效应问题。实验结果表明,对于MeV级的质子束,在Si元素固体的单晶、多晶、非晶中电子阻止本领有明显的差别,相对偏差至少大于5％,这个实验的测量误差小于3％。 | | 马忠权, 刘家瑞. | 共振核反应<sup>27</sup>Al（p,γ）<sup>28</sup>Si在测量电子阻止本领Sc中的应用（英文） | 新疆大学学报(自然科学版) | 1990 |
| 02 | 44-48 | 本文运用共振核反应27Al（p,γ）28Si 和 SOS 样品,系统地测量了两个诱导能量 Ep=774keV 和992keV 上,质子在固体中电子阻止本领的同素异形效应,并详细讨论了实验技术,实验误差小于3%. | | 刘家瑞,雷子明,杨锋,潘广炎,于德洪,孙湘. | Ar<sup>2+</sup>离子和H<sub>2</sub>,O<sub>2</sub>分子碰撞过程中激发态的研究 | 原子与分子物理学报 | 1990 |
| 01 | 1352-1365 | 在Ar2+离子和H2,O2分子碰撞实验研究中,发现这两个碰撞体系都存在三个激发通道:（1）双电子俘获激发通道,（2）单电子俘获激发通道,（3）靶直接激发通道。实验结果得到了ArⅠ,ArⅡ和HⅠ,OⅠ的发射截面,并分别比较了Ar2++H2,Ar2++O2,He2++H2,He2++O2碰撞体系的发射截面。 | | 刘家瑞,朱沛然,封爱国,李大万. | 用C离子的弹性反冲法测固体中氢分布 | 原子能科学技术 | 1990 |
| 03 | 7-12 | 文章介绍了用1.7MV小串列加速器提供的4—7MeV多电荷C离子,采用弹性反冲法(ERD)分析了α-Si:H中氢元素的深度分布。计算表明,近表面处的深度分辨率为15-30nm,可探测深度100—700nm。探讨了入射能量和散射几何条件的优化问题。比较了几种分析方法的测量结果。 | | 潘广炎,于德洪,杨锋,雷子明,刘家瑞,孙湘. | H<sub>m</sub><sup>+</sup>（m=1,2,3）离子与Li、Na原子碰撞中H<sub>a</sub>线的发射和靶激发 | 科学通报 | 1990 |
| 02 | 98-101 | 一、引言 对H++Li,Na碰撞过程,理论和实验的研究都达到了相当的程度,而对H1+,H3++Li,Na碰撞体系,只有少数的实验研究存在,Lavrov等在2—14keV能量范围内研究了H?rH2+,H3++Na体系,给出了靶原子Na共振线（589.0+589.6nm）的发射截面和偏振,另外,Allen等在1—25keV能量范围内对体系H+,H2+,H3+,H-+Na进行了研究,他们给出 | | 于德洪,刘家瑞,雷子明,杨锋,潘广炎,汪端伟,孙湘. | He<sup>+</sup>和He<sup>2+</sup>离子与碱金属原子Li碰撞中的靶激发 | 物理学报 | 1989 |
| 11 | 1849-1852 | 本文在q×（20—150）keV的能量范围内,通过光学测量,对He+和He-离子与碱余属原子Li碰撞过程中的靶激发过程进行了研究。由光学多道分析系统（OMA）,测得LiI670.8nm（2p→2s）,LiI610.4nm（3d→2p）,LiI460.3nm（4d→2p）和LiI812.6nm（3s→2p）谱线。给出所观察到的谱线的发射截面和相立的Li（2p）激发截面。对He+与Li碰撞过程,LiI670.8nm谱线发射截面与Aumayr等人相应的低能结果能够比较好地衔接。对He2+与Li碰撞过程,LiI670.8nm谱线发射截面与Ermolaev等人的理论结果及Kadota等人的实验结果在实验误差范围内符合得很好。 | | 于德洪,刘家瑞,雷子明,杨锋,潘广炎,汪端伟,孙湘. | He<sup>+</sup>和He<sup>2+</sup>离子与碱金属原子Na碰撞中靶激发过程的实验研究 | 物理学报 | 1989 |
| 11 | 1853-1857 | 本文通过光学方法,在q×（20—140）keV能量范围内,研究了He+和He2+离子与碱金属原子Na碰撞中的靶激发过程。通过光学多道分析系统（OMA）,对He+与Na碰撞过程,观察到NaI589.0+589.6nm（3p→3s）,NaI818.3nm（3d→3p）和NaI568.8nm（4d→3p）等谱线。对He2+与Na碰撞过程,只观察到 NaI589.0+589.6nm谱线。计算了所有观察到的谱线的发射截面和Na（3p）的激发截面。实验结果表明入射离子的库仑势对靶激发过程的作用非常明显。对He2+与Na碰撞过程,NaI D172谱线的发射截面与仅有的Na（3p）激发截面的理论值在误差范围内符合得很好。 | | 李玉璞,王佩璇,刘家瑞,朱沛然,杨锋,张国光,马如璋. | 用质子弹性散射法研究不锈钢中注入的氦 | 核技术 | 1989 |
| 11 | 653-656 | 用质子弹性散射法研究了316L不锈钢中注入的氦。在77—673K温区,30—170keV能区完成了不同剂量(1016—3×1017/cm2)的He注入。当靶温≤RT时,He能被不锈钢有效地捕获且最大浓度随剂量的增加而线性增加。在给定的剂量下,当靶温较高时,被捕获的He的数量Q随温度增加而减少,这意味着在较高的温度下注He,同时有He的再发射发生。比较不同靶温下注He得到的He分布可以看出:注入时He的捕获和迁移强烈依赖于靶温。 | | 刘家瑞,张建华,李毅. | 晶格原子间非简谐相互作用对离子注入的影响 | 物理学报 | 1989 |
| 09 | 1400-1405 | 本文用经典力学中推广的朗之万方程研究了离子注入中入射离子与固体的相互作用。在计入晶格原子间的非简谐力相互作用的情况下,得到了入射离子与靶原子之间的能量交换,靶原子对入射离子的核阻止本领和入射离子在靶中的投影射程分布,同时还讨论了入射离子激发的固体声子谱对核阻止的影响。将以上所得结果在低能范围与TRIM88的计算结果进行了比较,二者符合较好。 | | 雷子明,杨锋,于德洪,刘家瑞,潘广炎,孙湘. | Ar<sup>2+</sup>与Li,Na原子碰撞中单电子俘获过程的实验研究 | 物理学报 | 1989 |
| 09 | 1515-1520 | 对Ar2+与Li,Na碰撞过程中由于单电子俘获而产生的Arll谱线进行了绝对测量,给出各谱线的发射截面数据。入射离子能量为40—300keV。从发射截面对势能亏损的依赖关系,发现对应中等△E（>0）值的过程具有较大的截面。并且还发现与观察到的光谱线相应的激发态属于一个电子组态中高J量子数的态。 | | 李玉璞,王佩璇,马如璋,张国光,刘家瑞,朱沛然,邱长青,徐田冰,杨锋. | 离子束技术在金属中氦行为研究中的应用 | 物理 | 1989 |
| 09 | 551-554+571 | 结合我们近期的研究工作，本文介绍和讨论了离子束技术在金属中氦行为研究中的应用，还介绍和讨论了氦在金属中的基本特性，如氦的捕获、迁移和氦泡结构等． | | 潘广炎,雷子明,杨锋,刘家瑞,于德洪,孙湘. | He<sup>2+</sup>离子和H<sub>2</sub>,O<sub>2</sub>分子碰撞过程中电子俘获和靶激发的发射截面 | 物理学报 | 1989 |
| 08 | 1306-1312 | 实验结果表明:在He2+和H2,O2碰撞过程中存在着双电子俘获而产生激发态的过程,同时也存在着单电子俘获而产生激发态的过程。在靶H2,O2直接激发过程中,测量到了巴耳末系Hα,Hβ,Hγ和OI的发射谱。本文给出随入射离子速度变化的Hel,Hell和Hα,Hβ,Hγ,OI谱线的发射截面。 | | 刘家瑞,雷子明,杨锋,潘广炎,于德洪,孙湘. | H<sub>1</sub><sup>+</sup>,H<sub>2</sub><sup>+</sup>,H<sub>3</sub><sup>+</sup>和He,Ne,Ar碰撞过程中的巴耳末系H<sub>α</sub>,H<sub>β</sub>,H<sub>γ</sub>发射 | 物理学报 | 1989 |
| 08 | 1313-1321 | 实验利用TN-1710光学多道分析系统（OMA）,对H1+,H2+,H3+和He,Ne,Ar碰撞过程中产生的巴耳末系Hα,Hβ,Hγ发射进行了测量,入射离子H1+,H2+,H3+的实验室能量范围为50—150keV。本文给出Hα,Hβ,Hγ谱线的发射截面。实验结果表明:在H3+离子和He,Ne,Ar原子碰撞过程中,Hα的发射截面分别比H2+,H1+离子和He,Ne,Ar原子碰撞过程的大,也就是说,电子俘获几率,前者比后者大,而H1+离子和He,Ne,Ar原子碰撞过程的最小。 | | 李玉璞,王佩璇,张国光,马如璋,刘家瑞,朱沛然,邱长青. | He在HR-1型不锈钢中的捕获与释放研究 | 物理学报 | 1989 |
| 07 | 1122-1126+1215 | 对HR-1型奥氏体不锈钢在室温下注入了70keV 5×1016—1018cm2的4He离子,进行了上升至1273K的恒时退火实验。使用2.5MeV的质子弹性散射、TEM和SEM分析法研究了He在其中的捕获、迁移与释放特性。 | | 李玉璞,陈坚,刘家瑞,章其初. | 温度对Ar<sup>+</sup>诱导Au-Si界面原子混合的影响 | 原子与分子物理学报 | 1989 |
| 02 | 1035-1040 | 本文在77至573K温区研究了Ar+诱导的Au-Si界面的原子混合现象。温度对混合结果有强烈的影响。Q（S）i—T曲线的特征与Cr-Si等体系是不同的;得到了具有确定组份比的Au48Si51（≈AuSi）均匀混合层;T>32℃时,深入到Si中的Au原子呈指数衰减的尾巴,为解释此指数尾巴,提出了填隙原子增强扩散机制及方程。 | | 宋增福,张丽珠,雷子明,潘广炎,刘家瑞,刘文天,丁晓春,徐端夫,吴瑾光,徐光宪,蔡继业. | Y-Ba-Ag-O和Y-Ba-Cu-O体系的束流光谱 | 北京大学学报(自然科学版) | 1989 |
| 03 | 257-260 | 首次研究了Y-Ba-Ag-O、Y-Ba-Ag-Cu-O和Y-Ba-Cu-O体系的束流谱,发现它们的发光主要是由体系中的Ag+;（对Y-Ba-Ag-O和Y-Ba-Ag-Cu-O）和Cu+（对Y-Ba-Cu-O）的能级（能带）间的跃迁所辐射的荧光谱。作者对这些谱线作了初步指认。 | | 高文玉,李宏成,王瑞兰,刘家瑞. | Mo/Si体系的离子束混合机制研究 | 物理学报 | 1989 |
| 05 | 728-734 | 本文采用卢瑟福背散射（RBS）分析技术详细测量了Mo/Si体系在Ar+和 Xe7+离子束轰击下界面混合和反应随温度、剂量和剂量率的依赖关系。得到了许多新的结果。结果表明,以前的空位扩散机制、单级联间隙原子扩散机制和热峰模型都不能解释Mo/Si体系的离子束混合。我们结合固体扩散理论提出了间隙原子扩散和反应机制,圆满地解释了实验结果。 | | 杨锋,雷子明,刘家瑞,潘广炎,于德洪,孙湘. | 双电荷离子Ar<sup>2+</sup>与He、Ne原子碰撞中的发射截面 | 原子与分子物理学报 | 1989 |
| 01 | 945-958 | 双电荷离子Ar2+和He、Ne原子碰撞中,存在着三种碰撞激发过程,一是双电子俘获激发过程,二是单电子俘获激发过程,三是直接激发过程。实验用光学多道分析系统（OMA）对这些过程进行了光学测量,得到了ArⅠ、ArⅡ、NeⅠ、NeⅡ、HeⅠ、HeⅡ谱线的发射截面,并对这些发射截面进行了比较,发现在入射离子速度相同的情况下,Ar2++Ne碰撞体系的发射截面要比Ar（2+）+He碰撞体系的大。OMA的光谱波长范围是200—800um。入射离子Ar（2+）的能量范围是140—340keV。 | | 吴春武,殷士端,张敬平,肖光明,刘家瑞,朱沛然. | InGaAs/GaAs应变异质结中的反常离子沟道效应 | 物理学报 | 1989 |
| 01 | 83-90 | 用5.8,3.0和1.2MeV的Li离子对用MBE制备的In0.25Ga0.75As/GaAs（100）异质结在（100）面中沿[100]及[110]轴进行角扫描。5.8MeV时,[110]轴外延层与衬底沟道对准角的差值为0.90°,从而计算出其晶格失配度为1.62％。3.0MeV时,背散射角扫描谱出现了严重的不对称现象。若离子以1.2MeV入射,沟道对准角的差值及衬底沟道的半角宽大大地偏离实际值。本文对以上反常现象从物理机理上进行了分析,给出了这些反常离子沟道效应产生的原因和条件。 | | 于德洪,杨锋,雷子明,潘广炎,刘家瑞. | 电子与原子He,Ar碰撞过程中激发态的实验研究 | 物理学报 | 1988 |
| 12 | 1965-1971 | 我们通过光学方法研究了电子与原子He,Ar碰撞过程中靶的激发过程。利用光学多道分析系统(OMA)对发射光谱进行了测量,给出了绝对发射截面数据。入射电子的实验室能量范围为200—500eV。 | | 宋增福,谢大弢,潘广炎,雷子明,刘家瑞,杨丰,张丽珠,刘文天,丁晓春,徐端夫,吴瑾光,徐光宪. | 高T<sub>c</sub>YBa<sub>2</sub>Cu<sub>3</sub>O<sub>x</sub>中Cu离子价态的H<sub>2</sub><sup>+</sup>束流光谱研究 | 红外研究(A辑) | 1988 |
| Z1 | 339-342 | 对高Tc YBa2Cu3Ox及名义组成为YBa2Ag3Ox和YBa2Cu1.5Ag1.5Ox体系进行了H2+束流光谱的比较研究,证实YBa2Cu3Ox的束流光谱主要是Cu离子的贡献。通过对谱带的指认,讨论了Cu离子可能存在的价态。 | | 雷子明,杨锋,刘家瑞,潘广炎,于德洪,孙湘. | 双电荷离子He<sup>2+</sup>与Ne,Ar原子碰撞中的激发态 | 物理学报 | 1988 |
| 08 | 1244-1253 | 实验用光学多道分析系统（OMA）测量了He2+和Ne,Ar碰撞过程中的发射光谱,结果表明,这些碰撞体系存在着三种激发过程:双电子俘获激发过程、单电子俘获激发过程和直接激发过程。给出了HeI,HeII,NeI,NeII和ArI,ArII谱线的发射截面,并对He2++Ne和He2++Ar两个碰撞体系的发射截面作了一些比较,发现在入射离子速度相同的情况下,后者的发射截面要比前者大得多,并对此进行了定性讨论。OMA的光谱波长范围为200—800nm。入射离子He2+的能量范围为140—340keV。 | | 刘家瑞,雷子明,杨锋,潘广炎,于德洪,孙湘. | 单、双电荷离子与原子碰撞中的激发态和发射截面比较 | 物理学报 | 1988 |
| 08 | 1254-1259 | 本文给出了单、双电荷离子和He,Ne,Ar,碰撞过程中产生的激发态的实验结果。Heq+,Arq+（q=1,2）离子束实验室能量为（70—170）×qkeV。光学测量由光学多道分析系统（OMA）完成,波长范围为200—800nm。观察到单、双电荷离子和原子碰撞中各种不同的激发过程,讨论了发射截面和入射离子电荷数、势能亏损的依赖关系。 | | 潘广炎,雷子明,刘家瑞. | 离子和原子碰撞发射光谱 | 光谱学与光谱分析 | 1988 |
| 04 | 5-10 | 本实验利用光学多道分析系统（OMA）对He++Ne,He++Ar,Ne++He,Ne++Ar,Ar++He和Ar++Ne六个碰撞体系的发射光谱进行了测量,并对这些离子和原子碰撞过程中所产生的激发态进行了研究。实验证明:在六个碰撞体系中都存在着两个激发过程,一是电子俘获激发过程,另一是直接激发过程。本文还说明了从测量得到的发射光谱,由标准光源定标,可以确定绝对发射截面和激发截面,以及可以研究粒子数反转控制,寻找新的激光光源。 | | 刘家瑞,潘广炎,雷子明. | Ar<sup>+</sup>离子和He、Ne原子碰撞过程中的激发态和发射截面 | 原子与分子物理学报 | 1988 |
| 02 | 729-740 | 在Ar+离子和He、Ne原子碰撞中,存在着两种激发过程;一种是电子俘获激发过程,另一种是直接激发过程。本实验用光学多道分析系统（OMA）对所产生的丰富的光谱信息进行了光学测量,得到了ArⅠ、ArⅡ、NeⅠNeⅡ和HeⅠ的发射光谱,并分别给出了上述谱线的发射截面。 | | 刘家瑞,朱沛然,封爱国,李大万. | F离子弹性反冲法分析固体中H的深度分布 | 物理学报 | 1988 |
| 01 | 71-76 | 本文报道7—8MeVl4+离子弹性反冲法（ERD）分析固体中H的深度分布。实验和理论分析表明,近表面处的深度分辨率为200—300A。探讨了散射几何条件和入射能量等的最佳化问题。比较了同一样品用F离子ERD法与6.4MeV 1H(19F,αγ)15O核反应法（NRA）的测试结果。表明F离子ERD法是快速（5—10min）、低辐照（5—10μC）、深度分辨和灵敏度较好的分析固体中H的深度分布的一种方法。 | | 于桂菊,刘家瑞,邢磊,汪端伟. | 束箔激发的Li、B原子的非各向同性研究 | 原子与分子物理学报 | 1987 |
| 02 | 439-448 | 我们在900KeV的能量下对束箔激发的LiⅡ3d3D-4f3F(4672（?）)、LiⅢ4f2F-5g2G(4499（?）)和BⅢ4d2D-5f2F°(4487（?）)（可能还混有BⅢ4f2F-5g2G跃迁）这几条跃迁强线的圆偏振分量随箔倾角的变化进行了测量。结果清楚地说明了箔的宏观对称性在微观领域同样起着十分重要的作用,并且与公认的Band模型符合得很好。测量结果还显示出了对跃迁上能级角动量的明显的依赖性。 | | 雷子明,刘家瑞,潘广炎. | He<sup>+</sup>离子和Ne原子碰撞过程中激发态的研究 | 物理学报 | 1987 |
| 04 | 533-539 | 在He+离子和Ne原子碰撞过程中,我们发现两种碰撞激发过程,一种是电子俘获激发过程,另一种是直接激发过程。本实验用光学多道分析系统（OMA）对这些过程进行了光学测量,给出了发射截面数据。入射离子实验室能量范围为70—150keV。 | | 潘广炎,雷子明,刘家瑞. | Ne<sup>+</sup>离子和He原子碰撞过程中激发态的研究 | 原子与分子物理学报 | 1987 |
| 01 | 359-366 | 在Ne+和He碰撞过程的研究中,测量了NeⅠ、NeⅡ以及HeⅠ主量子数3～4的单态和三重态的发射截面。实验证明:此碰撞体系存在着两种激发过程,一种是电子俘获激发过程,另一种是直接激发过程,即电子组态重新排列激发过程。入射离子Ne+的实验室能量范围为70～150KeV° | | 雷子明,刘家瑞,潘广炎. | Ne<sup>+</sup>离子和Ar原子碰撞过程中激发态的研究 | 原子与分子物理学报 | 1987 |
| 01 | 367-376 | 在离子Ne+和原子Ar碰撞过程的研究中,测量了NeⅠ、NeⅡ的发射截面,以及ArⅠ、ArⅡ发射截面,并把本实验结果同Ne+离子和He原子碰撞体系进行了比较,发现本实验得到的发射截面大得多,而且入射离子Ne+的速度在0.37～0.55原子单位范围内,这个差别随入射离子速度的增加而增大。 | | 潘广炎,雷子明,刘家瑞. | He<sup>+</sup>离子和Ar原子碰撞过程中激发态的研究 | 物理学报 | 1987 |
| 03 | 301-307 | 在He+离子和Ar原子碰撞过程中,同样存在着电子俘获激发和直接激发两种过程。本文把实验结果同He+离子和Ne原子碰撞体系进行了比较,发现:在入射离子速度较小时,实验所得到的Hel三重态发射截面要大得多;当入射离子He+的速度大于一个原子单位（2.2×10～8cm/s）时,情况则相反。因此,在俘获电子过程中,势能亏损同He+离子的入射速度是两个非常重要的因素,而且它们之间存在一个竞争过程。入射离子He+的能量范围为70—150keV。 | | 刘家瑞,章其初. | 质子在α-LiIO<sub>3</sub>单晶中的沟道效应研究 | 物理学报 | 1987 |
| 01 | 54-59 | 利用MeV能量的准直质子束,在不同的质子能量下,测定了α-LiIO3单晶向的轴沟道参数角度半宽度ψ1/2和产额极小值χmin。在向静电场作用卞,首次观察到入射质子与表面处的Ⅰ原子沟道-背散射产额随电场作用时间而增加,并定量计算了表面无序Ⅰ原子数随静电场作用时间的关系。另外,入射质子与7Li原子沟道-核反应[7Li（p,α）4He]产生的α粒子产额也随电场作用时间而增加。 | | 潘广炎,雷子明,刘家瑞. | 离子和原子碰撞发射谱 | 量子电子学 | 1986 |
| 04 | 333-334 | 在离子和原子碰撞过程中,所产生的信息是非常丰富的,这引起了物理学家的极大兴趣,特别是对碰撞过程中的激发态更引人注意。因为人们一旦发现上能级的激发截面大于下能级激发截面,就说明有粒子数反转的机制存在,就是说找到了新的激光谱线。 最近,我们利用光学多道分析系统(Optical Multichannel Analysis System简称 | | 章其初,刘家瑞. | 在直流电场作用下α-LiIO<sub>3</sub>单晶的沟道行为 | 科学通报 | 1986 |
| 24 | 1864-1866 | a-LiIO3晶体是一种离子导体,加上c向静电场后,已观察到一系列的异常现象,如中子衍射增强,光衍射增强。因此,引起人们极大注意。在c向静电场作用下,a-LilO3单晶的沟道效应研究也有报道,但没有观察到沟道行为的变化。本工作用MeV能量的质子束,较精密地测定了a-LiIO3单晶轴沟道参数角度半宽度（?）1/2和产额极小值xmin。在c向静电场作用下,已观察到轴沟道行为的变化,并进行了定量计算和物理解释。 | | 郗小星,冉启泽,刘家瑞,管惟炎. | 用于液氦温区离子注入的低温装置 | 低温物理学报 | 1986 |
| 04 | 308-311 | 本文报道一种用于液氦温区离子注入的低温装置。利用它可以在T | | 朱沛然,刘家瑞. | 快离子束激光光谱技术 | 原子与分子物理学报 | 1986 |
| 02 | 169-174 | 本文阐述了快离子束激光光谱技术的发展及其特点,简要介绍了分子离子光碎片光谱、高分辨光谱和时间分辨光谱。 | | 赵光林,刘家瑞,周俊思,郑家祺,陈熙琛,王祖仑,郗小星,李政孝,管惟炎. | 液氮温度下Si<sup>+</sup>离子注入对急冷Al-Si-Ge合金超导电性的影响 | 低温物理 | 1984 |
| 01 | 20-22 | 本文报道,在液氮温度下Si+离子注入对急冷Al-Si-Ge合金超导电性的影响。结果表明,经低温离子注入后的样品,存在一个Tc更高的超导转变。 | | 刘家瑞,于桂菊,刘万银,汪端伟,刘汉鹏,孙寅官,尚世铉. | 碳的束箔光谱、能级寿命和跃迁几率 | 核技术 | 1983 |
| 02 | 22-24+73-74 | 碳离子是高温等离子体中主要的杂质之一,在用光学方法测定高温等离子体中杂质浓度和分布时能级寿命参数带来很大的不确定性和误差。我们将用束箔光谱方法对高温等离子体有关杂质光谱能级寿命和跃迁几率进行研究,这里只给出碳的束箔光谱研究的初步结果。 | | 章其初,郑宗爽,刘家瑞. | 采用氢原子束测定空心阴极放电管中等离子体密度 | 科学通报 | 1982 |
| 14 | 845-847 | 最近十几年来,采用各种粒子束诊断等离子体的研究发展很快。其中利用中性原子束通过等离子体后的衰减,可测量等离子体的线密度。该方法的优点是测定等离子体参数具有良好的空间分辨和时间分辨,且对等离子体没有扰动。 本工作是用几KeV能量的氢原子束通过空心阴极放电产生的氢等离子体后的衰减,测定质子线密度。束的衰减主要是由于氢原子与等离子体中的质子之间电荷交换反应引起。能有效地测定质子线密度的范围是从7×1013到2×1015cm-2。 | | 任孟眉,封爱国,朱沛然,刘家瑞,李大万. | 弹性反冲分析实验参数的计算与优化 | 核技术 | 1991 |
| 01 | 8-12 | 本文所介绍的优化程序用以选择弹性反冲分析的最佳实验条件,这对于在低能范围内用小型加速器来分析固体中轻元素的分布极为有用。 | | 王佩璇, 李玉璞, 刘家瑞, 倪然夫. | 金属中氦的特性及不锈钢氦脆问題 | 核科学与工程 | 1989 |
| 02 | 119-130+4 | 本文综述了有关金属中的氦的国外文献,扼要介绍了研究概况及目前水平,着重讨论了金属中氦的形态、迁移及分布特点,以及其宏观效应和不锈钢氦脆问题。文中还包括了作者对316L型不锈钢的部分研究成果。 | | 刘家瑞,周俊思,李玉璞,吴桢. | 离子注入用高低温变温靶室 | 核技术 | 1988 |
| 02 | 41-42+44-63 | 本文介绍了一个在77-800K范围可变温度下进行离子注入和就地电学测量的靶室。该靶室曾为金属、硅化物以及某些超导材料的离子束混合实验在10W左右的束流功率下使用了几年,温度漂移在±3K。 | | 杨锋,刘家瑞. | 离子注入、分析联用靶室 | 核技术 | 1987 |
| 12 | 41-43+60-61 | 近年来,离子注入和离子束分析技术,应用相当广泛,已扩展到许多新的领域,形成了一种多学科性的边缘学科。 离子注入已作为一种成熟的技术广泛地应用在半导体工业上,在半导体制造工艺方面,它比传统的热扩散法显示出多方面的优越性。同时在材料改性方面也引起人们的极大兴趣,许多金属部件在实际使用时起作用的是金属表面的性质,而离子注入正好是能够改变金属表面性质(如硬度、磨损、腐蚀等)的有效途径。此外,离子注入技术用来改变光学表面指定区域的反射率、折射率,这在“集成光学”中是一项有效技术,也有人利用离子注入技术研制记忆元件(如磁泡)以及提高超导材料的超导性能等。 | | 简佩薰, 王龙, 任育锋, 郑少白, 刘家瑞, 刘春成, 李志敏. | CT-6托卡马克装置上的质谱测量 | 核聚变 | 1980 | 1 | 03 | 205-210 | 一、引言由于研究受控核聚变装置中杂质和表面问题的兴趣日益增进,质谱测量已成为研究托卡马克装置中等离子体和壁相互作用的必要手段。在一些装置上已进行了这一工作。在 CT-6托卡马克装置运转初期,曾用回旋质谱计对系统的残余气体成份进行过分析。本文则总结该装置换上新真空室后,用四极质谱计和小质谱计进行质谱测量的结果。这些测量主要可以分为两类:一类是随着烘烤,放电清洗的进展,系统残余气体质谱的变化;另一类是放电前后质谱随时间的瞬态变化。 |
| Author-作者 | Title-题名 | Editor-主编 | 会议录名称 | 主办单位 | 学会名称 | PageCount-页码 | 摘要 | | 黎明, 何俊, 杨铮, 周霖, 刘传胜, 郭立平, 蒋昌忠, 杨世柏, 刘家瑞, J.C.Lee, 付德君, 范湘军. | 加速器-电镜联机装置及其应用研究 |
| 中国核科学技术进展报告——中国核学会2009年学术年会论文集（第一卷·第6册） | 中国核学会 |
| 467-476 | 在武汉大学建立了我国首台加速器—电镜联机装置,该装置由美国GIC 2×1.7MV串列加速器、国产200kV离子注入机和日立H800型透射电镜组成,经自行设计的离子传输管道进行了联机实验,离子传输系统用LEADS软件进行了光路优化。来自串列加速器的离子束经开关磁铁后直接进入联机离子光路;来自离子注入机的离子束经90°磁偏转、磁四极透镜聚焦进入联机光路,直至电镜样品。用离子注入机进行了气体离子引入电镜及单晶Si、GaAs、Ag纳米晶和超临界反应堆材料（C276和6XN）的离子注入辐照实验。束流调试表明,115keV氮离子在电镜入口测得束流强度达180nA,电镜样品可在倾斜52°条件下进行离子辐照。加速器、离子注入机、透射电镜即可独立运行,互不影响,也可联机运行,满足注入样品原位观测微结构变化的要求。对单晶Si和Ag纳米晶样品的离子注入的原位结构观测结果表明,样品在注入至一定剂量时发生明显的多晶和非晶化,单晶Si出现非晶化的临界剂量在10<sup>14</sup>cm<sup>-2</sup>。C276材料经1×10<sup>15</sup>cm<sup>-2</sup>的Ar离子辐照后,产生尺寸3～12nm的位错环,其密度随剂量的提高而增大,至5×10<sup>15</sup>cm<sup>-2</sup>出现多晶,剂量超过3×10<sup>16</sup>cm<sup>-2</sup>出现非晶化。在加速器-电镜联机光路上安装有在线RBS靶室,用对离子束辐照的材料进行元素成分和晶格定位测试。在靠近电镜端安装有50kV低能离子源,用于开展核材料中氦泡形成过程的原位观测。 | | 刘传胜, 黎明, 何俊, 杨铮, 周霖, 王泽松, 郭立平, 蒋昌忠, 杨世柏, 刘家瑞, J.C.Lee, 付德君, 范湘军. | 加速器联机装置运行状况 |
| 2010全国荷电粒子源、粒子束学术会议论文集 | 中国电工技术学会电子束离子束专业委员会、中国电子学会焊接专业委员会、粒子加速器学会离子源专业组、中国机械工程学会焊接分会高能束焊接专业委员会、北京电机工程学会加速器专业委员会 |
| 43-53 | 武汉大学加速器联机系统于2008年初步建成,200kV离子注入机至透射电镜束线进行了运行调试,开展了气体离子注入单晶Si、GaAs、Ag纳米晶和超临界反应堆材料（C276和6XN）的原位结构研究。结果表明,样品在注入至一定剂量时发生明显的多晶和非晶化,单晶Si出现非晶化的临界剂量在1014 cm<sup>-2</sup>。C276材料经1×1015cm-2的Ar离子辐照后,产生尺寸3-12nm的位错环,其密度随剂量的提高而增大,至5×1015cm-2出现多晶,剂量超过3×1016cm-2出现非晶化。在加速器-电镜联机光路上安装有在线RBS靶室,用于对离子束辐照的材料进行元素成分和晶格定位测试。在靠近电镜端安装有50kV低能离子源,用于开展核材料中氦泡形成过程的原位观测。对RBS/C装置进行了数字化改造,用Labview控制系统运行,目前可进行计算机控制的背散射沟道测试。 |
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